Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5501
Gene name Gene Name - the full gene name approved by the HGNC.
Protein phosphatase 1 catalytic subunit gamma
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PPP1CC
Synonyms (NCBI Gene) Gene synonyms aliases
PP-1G, PP1C, PPP1G
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12q24.11
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene belongs to the protein phosphatase family, PP1 subfamily. PP1 is an ubiquitous serine/threonine phosphatase that regulates many cellular processes, including cell division. It is expressed in mammalian cells as three close
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT028665 hsa-miR-30a-5p Proteomics 18668040
MIRT050065 hsa-miR-26a-5p CLASH 23622248
MIRT050049 hsa-miR-26b-5p CLASH 23622248
MIRT049174 hsa-miR-92a-3p CLASH 23622248
MIRT046498 hsa-miR-15b-5p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000164 Component Protein phosphatase type 1 complex IEA
GO:0000777 Component Condensed chromosome kinetochore IEA
GO:0000781 Component Chromosome, telomeric region IDA 24270157
GO:0003723 Function RNA binding HDA 22681889
GO:0004721 Function Phosphoprotein phosphatase activity TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
176914 9283 ENSG00000186298
Protein
UniProt ID P36873
Protein name Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G) (EC 3.1.3.16) (Protein phosphatase 1C catalytic subunit)
Protein function Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets (PubMed:17936702, PubMed:25012651). Protein phosphatase 1 (PP1) is essential for cell
PDB 1IT6 , 1JK7 , 1U32 , 2BCD , 2BDX , 4UT2 , 4UT3 , 5INB , 5J28 , 7SD0 , 8B5R
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF16891 STPPase_N 9 56 Serine-threonine protein phosphatase N-terminal domain Family
PF00149 Metallophos 57 252 Calcineurin-like phosphoesterase Domain
Sequence
Sequence length 323
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Bipolar Disorder Bipolar Disorder GWAS
Schizophrenia Schizophrenia GWAS
Associations from Text Mining
Disease Name Relationship Type References
Breast Neoplasms Associate 34964699
Carcinoma Non Small Cell Lung Associate 33106373
Death Associate 26720340
Myasthenia Gravis Associate 25705681
Neoplasms Associate 16630891, 26720340