Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10891
Gene name Gene Name - the full gene name approved by the HGNC.
PPARG coactivator 1 alpha
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PPARGC1A
Synonyms (NCBI Gene) Gene synonyms aliases
LEM6, PGC-1(alpha), PGC-1alpha, PGC-1v, PGC1, PGC1A, PPARGC1
Chromosome Chromosome number
4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4p15.2
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protei
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT006280 hsa-miR-23a-3p Luciferase reporter assay 22318941
MIRT006280 hsa-miR-23a-3p Luciferase reporter assay 22318941
MIRT006280 hsa-miR-23a-3p Luciferase reporter assay 22318941
MIRT006280 hsa-miR-23a-3p Luciferase reporter assay 22318941
MIRT006280 hsa-miR-23a-3p Luciferase reporter assay 22318941
Transcription factors
Transcription factor Regulation Reference
CRTC1 Activation 10893434
MEF2A Unknown 18222924
MITF Activation 23416000
TP53 Unknown 19139068
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000302 Process Response to reactive oxygen species IEA
GO:0000422 Process Autophagy of mitochondrion IEA
GO:0000785 Component Chromatin IC 27471003
GO:0001659 Process Temperature homeostasis TAS 1258810
GO:0001678 Process Cellular glucose homeostasis NAS 11854298
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
604517 9237 ENSG00000109819
Protein
UniProt ID Q9UBK2
Protein name Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1-alpha) (PPAR-gamma coactivator 1-alpha) (PPARGC-1-alpha) (Ligand effect modulator 6)
Protein function Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:10713165, PubMed:20005308, PubMed:21376232, PubMed:28363985, PubMed:32433991). Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor o
PDB 1XB7 , 3B1M , 3CS8 , 3D24 , 3U9Q , 3V9T , 3V9V , 4QJR , 4QK4 , 5Q0I , 5TWO , 5UNJ , 5Z5S , 5Z6S , 6AD9 , 6FZF , 6FZP , 6IZM , 6IZN , 6K0T , 6KXX , 6KXY , 6LN4 , 6MS7 , 6NWK , 6NWL , 6T1V , 6W9K , 6W9L , 7E2E , 7KHT , 7PRV , 7PRW , 7PRX , 8BF1 , 8DK4 , 9F7W , 9F7X
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00076 RRM_1 679 742 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Domain
Tissue specificity TISSUE SPECIFICITY: Heart, skeletal muscle, liver and kidney. Expressed at lower levels in brain and pancreas and at very low levels in the intestine and white adipose tissue. In skeletal muscle, levels were lower in obese than in lean subjects and fastin
Sequence
MAWDMCNQDSESVWSDIECAALVGEDQPLCPDLPELDLSELDVNDLDTDSFLGGLKWCSD
QSEIISNQYNNEPSNIFEKIDEENEANLLAVLTETLDSLPVDEDGLPSFDALTDGDVTTD
NEASPSSMPDGTPPPQEAEEPSLLKKLLLAPANTQLSYNECSGLSTQNHANHNHRIRTNP
AIVKTENSWSNKAKSICQQQKPQRRPCSELLKYLTTNDDPPHTKPTENRNSSRDKCTSKK
KSHTQSQSQHLQAKPTTLSLPLTPESPNDPKGSPFENKTIERTLSVELSGTAGLTPPTTP
PHKANQDNPFRASPKLKSSCKTVVPPPSKKPRYSESSGTQGNNSTKKGPEQSELYAQLSK
SSVLTGGHEERKTKRPSLRLFGDHDYCQSINSKTEILINISQELQDSRQLENKDVSSDWQ
GQICSSTDSDQCYLRETLEASKQVSPCSTRKQLQDQEIRAELNKHFGHPSQAVFDDEADK
TGELRDSDFSNEQFSKLPMFINSGLAMDGLFDDSEDESDKLSYPWDGTQSYSLFNVSPSC
SSFNSPCRDSVSPPKSLFSQRPQRMRSRSRSFSRHRSCSRSPYSRSRSRSPGSRSSSRSC
YYYESSHYRHRTHRNSPLYVRSRSRSPYSRRPRYDSYEEYQHERLKREEYRREYEKRESE
RAKQRERQRQKAIEERRVIYVGKIRPDTTRTELRDRFEVFGEIEECTVNLRDDGDSYGFI
TYRYTCDAFAALENGYTLRRSN
ETDFELYFCGRKQFFKSNYADLDSNSDDFDPASTKSKY
DSLDFDSLLKEAQRSLRR
Sequence length 798
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Schizophrenia Schizophrenia GWAS
Gout Gout GWAS
Pulmonary Emphysema Pulmonary Emphysema GWAS
Neuroticism Neuroticism GWAS
Associations from Text Mining
Disease Name Relationship Type References
Acidosis Inhibit 26656911
Acute Kidney Injury Associate 29268263
Adenocarcinoma Associate 36103249
Adenocarcinoma Follicular Associate 21454643
Adenocarcinoma of Lung Associate 25331784
Adrenal Hyperplasia Congenital Associate 34373561
AIDS Associated Nephropathy Inhibit 31238091
Alopecia Associate 35279334
Alzheimer Disease Inhibit 22077634
Alzheimer Disease Associate 31081111, 31283791, 40642087