Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs Transcription factors Other IDs
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	5423
Gene name Gene Name - the full gene name approved by the HGNC.	DNA polymerase beta
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	POLB
Synonyms (NCBI Gene) Gene synonyms aliases	-
Chromosome Chromosome number	8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	8p11.21
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a DNA polymerase involved in base excision and repair, also called gap-filling DNA synthesis. The encoded protein, acting as a monomer, is normally found in the cytoplasm, but it translocates to the nucleus upon DNA dam

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miRTarBase ID	miRNA	Experiments	Reference
MIRT051150	hsa-miR-16-5p	CLASH	23622248
MIRT035975	hsa-miR-1301-3p	CLASH	23622248

Transcription factors

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Transcription factor	Regulation	Reference
ATF2	Activation	10518804

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GO ID	Ontology	Definition	Evidence	Reference
GO:0001701	Process	In utero embryonic development	IEA
GO:0003684	Function	Damaged DNA binding	IEA
GO:0003887	Function	DNA-directed DNA polymerase activity	IBA	21873635
GO:0003887	Function	DNA-directed DNA polymerase activity	IDA	9207062, 16600869
GO:0003887	Function	DNA-directed DNA polymerase activity	TAS
GO:0003906	Function	DNA-(apurinic or apyrimidinic site) endonuclease activity	TAS
GO:0005515	Function	Protein binding	IPI	9207062, 15520167, 25260657, 25416956, 25910212, 26496610, 28514442, 31515488, 32814053
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005634	Component	Nucleus	IDA	19713937, 21362556
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IDA	15725623, 19713937, 21362556
GO:0005874	Component	Microtubule	IDA	15725623
GO:0005876	Component	Spindle microtubule	IDA	15725623
GO:0006261	Process	DNA-dependent DNA replication	TAS	8168825
GO:0006281	Process	DNA repair	TAS	8168825
GO:0006284	Process	Base-excision repair	IBA	21873635
GO:0006284	Process	Base-excision repair	IDA	16600869
GO:0006284	Process	Base-excision repair	IMP	21362556
GO:0006286	Process	Base-excision repair, base-free sugar-phosphate removal	TAS
GO:0006287	Process	Base-excision repair, gap-filling	IEA
GO:0006288	Process	Base-excision repair, DNA ligation	TAS
GO:0006290	Process	Pyrimidine dimer repair	IEA
GO:0006297	Process	Nucleotide-excision repair, DNA gap filling	IMP	20227374
GO:0006303	Process	Double-strand break repair via nonhomologous end joining	IBA	21873635
GO:0006954	Process	Inflammatory response	IEA
GO:0006974	Process	Cellular response to DNA damage stimulus	IMP	21362556
GO:0007435	Process	Salivary gland morphogenesis	IEA
GO:0007568	Process	Aging	IEA
GO:0008017	Function	Microtubule binding	IDA	15725623
GO:0008630	Process	Intrinsic apoptotic signaling pathway in response to DNA damage	IEA
GO:0010332	Process	Response to gamma radiation	IEA
GO:0016446	Process	Somatic hypermutation of immunoglobulin genes	IEA
GO:0016579	Process	Protein deubiquitination	TAS
GO:0016829	Function	Lyase activity	IDA	16600869
GO:0019899	Function	Enzyme binding	IPI	16600869, 19713937, 21362556
GO:0032991	Component	Protein-containing complex	IDA	25378300
GO:0045471	Process	Response to ethanol	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0048535	Process	Lymph node development	IEA
GO:0048536	Process	Spleen development	IEA
GO:0048872	Process	Homeostasis of number of cells	IEA
GO:0051402	Process	Neuron apoptotic process	IEA
GO:0055093	Process	Response to hyperoxia	IEA
GO:0071707	Process	Immunoglobulin heavy chain V-D-J recombination	IEA
GO:0071897	Process	DNA biosynthetic process	IEA

MIM	HGNC	e!Ensembl
174760	9174	ENSG00000070501

Protein

UniProt ID

P06746

Protein name

DNA polymerase beta (EC 2.7.7.7) (5'-deoxyribose-phosphate lyase) (5'-dRP lyase) (EC 4.2.99.-) (AP lyase) (EC 4.2.99.18)

Protein function

Repair polymerase that plays a key role in base-excision repair (PubMed:10556592, PubMed:9207062, PubMed:9572863). During this process, the damaged base is excised by specific DNA glycosylases, the DNA backbone is nicked at the abasic site by an

PDB

1BPX , 1BPY , 1BPZ , 1MQ2 , 1MQ3 , 1TV9 , 1TVA , 1ZJM , 1ZJN , 1ZQA , 1ZQB , 1ZQC , 1ZQD , 1ZQE , 1ZQF , 1ZQG , 1ZQH , 1ZQI , 1ZQJ , 1ZQK , 1ZQL , 1ZQM , 1ZQN , 1ZQO , 1ZQP , 1ZQQ , 1ZQR , 1ZQS , 1ZQT , 2FMP , 2FMQ , 2FMS , 2I9G , 2ISO , 2ISP , 2P66 , 2PXI , 3C2K , 3C2L , 3C2M , 3GDX , 3ISB , 3ISC , 3ISD , 3JPN , 3JPO , 3JPP , 3JPQ , 3JPR , 3JPS , 3JPT

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF14716	HHH_8	12 → 78	Helix-hairpin-helix domain	Domain
PF10391	DNA_pol_lambd_f	98 → 147	Fingers domain of DNA polymerase lambda	Domain
PF14792	DNA_pol_B_palm	149 → 262	DNA polymerase beta palm	Domain
PF14791	DNA_pol_B_thumb	268 → 334	DNA polymerase beta thumb	Family

Sequence

MSKRKAPQETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAK
KLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIK
TLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGS
FRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQ
LPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRP
LGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE

Sequence length

335

Interactions

View interactions

POLB (DNA polymerase beta)