Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs Other IDs Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	51196
Gene name Gene Name - the full gene name approved by the HGNC.	Phospholipase C epsilon 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PLCE1
Synonyms (NCBI Gene) Gene synonyms aliases	NPHS3, PLCE, PPLC
Disease Acronyms (UniProt) Disease acronyms from UniProt database	NPHS3
Chromosome Chromosome number	10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	10q23.33
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a phospholipase enzyme that catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate to generate two second messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). These second messengers subsequently regulate va

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SNP ID	Visualize variation	Clinical significance	Consequence
rs121912601	C>T	Pathogenic	Stop gained, coding sequence variant
rs121912602	C>G,T	Pathogenic	Stop gained, missense variant, coding sequence variant
rs121912604	C>T	Pathogenic	Genic downstream transcript variant, stop gained, coding sequence variant
rs121912605	C>T	Pathogenic	Missense variant, coding sequence variant
rs267606954	C>T	Pathogenic	Coding sequence variant, genic upstream transcript variant, stop gained
rs267606955	C>A,G,T	Pathogenic	Coding sequence variant, stop gained, synonymous variant, missense variant
rs752029771	G>T	Likely-pathogenic	Coding sequence variant, missense variant
rs762245091	A>G	Likely-pathogenic	Coding sequence variant, missense variant
rs775052849	C>A,T	Pathogenic	Coding sequence variant, synonymous variant, stop gained, genic downstream transcript variant
rs876657369	G>-	Pathogenic	Coding sequence variant, frameshift variant, genic upstream transcript variant
rs876657370	G>-	Pathogenic	Coding sequence variant, frameshift variant
rs895782232	C>T	Pathogenic	Coding sequence variant, stop gained
rs1589413498	G>A	Pathogenic	Coding sequence variant, stop gained
rs1589433172	T>C	Likely-pathogenic	Coding sequence variant, missense variant
rs1589509476	T>G	Likely-pathogenic	Genic downstream transcript variant, coding sequence variant, stop gained

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miRTarBase ID	miRNA	Experiments	Reference
MIRT017291	hsa-miR-335-5p	Microarray	18185580
MIRT024850	hsa-miR-215-5p	Microarray	19074876
MIRT026288	hsa-miR-192-5p	Microarray	19074876
MIRT713660	hsa-miR-5000-5p	HITS-CLIP	19536157
MIRT713659	hsa-miR-584-3p	HITS-CLIP	19536157
MIRT713658	hsa-miR-4277	HITS-CLIP	19536157
MIRT713657	hsa-miR-605-3p	HITS-CLIP	19536157
MIRT713656	hsa-miR-4493	HITS-CLIP	19536157
MIRT713655	hsa-miR-6126	HITS-CLIP	19536157
MIRT713654	hsa-miR-3611	HITS-CLIP	19536157
MIRT713660	hsa-miR-5000-5p	HITS-CLIP	19536157
MIRT713659	hsa-miR-584-3p	HITS-CLIP	19536157
MIRT713658	hsa-miR-4277	HITS-CLIP	19536157
MIRT713657	hsa-miR-605-3p	HITS-CLIP	19536157
MIRT713656	hsa-miR-4493	HITS-CLIP	19536157
MIRT713655	hsa-miR-6126	HITS-CLIP	19536157
MIRT713654	hsa-miR-3611	HITS-CLIP	19536157
MIRT607402	hsa-miR-8485	HITS-CLIP	23313552
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	23313552
MIRT614869	hsa-miR-4789-3p	HITS-CLIP	23313552
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	23313552
MIRT607399	hsa-miR-4269	HITS-CLIP	23313552
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	23313552
MIRT607402	hsa-miR-8485	HITS-CLIP	23313552
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	23313552
MIRT614869	hsa-miR-4789-3p	HITS-CLIP	23313552
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	23313552
MIRT607399	hsa-miR-4269	HITS-CLIP	23313552
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	23313552
MIRT607402	hsa-miR-8485	HITS-CLIP	23824327
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT607399	hsa-miR-4269	HITS-CLIP	23824327
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT674694	hsa-miR-490-3p	HITS-CLIP	23824327
MIRT674693	hsa-miR-34b-3p	HITS-CLIP	23824327
MIRT674692	hsa-miR-7851-3p	HITS-CLIP	23824327
MIRT674691	hsa-miR-6808-5p	HITS-CLIP	23824327
MIRT674690	hsa-miR-6893-5p	HITS-CLIP	23824327
MIRT674689	hsa-miR-940	HITS-CLIP	23824327
MIRT674688	hsa-miR-3929	HITS-CLIP	23824327
MIRT674687	hsa-miR-4419b	HITS-CLIP	23824327
MIRT674686	hsa-miR-4478	HITS-CLIP	23824327
MIRT674685	hsa-miR-3614-5p	HITS-CLIP	23824327
MIRT674684	hsa-miR-6500-3p	HITS-CLIP	23824327
MIRT674683	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT614866	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT674682	hsa-miR-3192-5p	HITS-CLIP	23824327
MIRT674681	hsa-miR-1827	HITS-CLIP	23824327
MIRT674680	hsa-miR-6134	HITS-CLIP	23824327
MIRT674679	hsa-miR-377-5p	HITS-CLIP	23824327
MIRT674678	hsa-miR-6086	HITS-CLIP	23824327
MIRT674677	hsa-miR-4722-5p	HITS-CLIP	23824327
MIRT674676	hsa-miR-7160-5p	HITS-CLIP	23824327
MIRT674675	hsa-miR-3689d	HITS-CLIP	23824327
MIRT674674	hsa-miR-6851-5p	HITS-CLIP	23824327
MIRT674673	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT674672	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT674671	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT674670	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT674669	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT674668	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT674667	hsa-miR-6880-5p	HITS-CLIP	23824327
MIRT674666	hsa-miR-7847-3p	HITS-CLIP	23824327
MIRT674665	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT674664	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT674663	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT674662	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT674661	hsa-miR-3689c	HITS-CLIP	23824327
MIRT674659	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT674660	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT674658	hsa-miR-665	HITS-CLIP	23824327
MIRT607402	hsa-miR-8485	HITS-CLIP	23824327
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT614869	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT607399	hsa-miR-4269	HITS-CLIP	23824327
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT614868	hsa-miR-4324	HITS-CLIP	23824327
MIRT614867	hsa-miR-544b	HITS-CLIP	23824327
MIRT614860	hsa-miR-1200	HITS-CLIP	23824327
MIRT607402	hsa-miR-8485	HITS-CLIP	23824327
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT614869	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT607399	hsa-miR-4269	HITS-CLIP	23824327
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT614868	hsa-miR-4324	HITS-CLIP	23824327
MIRT614867	hsa-miR-544b	HITS-CLIP	23824327
MIRT614866	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT614865	hsa-miR-3975	HITS-CLIP	23824327
MIRT614864	hsa-miR-2467-5p	HITS-CLIP	23824327
MIRT614863	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT614862	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT614861	hsa-miR-3188	HITS-CLIP	23824327
MIRT614860	hsa-miR-1200	HITS-CLIP	23824327
MIRT645795	hsa-miR-4438	HITS-CLIP	23824327
MIRT645794	hsa-miR-1913	HITS-CLIP	23824327
MIRT645793	hsa-miR-324-3p	HITS-CLIP	23824327
MIRT645792	hsa-miR-18a-3p	HITS-CLIP	23824327
MIRT645791	hsa-miR-4653-3p	HITS-CLIP	23824327
MIRT645790	hsa-miR-6807-5p	HITS-CLIP	23824327
MIRT607402	hsa-miR-8485	HITS-CLIP	23824327
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT614869	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT607399	hsa-miR-4269	HITS-CLIP	23824327
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT614868	hsa-miR-4324	HITS-CLIP	23824327
MIRT614867	hsa-miR-544b	HITS-CLIP	23824327
MIRT614866	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT614865	hsa-miR-3975	HITS-CLIP	23824327
MIRT614864	hsa-miR-2467-5p	HITS-CLIP	23824327
MIRT614863	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT614862	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT614861	hsa-miR-3188	HITS-CLIP	23824327
MIRT614860	hsa-miR-1200	HITS-CLIP	23824327
MIRT607402	hsa-miR-8485	HITS-CLIP	23824327
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT614869	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT607399	hsa-miR-4269	HITS-CLIP	23824327
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT614868	hsa-miR-4324	HITS-CLIP	23824327
MIRT614867	hsa-miR-544b	HITS-CLIP	23824327
MIRT614866	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT614865	hsa-miR-3975	HITS-CLIP	23824327
MIRT614864	hsa-miR-2467-5p	HITS-CLIP	23824327
MIRT614863	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT614862	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT614861	hsa-miR-3188	HITS-CLIP	23824327
MIRT614860	hsa-miR-1200	HITS-CLIP	23824327
MIRT607402	hsa-miR-8485	HITS-CLIP	23824327
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT607399	hsa-miR-4269	HITS-CLIP	23824327
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT607402	hsa-miR-8485	HITS-CLIP	23824327
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT607399	hsa-miR-4269	HITS-CLIP	23824327
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT614868	hsa-miR-4324	HITS-CLIP	23824327
MIRT614867	hsa-miR-544b	HITS-CLIP	23824327
MIRT614866	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT614865	hsa-miR-3975	HITS-CLIP	23824327
MIRT614864	hsa-miR-2467-5p	HITS-CLIP	23824327
MIRT614863	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT614862	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT614861	hsa-miR-3188	HITS-CLIP	23824327
MIRT614860	hsa-miR-1200	HITS-CLIP	23824327
MIRT607402	hsa-miR-8485	HITS-CLIP	23824327
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT607399	hsa-miR-4269	HITS-CLIP	23824327
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT607402	hsa-miR-8485	HITS-CLIP	23824327
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT607399	hsa-miR-4269	HITS-CLIP	23824327
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT607402	hsa-miR-8485	HITS-CLIP	23824327
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT614869	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT607399	hsa-miR-4269	HITS-CLIP	23824327
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT614868	hsa-miR-4324	HITS-CLIP	23824327
MIRT614867	hsa-miR-544b	HITS-CLIP	23824327
MIRT614866	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT614865	hsa-miR-3975	HITS-CLIP	23824327
MIRT614864	hsa-miR-2467-5p	HITS-CLIP	23824327
MIRT614863	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT614862	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT614861	hsa-miR-3188	HITS-CLIP	23824327
MIRT614860	hsa-miR-1200	HITS-CLIP	23824327
MIRT607402	hsa-miR-8485	HITS-CLIP	23824327
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT614869	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT607399	hsa-miR-4269	HITS-CLIP	23824327
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT614868	hsa-miR-4324	HITS-CLIP	23824327
MIRT614867	hsa-miR-544b	HITS-CLIP	23824327
MIRT614866	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT614865	hsa-miR-3975	HITS-CLIP	23824327
MIRT614864	hsa-miR-2467-5p	HITS-CLIP	23824327
MIRT614863	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT614862	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT614861	hsa-miR-3188	HITS-CLIP	23824327
MIRT614860	hsa-miR-1200	HITS-CLIP	23824327
MIRT607402	hsa-miR-8485	HITS-CLIP	24906430
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	24906430
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	24906430
MIRT607399	hsa-miR-4269	HITS-CLIP	24906430
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	24906430
MIRT674681	hsa-miR-1827	PAR-CLIP	27292025
MIRT674682	hsa-miR-3192-5p	PAR-CLIP	27292025
MIRT674693	hsa-miR-34b-3p	PAR-CLIP	27292025
MIRT674693	hsa-miR-34b-3p	PAR-CLIP	27292025
MIRT674685	hsa-miR-3614-5p	PAR-CLIP	27292025
MIRT674685	hsa-miR-3614-5p	PAR-CLIP	27292025
MIRT674675	hsa-miR-3689d	PAR-CLIP	27292025
MIRT674677	hsa-miR-4722-5p	PAR-CLIP	27292025
MIRT674694	hsa-miR-490-3p	PAR-CLIP	27292025
MIRT674694	hsa-miR-490-3p	PAR-CLIP	27292025
MIRT674680	hsa-miR-6134	PAR-CLIP	27292025
MIRT674684	hsa-miR-6500-3p	PAR-CLIP	27292025
MIRT674684	hsa-miR-6500-3p	PAR-CLIP	27292025
MIRT674691	hsa-miR-6808-5p	PAR-CLIP	27292025
MIRT674674	hsa-miR-6851-5p	PAR-CLIP	27292025
MIRT674667	hsa-miR-6880-5p	PAR-CLIP	27292025
MIRT674690	hsa-miR-6893-5p	PAR-CLIP	27292025
MIRT674666	hsa-miR-7847-3p	PAR-CLIP	27292025
MIRT674692	hsa-miR-7851-3p	PAR-CLIP	27292025
MIRT674692	hsa-miR-7851-3p	PAR-CLIP	27292025
MIRT674689	hsa-miR-940	PAR-CLIP	27292025
MIRT607399	hsa-miR-4269	HITS-CLIP	27418678
MIRT607399	hsa-miR-4269	HITS-CLIP	27418678
MIRT607399	hsa-miR-4269	HITS-CLIP	27418678
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	27418678
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	27418678
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	27418678
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	27418678
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	27418678
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	27418678
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	27418678
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	27418678
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	27418678
MIRT607402	hsa-miR-8485	HITS-CLIP	27418678
MIRT607402	hsa-miR-8485	HITS-CLIP	27418678
MIRT607402	hsa-miR-8485	HITS-CLIP	27418678
MIRT607402	hsa-miR-8485	HITS-CLIP	27418678
MIRT607402	hsa-miR-8485	HITS-CLIP	27418678
MIRT607402	hsa-miR-8485	HITS-CLIP	27418678
MIRT713660	hsa-miR-5000-5p	HITS-CLIP	19536157
MIRT713659	hsa-miR-584-3p	HITS-CLIP	19536157
MIRT713658	hsa-miR-4277	HITS-CLIP	19536157
MIRT713657	hsa-miR-605-3p	HITS-CLIP	19536157
MIRT713656	hsa-miR-4493	HITS-CLIP	19536157
MIRT713655	hsa-miR-6126	HITS-CLIP	19536157
MIRT713654	hsa-miR-3611	HITS-CLIP	19536157
MIRT713660	hsa-miR-5000-5p	HITS-CLIP	19536157
MIRT713659	hsa-miR-584-3p	HITS-CLIP	19536157
MIRT713658	hsa-miR-4277	HITS-CLIP	19536157
MIRT713657	hsa-miR-605-3p	HITS-CLIP	19536157
MIRT713656	hsa-miR-4493	HITS-CLIP	19536157
MIRT713655	hsa-miR-6126	HITS-CLIP	19536157
MIRT713654	hsa-miR-3611	HITS-CLIP	19536157
MIRT607402	hsa-miR-8485	HITS-CLIP	23313552
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	23313552
MIRT614869	hsa-miR-4789-3p	HITS-CLIP	23313552
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	23313552
MIRT607399	hsa-miR-4269	HITS-CLIP	23313552
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	23313552
MIRT607402	hsa-miR-8485	HITS-CLIP	23313552
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	23313552
MIRT614869	hsa-miR-4789-3p	HITS-CLIP	23313552
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	23313552
MIRT607399	hsa-miR-4269	HITS-CLIP	23313552
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	23313552
MIRT607402	hsa-miR-8485	HITS-CLIP	23824327
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT607399	hsa-miR-4269	HITS-CLIP	23824327
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT674694	hsa-miR-490-3p	HITS-CLIP	23824327
MIRT674693	hsa-miR-34b-3p	HITS-CLIP	23824327
MIRT674692	hsa-miR-7851-3p	HITS-CLIP	23824327
MIRT674691	hsa-miR-6808-5p	HITS-CLIP	23824327
MIRT674690	hsa-miR-6893-5p	HITS-CLIP	23824327
MIRT674689	hsa-miR-940	HITS-CLIP	23824327
MIRT674688	hsa-miR-3929	HITS-CLIP	23824327
MIRT674687	hsa-miR-4419b	HITS-CLIP	23824327
MIRT674686	hsa-miR-4478	HITS-CLIP	23824327
MIRT674685	hsa-miR-3614-5p	HITS-CLIP	23824327
MIRT674684	hsa-miR-6500-3p	HITS-CLIP	23824327
MIRT674683	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT614866	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT674682	hsa-miR-3192-5p	HITS-CLIP	23824327
MIRT674681	hsa-miR-1827	HITS-CLIP	23824327
MIRT674680	hsa-miR-6134	HITS-CLIP	23824327
MIRT674679	hsa-miR-377-5p	HITS-CLIP	23824327
MIRT674678	hsa-miR-6086	HITS-CLIP	23824327
MIRT674677	hsa-miR-4722-5p	HITS-CLIP	23824327
MIRT674676	hsa-miR-7160-5p	HITS-CLIP	23824327
MIRT674675	hsa-miR-3689d	HITS-CLIP	23824327
MIRT674674	hsa-miR-6851-5p	HITS-CLIP	23824327
MIRT674673	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT674672	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT674671	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT674670	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT674669	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT674668	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT674667	hsa-miR-6880-5p	HITS-CLIP	23824327
MIRT674666	hsa-miR-7847-3p	HITS-CLIP	23824327
MIRT674665	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT674664	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT674663	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT674662	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT674661	hsa-miR-3689c	HITS-CLIP	23824327
MIRT674659	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT674660	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT674658	hsa-miR-665	HITS-CLIP	23824327
MIRT607402	hsa-miR-8485	HITS-CLIP	23824327
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT614869	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT607399	hsa-miR-4269	HITS-CLIP	23824327
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT614868	hsa-miR-4324	HITS-CLIP	23824327
MIRT614867	hsa-miR-544b	HITS-CLIP	23824327
MIRT614860	hsa-miR-1200	HITS-CLIP	23824327
MIRT607402	hsa-miR-8485	HITS-CLIP	23824327
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT614869	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT607399	hsa-miR-4269	HITS-CLIP	23824327
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT614868	hsa-miR-4324	HITS-CLIP	23824327
MIRT614867	hsa-miR-544b	HITS-CLIP	23824327
MIRT614866	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT614865	hsa-miR-3975	HITS-CLIP	23824327
MIRT614864	hsa-miR-2467-5p	HITS-CLIP	23824327
MIRT614863	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT614862	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT614861	hsa-miR-3188	HITS-CLIP	23824327
MIRT614860	hsa-miR-1200	HITS-CLIP	23824327
MIRT645795	hsa-miR-4438	HITS-CLIP	23824327
MIRT645794	hsa-miR-1913	HITS-CLIP	23824327
MIRT645793	hsa-miR-324-3p	HITS-CLIP	23824327
MIRT645792	hsa-miR-18a-3p	HITS-CLIP	23824327
MIRT645791	hsa-miR-4653-3p	HITS-CLIP	23824327
MIRT645790	hsa-miR-6807-5p	HITS-CLIP	23824327
MIRT607402	hsa-miR-8485	HITS-CLIP	23824327
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT614869	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT607399	hsa-miR-4269	HITS-CLIP	23824327
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT614868	hsa-miR-4324	HITS-CLIP	23824327
MIRT614867	hsa-miR-544b	HITS-CLIP	23824327
MIRT614866	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT614865	hsa-miR-3975	HITS-CLIP	23824327
MIRT614864	hsa-miR-2467-5p	HITS-CLIP	23824327
MIRT614863	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT614862	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT614861	hsa-miR-3188	HITS-CLIP	23824327
MIRT614860	hsa-miR-1200	HITS-CLIP	23824327
MIRT607402	hsa-miR-8485	HITS-CLIP	23824327
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT614869	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT607399	hsa-miR-4269	HITS-CLIP	23824327
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT614868	hsa-miR-4324	HITS-CLIP	23824327
MIRT614867	hsa-miR-544b	HITS-CLIP	23824327
MIRT614866	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT614865	hsa-miR-3975	HITS-CLIP	23824327
MIRT614864	hsa-miR-2467-5p	HITS-CLIP	23824327
MIRT614863	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT614862	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT614861	hsa-miR-3188	HITS-CLIP	23824327
MIRT614860	hsa-miR-1200	HITS-CLIP	23824327
MIRT607402	hsa-miR-8485	HITS-CLIP	23824327
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT607399	hsa-miR-4269	HITS-CLIP	23824327
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT607402	hsa-miR-8485	HITS-CLIP	23824327
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT607399	hsa-miR-4269	HITS-CLIP	23824327
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT614868	hsa-miR-4324	HITS-CLIP	23824327
MIRT614867	hsa-miR-544b	HITS-CLIP	23824327
MIRT614866	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT614865	hsa-miR-3975	HITS-CLIP	23824327
MIRT614864	hsa-miR-2467-5p	HITS-CLIP	23824327
MIRT614863	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT614862	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT614861	hsa-miR-3188	HITS-CLIP	23824327
MIRT614860	hsa-miR-1200	HITS-CLIP	23824327
MIRT607402	hsa-miR-8485	HITS-CLIP	23824327
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT607399	hsa-miR-4269	HITS-CLIP	23824327
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT607402	hsa-miR-8485	HITS-CLIP	23824327
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT607399	hsa-miR-4269	HITS-CLIP	23824327
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT607402	hsa-miR-8485	HITS-CLIP	23824327
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT614869	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT607399	hsa-miR-4269	HITS-CLIP	23824327
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT614868	hsa-miR-4324	HITS-CLIP	23824327
MIRT614867	hsa-miR-544b	HITS-CLIP	23824327
MIRT614866	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT614865	hsa-miR-3975	HITS-CLIP	23824327
MIRT614864	hsa-miR-2467-5p	HITS-CLIP	23824327
MIRT614863	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT614862	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT614861	hsa-miR-3188	HITS-CLIP	23824327
MIRT614860	hsa-miR-1200	HITS-CLIP	23824327
MIRT607402	hsa-miR-8485	HITS-CLIP	23824327
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT614869	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT607399	hsa-miR-4269	HITS-CLIP	23824327
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT614868	hsa-miR-4324	HITS-CLIP	23824327
MIRT614867	hsa-miR-544b	HITS-CLIP	23824327
MIRT614866	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT614865	hsa-miR-3975	HITS-CLIP	23824327
MIRT614864	hsa-miR-2467-5p	HITS-CLIP	23824327
MIRT614863	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT614862	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT614861	hsa-miR-3188	HITS-CLIP	23824327
MIRT614860	hsa-miR-1200	HITS-CLIP	23824327
MIRT2070562	hsa-miR-135a	CLIP-seq
MIRT2070563	hsa-miR-135b	CLIP-seq
MIRT2070564	hsa-miR-3140-3p	CLIP-seq
MIRT2070565	hsa-miR-4325	CLIP-seq
MIRT2070566	hsa-miR-450b-5p	CLIP-seq
MIRT2070567	hsa-miR-507	CLIP-seq
MIRT2070568	hsa-miR-557	CLIP-seq
MIRT2070569	hsa-miR-604	CLIP-seq
MIRT2070570	hsa-miR-647	CLIP-seq
MIRT2297666	hsa-miR-628-5p	CLIP-seq

Show/Hide all(36)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0000187	Process	Activation of MAPK activity	IDA	11022047
GO:0001558	Process	Regulation of cell growth	TAS	11022047
GO:0004435	Function	Phosphatidylinositol phospholipase C activity	IBA	21873635
GO:0004435	Function	Phosphatidylinositol phospholipase C activity	IDA	11022047, 11022048
GO:0004629	Function	Phospholipase C activity	IDA	11022047
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	TAS	11022047
GO:0005515	Function	Protein binding	IPI	11022048, 29058690
GO:0005829	Component	Cytosol	IDA	11022048
GO:0005886	Component	Plasma membrane	IDA	11022048
GO:0005886	Component	Plasma membrane	TAS
GO:0006651	Process	Diacylglycerol biosynthetic process	IMP	29058690
GO:0006651	Process	Diacylglycerol biosynthetic process	TAS	11022047
GO:0006940	Process	Regulation of smooth muscle contraction	TAS	11022047
GO:0007010	Process	Cytoskeleton organization	NAS	11022047
GO:0007173	Process	Epidermal growth factor receptor signaling pathway	IMP	29058690
GO:0007173	Process	Epidermal growth factor receptor signaling pathway	NAS	11022048
GO:0007200	Process	Phospholipase C-activating G protein-coupled receptor signaling pathway	IDA	11022047, 11022048
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	TAS	11022047
GO:0007265	Process	Ras protein signal transduction	IDA	11022048
GO:0007507	Process	Heart development	TAS	11022047
GO:0008277	Process	Regulation of G protein-coupled receptor signaling pathway	IDA	11022047
GO:0010592	Process	Positive regulation of lamellipodium assembly	IMP	29058690
GO:0016042	Process	Lipid catabolic process	IEA
GO:0019722	Process	Calcium-mediated signaling	NAS	11022048
GO:0019722	Process	Calcium-mediated signaling	TAS	11022047
GO:0019899	Function	Enzyme binding	IPI	11022048
GO:0030027	Component	Lamellipodium	IDA	29058690
GO:0031267	Function	Small GTPase binding	IDA	11022048
GO:0032835	Process	Glomerulus development	IMP	17086182
GO:0043647	Process	Inositol phosphate metabolic process	TAS
GO:0045859	Process	Regulation of protein kinase activity	IDA	11022047
GO:0046578	Process	Regulation of Ras protein signal transduction	IDA	11022047
GO:0046872	Function	Metal ion binding	IEA
GO:0048015	Process	Phosphatidylinositol-mediated signaling	IBA	21873635
GO:0048016	Process	Inositol phosphate-mediated signaling	TAS	11022047

MIM	HGNC	e!Ensembl
608414	17175	ENSG00000138193

Protein

UniProt ID

Q9P212

Protein name

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (EC 3.1.4.11) (Pancreas-enriched phospholipase C) (Phosphoinositide phospholipase C-epsilon-1) (Phospholipase C-epsilon-1) (PLC-epsilon-1)

Protein function

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates smal

PDB

2BYE , 2BYF , 2C5L

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00617	RasGEF	534 → 762	RasGEF domain	Family
PF09279	EF-hand_like	1323 → 1381	Phosphoinositide-specific phospholipase C, efhand-like	Domain
PF00388	PI-PLC-X	1394 → 1541	Phosphatidylinositol-specific phospholipase C, X domain	Family
PF00387	PI-PLC-Y	1740 → 1844	Phosphatidylinositol-specific phospholipase C, Y domain	Family
PF00168	C2	1870 → 1971	C2 domain	Domain
PF00788	RA	2135 → 2238	Ras association (RalGDS/AF-6) domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. Expressed in podocytes (PubMed:29058690). {ECO:0000269|PubMed:15558028, ECO:0000269|PubMed:29058690}.; TISSUE SPECIFICITY: [Isoform 1]: Broadly expressed and only absent in peripheral blood leukocytes. {ECO:0000269|Pu

Sequence

MTSEEMTASVLIPVTQRKVVSAQSAADESSEKVSDINISKAHTVRRSGETSHTISQLNKL
KEEPSGSNLPKILSIAREKIVSDENSNEKCWEKIMPDSAKNLNINCNNILRNHQHGLPQR
QFYEMYNSVAEEDLCLETGIPSPLERKVFPGIQLELDRPSMGISPLGNQSVIIETGRAHP
DSRRAVFHFHYEVDRRMSDTFCTLSENLILDDCGNCVPLPGGEEKQKKNYVAYTCKLMEL
AKNCDNKNEQLQCDHCDTLNDKYFCFEGSCEKVDMVYSGDSFCRKDFTDSQAAKTFLSHF
EDFPDNCDDVEEDAFKSKKERSTLLVRRFCKNDREVKKSVYTGTRAIVRTLPSGHIGLTA
WSYIDQKRNGPLLPCGRVMEPPSTVEIRQDGSQRLSEAQWYPIYNAVRREETENTVGSLL
HFLTKLPASETAHGRISVGPCLKQCVRDTVCEYRATLQRTSISQYITGSLLEATTSLGAR
SGLLSTFGGSTGRMMLKERQPGPSVANSNALPSSSAGISKELIDLQPLIQFPEEVASILM
EQEQTIYRRVLPVDYLCFLTRDLGTPECQSSLPCLKASISASILTTQNGEHNALEDLVMR
FNEVSSWVTWLILTAGSMEEKREVFSYLVHVAKCCWNMGNYNAVMEFLAGLRSRKVLKMW
QFMDQSDIETMRSLKDAMAQHESSCEYRKVVTRALHIPGCKVVPFCGVFLKELCEVLDGA
SGLMKLCPRYNSQEETLEFVADYSGQDNFLQRVGQNGLKNSEKESTVNSIFQVIRSCNRS
LETDEEDSPSEGNSSRKSSLKDKSRWQFIIGDLLDSDNDIFEQSKEYDSHGSEDSQKAFD
HGTELIPWYVLSIQADVHQFLLQGATVIHYDQDTHLSARCFLQLQPDNSTLTWVKPTTAS
PASSKAKLGVLNNTAEPGKFPLLGNAGLSSLTEGVLDLFAVKAVYMGHPGIDIHTVCVQN
KLGSMFLSETGVTLLYGLQTTDNRLLHFVAPKHTAKMLFSGLLELTRAVRKMRKFPDQRQ
QWLRKQYVSLYQEDGRYEGPTLAHAVELFGGRRWSARNPSPGTSAKNAEKPNMQRNNTLG
ISTTKKKKKILMRGESGEVTDDEMATRKAKMHKECRSRSGSDPQDINEQEESEVNAIANP
PNPLPSRRAHSLTTAGSPNLAAGTSSPIRPVSSPVLSSSNKSPSSAWSSSSWHGRIKGGM
KGFQSFMVSDSNMSFVEFVELFKSFSVRSRKDLKDLFDVYAVPCNRSGSESAPLYTNLTI
DENTSDLQPDLDLLTRNVSDLGLFIKSKQQLSDNQRQISDAIAAASIVTNGTGIESTSLG
IFGVGILQLNDFLVNCQGEHCTYDEILSIIQKFEPSISMCHQGLMSFEGFARFLMDKENF
ASKNDESQENIKELQLPLSYYYIESSHNTYLTGHQLKGESSVELYSQVLLQGCRSVELDC
WDGDDGMPIIYHGHTLTTKIPFKEVVEAIDRSAFINSDLPIIISIENHCSLPQQRKMAEI
FKTVFGEKLVTKFLFETDFSDDPMLPSPDQLRKKVLLKNKKLKAHQTPVDILKQKAHQLA
SMQVQAYNGGNANPRPANNEEEEDEEDEYDYDYESLSDDNILEDRPENKSCNDKLQFEYN
EEIPKRIKKADNSACNKGKVYDMELGEEFYLDQNKKESRQIAPELSDLVIYCQAVKFPGL
STLNASGSSRGKERKSRKSIFGNNPGRMSPGETASFNKTSGKSSCEGIRQTWEESSSPLN
PTTSLSAIIRTPKCYHISSLNENAAKRLCRRYSQKLTQHTACQLLRTYPAATRIDSSNPN
PLMFWLHGIQLVALNYQTDDLPLHLNAAMFEANGGCGYVLKPPVLWDKNCPMYQKFSPLE
RDLDSMDPAVYSLTIVSGQNVCPSNSMGSPCIEVDVLGMPLDSCHFRTKPIHRNTLNPMW
NEQFLFHVHFEDLVFLRFAVVENNSSAVTAQRIIPLKALKRGYRHLQLRNLHNEVLEISS
LFINSRRMEENSSGNTMSASSMFNTEERKCLQTHRVTVHGVPGPEPFTVFTINGGTKAKQ
LLQQILTNEQDIKPVTTDYFLMEEKYFISKEKNECRKQPFQRAIGPEEEIMQILSSWFPE
EGYMGRIVLKTQQENLEEKNIVQDDKEVILSSEEESFFVQVHDVSPEQPRTVIKAPRVST
AQDVIQQTLCKAKYSYSILSNPNPSDYVLLEEVVKDTTNKKTTTPKSSQRVLLDQECVFQ
AQSKWKGAGKFILKLKEQVQASREDKKKGISFASELKKLTKSTKQPRGLTSPSQLLTSES
IQTKEEKPVGGLSSSDTMDYRQ

Sequence length

2302

Interactions

View interactions

Show/Hide Unknown Diseases (6)

Disease term	Disease name	Source
Unknown
Nephrotic Syndrome	familial idiopathic steroid-resistant nephrotic syndrome	GenCC
Hypertension	Hypertension	GWAS
Glaucoma	Glaucoma	GWAS
Coronary artery disease	Coronary artery disease	GWAS
Intracranial Aneurysm	Intracranial Aneurysm	GWAS
Metabolic Syndrome	Metabolic Syndrome	GWAS

Show/Hide Text Mining Associations (44)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenocarcinoma	Associate	30931333
Carcinogenesis	Associate	23077637, 23390063, 24254309, 24935391, 25041015, 25434319
Carcinoma Hepatocellular	Associate	28418898, 32323856, 34967552
Carcinoma Non Small Cell Lung	Associate	31364122, 35220468
Cardiotoxicity	Inhibit	28851949
Colitis Ulcerative	Associate	37843347
Colorectal Neoplasms	Inhibit	21909432
Colorectal Neoplasms	Associate	24146276, 24496148, 34959120, 35349390, 37843347
Death	Associate	28418898
Diabetic Nephropathies	Inhibit	37916327
Esophageal Neoplasms	Associate	21427165, 21689432, 22412849, 23390063, 24867265, 24935391, 25422186, 25854357, 26176862, 30450849, 30931333, 32869542
Esophageal Neoplasms	Stimulate	25041015
Esophageal Squamous Cell Carcinoma	Associate	20729852, 21689432, 22805490, 22865593, 23390063, 24867265, 25008389, 25041015, 25139097, 26657507, 33162810, 33650665
Esophageal Squamous Cell Carcinoma	Stimulate	28849204
Esophagitis	Associate	23390063
Essential Hypertension	Associate	32555714
Gallbladder Neoplasms	Associate	24863943
Gastritis Atrophic	Associate	23077637
Gastrointestinal Neoplasms	Associate	22805490
Glaucoma	Associate	31816047
Glomerulosclerosis Focal Segmental	Associate	18975016, 20591883
Helicobacter Infections	Associate	24069371
Hypertension	Associate	28851949, 37175507
Inflammation	Associate	23077637, 23390063, 24069371, 28849204
Kidney Failure Chronic	Associate	18975016
Lung Neoplasms	Associate	26176862
Macular Degeneration	Associate	31816047
Mesangial sclerosis diffuse	Associate	18975016, 19037252, 20591883, 21365190
Mitochondrial Diseases	Associate	21365190
Mitral Valve Insufficiency	Stimulate	27907007
Neoplasm Metastasis	Associate	26657507, 28849204
Neoplasms	Associate	20729852, 24496148, 24935391, 25434319, 26176862, 26320491, 26657507, 26683024, 27127881, 28418898, 30931333, 32777176, 34967552, 35349390, 35765945
Neoplasms	Inhibit	22412849
Neoplasms	Stimulate	25041015
Neoplasms Squamous Cell	Associate	22805490
Nephronophthisis 3	Associate	31922211
Nephrosis congenital	Associate	31013750
Nephrotic Syndrome	Associate	18975016, 20591883, 23349334, 24742477, 29058690, 29127259, 35920919, 37670083
Oropharyngeal Neoplasms	Associate	21689432
Osteosarcoma	Associate	35765945
Pulmonary Arterial Hypertension	Associate	37176017
Retinal Detachment	Associate	31816047
Squamous Cell Carcinoma of Head and Neck	Associate	21689432, 33162810
Stomach Neoplasms	Associate	20729852, 21427165, 21689432, 22412849, 22805490, 23077637, 24069371, 24254309, 24867265, 25434319, 25658482, 26176862, 27127881, 29983348, 30931333, 32777176 View all (1 more)

PLCE1 (phospholipase C epsilon 1)