Gene Gene information from NCBI Gene database.
Entrez ID 113026
Gene name Phospholipase C delta 3
Gene symbol PLCD3
Synonyms (NCBI Gene)
PLC-delta-3
Chromosome 17
Chromosome location 17q21.31
Summary This gene encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a vari
miRNA miRNA information provided by mirtarbase database.
389
miRTarBase ID miRNA Experiments Reference
MIRT018736 hsa-miR-335-5p Microarray 18185580
MIRT044610 hsa-miR-320a CLASH 23622248
MIRT755438 hsa-miR-34a-5p Luciferase reporter assayWestern blottingqRT-PCR 37079115
MIRT1239800 hsa-miR-1 CLIP-seq
MIRT1239801 hsa-miR-10a CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
17
GO ID Ontology Definition Evidence Reference
GO:0001525 Process Angiogenesis IEA
GO:0004435 Function Phosphatidylinositol-4,5-bisphosphate phospholipase C activity IBA
GO:0004435 Function Phosphatidylinositol-4,5-bisphosphate phospholipase C activity IEA
GO:0005737 Component Cytoplasm IEA
GO:0005886 Component Plasma membrane IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
608795 9061 ENSG00000161714
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8N3E9
Protein name 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-3) (Phospholipase C-delta-3) (PLC-delta-3)
Protein function Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) fr
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF14788 EF-hand_10 201 250 EF hand Domain
PF00388 PI-PLC-X 339 483 Phosphatidylinositol-specific phospholipase C, X domain Family
PF00387 PI-PLC-Y 528 642 Phosphatidylinositol-specific phospholipase C, Y domain Family
PF00168 C2 660 769 C2 domain Domain
Tissue specificity TISSUE SPECIFICITY: Present in corneal epithelial cells (at protein level). {ECO:0000269|PubMed:15505048}.
Sequence
MLCGRWRRCRRPPEEPPVAAQVAAQVAAPVALPSPPTPSDGGTKRPGLRALKKMGLTEDE
DVRAMLRGSRLRKIRSRTWHKERLYRLQEDGLSVWFQRRIPRAPSQHIFFVQHIEAVREG
HQSEGLRRFGGAFAPARCLTIAFKGRRKNLDLAAPTAEEAQRWVRGLTKLRARLDAMSQR
ERLDHWIHSYLHRADSNQDSKMSFKEIKSLLRMVNVDMNDMYAYLLFKECDHSNNDRLEG
AEIEEFLRRL
LKRPELEEIFHQYSGEDRVLSAPELLEFLEDQGEEGATLARAQQLIQTYE
LNETAKQHELMTLDGFMMYLLSPEGAALDNTHTCVFQDMNQPLAHYFISSSHNTYLTDSQ
IGGPSSTEAYVRAFAQGCRCVELDCWEGPGGEPVIYHGHTLTSKILFRDVVQAVRDHAFT
LSPYPVILSLENHCGLEQQAAMARHLCTILGDMLVTQALDSPNPEELPSPEQLKGRVLVK
GKK
LPAARSEDGRALSDREEEEEDDEEEEEEVEAAAQRRLAKQISPELSALAVYCHATRL
RTLHPAPNAPQPCQVSSLSERKAKKLIREAGNSFVRHNARQLTRVYPLGLRMNSANYSPQ
EMWNSGCQLVALNFQTPGYEMDLNAGRFLVNGQCGYVLKPAC
LRQPDSTFDPEYPGPPRT
TLSIQVLTAQQLPKLNAEKPHSIVDPLVRIEIHGVPADCARQETDYVLNNGFNPRWGQTL
QFQLRAPELALVRFVVEDYDATSPNDFVGQFTLPLSSLKQGYRHIHLLS
KDGASLSPATL
FIQIRIQRS
Sequence length 789
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Malignant tumor of esophagus Uncertain significance rs1034442739 RCV005939396
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 37589509
Alcoholism Stimulate 31808619
Carcinogenesis Associate 33674820
Carcinoma Pancreatic Ductal Stimulate 31808619
Cataract Age Related Nuclear Associate 36071682
Hypertension Associate 19430483
Lymphatic Metastasis Associate 33674820
Nasopharyngeal Carcinoma Associate 29115528
Thyroid Neoplasms Associate 32489258, 33674820