PLCD3 (phospholipase C delta 3)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 113026 |
| Gene name | Phospholipase C delta 3 |
| Gene symbol | PLCD3 |
| Synonyms (NCBI Gene) |
PLC-delta-3
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| Chromosome | 17 |
| Chromosome location | 17q21.31 |
| Summary | This gene encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a vari |
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miRNA
miRNA information provided by mirtarbase database.
389
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
17
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q8N3E9 | |||||||||||||||||||||||||
| Protein name | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-3) (Phospholipase C-delta-3) (PLC-delta-3) | |||||||||||||||||||||||||
| Protein function | Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) fr | |||||||||||||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Present in corneal epithelial cells (at protein level). {ECO:0000269|PubMed:15505048}. | |||||||||||||||||||||||||
| Sequence |
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| Sequence length | 789 | |||||||||||||||||||||||||
| Interactions | View interactions | |||||||||||||||||||||||||
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Associated diseases
Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
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