PLCD3 (phospholipase C delta 3)
| Gene | |
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
113026 |
|
Gene name
Gene Name - the full gene name approved by the HGNC.
|
Phospholipase C delta 3 |
|
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
|
PLCD3 |
|
Synonyms (NCBI Gene)
Gene synonyms aliases
|
PLC-delta-3 |
|
Chromosome
Chromosome number
|
17 |
|
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
17q21.31 |
|
Summary
Summary of gene provided in NCBI Entrez Gene.
|
This gene encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a vari |
|
miRNA
miRNA information provided by mirtarbase database.
|
|||||||||||||||||||||||||
|
|||||||||||||||||||||||||
|
Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
|
|||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||
|
Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
|
|||||||
|
|||||||
| Protein | ||||||||||||||||||||||||||
| UniProt ID | Q8N3E9 | |||||||||||||||||||||||||
| Protein name | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-3) (Phospholipase C-delta-3) (PLC-delta-3) | |||||||||||||||||||||||||
| Protein function | Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) fr | |||||||||||||||||||||||||
| Family and domains |
Pfam
|
|||||||||||||||||||||||||
| Tissue specificity | TISSUE SPECIFICITY: Present in corneal epithelial cells (at protein level). {ECO:0000269|PubMed:15505048}. | |||||||||||||||||||||||||
| Sequence |
|
|||||||||||||||||||||||||
| Sequence length | 789 | |||||||||||||||||||||||||
| Interactions | View interactions | |||||||||||||||||||||||||
|
Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
|
||||||||||||||||||||||||||||||||||
|
||||||||||||||||||||||||||||||||||
|
||||||||||||||||||||||||||||||||||