Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs Other IDs Associated diseases
Entrez ID	5330
Gene name	Phospholipase C beta 2
Gene symbol	PLCB2
Synonyms (NCBI Gene)	PLC-beta-2
Chromosome	15
Chromosome location	15q15.1
Summary	The protein encoded by this gene is a phosphodiesterase that catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate to the second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol. The encoded protein is activated by G proteins a

Show/Hide all (55)

miRTarBase ID	miRNA	Experiments	Reference
MIRT028821	hsa-miR-26b-5p	Microarray	19088304
MIRT496162	hsa-miR-4762-5p	PAR-CLIP	22291592
MIRT496162	hsa-miR-4762-5p	PAR-CLIP	22291592
MIRT1239635	hsa-let-7a	CLIP-seq
MIRT1239636	hsa-let-7b	CLIP-seq
MIRT1239637	hsa-let-7c	CLIP-seq
MIRT1239638	hsa-let-7d	CLIP-seq
MIRT1239639	hsa-let-7e	CLIP-seq
MIRT1239640	hsa-let-7f	CLIP-seq
MIRT1239641	hsa-let-7g	CLIP-seq
MIRT1239642	hsa-let-7i	CLIP-seq
MIRT1239643	hsa-miR-1273f	CLIP-seq
MIRT1239644	hsa-miR-1294	CLIP-seq
MIRT1239645	hsa-miR-145	CLIP-seq
MIRT1239646	hsa-miR-196a	CLIP-seq
MIRT1239647	hsa-miR-196b	CLIP-seq
MIRT1239648	hsa-miR-202	CLIP-seq
MIRT1239649	hsa-miR-2467-3p	CLIP-seq
MIRT1239650	hsa-miR-371-3p	CLIP-seq
MIRT1239651	hsa-miR-371b-3p	CLIP-seq
MIRT1239652	hsa-miR-4270	CLIP-seq
MIRT1239653	hsa-miR-4297	CLIP-seq
MIRT1239654	hsa-miR-4300	CLIP-seq
MIRT1239655	hsa-miR-4316	CLIP-seq
MIRT1239656	hsa-miR-4441	CLIP-seq
MIRT1239657	hsa-miR-4458	CLIP-seq
MIRT1239658	hsa-miR-4476	CLIP-seq
MIRT1239659	hsa-miR-4500	CLIP-seq
MIRT1239660	hsa-miR-4514	CLIP-seq
MIRT1239661	hsa-miR-4534	CLIP-seq
MIRT1239662	hsa-miR-455-3p	CLIP-seq
MIRT1239663	hsa-miR-4677-3p	CLIP-seq
MIRT1239664	hsa-miR-4692	CLIP-seq
MIRT1239665	hsa-miR-4716-3p	CLIP-seq
MIRT1239666	hsa-miR-4723-5p	CLIP-seq
MIRT1239667	hsa-miR-4727-5p	CLIP-seq
MIRT1239668	hsa-miR-4728-5p	CLIP-seq
MIRT1239669	hsa-miR-4755-3p	CLIP-seq
MIRT1239670	hsa-miR-4802-5p	CLIP-seq
MIRT1239671	hsa-miR-515-3p	CLIP-seq
MIRT1239672	hsa-miR-518d-5p	CLIP-seq
MIRT1239673	hsa-miR-519b-5p	CLIP-seq
MIRT1239674	hsa-miR-519c-5p	CLIP-seq
MIRT1239675	hsa-miR-519e	CLIP-seq
MIRT1239676	hsa-miR-520c-5p	CLIP-seq
MIRT1239677	hsa-miR-526a	CLIP-seq
MIRT1239678	hsa-miR-544	CLIP-seq
MIRT1239679	hsa-miR-920	CLIP-seq
MIRT1239680	hsa-miR-98	CLIP-seq
MIRT2070485	hsa-miR-3157-5p	CLIP-seq
MIRT1239660	hsa-miR-4514	CLIP-seq
MIRT1239664	hsa-miR-4692	CLIP-seq
MIRT2070486	hsa-miR-4792	CLIP-seq
MIRT2070487	hsa-miR-587	CLIP-seq
MIRT2297631	hsa-miR-125a-3p	CLIP-seq

Show/Hide all (35)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001580	Process	Detection of chemical stimulus involved in sensory perception of bitter taste	IEA
GO:0004435	Function	Phosphatidylinositol-4,5-bisphosphate phospholipase C activity	IBA
GO:0004435	Function	Phosphatidylinositol-4,5-bisphosphate phospholipase C activity	IDA	9188725
GO:0004435	Function	Phosphatidylinositol-4,5-bisphosphate phospholipase C activity	IEA
GO:0004435	Function	Phosphatidylinositol-4,5-bisphosphate phospholipase C activity	IMP	8519600
GO:0004435	Function	Phosphatidylinositol-4,5-bisphosphate phospholipase C activity	TAS	1644792
GO:0004629	Function	Phospholipase C activity	IEA
GO:0004629	Function	Phospholipase C activity	TAS	7649993
GO:0005509	Function	Calcium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	21115837
GO:0005543	Function	Phospholipid binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006644	Process	Phospholipid metabolic process	TAS	1644792
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007200	Process	Phospholipase C-activating G protein-coupled receptor signaling pathway	IEA
GO:0007200	Process	Phospholipase C-activating G protein-coupled receptor signaling pathway	ISS
GO:0008081	Function	Phosphoric diester hydrolase activity	IEA
GO:0016042	Process	Lipid catabolic process	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0031680	Component	G-protein beta/gamma-subunit complex	IEA
GO:0031683	Function	G-protein beta/gamma-subunit complex binding	IEA
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0046488	Process	Phosphatidylinositol metabolic process	IBA
GO:0046488	Process	Phosphatidylinositol metabolic process	IDA	9188725
GO:0046872	Function	Metal ion binding	IEA
GO:0048015	Process	Phosphatidylinositol-mediated signaling	IBA
GO:0050913	Process	Sensory perception of bitter taste	IEA
GO:0051209	Process	Release of sequestered calcium ion into cytosol	IBA
GO:0098992	Component	Neuronal dense core vesicle	IEA
GO:0120548	Function	Phosphatidylinositol phospholipase C activity	IEA

MIM	HGNC	e!Ensembl
604114	9055	ENSG00000137841

Q00722

Protein name

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-2) (Phospholipase C-beta-2) (PLC-beta-2)

Protein function

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (PubMed:1644792, PubMed:9188725). In neutrophils, partici

PDB

2FJU , 2ZKM

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF17787	PH_14	12 → 141	PH domain	Domain
PF09279	EF-hand_like	211 → 305	Phosphoinositide-specific phospholipase C, efhand-like	Domain
PF00388	PI-PLC-X	314 → 464	Phosphatidylinositol-specific phospholipase C, X domain	Family
PF00387	PI-PLC-Y	546 → 660	Phosphatidylinositol-specific phospholipase C, Y domain	Family
PF00168	C2	682 → 784	C2 domain	Domain
PF08703	PLC-beta_C	978 → 1153	PLC-beta C terminal	Domain

Sequence

MSLLNPVLLPPKVKAYLSQGERFIKWDDETTVASPVILRVDPKGYYLYWTYQSKEMEFLD
ITSIRDTRFGKFAKMPKSQKLRDVFNMDFPDNSFLLKTLTVVSGPDMVDLTFHNFVSYKE
NVGKAWAEDVLALVKHPLTANASRSTFLDKILVKLKMQLNSEGKIPVKNFFQMFPADRKR
VEAALSACHLPKGKNDAINPEDFPEPVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEH
LTKFINQKQRDSRLNSLLFPPARPDQVQGLIDKYEPSGINAQRGQLSPEGMVWFLCGPEN
SVLAQDKLLLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDC
WKGKPPDEEPIITHGFTMTTDIFFKEAIEAIAESAFKTSPYPIILSFENHVDSPRQQAKM
AEYCRTIFGDMLLTEPLEKFPLKPGVPLPSPEDLRGKILIKNKKNQFSGPTSSSKDTGGE
AEGSSPPSAPAGEGTVWAGEEGTELEEEEVEEEEEEESGNLDEEEIKKMQSDEGTAGLEV
TAYEEMSSLVNYIQPTKFVSFEFSAQKNRSYVISSFTELKAYDLLSKASVQFVDYNKRQM
SRIYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMAVFEFNGQSGYLLKHEF
MRRPDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKRRYRT
KLSPSTNSINPVWKEEPFVFEKILMPELASLRVAVMEEGNKFLGHRIIPINALNSGYHHL
CLHSESNMPLTMPALFIFLEMKDYIPGAWADLTVALANPIKFFSAHDTKSVKLKEAMGGL
PEKPFPLASPVASQVNGALAPTSNGSPAARAGAREEAMKEAAEPRTASLEELRELKGVVK
LQRRHEKELRELERRGARRWEELLQRGAAQLAELGPPGVGGVGACKLGPGKGSRKKRSLP
REESAGAAPGEGPEGVDGRVRELKDRLELELLRQGEEQYECVLKRKEQHVAEQISKMMEL
AREKQAAELKALKETSENDTKEMKKKLETKRLERIQGMTKVTTDKMAQERLKREINNSHI
QEVVQVIKQMTENLERHQEKLEEKQAACLEQIREMEKQFQKEALAEYEARMKGLEAEVKE
SVRACLRTCFPSEAKDKPERACECPPELCEQDPLIAKADAQESRL

Sequence length

1185

Interactions

View interactions

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Melanoma	Uncertain significance	rs765646154	RCV005939395
Oromandibular-limb hypogenesis spectrum	Likely benign	rs779256250, rs769251460	RCV000240468 RCV000240155
Thrombocytopenia	Uncertain significance	rs372130791	RCV003447734

Show/Hide Text Mining Associations (37)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Alzheimer Disease	Associate	28578378
Atherosclerosis	Associate	27465150
Breast Neoplasms	Associate	22905097, 24330829, 26521046, 28870198, 29512753, 30497437, 30582225
Carcinogenesis	Associate	12480928
Carcinoma Hepatocellular	Associate	30896816
Carcinoma Intraductal Noninfiltrating	Stimulate	30582225
Carcinoma Non Small Cell Lung	Associate	31080817
Carcinoma Renal Cell	Associate	28029655
Conversion Disorder	Associate	8781424
Crohn Disease	Associate	23437289
Dental Caries	Inhibit	36613519
Dental Caries	Associate	36613519
Diabetic Angiopathies	Associate	22916176
Drug Resistant Epilepsy	Associate	40646440
Epilepsy rolandic with paroxysmal exercise induced dystonia and writer's cramp	Associate	40646440
Hypertension	Associate	30226566
Hypoxia	Associate	30497437
Inflammation	Associate	27465150
Inflammatory Bowel Diseases	Associate	23437289
Leukemia Lymphoma Adult T Cell	Associate	37832654
Leukemia Myeloid	Associate	30497437
Leukemia Myeloid Acute	Associate	33536360
Liver Cirrhosis	Associate	25460309
Meningomyelocele	Associate	39774454
Microvascular Angina	Associate	22916176
Myocardial Infarction	Associate	30226566
Neoplasms	Associate	10638960, 22905097, 24330829, 30896816
Neoplasms	Inhibit	28870198
Obesity	Stimulate	22083550
Plaque Atherosclerotic	Associate	35990248
Polycystic Ovary Syndrome	Associate	26308735
Renal Insufficiency Chronic	Associate	30226566
Sarcoma Ewing	Associate	10638960
Stomach Diseases	Associate	22083550
Triple Negative Breast Neoplasms	Associate	24330829, 28870198
Tuberculosis Multidrug Resistant	Associate	29512753
Urinary Bladder Neoplasms	Associate	25921176

PLCB2 (phospholipase C beta 2)