PIK3R6 (phosphoinositide-3-kinase regulatory subunit 6)

Gene

• Entrez ID: 146850
• Gene name: Phosphoinositide-3-kinase regulatory subunit 6
• Gene symbol: PIK3R6
• Synonyms (NCBI Gene): C17orf38, HsT41028, p84 PIKAP, p87(PIKAP), p87PIKAP
• Chromosome: 17
• Chromosome location: 17p13.1
• Summary: Phosphoinositide 3-kinase gamma is a lipid kinase that produces the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate. The kinase is composed of a catalytic subunit and one of several regulatory subunits, and is chiefly activated by G protei

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1234905	hsa-miR-1343	CLIP-seq
MIRT1234906	hsa-miR-142-3p	CLIP-seq
MIRT1234907	hsa-miR-2861	CLIP-seq
MIRT1234908	hsa-miR-362-5p	CLIP-seq
MIRT1234909	hsa-miR-3667-3p	CLIP-seq
MIRT1234910	hsa-miR-3713	CLIP-seq
MIRT1234911	hsa-miR-4280	CLIP-seq
MIRT1234912	hsa-miR-4691-5p	CLIP-seq
MIRT1234913	hsa-miR-500b	CLIP-seq
MIRT1234914	hsa-miR-501-5p	CLIP-seq
MIRT2069177	hsa-miR-149	CLIP-seq
MIRT2069178	hsa-miR-3176	CLIP-seq
MIRT2069179	hsa-miR-3922-3p	CLIP-seq
MIRT2069180	hsa-miR-3926	CLIP-seq
MIRT2069181	hsa-miR-548s	CLIP-seq
MIRT2069182	hsa-miR-760	CLIP-seq
MIRT2069177	hsa-miR-149	CLIP-seq
MIRT2296302	hsa-miR-3064-5p	CLIP-seq
MIRT2296303	hsa-miR-3650	CLIP-seq
MIRT2296304	hsa-miR-3659	CLIP-seq
MIRT2296305	hsa-miR-4658	CLIP-seq
MIRT2296306	hsa-miR-4687-3p	CLIP-seq
MIRT2296307	hsa-miR-4794	CLIP-seq
MIRT2296308	hsa-miR-574-5p	CLIP-seq
MIRT2392526	hsa-miR-1262	CLIP-seq
MIRT2392527	hsa-miR-1293	CLIP-seq
MIRT2392528	hsa-miR-297	CLIP-seq
MIRT2392529	hsa-miR-3150a-3p	CLIP-seq
MIRT2392530	hsa-miR-3175	CLIP-seq
MIRT2296303	hsa-miR-3650	CLIP-seq
MIRT2392531	hsa-miR-378g	CLIP-seq
MIRT2392532	hsa-miR-4300	CLIP-seq
MIRT2392533	hsa-miR-4453	CLIP-seq
MIRT2392534	hsa-miR-4483	CLIP-seq
MIRT2392535	hsa-miR-4538	CLIP-seq
MIRT2392536	hsa-miR-4701-3p	CLIP-seq
MIRT2392537	hsa-miR-567	CLIP-seq
MIRT2392538	hsa-miR-920	CLIP-seq
MIRT2392539	hsa-miR-939	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001525	Process	Angiogenesis	IEA
GO:0005515	Function	Protein binding	IPI	21393242
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IEA
GO:0005942	Component	Phosphatidylinositol 3-kinase complex	IBA
GO:0005943	Component	Phosphatidylinositol 3-kinase complex, class IA	EXP	10358071
GO:0005944	Component	Phosphatidylinositol 3-kinase complex, class IB	IEA
GO:0005944	Component	Phosphatidylinositol 3-kinase complex, class IB	ISS
GO:0006955	Process	Immune response	NAS	31480354
GO:0007186	Process	G protein-coupled receptor signaling pathway	EXP	10358071
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	ISS
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	ISS
GO:0042269	Process	Regulation of natural killer cell mediated cytotoxicity	IBA
GO:0042269	Process	Regulation of natural killer cell mediated cytotoxicity	IDA	11062502
GO:0043406	Process	Positive regulation of MAP kinase activity	ISS
GO:0045582	Process	Positive regulation of T cell differentiation	IEA
GO:0045766	Process	Positive regulation of angiogenesis	IMP	21393242
GO:0046934	Function	1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	IEA
GO:0046934	Function	1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	ISS
GO:0046935	Function	1-phosphatidylinositol-3-kinase regulator activity	IBA
GO:0046935	Function	1-phosphatidylinositol-3-kinase regulator activity	IEA
GO:0046935	Function	1-phosphatidylinositol-3-kinase regulator activity	ISS

Other IDs

• MIM: 611462
• HGNC: 27101
• e!Ensembl: ENSG00000276231

Protein

• UniProt ID: Q5UE93
• Protein name: Phosphoinositide 3-kinase regulatory subunit 6 (Phosphoinositide 3-kinase gamma adapter protein of 87 kDa) (p84 PI3K adapter protein) (p84 PIKAP) (p87 PI3K adapter protein) (p87PIKAP)
• Protein function: Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G protein dimers than PIK3CG:PIK3R5 and its membran
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF10486	PI3K_1B_p101	6 → 300	Phosphoinositide 3-kinase gamma adapter protein p101 subunit	Family
  PF10486	PI3K_1B_p101	395 → 474	Phosphoinositide 3-kinase gamma adapter protein p101 subunit	Family
  PF10486	PI3K_1B_p101	468 → 753	Phosphoinositide 3-kinase gamma adapter protein p101 subunit	Family

• Sequence:

  MESSDVELDLQRSVQAVLRELSTQAPALQSNQGMWRWSLHKKVERDPGKSPVLVRILLRE
  LEKAESQDLRHVIIPLLHTVMYVLTKATGITEELYQRIYAFCTRLLTLPTPYCTVALDCA
  IRLKTEMAVPGTLYQRMVIAEQNLTNELYPYQERVFLFVDPELVSASVCSALLLEIEAAQ
  AQQTPETCMRHVVSHALQAALGEACHAGALHRKLQASPRRTLEHYFHAVVAALEQMASEA
  SPSREGHVERLEEIYCSLLGPAAGRCGGDLVQERPPSIPLPSPYITFHLWTGEEQLWKEL
  VLFLRPRSQLRLSADLEVLDLQGLRPDRELARVSVLSTDSGIERDLPTGADELPAPGSPE
  MERAGLQRKGGIKKRAWPLDFLMPGSWDGPPGLHRRTGRPSGDGEMLPGVSRLHTARVLV
  LGDDRMLGRLAQAYHRLRKRETQKFCLTPRLSLQLYYIPVLAPEKPAASRQPELGELATF
  LGRVDPWYQSNVNTLCPAIHKLAEMPPSLDTSRTVDPFILDVITYYIRMGTQPIYFQIYT
  VKIFFSDLSQDPTEDIFLIELKVKIQDSKFPKDGFSPRRRGVAEGPGAELSLCYQKALLS
  HRPREVTVSLRATGLILKAIPASDTEVSGSSHCPLPAAPVTDHTCLNVNVTEVVKSSNLA
  GKSFSTVTNTFRTNNIQIQSRDQRLLTLSLDKDDQRTFRDVVRFEVAPCPEPCSGAQKSK
  APWLNLHGQQEVEAIKAKPKPLLMPINTFSGIVQ

• Sequence length: 754