Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
8503
Gene name Gene Name - the full gene name approved by the HGNC.
Phosphoinositide-3-kinase regulatory subunit 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PIK3R3
Synonyms (NCBI Gene) Gene synonyms aliases
p55, p55-GAMMA, p55PIK
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p34.1
Summary Summary of gene provided in NCBI Entrez Gene.
Phosphatidylinositol 3-kinase (PI3K) phosphorylates phosphatidylinositol and similar compounds, which then serve as second messengers in growth signaling pathways. PI3K is composed of a catalytic and a regulatory subunit. The protein encoded by this gene
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT043293 hsa-miR-331-3p CLASH 23622248
MIRT042712 hsa-miR-346 CLASH 23622248
MIRT040803 hsa-miR-18a-3p CLASH 23622248
MIRT053541 hsa-miR-7-5p ELISA, Luciferase reporter assay, qRT-PCR, Western blot 23135998
MIRT726939 hsa-miR-19a-3p HITS-CLIP 22473208
Transcription factors
Transcription factor Regulation Reference
MZF1 Unknown 23509792
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001784 Function Phosphotyrosine residue binding IPI 20624904
GO:0001934 Process Positive regulation of protein phosphorylation IMP 28341552
GO:0002042 Process Cell migration involved in sprouting angiogenesis IGI 28341552
GO:0005515 Function Protein binding IPI 16273093, 17360667, 17500595, 19380743, 20598684, 21706016, 22402981, 24189400, 24658140, 24728074, 25241761, 25814554, 26496610, 28514442, 31515488, 31980649, 32296183, 32606738, 32814053
GO:0005829 Component Cytosol TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
606076 8981 ENSG00000117461
Protein
UniProt ID Q92569
Protein name Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase regulatory subunit gamma) (PI3K regulatory subunit gamma) (PtdIns-3-kinase regulatory subunit gamma) (Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma) (PI3-kinase subunit p55
Protein function Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00017 SH2 65 140 SH2 domain Domain
PF16454 PI3K_P85_iSH2 163 331 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Domain
PF00017 SH2 358 432 SH2 domain Domain
Tissue specificity TISSUE SPECIFICITY: Highest levels in brain and testis. Lower levels in adipose tissue, kidney, heart, lung and skeletal muscle.
Sequence
Sequence length 461
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Breast Cancer Breast Cancer Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients GWAS, CBGDA
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 24369052, 32064933
Alzheimer Disease Associate 22982105
Carcinogenesis Associate 34321458
Carcinoma Hepatocellular Associate 25608840, 31514484, 34120890
Carcinoma Hepatocellular Stimulate 37212524
Carcinoma Ovarian Epithelial Associate 30823895
Colorectal Neoplasms Associate 21978709, 23509792, 35988930
Congenital Hyperinsulinism Associate 23869231
Fetal Growth Retardation Associate 35430618
Gaucher Disease Associate 33568133