Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs Other IDs Associated diseases
Entrez ID	5294
Gene name	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
Gene symbol	PIK3CG
Synonyms (NCBI Gene)	IMD97PI3CGPI3KPI3KgammaPIK3p110gammap120-PI3K
Chromosome	7
Chromosome location	7q22.3
Summary	Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I catalytic subunit of PI3K. Like other class I catalytic subunits (p110-alpha p110-beta, and p110-delta)

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Show/Hide all (228)

miRTarBase ID	miRNA	Experiments	Reference
MIRT006815	hsa-miR-29b-3p	MicroarrayqRT-PCRWestern blot	22297492
MIRT006831	hsa-miR-126-3p	ImmunocytochemistryLuciferase reporter assayqRT-PCRWestern blot	22900072
MIRT019349	hsa-miR-148b-3p	Microarray	17612493
MIRT029342	hsa-miR-26b-5p	Microarray	19088304
MIRT006831	hsa-miR-126-3p	MicroarrayqRT-PCRWestern blotSILAC (Stable Isotope Labeling of Amino acids in Culture)	23142521
MIRT437359	hsa-miR-27a-3p	Luciferase reporter assayqRT-PCR	24086481
MIRT437359	hsa-miR-27a-3p	Luciferase reporter assayqRT-PCR	24086481
MIRT438408	hsa-miR-10a-5p	Luciferase reporter assayqRT-PCRWestern blot	24522205
MIRT438408	hsa-miR-10a-5p	Luciferase reporter assayqRT-PCRWestern blot	24522205
MIRT438277	hsa-miR-7-5p	Luciferase reporter assayWestern blot	24603851
MIRT438408	hsa-miR-10a-5p	Luciferase reporter assayqRT-PCRWestern blot	24522205
MIRT438408	hsa-miR-10a-5p	Luciferase reporter assayqRT-PCRWestern blot	24522205
MIRT438277	hsa-miR-7-5p	Luciferase reporter assayWestern blot	24603851
MIRT516718	hsa-miR-8485	HITS-CLIP	21572407
MIRT516717	hsa-miR-329-3p	HITS-CLIP	21572407
MIRT516716	hsa-miR-362-3p	HITS-CLIP	21572407
MIRT516715	hsa-miR-603	HITS-CLIP	21572407
MIRT516714	hsa-miR-4789-3p	HITS-CLIP	21572407
MIRT542013	hsa-miR-5580-3p	HITS-CLIP	21572407
MIRT516713	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT516707	hsa-miR-3941	HITS-CLIP	21572407
MIRT516706	hsa-miR-4789-5p	HITS-CLIP	21572407
MIRT516705	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT516704	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT693454	hsa-miR-548a-3p	HITS-CLIP	23313552
MIRT693453	hsa-miR-548ar-3p	HITS-CLIP	23313552
MIRT693452	hsa-miR-548az-3p	HITS-CLIP	23313552
MIRT693451	hsa-miR-548e-3p	HITS-CLIP	23313552
MIRT693450	hsa-miR-548f-3p	HITS-CLIP	23313552
MIRT693449	hsa-miR-5582-3p	HITS-CLIP	23313552
MIRT693448	hsa-miR-548g-3p	HITS-CLIP	23313552
MIRT516718	hsa-miR-8485	HITS-CLIP	23313552
MIRT516714	hsa-miR-4789-3p	HITS-CLIP	23313552
MIRT542013	hsa-miR-5580-3p	HITS-CLIP	23313552
MIRT693447	hsa-miR-3163	HITS-CLIP	23313552
MIRT542012	hsa-miR-410-3p	HITS-CLIP	23313552
MIRT516713	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT693446	hsa-miR-511-3p	HITS-CLIP	23313552
MIRT516712	hsa-miR-4679	HITS-CLIP	23313552
MIRT516711	hsa-miR-3689a-5p	HITS-CLIP	23313552
MIRT516710	hsa-miR-3689b-5p	HITS-CLIP	23313552
MIRT516709	hsa-miR-3689e	HITS-CLIP	23313552
MIRT516708	hsa-miR-3689f	HITS-CLIP	23313552
MIRT516705	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT516704	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT516718	hsa-miR-8485	PAR-CLIP	21572407
MIRT516717	hsa-miR-329-3p	PAR-CLIP	21572407
MIRT516716	hsa-miR-362-3p	PAR-CLIP	21572407
MIRT516715	hsa-miR-603	PAR-CLIP	21572407
MIRT516714	hsa-miR-4789-3p	PAR-CLIP	21572407
MIRT542013	hsa-miR-5580-3p	PAR-CLIP	21572407
MIRT542012	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT516713	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT516707	hsa-miR-3941	PAR-CLIP	21572407
MIRT516706	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT516705	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT516704	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT516718	hsa-miR-8485	PAR-CLIP	23446348
MIRT516717	hsa-miR-329-3p	PAR-CLIP	23446348
MIRT516716	hsa-miR-362-3p	PAR-CLIP	23446348
MIRT516715	hsa-miR-603	PAR-CLIP	23446348
MIRT516714	hsa-miR-4789-3p	PAR-CLIP	23446348
MIRT516713	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT516712	hsa-miR-4679	PAR-CLIP	23446348
MIRT516711	hsa-miR-3689a-5p	PAR-CLIP	23446348
MIRT516710	hsa-miR-3689b-5p	PAR-CLIP	23446348
MIRT516709	hsa-miR-3689e	PAR-CLIP	23446348
MIRT516708	hsa-miR-3689f	PAR-CLIP	23446348
MIRT516707	hsa-miR-3941	PAR-CLIP	23446348
MIRT516706	hsa-miR-4789-5p	PAR-CLIP	23446348
MIRT516705	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT516704	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT439973	hsa-miR-142-3p	HITS-CLIP	22473208
MIRT439973	hsa-miR-142-3p	HITS-CLIP	22473208
MIRT006831	hsa-miR-126-3p	Luciferase reporter assay	27729613
MIRT006831	hsa-miR-126-3p	qRT-PCRWestern blot	26659078
MIRT516718	hsa-miR-8485	HITS-CLIP	21572407
MIRT516717	hsa-miR-329-3p	HITS-CLIP	21572407
MIRT516716	hsa-miR-362-3p	HITS-CLIP	21572407
MIRT516715	hsa-miR-603	HITS-CLIP	21572407
MIRT516714	hsa-miR-4789-3p	HITS-CLIP	21572407
MIRT542013	hsa-miR-5580-3p	HITS-CLIP	21572407
MIRT516713	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT516707	hsa-miR-3941	HITS-CLIP	21572407
MIRT516706	hsa-miR-4789-5p	HITS-CLIP	21572407
MIRT516705	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT516704	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT693454	hsa-miR-548a-3p	HITS-CLIP	23313552
MIRT693453	hsa-miR-548ar-3p	HITS-CLIP	23313552
MIRT693452	hsa-miR-548az-3p	HITS-CLIP	23313552
MIRT693451	hsa-miR-548e-3p	HITS-CLIP	23313552
MIRT693450	hsa-miR-548f-3p	HITS-CLIP	23313552
MIRT693449	hsa-miR-5582-3p	HITS-CLIP	23313552
MIRT693448	hsa-miR-548g-3p	HITS-CLIP	23313552
MIRT516718	hsa-miR-8485	HITS-CLIP	23313552
MIRT516714	hsa-miR-4789-3p	HITS-CLIP	23313552
MIRT542013	hsa-miR-5580-3p	HITS-CLIP	23313552
MIRT693447	hsa-miR-3163	HITS-CLIP	23313552
MIRT542012	hsa-miR-410-3p	HITS-CLIP	23313552
MIRT516713	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT693446	hsa-miR-511-3p	HITS-CLIP	23313552
MIRT516712	hsa-miR-4679	HITS-CLIP	23313552
MIRT516711	hsa-miR-3689a-5p	HITS-CLIP	23313552
MIRT516710	hsa-miR-3689b-5p	HITS-CLIP	23313552
MIRT516709	hsa-miR-3689e	HITS-CLIP	23313552
MIRT516708	hsa-miR-3689f	HITS-CLIP	23313552
MIRT516705	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT516704	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT516718	hsa-miR-8485	PAR-CLIP	21572407
MIRT516717	hsa-miR-329-3p	PAR-CLIP	21572407
MIRT516716	hsa-miR-362-3p	PAR-CLIP	21572407
MIRT516715	hsa-miR-603	PAR-CLIP	21572407
MIRT516714	hsa-miR-4789-3p	PAR-CLIP	21572407
MIRT542013	hsa-miR-5580-3p	PAR-CLIP	21572407
MIRT542012	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT516713	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT516707	hsa-miR-3941	PAR-CLIP	21572407
MIRT516706	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT516705	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT516704	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT516718	hsa-miR-8485	PAR-CLIP	23446348
MIRT516717	hsa-miR-329-3p	PAR-CLIP	23446348
MIRT516716	hsa-miR-362-3p	PAR-CLIP	23446348
MIRT516715	hsa-miR-603	PAR-CLIP	23446348
MIRT516714	hsa-miR-4789-3p	PAR-CLIP	23446348
MIRT516713	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT516712	hsa-miR-4679	PAR-CLIP	23446348
MIRT516711	hsa-miR-3689a-5p	PAR-CLIP	23446348
MIRT516710	hsa-miR-3689b-5p	PAR-CLIP	23446348
MIRT516709	hsa-miR-3689e	PAR-CLIP	23446348
MIRT516708	hsa-miR-3689f	PAR-CLIP	23446348
MIRT516707	hsa-miR-3941	PAR-CLIP	23446348
MIRT516706	hsa-miR-4789-5p	PAR-CLIP	23446348
MIRT516705	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT516704	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT1234187	hsa-miR-1276	CLIP-seq
MIRT1234188	hsa-miR-1976	CLIP-seq
MIRT1234189	hsa-miR-24	CLIP-seq
MIRT1234190	hsa-miR-3199	CLIP-seq
MIRT1234191	hsa-miR-3653	CLIP-seq
MIRT1234192	hsa-miR-3658	CLIP-seq
MIRT1234193	hsa-miR-378g	CLIP-seq
MIRT1234194	hsa-miR-4269	CLIP-seq
MIRT1234195	hsa-miR-4437	CLIP-seq
MIRT1234196	hsa-miR-4438	CLIP-seq
MIRT1234197	hsa-miR-4496	CLIP-seq
MIRT1234198	hsa-miR-4514	CLIP-seq
MIRT1234199	hsa-miR-4674	CLIP-seq
MIRT1234200	hsa-miR-4692	CLIP-seq
MIRT1234201	hsa-miR-4722-3p	CLIP-seq
MIRT1234202	hsa-miR-4742-5p	CLIP-seq
MIRT1234203	hsa-miR-4778-3p	CLIP-seq
MIRT1234204	hsa-miR-5095	CLIP-seq
MIRT1234205	hsa-miR-619	CLIP-seq
MIRT1234206	hsa-miR-885-5p	CLIP-seq
MIRT2068989	hsa-miR-1200	CLIP-seq
MIRT2068990	hsa-miR-1289	CLIP-seq
MIRT2068991	hsa-miR-1343	CLIP-seq
MIRT2068992	hsa-miR-1911	CLIP-seq
MIRT1234188	hsa-miR-1976	CLIP-seq
MIRT1234189	hsa-miR-24	CLIP-seq
MIRT2068993	hsa-miR-3198	CLIP-seq
MIRT1234190	hsa-miR-3199	CLIP-seq
MIRT1234193	hsa-miR-378g	CLIP-seq
MIRT1234194	hsa-miR-4269	CLIP-seq
MIRT2068994	hsa-miR-4294	CLIP-seq
MIRT2068995	hsa-miR-4309	CLIP-seq
MIRT2068996	hsa-miR-4324	CLIP-seq
MIRT1234195	hsa-miR-4437	CLIP-seq
MIRT1234196	hsa-miR-4438	CLIP-seq
MIRT1234198	hsa-miR-4514	CLIP-seq
MIRT2068997	hsa-miR-4534	CLIP-seq
MIRT1234199	hsa-miR-4674	CLIP-seq
MIRT1234200	hsa-miR-4692	CLIP-seq
MIRT1234201	hsa-miR-4722-3p	CLIP-seq
MIRT1234202	hsa-miR-4742-5p	CLIP-seq
MIRT1234204	hsa-miR-5095	CLIP-seq
MIRT2068998	hsa-miR-544b	CLIP-seq
MIRT2068989	hsa-miR-1200	CLIP-seq
MIRT2068992	hsa-miR-1911	CLIP-seq
MIRT1234188	hsa-miR-1976	CLIP-seq
MIRT1234189	hsa-miR-24	CLIP-seq
MIRT2296006	hsa-miR-2467-3p	CLIP-seq
MIRT2296007	hsa-miR-3125	CLIP-seq
MIRT2296008	hsa-miR-3692	CLIP-seq
MIRT1234193	hsa-miR-378g	CLIP-seq
MIRT2296009	hsa-miR-3916	CLIP-seq
MIRT2296010	hsa-miR-3925-3p	CLIP-seq
MIRT1234194	hsa-miR-4269	CLIP-seq
MIRT2296011	hsa-miR-4308	CLIP-seq
MIRT2068996	hsa-miR-4324	CLIP-seq
MIRT1234195	hsa-miR-4437	CLIP-seq
MIRT1234196	hsa-miR-4438	CLIP-seq
MIRT1234198	hsa-miR-4514	CLIP-seq
MIRT2296012	hsa-miR-4530	CLIP-seq
MIRT1234199	hsa-miR-4674	CLIP-seq
MIRT2296013	hsa-miR-4685-5p	CLIP-seq
MIRT1234200	hsa-miR-4692	CLIP-seq
MIRT1234201	hsa-miR-4722-3p	CLIP-seq
MIRT1234202	hsa-miR-4742-5p	CLIP-seq
MIRT1234203	hsa-miR-4778-3p	CLIP-seq
MIRT1234204	hsa-miR-5095	CLIP-seq
MIRT2296014	hsa-miR-515-5p	CLIP-seq
MIRT2068998	hsa-miR-544b	CLIP-seq
MIRT1234205	hsa-miR-619	CLIP-seq
MIRT2296015	hsa-miR-766	CLIP-seq
MIRT2296016	hsa-miR-922	CLIP-seq
MIRT2068989	hsa-miR-1200	CLIP-seq
MIRT2068992	hsa-miR-1911	CLIP-seq
MIRT1234188	hsa-miR-1976	CLIP-seq
MIRT1234194	hsa-miR-4269	CLIP-seq
MIRT2068996	hsa-miR-4324	CLIP-seq
MIRT1234198	hsa-miR-4514	CLIP-seq
MIRT1234200	hsa-miR-4692	CLIP-seq
MIRT1234201	hsa-miR-4722-3p	CLIP-seq
MIRT1234202	hsa-miR-4742-5p	CLIP-seq
MIRT2068998	hsa-miR-544b	CLIP-seq
MIRT2593958	hsa-miR-500a	CLIP-seq
MIRT2593959	hsa-miR-539	CLIP-seq
MIRT2593960	hsa-miR-548aa	CLIP-seq
MIRT2593961	hsa-miR-548ac	CLIP-seq
MIRT2593962	hsa-miR-548d-3p	CLIP-seq
MIRT2593963	hsa-miR-548z	CLIP-seq
MIRT2593959	hsa-miR-539	CLIP-seq
MIRT2593960	hsa-miR-548aa	CLIP-seq
MIRT2593961	hsa-miR-548ac	CLIP-seq
MIRT2593962	hsa-miR-548d-3p	CLIP-seq
MIRT2593963	hsa-miR-548z	CLIP-seq

Show/Hide all (92)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0001525	Process	Angiogenesis	IEA
GO:0001819	Process	Positive regulation of cytokine production	TAS	19075988
GO:0002250	Process	Adaptive immune response	TAS	17290298
GO:0002376	Process	Immune system process	IEA
GO:0002407	Process	Dendritic cell chemotaxis	TAS	18278175
GO:0002675	Process	Positive regulation of acute inflammatory response	IEA
GO:0002679	Process	Respiratory burst involved in defense response	TAS	19075988
GO:0003376	Process	Sphingosine-1-phosphate receptor signaling pathway	IEA
GO:0003376	Process	Sphingosine-1-phosphate receptor signaling pathway	IMP	18558630
GO:0004672	Function	Protein kinase activity	TAS	19376709
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	12507995, 21393242, 23824069, 25556234, 32814053, 35512704
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	12507995
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0005942	Component	Phosphatidylinositol 3-kinase complex	IEA
GO:0005943	Component	Phosphatidylinositol 3-kinase complex, class IA	EXP	10358071
GO:0005943	Component	Phosphatidylinositol 3-kinase complex, class IA	IBA
GO:0005944	Component	Phosphatidylinositol 3-kinase complex, class IB	IBA
GO:0005944	Component	Phosphatidylinositol 3-kinase complex, class IB	IDA	12507995
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006897	Process	Endocytosis	IEA
GO:0006935	Process	Chemotaxis	IEA
GO:0006954	Process	Inflammatory response	IEA
GO:0006954	Process	Inflammatory response	TAS	17290298
GO:0006955	Process	Immune response	NAS	31480354
GO:0007186	Process	G protein-coupled receptor signaling pathway	EXP	10358071
GO:0007186	Process	G protein-coupled receptor signaling pathway	IDA	12507995
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS	7624799
GO:0007200	Process	Phospholipase C-activating G protein-coupled receptor signaling pathway	ISS
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IEA
GO:0010595	Process	Positive regulation of endothelial cell migration	IEA
GO:0010595	Process	Positive regulation of endothelial cell migration	IMP	18558630
GO:0010818	Process	T cell chemotaxis	TAS	18278175
GO:0010897	Process	Negative regulation of triglyceride catabolic process	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IDA	12507995
GO:0016020	Component	Membrane	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016303	Function	1-phosphatidylinositol-3-kinase activity	IBA
GO:0016303	Function	1-phosphatidylinositol-3-kinase activity	IDA	11277933, 16123124
GO:0016303	Function	1-phosphatidylinositol-3-kinase activity	IEA
GO:0016303	Function	1-phosphatidylinositol-3-kinase activity	TAS	7624799, 17290298
GO:0016477	Process	Cell migration	IBA
GO:0016740	Function	Transferase activity	IEA
GO:0030593	Process	Neutrophil chemotaxis	TAS	17290298
GO:0032252	Process	Secretory granule localization	IEA
GO:0033628	Process	Regulation of cell adhesion mediated by integrin	TAS	18278175
GO:0035005	Function	1-phosphatidylinositol-4-phosphate 3-kinase activity	IBA
GO:0035005	Function	1-phosphatidylinositol-4-phosphate 3-kinase activity	IDA	16123124
GO:0035005	Function	1-phosphatidylinositol-4-phosphate 3-kinase activity	IEA
GO:0035022	Process	Positive regulation of Rac protein signal transduction	IEA
GO:0035022	Process	Positive regulation of Rac protein signal transduction	IMP	18558630
GO:0035747	Process	Natural killer cell chemotaxis	TAS	18278175
GO:0036092	Process	Phosphatidylinositol-3-phosphate biosynthetic process	IBA
GO:0042098	Process	T cell proliferation	TAS	19075988
GO:0042110	Process	T cell activation	TAS	17290298
GO:0042802	Function	Identical protein binding	IPI	20562859, 23824069
GO:0043303	Process	Mast cell degranulation	TAS	17290298
GO:0043406	Process	Positive regulation of MAP kinase activity	IDA	12507995
GO:0043491	Process	Phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA
GO:0043491	Process	Phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA	12507995
GO:0043491	Process	Phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA
GO:0043491	Process	Phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP	18558630, 21840392
GO:0043491	Process	Phosphatidylinositol 3-kinase/protein kinase B signal transduction	TAS	17290298
GO:0045087	Process	Innate immune response	TAS	17290298
GO:0045765	Process	Regulation of angiogenesis	IMP	21840392
GO:0046854	Process	Phosphatidylinositol phosphate biosynthetic process	IDA	12502714
GO:0046854	Process	Phosphatidylinositol phosphate biosynthetic process	IEA
GO:0046875	Function	Ephrin receptor binding	IPI	11416136
GO:0046934	Function	1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	IBA
GO:0046934	Function	1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	IDA	12502714, 15135396, 16123124
GO:0046934	Function	1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	IEA
GO:0048015	Process	Phosphatidylinositol-mediated signaling	IBA
GO:0051897	Process	Positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA	12507995
GO:0055118	Process	Negative regulation of cardiac muscle contraction	TAS	19147653
GO:0070527	Process	Platelet aggregation	TAS	21035500
GO:0071320	Process	Cellular response to cAMP	IEA
GO:0072672	Process	Neutrophil extravasation	TAS	18278175
GO:0097284	Process	Hepatocyte apoptotic process	IEA
GO:0106310	Function	Protein serine kinase activity	IDA	12502714
GO:0106310	Function	Protein serine kinase activity	IEA
GO:1903169	Process	Regulation of calcium ion transmembrane transport	IEA
GO:2000270	Process	Negative regulation of fibroblast apoptotic process	IEA

MIM	HGNC	e!Ensembl
601232	8978	ENSG00000105851

P48736

Protein name

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PI3-kinase subunit gamma) (PI3K-gamma) (PI3Kgamma) (PtdIns-3-kinase subunit gamma) (EC 2.7.1.137) (EC 2.7.1.153) (EC 2.7.1.154) (Phosphatidylinositol 4,5-bisphosphate 3-kinase

Protein function

Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the memb

PDB

1E8Y , 1E8Z , 1HE8 , 2A4Z , 2A5U , 2CHW , 2CHX , 2CHZ , 2V4L , 3APC , 3APD , 3APF , 3CSF , 3CST , 3DBS , 3DPD , 3ENE , 3IBE , 3L08 , 3L13 , 3L16 , 3L17 , 3L54 , 3LJ3 , 3MJW , 3ML8 , 3ML9 , 3NZS , 3NZU , 3OAW , 3P2B , 3PRE , 3PRZ , 3PS6 , 3QAQ , 3QAR , 3QJZ , 3QK0 , 3R7Q , 3R7R , 3S2A , 3SD5 , 3T8M , 3TJP , 3TL5 , 3ZVV , 3ZW3 , 4ANU , 4ANV , 4ANW , 4ANX

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00794	PI3K_rbd	203 → 312	PI3-kinase family, ras-binding domain	Domain
PF00792	PI3K_C2	377 → 519	Phosphoinositide 3-kinase C2	Domain
PF00613	PI3Ka	543 → 733	Phosphoinositide 3-kinase family, accessory domain (PIK domain)	Family
PF00454	PI3_PI4_kinase	827 → 1044	Phosphatidylinositol 3- and 4-kinase	Family

Tissue specificity

TISSUE SPECIFICITY: Pancreas, skeletal muscle, liver and heart. {ECO:0000269|PubMed:7624799}.

Sequence

MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLH
VAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLD
CLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGL
VTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDT
PGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNG
EEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRK
FRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKI
KDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEY
VLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEG
DRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQ
QEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYL
LQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAY
LRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLP
ESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQ
DMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTG
AFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNL
FHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLAL
RHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGW
TVQFNWFLHLVLGIKQGEKHSA

Sequence length

1102

Interactions

View interactions

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Immunodeficiency 97 with autoinflammation	Pathogenic	rs376453517, rs2116619574, rs774060880	RCV002210952 RCV002210953 RCV002204560

Show/Hide Unknown Diseases (15)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Acute myeloid leukemia	Benign	rs61749915	RCV005922586
Colorectal cancer	Benign	rs61749915	RCV005922591
Cystic fibrosis	Uncertain significance	rs144565710, rs771090910	RCV003128435 RCV003128509
Gastric cancer	Benign	rs61749915	RCV005922592
Hepatocellular carcinoma	Benign	rs61749915	RCV005922587
Keratoconus	Uncertain significance	rs767360862	RCV000678669
Long QT syndrome	Uncertain significance	rs796052174	RCV000190177
Malignant lymphoma, large B-cell, diffuse	Benign	rs61749915	RCV005922590
Malignant tumor of esophagus	Benign	rs61749915	RCV005922588
Melanoma	Benign	rs61749915	RCV005922595
Ovarian serous cystadenocarcinoma	Benign	rs61749915	RCV005922593
PIK3CG-related disorder	Likely benign	rs185548488	RCV003921835
Prostate cancer	Uncertain significance	rs864622026	RCV000206396
Thymoma	Benign	rs61749915	RCV005922594
Uveal melanoma	Benign	rs61749915	RCV005922589

Show/Hide Text Mining Associations (74)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Acute Coronary Syndrome	Associate	28885323
Adenocarcinoma of Lung	Associate	31386689
Alzheimer Disease	Associate	22982105
Anodontia	Associate	39245801
Aortic Aneurysm Abdominal	Associate	38175709
Asthma	Associate	29298996
Atherosclerosis	Associate	24951662, 28260035, 34115567
Atrial Remodeling	Associate	39245801
Autoimmune Diseases	Associate	30018141
Blood Platelet Disorders	Associate	20526338
Breast Neoplasms	Associate	16582596, 20551053, 21172654, 30050147, 35383130, 36892268, 40650045
Breast Neoplasms	Stimulate	23500535
Calcinosis	Associate	24725463
Calcinosis Cutis	Stimulate	32891176
Carcinogenesis	Associate	26743283, 32366932, 38287309
Carcinoma Intraductal Noninfiltrating	Stimulate	23500535
Carcinoma Non Small Cell Lung	Associate	22363436
Carcinoma Renal Cell	Associate	29635281, 31259714, 40419510
Cardiovascular Abnormalities	Associate	35205232
Carotid Stenosis	Associate	28260035
Cerebral Infarction	Associate	36691064
Colorectal Neoplasms	Associate	11756194, 22675430, 27296289, 31548566, 35546360, 35785488
Coronary Disease	Associate	28885323
COVID 19	Associate	36139476
Endometrial Neoplasms	Associate	28860563
Endometriosis	Associate	40187212
GATA2 Deficiency	Associate	32004387
Glioblastoma	Associate	17513297, 19304958
Glioma	Associate	29931616
Heart Failure	Associate	39245801
Hematologic Diseases	Associate	11756194
Hepatitis C Chronic	Associate	32050950
Hypoxia	Associate	27581620, 39245801
Idiopathic Pulmonary Fibrosis	Associate	23439433
Immunologic Deficiency Syndromes	Associate	33661099
Infections	Associate	28892135, 33092168
Inflammation	Associate	26658747, 27310202, 33661099
Insulin Resistance	Stimulate	17986714
Ischemia	Associate	28885323
Keratoconus	Associate	33729517
Leukemia Lymphocytic Chronic B Cell	Associate	29479062
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	16291747
Leukemia Myeloid Acute	Associate	21449673
Leukoencephalopathy Progressive Multifocal	Associate	33092168
Lung Neoplasms	Associate	22363436
Lupus Erythematosus Systemic	Associate	39563449
Lymphoma B Cell	Stimulate	32004387
Lymphoma Large B Cell Diffuse	Associate	24418330
Lymphoma T Cell	Associate	30018141
Lymphoma T Cell Peripheral	Associate	32004387
Medulloblastoma	Associate	21652733
Melanoma	Stimulate	32891176
Mesothelioma Malignant	Associate	31752449
Mobius Syndrome	Associate	31033088
Neoplasm Metastasis	Associate	29975213, 35614407, 37591783
Neoplasms	Inhibit	11756194
Neoplasms	Associate	19221038, 19304958, 25288776, 25435355, 29931616, 30897085, 33266502, 33619913, 33661099, 35484501, 36014933, 37272097
Osteosarcoma	Associate	37272097
Ovarian Diseases	Associate	37033258
Pancreatic Neoplasms	Associate	20581473, 32272917
Plaque Atherosclerotic	Associate	28260035
Polycythemia Vera	Associate	25288776
Polyomavirus Infections	Associate	33092168
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	25871383, 27174919
Prostatic Neoplasms	Associate	23661456, 30179225, 31581661
Prostatic stromal proliferation of uncertain malignant potential	Associate	40650045
Retinoblastoma	Associate	32366932
Sarcopenia	Associate	39519004
Simpson Golabi Behmel syndrome	Associate	25915946, 25972378
Smoke Inhalation Injury	Associate	33619913
Squamous Cell Carcinoma of Head and Neck	Associate	26087196, 40650045
Stomach Neoplasms	Associate	37591783
Thrombocytosis	Associate	19221038
Triple Negative Breast Neoplasms	Associate	30227836

PIK3CG (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma)