Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
8864
Gene name Gene Name - the full gene name approved by the HGNC.
Period circadian regulator 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PER2
Synonyms (NCBI Gene) Gene synonyms aliases
FASPS, FASPS1
Disease Acronyms (UniProt) Disease acronyms from UniProt database
FASPS1
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2q37.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomoto
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs121908635 T>C Pathogenic Coding sequence variant, missense variant
rs1559332542 G>- Pathogenic Coding sequence variant, frameshift variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT030473 hsa-miR-24-3p qRT-PCR;Microarray 19748357
MIRT712329 hsa-miR-5688 HITS-CLIP 19536157
MIRT712328 hsa-miR-495-3p HITS-CLIP 19536157
MIRT712327 hsa-miR-367-3p HITS-CLIP 19536157
MIRT712326 hsa-miR-92b-3p HITS-CLIP 19536157
Transcription factors
Transcription factor Regulation Reference
ARNTL Activation 22750052
ARNTL Unknown 17660446
CLOCK Activation 22750052
CLOCK Unknown 17660446
NPAS2 Unknown 17660446
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IBA 21873635
GO:0000122 Process Negative regulation of transcription by RNA polymerase II ISS
GO:0000976 Function Transcription regulatory region sequence-specific DNA binding IBA 21873635
GO:0000976 Function Transcription regulatory region sequence-specific DNA binding ISS
GO:0001222 Function Transcription corepressor binding IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
603426 8846 ENSG00000132326
Protein
UniProt ID O15055
Protein name Period circadian protein homolog 2 (hPER2) (Circadian clock protein PERIOD 2)
Protein function Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in g
PDB 6OF7 , 8D7M , 8D7N , 8D7O
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF08447 PAS_3 344 432 PAS fold Domain
PF12114 Period_C 1046 1232 Period protein 2/3C-terminal region Family
Tissue specificity TISSUE SPECIFICITY: Widely expressed. Found in heart, brain, placenta, lung, liver, skeleatal muscle, kidney and pancreas. High levels in skeletal muscle and pancreas. Low levels in lung. Isoform 2 is expressed in keratinocytes (at protein level). {ECO:00
Sequence
MNGYAEFPPSPSNPTKEPVEPQPSQVPLQEDVDMSSGSSGHETNENCSTGRDSQGSDCDD
SGKELGMLVEPPDARQSPDTFSLMMAKSEHNPSTSGCSSDQSSKVDTHKELIKTLKELKV
HLPADKKAKGKASTLATLKYALRSVKQVKANEEYYQLLMSSEGHPCGADVPSYTVEEMES
VTSEHIVKNADMFAVAVSLVSGKILYISDQVASIFHCKRDAFSDAKFVEFLAPHDVGVFH
SFTSPYKLPLWSMCSGADSFTQECMEEKSFFCRVSVRKSHENEIRYHPFRMTPYLVKVRD
QQGAESQLCCLLLAERVHSGYEAPRIPPEKRIFTTTHTPNCLFQDVDERAVPLLGYLPQD
LIETPVLVQLHPSDRPLMLAIHKKILQSGGQPFDYSPIRFRARNGEYITLDTSWSSFINP
WSRKISFIIGRH
KVRVGPLNEDVFAAHPCTEEKALHPSIQELTEQIHRLLLQPVPHSGSS
GYGSLGSNGSHEHLMSQTSSSDSNGHEDSRRRRAEICKNGNKTKNRSHYSHESGEQKKKS
VTEMQTNPPAEKKAVPAMEKDSLGVSFPEELACKNQPTCSYQQISCLDSVIRYLESCNEA
ATLKRKCEFPANVPALRSSDKRKATVSPGPHAGEAEPPSRVNSRTGVGTHLTSLALPGKA
ESVASLTSQCSYSSTIVHVGDKKPQPELEMVEDAASGPESLDCLAGPALACGLSQEKEPF
KKLGLTKEVLAAHTQKEEQSFLQKFKEIRKLSIFQSHCHYYLQERSKGQPSERTAPGLRN
TSGIDSPWKKTGKNRKLKSKRVKPRDSSESTGSGGPVSARPPLVGLNATAWSPSDTSQSS
CPAVPFPAPVPAAYSLPVFPAPGTVAAPPAPPHASFTVPAVPVDLQHQFAVQPPPFPAPL
APVMAFMLPSYSFPSGTPNLPQAFFPSQPQFPSHPTLTSEMASASQPEFPSRTSIPRQPC
ACPATRATPPSAMGRASPPLFQSRSSSPLQLNLLQLEEAPEGGTGAMGTTGATETAAVGA
DCKPGTSRDQQPKAPLTRDEPSDTQNSDALSTSSGLLNLLLNEDLCSASGSAASESLGSG
SLGCDASPSGAGSSDTSHTSKYFGSIDSSENNHKAKMNTGMEESEHFIKCVLQDPIWLLM
ADADSSVMMTYQLPSRNLEAVLKEDREKLKLLQKLQPRFTESQKQELREVHQWMQTGGLP
AAIDVAECVYCENKEKGNICIPYEEDIPSLGL
SEVSDTKEDENGSPLNHRIEEQT
Sequence length 1255
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Advanced Sleep Phase Syndrome advanced sleep phase syndrome 1, advanced sleep phase syndrome GenCC
Irritable Bowel Syndrome Irritable Bowel Syndrome GWAS
Insomnia Insomnia GWAS
Associations from Text Mining
Disease Name Relationship Type References
Abortion Spontaneous Associate 25573754
Adenocarcinoma of Lung Associate 36385012
Alcoholism Associate 20187847
Asthenozoospermia Associate 35000095
Attention Deficit and Disruptive Behavior Disorders Associate 26512752, 34321570
Attention Deficit and Disruptive Behavior Disorders Inhibit 31708917
Attention Deficit Disorder with Hyperactivity Associate 30758328, 34275001
Bipolar Disorder Stimulate 33674753
Brain Injuries Associate 34321570
Brain Injuries Traumatic Stimulate 34321570