Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs Transcription factors Other IDs Associated diseases
Entrez ID	5105
Gene name	Phosphoenolpyruvate carboxykinase 1
Gene symbol	PCK1
Synonyms (NCBI Gene)	PCKDCPEPCK-CPEPCK1PEPCKC
Chromosome	20
Chromosome location	20q13.31
Summary	This gene is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expressio

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SNP ID	Visualize variation	Clinical significance	Consequence
rs147120329	C>T	Conflicting-interpretations-of-pathogenicity	5 prime UTR variant, missense variant, coding sequence variant
rs148684857	G>A	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Missense variant, coding sequence variant
rs201186470	G>A	Pathogenic, uncertain-significance	Missense variant, coding sequence variant
rs373906233	G>A	Likely-pathogenic	Coding sequence variant, missense variant

379

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miRTarBase ID	miRNA	Experiments	Reference
MIRT054920	hsa-miR-33b-5p	Luciferase reporter assayqRT-PCR	23716591
MIRT607464	hsa-miR-8485	HITS-CLIP	22927820
MIRT607463	hsa-miR-4789-3p	HITS-CLIP	22927820
MIRT607462	hsa-miR-5011-5p	HITS-CLIP	22927820
MIRT626357	hsa-miR-8064	HITS-CLIP	22927820
MIRT607461	hsa-miR-190a-3p	HITS-CLIP	22927820
MIRT607460	hsa-miR-1277-5p	HITS-CLIP	22927820
MIRT607464	hsa-miR-8485	HITS-CLIP	23313552
MIRT607463	hsa-miR-4789-3p	HITS-CLIP	23313552
MIRT607462	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT639566	hsa-let-7f-2-3p	HITS-CLIP	23313552
MIRT639565	hsa-miR-1185-1-3p	HITS-CLIP	23313552
MIRT639564	hsa-miR-1185-2-3p	HITS-CLIP	23313552
MIRT607461	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT607460	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT607464	hsa-miR-8485	HITS-CLIP	23313552
MIRT607463	hsa-miR-4789-3p	HITS-CLIP	23313552
MIRT607462	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT607461	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT607460	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT607464	hsa-miR-8485	HITS-CLIP	23824327
MIRT607463	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607462	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT607461	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT607460	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT607464	hsa-miR-8485	HITS-CLIP	23824327
MIRT607463	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607462	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT607461	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT607460	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT607464	hsa-miR-8485	HITS-CLIP	23824327
MIRT607463	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607462	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT607461	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT607460	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT607464	hsa-miR-8485	HITS-CLIP	23824327
MIRT607463	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607462	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT607461	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT607460	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT607464	hsa-miR-8485	HITS-CLIP	23824327
MIRT607463	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607462	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT626357	hsa-miR-8064	HITS-CLIP	23824327
MIRT607461	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT607460	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT607464	hsa-miR-8485	HITS-CLIP	23824327
MIRT607463	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607462	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT607461	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT607460	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT607464	hsa-miR-8485	HITS-CLIP	23824327
MIRT607463	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607462	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT639566	hsa-let-7f-2-3p	HITS-CLIP	23824327
MIRT639565	hsa-miR-1185-1-3p	HITS-CLIP	23824327
MIRT639564	hsa-miR-1185-2-3p	HITS-CLIP	23824327
MIRT607461	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT607460	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT607464	hsa-miR-8485	HITS-CLIP	23824327
MIRT607463	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607462	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT639566	hsa-let-7f-2-3p	HITS-CLIP	23824327
MIRT639565	hsa-miR-1185-1-3p	HITS-CLIP	23824327
MIRT639564	hsa-miR-1185-2-3p	HITS-CLIP	23824327
MIRT607461	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT607460	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT607464	hsa-miR-8485	HITS-CLIP	23824327
MIRT607463	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607462	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT607461	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT607460	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT620256	hsa-miR-548a-3p	HITS-CLIP	23824327
MIRT620255	hsa-miR-548ar-3p	HITS-CLIP	23824327
MIRT620254	hsa-miR-548az-3p	HITS-CLIP	23824327
MIRT620253	hsa-miR-548e-3p	HITS-CLIP	23824327
MIRT620252	hsa-miR-548f-3p	HITS-CLIP	23824327
MIRT620251	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT620250	hsa-miR-3163	HITS-CLIP	23824327
MIRT620249	hsa-miR-7151-5p	HITS-CLIP	23824327
MIRT620248	hsa-miR-330-3p	HITS-CLIP	23824327
MIRT620247	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT620246	hsa-miR-7159-3p	HITS-CLIP	23824327
MIRT620245	hsa-miR-4482-3p	HITS-CLIP	23824327
MIRT607464	hsa-miR-8485	HITS-CLIP	23824327
MIRT607463	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607462	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT607461	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT607460	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT647684	hsa-miR-548aa	HITS-CLIP	23824327
MIRT647683	hsa-miR-548ap-3p	HITS-CLIP	23824327
MIRT647682	hsa-miR-548t-3p	HITS-CLIP	23824327
MIRT620249	hsa-miR-7151-5p	HITS-CLIP	23824327
MIRT620248	hsa-miR-330-3p	HITS-CLIP	23824327
MIRT620247	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT620246	hsa-miR-7159-3p	HITS-CLIP	23824327
MIRT620245	hsa-miR-4482-3p	HITS-CLIP	23824327
MIRT607464	hsa-miR-8485	HITS-CLIP	23824327
MIRT607463	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607462	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT607461	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT607460	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT607464	hsa-miR-8485	HITS-CLIP	23824327
MIRT607463	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607462	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT639566	hsa-let-7f-2-3p	HITS-CLIP	23824327
MIRT639565	hsa-miR-1185-1-3p	HITS-CLIP	23824327
MIRT639564	hsa-miR-1185-2-3p	HITS-CLIP	23824327
MIRT607461	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT607460	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT607464	hsa-miR-8485	HITS-CLIP	23824327
MIRT607463	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607462	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT607461	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT607460	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT607464	hsa-miR-8485	HITS-CLIP	23824327
MIRT607463	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607462	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT607461	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT607460	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT607464	hsa-miR-8485	HITS-CLIP	23824327
MIRT607463	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607462	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT607461	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT607460	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT607464	hsa-miR-8485	HITS-CLIP	23824327
MIRT607463	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607462	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT607461	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT607460	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT607464	hsa-miR-8485	HITS-CLIP	23824327
MIRT607463	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607462	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT607461	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT607460	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT607464	hsa-miR-8485	HITS-CLIP	23824327
MIRT607463	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607462	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT607461	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT607460	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT607464	hsa-miR-8485	HITS-CLIP	23824327
MIRT607463	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607462	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT626357	hsa-miR-8064	HITS-CLIP	23824327
MIRT607461	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT607460	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT607464	hsa-miR-8485	HITS-CLIP	23824327
MIRT607463	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607462	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT607461	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT607460	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT620256	hsa-miR-548a-3p	HITS-CLIP	23824327
MIRT620255	hsa-miR-548ar-3p	HITS-CLIP	23824327
MIRT620254	hsa-miR-548az-3p	HITS-CLIP	23824327
MIRT620253	hsa-miR-548e-3p	HITS-CLIP	23824327
MIRT620252	hsa-miR-548f-3p	HITS-CLIP	23824327
MIRT620251	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT620250	hsa-miR-3163	HITS-CLIP	23824327
MIRT620249	hsa-miR-7151-5p	HITS-CLIP	23824327
MIRT620248	hsa-miR-330-3p	HITS-CLIP	23824327
MIRT620247	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT620246	hsa-miR-7159-3p	HITS-CLIP	23824327
MIRT620245	hsa-miR-4482-3p	HITS-CLIP	23824327
MIRT607464	hsa-miR-8485	HITS-CLIP	23824327
MIRT607463	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607462	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT607461	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT607460	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT607464	hsa-miR-8485	HITS-CLIP	23824327
MIRT607463	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607462	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT607461	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT607460	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT607464	hsa-miR-8485	HITS-CLIP	23824327
MIRT607463	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607462	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT607461	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT607460	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT607464	hsa-miR-8485	HITS-CLIP	24906430
MIRT607463	hsa-miR-4789-3p	HITS-CLIP	24906430
MIRT607462	hsa-miR-5011-5p	HITS-CLIP	24906430
MIRT607461	hsa-miR-190a-3p	HITS-CLIP	24906430
MIRT607460	hsa-miR-1277-5p	HITS-CLIP	24906430
MIRT639566	hsa-let-7f-2-3p	HITS-CLIP	27418678
MIRT639565	hsa-miR-1185-1-3p	HITS-CLIP	27418678
MIRT639564	hsa-miR-1185-2-3p	HITS-CLIP	27418678
MIRT576690	hsa-miR-1277-5p	HITS-CLIP	27418678
MIRT576690	hsa-miR-1277-5p	HITS-CLIP	27418678
MIRT576691	hsa-miR-190a-3p	HITS-CLIP	27418678
MIRT576691	hsa-miR-190a-3p	HITS-CLIP	27418678
MIRT576694	hsa-miR-4789-3p	HITS-CLIP	27418678
MIRT576694	hsa-miR-4789-3p	HITS-CLIP	27418678
MIRT576693	hsa-miR-5011-5p	HITS-CLIP	27418678
MIRT576693	hsa-miR-5011-5p	HITS-CLIP	27418678
MIRT576692	hsa-miR-8064	HITS-CLIP	27418678
MIRT576695	hsa-miR-8485	HITS-CLIP	27418678
MIRT576695	hsa-miR-8485	HITS-CLIP	27418678
MIRT639566	hsa-let-7f-2-3p	HITS-CLIP	28735896
MIRT639565	hsa-miR-1185-1-3p	HITS-CLIP	28735896
MIRT639564	hsa-miR-1185-2-3p	HITS-CLIP	28735896
MIRT576690	hsa-miR-1277-5p	HITS-CLIP	28735896
MIRT576693	hsa-miR-5011-5p	HITS-CLIP	28735896
MIRT576695	hsa-miR-8485	HITS-CLIP	22927820
MIRT576694	hsa-miR-4789-3p	HITS-CLIP	22927820
MIRT576693	hsa-miR-5011-5p	HITS-CLIP	22927820
MIRT576692	hsa-miR-8064	HITS-CLIP	22927820
MIRT576691	hsa-miR-190a-3p	HITS-CLIP	22927820
MIRT576690	hsa-miR-1277-5p	HITS-CLIP	22927820
MIRT576695	hsa-miR-8485	HITS-CLIP	23313552
MIRT576694	hsa-miR-4789-3p	HITS-CLIP	23313552
MIRT576693	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT639566	hsa-let-7f-2-3p	HITS-CLIP	23313552
MIRT639565	hsa-miR-1185-1-3p	HITS-CLIP	23313552
MIRT639564	hsa-miR-1185-2-3p	HITS-CLIP	23313552
MIRT576691	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT576690	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT576695	hsa-miR-8485	HITS-CLIP	23313552
MIRT576694	hsa-miR-4789-3p	HITS-CLIP	23313552
MIRT576693	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT576691	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT576690	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT576695	hsa-miR-8485	HITS-CLIP	23824327
MIRT576694	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT576693	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT576691	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT576690	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT576695	hsa-miR-8485	HITS-CLIP	23824327
MIRT576694	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT576693	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT576691	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT576690	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT576695	hsa-miR-8485	HITS-CLIP	23824327
MIRT576694	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT576693	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT576691	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT576690	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT576695	hsa-miR-8485	HITS-CLIP	23824327
MIRT576694	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT576693	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT576691	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT576690	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT576695	hsa-miR-8485	HITS-CLIP	23824327
MIRT576694	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT576693	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT576692	hsa-miR-8064	HITS-CLIP	23824327
MIRT576691	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT576690	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT576695	hsa-miR-8485	HITS-CLIP	23824327
MIRT576694	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT576693	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT576691	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT576690	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT576695	hsa-miR-8485	HITS-CLIP	23824327
MIRT576694	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT576693	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT639566	hsa-let-7f-2-3p	HITS-CLIP	23824327
MIRT639565	hsa-miR-1185-1-3p	HITS-CLIP	23824327
MIRT639564	hsa-miR-1185-2-3p	HITS-CLIP	23824327
MIRT576691	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT576690	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT576695	hsa-miR-8485	HITS-CLIP	23824327
MIRT576694	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT576693	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT639566	hsa-let-7f-2-3p	HITS-CLIP	23824327
MIRT639565	hsa-miR-1185-1-3p	HITS-CLIP	23824327
MIRT639564	hsa-miR-1185-2-3p	HITS-CLIP	23824327
MIRT576691	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT576690	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT576695	hsa-miR-8485	HITS-CLIP	23824327
MIRT576694	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT576693	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT576691	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT576690	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT620256	hsa-miR-548a-3p	HITS-CLIP	23824327
MIRT620255	hsa-miR-548ar-3p	HITS-CLIP	23824327
MIRT620254	hsa-miR-548az-3p	HITS-CLIP	23824327
MIRT620253	hsa-miR-548e-3p	HITS-CLIP	23824327
MIRT620252	hsa-miR-548f-3p	HITS-CLIP	23824327
MIRT620251	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT620250	hsa-miR-3163	HITS-CLIP	23824327
MIRT620249	hsa-miR-7151-5p	HITS-CLIP	23824327
MIRT620248	hsa-miR-330-3p	HITS-CLIP	23824327
MIRT620247	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT620246	hsa-miR-7159-3p	HITS-CLIP	23824327
MIRT620245	hsa-miR-4482-3p	HITS-CLIP	23824327
MIRT576695	hsa-miR-8485	HITS-CLIP	23824327
MIRT576694	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT576693	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT576691	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT576690	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT647684	hsa-miR-548aa	HITS-CLIP	23824327
MIRT647683	hsa-miR-548ap-3p	HITS-CLIP	23824327
MIRT647682	hsa-miR-548t-3p	HITS-CLIP	23824327
MIRT620249	hsa-miR-7151-5p	HITS-CLIP	23824327
MIRT620248	hsa-miR-330-3p	HITS-CLIP	23824327
MIRT620247	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT620246	hsa-miR-7159-3p	HITS-CLIP	23824327
MIRT620245	hsa-miR-4482-3p	HITS-CLIP	23824327
MIRT576695	hsa-miR-8485	HITS-CLIP	23824327
MIRT576694	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT576693	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT576691	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT576690	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT576695	hsa-miR-8485	HITS-CLIP	23824327
MIRT576694	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT576693	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT639566	hsa-let-7f-2-3p	HITS-CLIP	23824327
MIRT639565	hsa-miR-1185-1-3p	HITS-CLIP	23824327
MIRT639564	hsa-miR-1185-2-3p	HITS-CLIP	23824327
MIRT576691	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT576690	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT576695	hsa-miR-8485	HITS-CLIP	23824327
MIRT576694	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT576693	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT576691	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT576690	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT576695	hsa-miR-8485	HITS-CLIP	23824327
MIRT576694	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT576693	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT576691	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT576690	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT576695	hsa-miR-8485	HITS-CLIP	23824327
MIRT576694	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT576693	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT576691	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT576690	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT576695	hsa-miR-8485	HITS-CLIP	23824327
MIRT576694	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT576693	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT576691	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT576690	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT576695	hsa-miR-8485	HITS-CLIP	23824327
MIRT576694	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT576693	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT576691	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT576690	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT576695	hsa-miR-8485	HITS-CLIP	23824327
MIRT576694	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT576693	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT576691	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT576690	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT576695	hsa-miR-8485	HITS-CLIP	23824327
MIRT576694	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT576693	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT576692	hsa-miR-8064	HITS-CLIP	23824327
MIRT576691	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT576690	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT576695	hsa-miR-8485	HITS-CLIP	23824327
MIRT576694	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT576693	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT576691	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT576690	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT620256	hsa-miR-548a-3p	HITS-CLIP	23824327
MIRT620255	hsa-miR-548ar-3p	HITS-CLIP	23824327
MIRT620254	hsa-miR-548az-3p	HITS-CLIP	23824327
MIRT620253	hsa-miR-548e-3p	HITS-CLIP	23824327
MIRT620252	hsa-miR-548f-3p	HITS-CLIP	23824327
MIRT620251	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT620250	hsa-miR-3163	HITS-CLIP	23824327
MIRT620249	hsa-miR-7151-5p	HITS-CLIP	23824327
MIRT620248	hsa-miR-330-3p	HITS-CLIP	23824327
MIRT620247	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT620246	hsa-miR-7159-3p	HITS-CLIP	23824327
MIRT620245	hsa-miR-4482-3p	HITS-CLIP	23824327
MIRT576695	hsa-miR-8485	HITS-CLIP	23824327
MIRT576694	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT576693	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT576691	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT576690	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT576695	hsa-miR-8485	HITS-CLIP	23824327
MIRT576694	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT576693	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT576691	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT576690	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT576695	hsa-miR-8485	HITS-CLIP	23824327
MIRT576694	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT576693	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT576691	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT576690	hsa-miR-1277-5p	HITS-CLIP	23824327

Show/Hide all (4)

Transcription factor	Regulation	Reference
ATF2	Activation	12453892
CEBPA	Unknown	12237288
SP1	Activation	14744869
SREBF1	Repression	14744869

Show/Hide all (76)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000287	Function	Magnesium ion binding	IDA	11851336
GO:0004611	Function	Phosphoenolpyruvate carboxykinase activity	IEA
GO:0004613	Function	Phosphoenolpyruvate carboxykinase (GTP) activity	EXP	11851336
GO:0004613	Function	Phosphoenolpyruvate carboxykinase (GTP) activity	IBA
GO:0004613	Function	Phosphoenolpyruvate carboxykinase (GTP) activity	IDA	30193097, 32322062
GO:0004613	Function	Phosphoenolpyruvate carboxykinase (GTP) activity	IEA
GO:0004613	Function	Phosphoenolpyruvate carboxykinase (GTP) activity	IMP	26971250
GO:0004613	Function	Phosphoenolpyruvate carboxykinase (GTP) activity	ISS
GO:0005525	Function	GTP binding	IDA	11851336
GO:0005525	Function	GTP binding	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0005739	Component	Mitochondrion	IBA
GO:0005783	Component	Endoplasmic reticulum	IDA	32322062
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA	32322062
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006006	Process	Glucose metabolic process	IMP	14764811
GO:0006094	Process	Gluconeogenesis	IBA
GO:0006094	Process	Gluconeogenesis	IDA	30193097
GO:0006094	Process	Gluconeogenesis	IEA
GO:0006094	Process	Gluconeogenesis	IEA
GO:0006094	Process	Gluconeogenesis	IMP	26971250
GO:0006094	Process	Gluconeogenesis	ISS
GO:0006094	Process	Gluconeogenesis	TAS
GO:0006107	Process	Oxaloacetate metabolic process	IBA
GO:0006107	Process	Oxaloacetate metabolic process	IDA	30193097
GO:0006107	Process	Oxaloacetate metabolic process	IEA
GO:0006607	Process	NLS-bearing protein import into nucleus	IDA	14645851
GO:0006607	Process	NLS-bearing protein import into nucleus	ISS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0009617	Process	Response to bacterium	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016829	Function	Lyase activity	IEA
GO:0016831	Function	Carboxy-lyase activity	IEA
GO:0017076	Function	Purine nucleotide binding	IEA
GO:0018105	Process	Peptidyl-serine phosphorylation	IDA	32322062
GO:0019543	Process	Propionate catabolic process	IBA
GO:0030145	Function	Manganese ion binding	IBA
GO:0030145	Function	Manganese ion binding	IDA	11851336
GO:0030145	Function	Manganese ion binding	IEA
GO:0031406	Function	Carboxylic acid binding	IDA	11851336
GO:0032868	Process	Response to insulin	IDA	14764811
GO:0032869	Process	Cellular response to insulin stimulus	IBA
GO:0032869	Process	Cellular response to insulin stimulus	IDA	32322062
GO:0036316	Process	SREBP-SCAP complex retention in endoplasmic reticulum	IDA	12202038, 15899885, 32322062
GO:0042593	Process	Glucose homeostasis	ISS
GO:0042594	Process	Response to starvation	IBA
GO:0043382	Process	Positive regulation of memory T cell differentiation	IEA
GO:0043382	Process	Positive regulation of memory T cell differentiation	ISS
GO:0043648	Process	Dicarboxylic acid metabolic process	IEA
GO:0045542	Process	Positive regulation of cholesterol biosynthetic process	IDA	12177166
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0046166	Process	Glyceraldehyde-3-phosphate biosynthetic process	IEA
GO:0046327	Process	Glycerol biosynthetic process from pyruvate	IBA
GO:0046327	Process	Glycerol biosynthetic process from pyruvate	IEA
GO:0046327	Process	Glycerol biosynthetic process from pyruvate	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0046889	Process	Positive regulation of lipid biosynthetic process	IDA	32322062
GO:0046890	Process	Regulation of lipid biosynthetic process	IDA	32322062
GO:0051365	Process	Cellular response to potassium ion starvation	IEA
GO:0051604	Process	Protein maturation	EXP	11163209
GO:0051604	Process	Protein maturation	IDA	11163209
GO:0051604	Process	Protein maturation	IMP	21719679
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0070365	Process	Hepatocyte differentiation	IBA
GO:0071333	Process	Cellular response to glucose stimulus	IBA
GO:0071333	Process	Cellular response to glucose stimulus	IDA	30193097
GO:0071549	Process	Cellular response to dexamethasone stimulus	IBA
GO:0072350	Process	Tricarboxylic acid metabolic process	IDA	30193097
GO:0106264	Function	Protein serine kinase activity (using GTP as donor)	IDA	32322062
GO:0106264	Function	Protein serine kinase activity (using GTP as donor)	IEA

MIM	HGNC	e!Ensembl
614168	8724	ENSG00000124253

P35558

Protein name

Phosphoenolpyruvate carboxykinase, cytosolic [GTP] (PEPCK-C) (EC 4.1.1.32) (Serine-protein kinase PCK1) (EC 2.7.11.-)

Protein function

Cytosolic phosphoenolpyruvate carboxykinase that catalyzes the reversible decarboxylation and phosphorylation of oxaloacetate (OAA) and acts as the rate-limiting enzyme in gluconeogenesis (PubMed:24863970, PubMed:26971250, PubMed:28216384, PubMe

PDB

1KHB , 1KHE , 1KHF , 1KHG , 1M51 , 1NHX , 2GMV

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF17297	PEPCK_N	29 → 256	Phosphoenolpyruvate carboxykinase N-terminal domain	Domain
PF00821	PEPCK_GTP	260 → 619	Phosphoenolpyruvate carboxykinase C-terminal P-loop domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Major sites of expression are liver, kidney and adipocytes. {ECO:0000269|PubMed:8490617}.

Sequence

MPPQLQNGLNLSAKVVQGSLDSLPQAVREFLENNAELCQPDHIHICDGSEEENGRLLGQM
EEEGILRRLKKYDNCWLALTDPRDVARIESKTVIVTQEQRDTVPIPKTGLSQLGRWMSEE
DFEKAFNARFPGCMKGRTMYVIPFSMGPLGSPLSKIGIELTDSPYVVASMRIMTRMGTPV
LEAVGDGEFVKCLHSVGCPLPLQKPLVNNWPCNPELTLIAHLPDRREIISFGSGYGGNSL
LGKKCFALRMASRLAKEEGWLAEHMLILGITNPEGEKKYLAAAFPSACGKTNLAMMNPSL
PGWKVECVGDDIAWMKFDAQGHLRAINPENGFFGVAPGTSVKTNPNAIKTIQKNTIFTNV
AETSDGGVYWEGIDEPLASGVTITSWKNKEWSSEDGEPCAHPNSRFCTPASQCPIIDAAW
ESPEGVPIEGIIFGGRRPAGVPLVYEALSWQHGVFVGAAMRSEATAAAEHKGKIIMHDPF
AMRPFFGYNFGKYLAHWLSMAQHPAAKLPKIFHVNWFRKDKEGKFLWPGFGENSRVLEWM
FNRIDGKASTKLTPIGYIPKEDALNLKGLGHINMMELFSISKEFWEKEVEDIEKYLEDQV
NADLPCEIEREILALKQRISQM

Sequence length

622

Interactions

View interactions

123

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phosphoenolpyruvate carboxykinase deficiency, cytosolic	Pathogenic; Likely pathogenic	rs2070161874, rs776767788	RCV003228696 RCV001198900

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Clear cell carcinoma of kidney	Uncertain significance; Conflicting classifications of pathogenicity	rs151290242, rs41302559	RCV005939383 RCV005910209
Colon adenocarcinoma	Conflicting classifications of pathogenicity	rs41302559	RCV005910207
Hepatocellular carcinoma	Conflicting classifications of pathogenicity	rs41302559	RCV005910208
Ovarian serous cystadenocarcinoma	Conflicting classifications of pathogenicity	rs41302559	RCV005910210
PCK1-related disorder	Likely benign; Uncertain significance; Conflicting classifications of pathogenicity	rs768311154, rs1249357800, rs1194696584, rs534949125, rs375595139, rs973853096, rs771109436, rs771750002, rs2515806246, rs11552146, rs148684857, rs147120329, rs28359542, rs28359550, rs41302559 View all (4 more)	RCV003923433 RCV003946478 RCV003412261 RCV003966642 RCV003899095 RCV003962131 RCV003971887 RCV003957076 RCV003952256 RCV004752863 RCV003932356 RCV003936100 RCV003918480 RCV003905905 RCV003926126 RCV003930815 RCV003923273 RCV003923268 RCV003963078
Phosphoenolpyruvate carboxykinase (GTP) deficiency	Uncertain significance; Likely benign	rs201179319, rs141075201, rs760440639, rs139008325, rs147972610	RCV000408339 RCV000395261 RCV000296804 RCV000299330 RCV000305081 RCV000279523 RCV000366703 RCV000271924 RCV000405865 RCV000331645 RCV000372126 RCV000334524 RCV000269954

Show/Hide Text Mining Associations (35)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma	Associate	35109912
Alzheimer Disease	Associate	18830724, 21152065
Androgen Insensitivity Syndrome	Associate	24863970
Atherosclerosis	Associate	37904164
Brain Diseases	Associate	37924129
Breast Neoplasms	Associate	32028860, 39684297
Carcinogenesis	Associate	39684297
Carcinoma Hepatocellular	Associate	31406102, 33865459, 34238253
Carcinoma Hepatocellular	Inhibit	37166978
Carcinoma Renal Cell	Associate	27748938, 34528699
Cardiovascular Diseases	Associate	37904164
Colitis Ulcerative	Associate	33686088
Colonic Neoplasms	Associate	35109912
Colorectal Neoplasms	Associate	36193307, 37475862
Diabetes Gestational	Associate	30805369
Diabetes Mellitus	Associate	26280835, 37904164
Diabetes Mellitus Type 2	Associate	19725958, 22932905, 30805369
Genetic Diseases Inborn	Associate	37924129
Hypoglycemia	Associate	24863970, 37924129
Infarction	Associate	20574532
Inflammation	Associate	39463224
Inflammatory Bowel Diseases	Associate	39273699
Lewy Body Disease	Associate	20574532
Malaria	Associate	36193307
Melanoma	Associate	36700470
Mental Disorders	Associate	26280835
Microphthalmia Syndromic 10	Associate	21152065
Multiple Sclerosis	Associate	21152065
Neoplasm Metastasis	Associate	32777161
Neoplasms	Associate	29259235, 36700470, 39684297
Obesity	Associate	20134411, 26280835
Osteoarthritis	Inhibit	39463224
Phosphoenolpyruvate carboxykinase deficiency	Associate	37924129
Smith Magenis Syndrome	Associate	24863970
Triple Negative Breast Neoplasms	Associate	39529035

PCK1 (phosphoenolpyruvate carboxykinase 1)