OGDHL (oxoglutarate dehydrogenase L)

Gene
Gene SNPs Other IDs
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
55753
Gene name Gene Name - the full gene name approved by the HGNC.
Oxoglutarate dehydrogenase L
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
OGDHL
Synonyms (NCBI Gene) Gene synonyms aliases
YOBELN
Disease Acronyms (UniProt) Disease acronyms from UniProt database
YOBELN
Chromosome Chromosome number
10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10q11.23
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is similar to oxoglutarate dehydrogenase (OGDH) of the OGDH complex, which degrades glucose and glutamate. This gene encodes several isoforms, including some that appear to localize to mitochondria. The encoded protein dow
SNPs SNP information provided by dbSNP.
Gene SNPs Other IDs
Show/Hide all(1)
SNP ID Visualize variation Clinical significance Consequence
rs773888308 G>A,C Uncertain-significance, likely-pathogenic Coding sequence variant, missense variant, non coding transcript variant
miRNA miRNA information provided by mirtarbase database.
Gene SNPs Other IDs
Show/Hide all(15)
miRTarBase ID miRNA Experiments Reference
MIRT018923 hsa-miR-335-5p Microarray 18185580
MIRT038289 hsa-miR-130b-5p CLASH 23622248
MIRT734172 hsa-miR-193a-5p Immunohistochemistry (IHC), Luciferase reporter assay, qRT-PCR, Western blotting 32489562
MIRT2058523 hsa-miR-3064-5p CLIP-seq
MIRT2058524 hsa-miR-3162-3p CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs Other IDs
Show/Hide all(9)
GO ID Ontology Definition Evidence Reference
GO:0004591 Function Oxoglutarate dehydrogenase (succinyl-transferring) activity IBA 21873635
GO:0005515 Function Protein binding IPI 21988832, 32296183
GO:0005739 Component Mitochondrion IBA 21873635
GO:0005759 Component Mitochondrial matrix IEA
GO:0006096 Process Glycolytic process IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs Other IDs
MIM HGNC e!Ensembl
617513 25590 ENSG00000197444
Protein
Gene SNPs Other IDs
UniProt ID Q9ULD0
Protein name 2-oxoglutarate dehydrogenase-like, mitochondrial (EC 1.2.4.2) (2-oxoglutarate dehydrogenase complex component E1-like) (OGDC-E1-like) (Alpha-ketoglutarate dehydrogenase-like)
Protein function 2-oxoglutarate dehydrogenase (E1-like) component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDHC) which mediates the decarboxylation of alpha-ketoglutarate in the tricarboxylic acid cycle. The OGDHC complex catalyzes the overall c
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF16078 2-oxogl_dehyd_N 42 → 81 2-oxoglutarate dehydrogenase N-terminus Family
PF00676 E1_dh 243 → 569 Dehydrogenase E1 component Family
PF02779 Transket_pyr 636 → 852 Transketolase, pyrimidine binding domain Domain
PF16870 OxoGdeHyase_C 855 → 1000 2-oxoglutarate dehydrogenase C-terminal Family
Tissue specificity TISSUE SPECIFICITY: Expressed in the brain and the liver. {ECO:0000269|PubMed:23152800, ECO:0000269|PubMed:31175094}.
Sequence 
MSQLRLLPSRLGVQAARLLAAHDVPVFGWRSRSSGPPATFPSSKGGGGSSYMEEMYFAWL
ENPQSVHKSWDSFFREASEEAFSGSAQPRPPSVVHESRSAVSSRTKTSKLVEDHLAVQSL
IRAYQIRGHHVAQLDPLGILDADLDSFVPSDLITTIDKLAFYDLQEADLDKEFQLPTTTF
IGGSENTLSLREIIRRLENTYCQHIGLEFMFINDVEQCQWIRQKFETPGVMQFSSEEKRT
LLARLVRSMRFEDFLARKWSSEKRFGLEGCEVMIPALKTIIDKSSEMGIENVILGMPHRG
RLNVLANVIRKDLEQIFCQFDPKLEAADEGSGDVKYHLGMYHERINRVTNRNITLSLVAN
PSHLEAVDPVVQGKTKAEQFYRGDAQGKKVMSILVHGDAAFAGQGVVYETFHLSDLPSYT
TNGTVHVVVNNQIGFTTDPRMARSSPYPTDVARVVNAPIFHVNADDPEAVIYVCSVAAEW
RNTFNKDVVVDLVCYRRRGHNEMDEPMFTQPLMYKQIHRQVPVLKKYADKLIAEGTVTLQ
EFEEEIAKYDRICEEAYGRSKDKKILHIKHWLDSPWPGFFNVDGEPKSMTCPATGIPEDM
LTHIGSVASSVPLEDFKIHTGLSRILRGRADMTKNRTVDWALAEYMAFGSLLKEGIHVRL
SGQDVERGTFSHRHHVLHDQEVDRRTCVPMNHLWPDQAPYTVCNSSLSEYGVLGFELGYA
MASPNALVLWEAQFGDFHNTAQCIIDQFISTGQAKWVRHNGIVLLLPHGMEGMGPEHSSA
RPERFLQMSNDDSDAYPAFTKDFEVSQLYDCNWIVVNCSTPANYFHVLRRQILLPFRKPL
IIFTPKSLLRHPEAKSSFDQMVSGTSFQRVIPEDGAAARAPEQVQRLIFCTGKVYYDLVK
ERSSQDLEEKVAITRLEQISPFPFDLIKQEAEKYPGAELAWCQEEHKNMGYYDYISPRFM
TILRRARPIWYVGRDPAAAPATGNRNTHLVSLKKFLDTAFNLQAFEGKTF
Sequence length 1010
Interactions View interactions