NT5C2 (5'-nucleotidase, cytosolic II)
Gene | |
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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22978 |
Gene name
Gene Name - the full gene name approved by the HGNC.
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5'-nucleotidase, cytosolic II |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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NT5C2 |
Synonyms (NCBI Gene)
Gene synonyms aliases
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GMP, NT5B, PNT5, SPG45, SPG65, cN-II |
Disease Acronyms (UniProt)
Disease acronyms from UniProt database
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SPG45 |
Chromosome
Chromosome number
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10 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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10q24.32-q24.33 |
Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes a hydrolase that serves as an important role in cellular purine metabolism by acting primarily on inosine 5`-monophosphate and other purine nucleotides. [provided by RefSeq, Oct 2011] |
SNPs
SNP information provided by dbSNP.
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein | |||||||||||
UniProt ID | P49902 | ||||||||||
Protein name | Cytosolic purine 5'-nucleotidase (EC 3.1.3.5) (EC 3.1.3.99) (Cytosolic 5'-nucleotidase II) (cN-II) (Cytosolic IMP/GMP-specific 5'-nucleotidase) (Cytosolic nucleoside phosphotransferase 5'N) (EC 2.7.1.77) (High Km 5'-nucleotidase) | ||||||||||
Protein function | Broad specificity cytosolic 5'-nucleotidase that catalyzes the dephosphorylation of 6-hydroxypurine nucleoside 5'-monophosphates (PubMed:10092873, PubMed:12907246, PubMed:1659319, PubMed:9371705). In addition, possesses a phosphotransferase acti | ||||||||||
PDB | 2J2C , 2JC9 , 2JCM , 2XCV , 2XCW , 2XCX , 2XJB , 2XJC , 2XJD , 2XJE , 2XJF , 4H4B , 5CQZ , 5CR7 , 5K7Y , 5L4Z , 5L50 , 5OPK , 5OPL , 5OPM , 5OPN , 5OPO , 5OPP , 6DD3 , 6DDB , 6DDC , 6DDH , 6DDK , 6DDL , 6DDO , 6DDQ , 6DDX , 6DDY , 6DDZ , 6DE0 , 6DE1 , 6DE2 , 6DE3 , 6FIR , 6FIS , 6FIU , 6FIW , 6FXH | ||||||||||
Family and domains |
Pfam
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Tissue specificity | TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:9371705}. | ||||||||||
Sequence | |||||||||||
Sequence length | 561 | ||||||||||
Interactions | View interactions |
Associated diseases
Disease information provided by ClinVar, GenCC, and GWAS databases.
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