Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4893
Gene name Gene Name - the full gene name approved by the HGNC.
NRAS proto-oncogene, GTPase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
NRAS
Synonyms (NCBI Gene) Gene synonyms aliases
ALPS4, CMNS, KRAS, N-ras, NCMS, NRAS1, NS6
Disease Acronyms (UniProt) Disease acronyms from UniProt database
CMNS, NCMS, NS6
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p13.2
Summary Summary of gene provided in NCBI Entrez Gene.
This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has i
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs11554290 T>A,C,G Pathogenic, likely-pathogenic Missense variant, coding sequence variant
rs121434595 C>A,G,T Likely-pathogenic, pathogenic Missense variant, coding sequence variant
rs121434596 C>A,G,T Likely-pathogenic, pathogenic Missense variant, coding sequence variant
rs121913237 C>A,G,T Likely-pathogenic, pathogenic Missense variant, coding sequence variant
rs121913248 C>G,T Likely-pathogenic Missense variant, coding sequence variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT003836 hsa-let-7b-5p Immunohistochemistry, qRT-PCR 19966857
MIRT001854 hsa-let-7a-5p Luciferase reporter assay, Microarray 15766527
MIRT004531 hsa-let-7c-5p Microarray, Northern blot, qRT-PCR, Western blot 15766527
MIRT003903 hsa-miR-20a-5p Western blot 19110058
MIRT001854 hsa-let-7a-5p Western blot 19110058
Transcription factors
Transcription factor Regulation Reference
AR Repression 16281084
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IEA
GO:0000165 Process MAPK cascade TAS
GO:0001938 Process Positive regulation of endothelial cell proliferation IMP 23619365
GO:0002223 Process Stimulatory C-type lectin receptor signaling pathway TAS
GO:0003924 Function GTPase activity IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
164790 7989 ENSG00000213281
Protein
UniProt ID P01111
Protein name GTPase NRas (EC 3.6.5.2) (Transforming protein N-Ras)
Protein function Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
PDB 2N9C , 3CON , 5UHV , 6E6H , 6MPP , 6ULI , 6ULK , 6ULN , 6ULR , 6UON , 6WGH , 6ZIO , 6ZIR , 6ZIZ , 7F68 , 7OW3 , 7OW4 , 7OW5 , 7OW6 , 7PB2 , 8TBI , 8VM2
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00071 Ras 5 165 Ras family Domain
Sequence
Sequence length 189
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Noonan Syndrome Noonan syndrome GenCC
Costello Syndrome Costello syndrome GenCC
Noonan syndrome with multiple lentigines Noonan syndrome with multiple lentigines GenCC
Associations from Text Mining
Disease Name Relationship Type References
Abdominal Neoplasms Associate 38254245
Aberrant Crypt Foci Associate 29222172
Acute erythroleukemia Associate 2200539
Adenocarcinoma Associate 23196793, 26317919, 26536055, 28097440, 28179590, 36788068
Adenocarcinoma Follicular Associate 24820091, 27264674, 31077238, 7951583
Adenocarcinoma Mucinous Associate 37296579
Adenocarcinoma of Lung Associate 22975805, 26098749, 26682952, 27151654, 31446140, 31532708, 35212617
Adenoma Associate 1452458, 27494611
Adenomatous Polyposis Coli Associate 28141798
Adrenocortical Carcinoma Associate 25078331