Gene Gene information from NCBI Gene database.
Entrez ID 4893
Gene name NRAS proto-oncogene, GTPase
Gene symbol NRAS
Synonyms (NCBI Gene)
ALPS4CMNSKRASN-rasNCMSNRAS1NS6
Chromosome 1
Chromosome location 1p13.2
Summary This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has i
SNPs SNP information provided by dbSNP.
19
SNP ID Visualize variation Clinical significance Consequence
rs11554290 T>A,C,G Pathogenic, likely-pathogenic Missense variant, coding sequence variant
rs121434595 C>A,G,T Likely-pathogenic, pathogenic Missense variant, coding sequence variant
rs121434596 C>A,G,T Likely-pathogenic, pathogenic Missense variant, coding sequence variant
rs121913237 C>A,G,T Likely-pathogenic, pathogenic Missense variant, coding sequence variant
rs121913248 C>G,T Likely-pathogenic Missense variant, coding sequence variant
miRNA miRNA information provided by mirtarbase database.
1606
miRTarBase ID miRNA Experiments Reference
MIRT003836 hsa-let-7b-5p ImmunohistochemistryqRT-PCR 19966857
MIRT001854 hsa-let-7a-5p Luciferase reporter assayMicroarray 15766527
MIRT004531 hsa-let-7c-5p MicroarrayNorthern blotqRT-PCRWestern blot 15766527
MIRT003903 hsa-miR-20a-5p Western blot 19110058
MIRT001854 hsa-let-7a-5p Western blot 19110058
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
AR Repression 16281084
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
31
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IEA
GO:0000139 Component Golgi membrane TAS
GO:0000165 Process MAPK cascade IEA
GO:0000165 Process MAPK cascade TAS
GO:0000166 Function Nucleotide binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
164790 7989 ENSG00000213281
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P01111
Protein name GTPase NRas (EC 3.6.5.2) (Transforming protein N-Ras)
Protein function Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
PDB 2N9C , 3CON , 5UHV , 6E6H , 6MPP , 6ULI , 6ULK , 6ULN , 6ULR , 6UON , 6WGH , 6ZIO , 6ZIR , 6ZIZ , 7F68 , 7OW3 , 7OW4 , 7OW5 , 7OW6 , 7PB2 , 8TBI , 8VM2
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00071 Ras 5 165 Ras family Domain
Sequence
Sequence length 189
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
454
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Acute megakaryoblastic leukemia in down syndrome Likely pathogenic; Pathogenic rs121434596 RCV001293767
Acute myeloid leukemia Likely pathogenic; Pathogenic rs121434595, rs121434596 RCV000438070
RCV005887522
Acute myeloid leukemia with NPM1 somatic mutations Likely pathogenic; Pathogenic rs121434596 RCV006253597
Anemia Likely pathogenic rs1570874751 RCV001003789
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Alveolar rhabdomyosarcoma Conflicting classifications of pathogenicity rs121913254 RCV006253768
Atypical teratoid rhabdoid tumor Conflicting classifications of pathogenicity rs121913254 RCV006253770
Focal-onset seizure Conflicting classifications of pathogenicity rs1393160852 RCV001775214
Malignant peripheral nerve sheath tumor Conflicting classifications of pathogenicity rs121913254 RCV006253772
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Abdominal Neoplasms Associate 38254245
Aberrant Crypt Foci Associate 29222172
Acute erythroleukemia Associate 2200539
Adenocarcinoma Associate 23196793, 26317919, 26536055, 28097440, 28179590, 36788068
Adenocarcinoma Follicular Associate 24820091, 27264674, 31077238, 7951583
Adenocarcinoma Mucinous Associate 37296579
Adenocarcinoma of Lung Associate 22975805, 26098749, 26682952, 27151654, 31446140, 31532708, 35212617
Adenoma Associate 1452458, 27494611
Adenomatous Polyposis Coli Associate 28141798
Adrenocortical Carcinoma Associate 25078331