NECTIN3 (nectin cell adhesion molecule 3)

Gene
Gene SNPs Other IDs Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
25945
Gene name Gene Name - the full gene name approved by the HGNC.
Nectin cell adhesion molecule 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
NECTIN3
Synonyms (NCBI Gene) Gene synonyms aliases
CD113, CDW113, NECTIN-3, PPR3, PRR3, PVRL3, PVRR3
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3q13.13
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the nectin family of proteins, which function as adhesion molecules at adherens junctions. This family member interacts with other nectin-like proteins and with afadin, a filamentous actin-binding protein involved in the regu
SNPs SNP information provided by dbSNP.
Gene SNPs Other IDs Associated diseases
Show/Hide all(1)
SNP ID Visualize variation Clinical significance Consequence
rs79006549 A>C,G Likely-pathogenic Coding sequence variant, missense variant, non coding transcript variant
miRNA miRNA information provided by mirtarbase database.
Gene SNPs Other IDs Associated diseases
Show/Hide all(26)
miRTarBase ID miRNA Experiments Reference
MIRT450740 hsa-miR-548n PAR-CLIP 22100165
MIRT450739 hsa-miR-548a-5p PAR-CLIP 22100165
MIRT450738 hsa-miR-548ab PAR-CLIP 22100165
MIRT450737 hsa-miR-548ad-5p PAR-CLIP 22100165
MIRT450736 hsa-miR-548ae-5p PAR-CLIP 22100165
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs Other IDs Associated diseases
Show/Hide all(23)
GO ID Ontology Definition Evidence Reference
GO:0002089 Process Lens morphogenesis in camera-type eye IEA
GO:0005515 Function Protein binding IPI 19011627, 21982860, 23758976, 25416956, 31515488, 32814053
GO:0005886 Component Plasma membrane ISS
GO:0005886 Component Plasma membrane TAS
GO:0005911 Component Cell-cell junction ISS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs Other IDs Associated diseases
MIM HGNC e!Ensembl
607147 17664 ENSG00000177707
Protein
Gene SNPs Other IDs Associated diseases
UniProt ID Q9NQS3
Protein name Nectin-3 (CDw113) (Nectin cell adhesion molecule 3) (Poliovirus receptor-related protein 3) (CD antigen CD113)
Protein function Cell adhesion molecule that promotes cell-cell adhesion through heterophilic trans-interactions with nectins-like or other nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions (PubMed:16216929). Trans-interaction with P
PDB 4FOM
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07686 V-set 61 → 167 Immunoglobulin V-set domain Domain
PF08205 C2-set_2 173 → 257 CD80-like C2-set immunoglobulin domain Domain
Tissue specificity TISSUE SPECIFICITY: Predominantly expressed in testis and placenta as well as in many cell lines, including epithelial cell lines. {ECO:0000269|PubMed:11024295}.
Sequence 
MARTLRPSPLCPGGGKAQLSSASLLGAGLLLQPPTPPPLLLLLFPLLLFSRLCGALAGPI
IVEPHVTAVWGKNVSLKCLIEVNETITQISWEKIHGKSSQTVAVHHPQYGFSVQGEYQGR
VLFKNYSLNDATITLHNIGFSDSGKYICKAVTFPLGNAQSSTTVTVLVEPTVSLIKGPDS
LIDGGNETVAAICIAATGKPVAHIDWEGDLGEMESTTTSFPNETATIISQYKLFPTRFAR
GRRITCVVKHPALEKDIRYSFILDIQYAPEVSVTGYDGNWFVGRKGVNLKCNADANPPPF
KSVWSRLDGQWPDGLLASDNTLHFVHPLTFNYSGVYICKVTNSLGQRSDQKVIYISDPPT
TTTLQPTIQWHPSTADIEDLATEPKKLPFPLSTLATIKDDTIATIIASVVGGALFIVLVS
VLAGIFCYRRRRTFRGDYFAKNYIPPSDMQKESQIDVLQQDELDSYPDSVKKENKNPVNN
LIRKDYLEEPEKTQWNNVENLNRFERPMDYYEDLKMGMKFVSDEHYDENEDDLVSHVDGS
VISRREWYV
Sequence length 549
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene SNPs Other IDs Associated diseases
Show/Hide Unknown Diseases (4)
Unknown
Disease term Disease name Evidence References Source
Coenzyme Q10 Deficiency Coenzyme Q10 Deficiency GWAS
Neuroticism Neuroticism GWAS
Glioblastoma Glioblastoma CRISPR screening of E3 ubiquitin ligases reveals Ring Finger Protein 185 as a novel tumor suppressor in glioblastoma repressed by promoter hypermethylation and miR-587 GWAS, CBGDA
Ischemic Stroke Ischemic Stroke GWAS
Show/Hide Text Mining Associations (17)
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 30469078
Breast Neoplasms Associate 24386110, 37643511
Calcinosis Cutis Inhibit 24386110
Colorectal Neoplasms Associate 26177744
Colorectal Neoplasms Inhibit 37958883
Lymphatic Metastasis Associate 18084611
Lymphatic Vessel Tumors Associate 18084611
Nasopharyngeal Carcinoma Associate 33038291
Neoplasm Metastasis Associate 24386110, 26177744, 37958883
Neoplasms Associate 26177744, 37244912