Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs Other IDs
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	103910
Gene name Gene Name - the full gene name approved by the HGNC.	Myosin light chain 12B
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	MYL12B
Synonyms (NCBI Gene) Gene synonyms aliases	MLC-B, MRLC2
Chromosome Chromosome number	18
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	18p11.31
Summary Summary of gene provided in NCBI Entrez Gene.	The activity of nonmuscle myosin II (see MYH9; MIM 160775) is regulated by phosphorylation of a regulatory light chain, such as MRLC2. This phosphorylation results in higher MgATPase activity and the assembly of myosin II filaments (Iwasaki et al., 2001 [

Show/Hide all(274)

miRTarBase ID	miRNA	Experiments	Reference
MIRT041406	hsa-miR-193b-3p	CLASH	23622248
MIRT080003	hsa-miR-4311	PAR-CLIP	20371350
MIRT561170	hsa-miR-582-3p	PAR-CLIP	20371350
MIRT561171	hsa-miR-3617-5p	PAR-CLIP	20371350
MIRT561169	hsa-miR-641	PAR-CLIP	20371350
MIRT080000	hsa-miR-379-3p	PAR-CLIP	20371350
MIRT080001	hsa-miR-411-3p	PAR-CLIP	20371350
MIRT080004	hsa-miR-4251	PAR-CLIP	20371350
MIRT561168	hsa-miR-4329	PAR-CLIP	20371350
MIRT561167	hsa-miR-6761-5p	PAR-CLIP	20371350
MIRT080005	hsa-miR-548ao-5p	PAR-CLIP	20371350
MIRT080006	hsa-miR-548ax	PAR-CLIP	20371350
MIRT080002	hsa-miR-1253	PAR-CLIP	20371350
MIRT080009	hsa-miR-6770-5p	PAR-CLIP	20371350
MIRT080003	hsa-miR-4311	PAR-CLIP	20371350
MIRT561170	hsa-miR-582-3p	PAR-CLIP	20371350
MIRT561171	hsa-miR-3617-5p	PAR-CLIP	20371350
MIRT561169	hsa-miR-641	PAR-CLIP	20371350
MIRT080000	hsa-miR-379-3p	PAR-CLIP	20371350
MIRT080001	hsa-miR-411-3p	PAR-CLIP	20371350
MIRT080004	hsa-miR-4251	PAR-CLIP	20371350
MIRT561168	hsa-miR-4329	PAR-CLIP	20371350
MIRT561167	hsa-miR-6761-5p	PAR-CLIP	20371350
MIRT080005	hsa-miR-548ao-5p	PAR-CLIP	20371350
MIRT080006	hsa-miR-548ax	PAR-CLIP	20371350
MIRT080002	hsa-miR-1253	PAR-CLIP	20371350
MIRT080009	hsa-miR-6770-5p	PAR-CLIP	20371350
MIRT1168541	hsa-miR-1275	CLIP-seq
MIRT1168542	hsa-miR-1305	CLIP-seq
MIRT1168543	hsa-miR-300	CLIP-seq
MIRT1168544	hsa-miR-302a	CLIP-seq
MIRT1168545	hsa-miR-302b	CLIP-seq
MIRT1168546	hsa-miR-302c	CLIP-seq
MIRT1168547	hsa-miR-302d	CLIP-seq
MIRT1168548	hsa-miR-302e	CLIP-seq
MIRT1168549	hsa-miR-3617	CLIP-seq
MIRT1168550	hsa-miR-372	CLIP-seq
MIRT1168551	hsa-miR-373	CLIP-seq
MIRT1168552	hsa-miR-381	CLIP-seq
MIRT1168553	hsa-miR-4271	CLIP-seq
MIRT1168554	hsa-miR-4447	CLIP-seq
MIRT1168555	hsa-miR-4472	CLIP-seq
MIRT1168556	hsa-miR-4525	CLIP-seq
MIRT1168557	hsa-miR-4639-5p	CLIP-seq
MIRT1168558	hsa-miR-4665-5p	CLIP-seq
MIRT1168559	hsa-miR-4666-3p	CLIP-seq
MIRT1168560	hsa-miR-4699-5p	CLIP-seq
MIRT1168561	hsa-miR-4723-5p	CLIP-seq
MIRT1168562	hsa-miR-4725-3p	CLIP-seq
MIRT1168563	hsa-miR-4789-5p	CLIP-seq
MIRT1168564	hsa-miR-520a-3p	CLIP-seq
MIRT1168565	hsa-miR-520b	CLIP-seq
MIRT1168566	hsa-miR-520c-3p	CLIP-seq
MIRT1168567	hsa-miR-520d-3p	CLIP-seq
MIRT1168568	hsa-miR-520e	CLIP-seq
MIRT1168569	hsa-miR-561	CLIP-seq
MIRT1168570	hsa-miR-625	CLIP-seq
MIRT1168571	hsa-miR-7	CLIP-seq
MIRT1168541	hsa-miR-1275	CLIP-seq
MIRT1168572	hsa-miR-1285	CLIP-seq
MIRT1168573	hsa-miR-1299	CLIP-seq
MIRT1168542	hsa-miR-1305	CLIP-seq
MIRT1168574	hsa-miR-145	CLIP-seq
MIRT1168575	hsa-miR-23a	CLIP-seq
MIRT1168576	hsa-miR-23b	CLIP-seq
MIRT1168577	hsa-miR-23c	CLIP-seq
MIRT1168543	hsa-miR-300	CLIP-seq
MIRT1168544	hsa-miR-302a	CLIP-seq
MIRT1168545	hsa-miR-302b	CLIP-seq
MIRT1168546	hsa-miR-302c	CLIP-seq
MIRT1168547	hsa-miR-302d	CLIP-seq
MIRT1168548	hsa-miR-302e	CLIP-seq
MIRT1168578	hsa-miR-3180-5p	CLIP-seq
MIRT1168579	hsa-miR-3187-5p	CLIP-seq
MIRT1168580	hsa-miR-320a	CLIP-seq
MIRT1168581	hsa-miR-320b	CLIP-seq
MIRT1168582	hsa-miR-320c	CLIP-seq
MIRT1168583	hsa-miR-320d	CLIP-seq
MIRT1168584	hsa-miR-3613-3p	CLIP-seq
MIRT1168549	hsa-miR-3617	CLIP-seq
MIRT1168550	hsa-miR-372	CLIP-seq
MIRT1168551	hsa-miR-373	CLIP-seq
MIRT1168585	hsa-miR-378g	CLIP-seq
MIRT1168552	hsa-miR-381	CLIP-seq
MIRT1168586	hsa-miR-382	CLIP-seq
MIRT1168587	hsa-miR-3920	CLIP-seq
MIRT1168553	hsa-miR-4271	CLIP-seq
MIRT1168588	hsa-miR-4310	CLIP-seq
MIRT1168589	hsa-miR-4314	CLIP-seq
MIRT1168590	hsa-miR-4429	CLIP-seq
MIRT1168554	hsa-miR-4447	CLIP-seq
MIRT1168555	hsa-miR-4472	CLIP-seq
MIRT1168591	hsa-miR-4486	CLIP-seq
MIRT1168556	hsa-miR-4525	CLIP-seq
MIRT1168557	hsa-miR-4639-5p	CLIP-seq
MIRT1168558	hsa-miR-4665-5p	CLIP-seq
MIRT1168559	hsa-miR-4666-3p	CLIP-seq
MIRT1168560	hsa-miR-4699-5p	CLIP-seq
MIRT1168561	hsa-miR-4723-5p	CLIP-seq
MIRT1168562	hsa-miR-4725-3p	CLIP-seq
MIRT1168592	hsa-miR-4738-3p	CLIP-seq
MIRT1168563	hsa-miR-4789-5p	CLIP-seq
MIRT1168593	hsa-miR-499-3p	CLIP-seq
MIRT1168594	hsa-miR-499a-3p	CLIP-seq
MIRT1168564	hsa-miR-520a-3p	CLIP-seq
MIRT1168565	hsa-miR-520b	CLIP-seq
MIRT1168566	hsa-miR-520c-3p	CLIP-seq
MIRT1168567	hsa-miR-520d-3p	CLIP-seq
MIRT1168568	hsa-miR-520e	CLIP-seq
MIRT1168569	hsa-miR-561	CLIP-seq
MIRT1168595	hsa-miR-607	CLIP-seq
MIRT1168596	hsa-miR-612	CLIP-seq
MIRT1168597	hsa-miR-622	CLIP-seq
MIRT1168570	hsa-miR-625	CLIP-seq
MIRT1168598	hsa-miR-627	CLIP-seq
MIRT1168599	hsa-miR-653	CLIP-seq
MIRT1168571	hsa-miR-7	CLIP-seq
MIRT1168600	hsa-miR-875-3p	CLIP-seq
MIRT1168541	hsa-miR-1275	CLIP-seq
MIRT1168574	hsa-miR-145	CLIP-seq
MIRT1168578	hsa-miR-3180-5p	CLIP-seq
MIRT1168587	hsa-miR-3920	CLIP-seq
MIRT1168553	hsa-miR-4271	CLIP-seq
MIRT1168554	hsa-miR-4447	CLIP-seq
MIRT1168555	hsa-miR-4472	CLIP-seq
MIRT1168556	hsa-miR-4525	CLIP-seq
MIRT1168558	hsa-miR-4665-5p	CLIP-seq
MIRT1168561	hsa-miR-4723-5p	CLIP-seq
MIRT1168562	hsa-miR-4725-3p	CLIP-seq
MIRT1168597	hsa-miR-622	CLIP-seq
MIRT1168570	hsa-miR-625	CLIP-seq
MIRT1168573	hsa-miR-1299	CLIP-seq
MIRT1168574	hsa-miR-145	CLIP-seq
MIRT1168543	hsa-miR-300	CLIP-seq
MIRT1168544	hsa-miR-302a	CLIP-seq
MIRT1168545	hsa-miR-302b	CLIP-seq
MIRT1168546	hsa-miR-302c	CLIP-seq
MIRT1168547	hsa-miR-302d	CLIP-seq
MIRT1168548	hsa-miR-302e	CLIP-seq
MIRT1168578	hsa-miR-3180-5p	CLIP-seq
MIRT1168550	hsa-miR-372	CLIP-seq
MIRT1168551	hsa-miR-373	CLIP-seq
MIRT1168552	hsa-miR-381	CLIP-seq
MIRT1168587	hsa-miR-3920	CLIP-seq
MIRT1168557	hsa-miR-4639-5p	CLIP-seq
MIRT1168559	hsa-miR-4666-3p	CLIP-seq
MIRT1168563	hsa-miR-4789-5p	CLIP-seq
MIRT1168564	hsa-miR-520a-3p	CLIP-seq
MIRT1168565	hsa-miR-520b	CLIP-seq
MIRT1168566	hsa-miR-520c-3p	CLIP-seq
MIRT1168567	hsa-miR-520d-3p	CLIP-seq
MIRT1168568	hsa-miR-520e	CLIP-seq
MIRT1168597	hsa-miR-622	CLIP-seq
MIRT1168600	hsa-miR-875-3p	CLIP-seq
MIRT1168541	hsa-miR-1275	CLIP-seq
MIRT1168572	hsa-miR-1285	CLIP-seq
MIRT1168573	hsa-miR-1299	CLIP-seq
MIRT1168542	hsa-miR-1305	CLIP-seq
MIRT1168574	hsa-miR-145	CLIP-seq
MIRT1168575	hsa-miR-23a	CLIP-seq
MIRT1168576	hsa-miR-23b	CLIP-seq
MIRT1168577	hsa-miR-23c	CLIP-seq
MIRT1168543	hsa-miR-300	CLIP-seq
MIRT1168544	hsa-miR-302a	CLIP-seq
MIRT1168545	hsa-miR-302b	CLIP-seq
MIRT1168546	hsa-miR-302c	CLIP-seq
MIRT1168547	hsa-miR-302d	CLIP-seq
MIRT1168548	hsa-miR-302e	CLIP-seq
MIRT1168578	hsa-miR-3180-5p	CLIP-seq
MIRT1168579	hsa-miR-3187-5p	CLIP-seq
MIRT1168580	hsa-miR-320a	CLIP-seq
MIRT1168581	hsa-miR-320b	CLIP-seq
MIRT1168582	hsa-miR-320c	CLIP-seq
MIRT1168583	hsa-miR-320d	CLIP-seq
MIRT2277392	hsa-miR-338-3p	CLIP-seq
MIRT1168550	hsa-miR-372	CLIP-seq
MIRT1168551	hsa-miR-373	CLIP-seq
MIRT1168585	hsa-miR-378g	CLIP-seq
MIRT1168552	hsa-miR-381	CLIP-seq
MIRT1168586	hsa-miR-382	CLIP-seq
MIRT1168587	hsa-miR-3920	CLIP-seq
MIRT1168553	hsa-miR-4271	CLIP-seq
MIRT1168589	hsa-miR-4314	CLIP-seq
MIRT1168590	hsa-miR-4429	CLIP-seq
MIRT1168554	hsa-miR-4447	CLIP-seq
MIRT1168555	hsa-miR-4472	CLIP-seq
MIRT1168591	hsa-miR-4486	CLIP-seq
MIRT1168556	hsa-miR-4525	CLIP-seq
MIRT2277393	hsa-miR-4530	CLIP-seq
MIRT1168557	hsa-miR-4639-5p	CLIP-seq
MIRT1168558	hsa-miR-4665-5p	CLIP-seq
MIRT1168559	hsa-miR-4666-3p	CLIP-seq
MIRT2277394	hsa-miR-4668-3p	CLIP-seq
MIRT1168561	hsa-miR-4723-5p	CLIP-seq
MIRT1168562	hsa-miR-4725-3p	CLIP-seq
MIRT1168592	hsa-miR-4738-3p	CLIP-seq
MIRT1168563	hsa-miR-4789-5p	CLIP-seq
MIRT1168593	hsa-miR-499-3p	CLIP-seq
MIRT1168594	hsa-miR-499a-3p	CLIP-seq
MIRT1168564	hsa-miR-520a-3p	CLIP-seq
MIRT1168565	hsa-miR-520b	CLIP-seq
MIRT1168566	hsa-miR-520c-3p	CLIP-seq
MIRT1168567	hsa-miR-520d-3p	CLIP-seq
MIRT1168568	hsa-miR-520e	CLIP-seq
MIRT2277395	hsa-miR-545	CLIP-seq
MIRT2277396	hsa-miR-548aa	CLIP-seq
MIRT2277397	hsa-miR-548c-3p	CLIP-seq
MIRT2277398	hsa-miR-548p	CLIP-seq
MIRT1168596	hsa-miR-612	CLIP-seq
MIRT1168597	hsa-miR-622	CLIP-seq
MIRT1168570	hsa-miR-625	CLIP-seq
MIRT1168599	hsa-miR-653	CLIP-seq
MIRT1168600	hsa-miR-875-3p	CLIP-seq
MIRT1168574	hsa-miR-145	CLIP-seq
MIRT1168543	hsa-miR-300	CLIP-seq
MIRT1168544	hsa-miR-302a	CLIP-seq
MIRT1168545	hsa-miR-302b	CLIP-seq
MIRT1168546	hsa-miR-302c	CLIP-seq
MIRT1168547	hsa-miR-302d	CLIP-seq
MIRT1168548	hsa-miR-302e	CLIP-seq
MIRT1168578	hsa-miR-3180-5p	CLIP-seq
MIRT1168550	hsa-miR-372	CLIP-seq
MIRT1168551	hsa-miR-373	CLIP-seq
MIRT1168552	hsa-miR-381	CLIP-seq
MIRT1168586	hsa-miR-382	CLIP-seq
MIRT1168587	hsa-miR-3920	CLIP-seq
MIRT1168557	hsa-miR-4639-5p	CLIP-seq
MIRT1168559	hsa-miR-4666-3p	CLIP-seq
MIRT1168592	hsa-miR-4738-3p	CLIP-seq
MIRT1168563	hsa-miR-4789-5p	CLIP-seq
MIRT1168564	hsa-miR-520a-3p	CLIP-seq
MIRT1168565	hsa-miR-520b	CLIP-seq
MIRT1168566	hsa-miR-520c-3p	CLIP-seq
MIRT1168567	hsa-miR-520d-3p	CLIP-seq
MIRT1168568	hsa-miR-520e	CLIP-seq
MIRT1168597	hsa-miR-622	CLIP-seq
MIRT1168599	hsa-miR-653	CLIP-seq
MIRT1168573	hsa-miR-1299	CLIP-seq
MIRT1168542	hsa-miR-1305	CLIP-seq
MIRT1168574	hsa-miR-145	CLIP-seq
MIRT1168543	hsa-miR-300	CLIP-seq
MIRT1168544	hsa-miR-302a	CLIP-seq
MIRT1168545	hsa-miR-302b	CLIP-seq
MIRT1168546	hsa-miR-302c	CLIP-seq
MIRT1168547	hsa-miR-302d	CLIP-seq
MIRT1168548	hsa-miR-302e	CLIP-seq
MIRT1168578	hsa-miR-3180-5p	CLIP-seq
MIRT1168584	hsa-miR-3613-3p	CLIP-seq
MIRT1168550	hsa-miR-372	CLIP-seq
MIRT1168551	hsa-miR-373	CLIP-seq
MIRT1168552	hsa-miR-381	CLIP-seq
MIRT1168587	hsa-miR-3920	CLIP-seq
MIRT1168557	hsa-miR-4639-5p	CLIP-seq
MIRT1168559	hsa-miR-4666-3p	CLIP-seq
MIRT1168563	hsa-miR-4789-5p	CLIP-seq
MIRT1168593	hsa-miR-499-3p	CLIP-seq
MIRT1168594	hsa-miR-499a-3p	CLIP-seq
MIRT1168564	hsa-miR-520a-3p	CLIP-seq
MIRT1168565	hsa-miR-520b	CLIP-seq
MIRT1168566	hsa-miR-520c-3p	CLIP-seq
MIRT1168567	hsa-miR-520d-3p	CLIP-seq
MIRT1168568	hsa-miR-520e	CLIP-seq
MIRT1168597	hsa-miR-622	CLIP-seq
MIRT1168600	hsa-miR-875-3p	CLIP-seq
MIRT1168549	hsa-miR-3617	CLIP-seq
MIRT1168560	hsa-miR-4699-5p	CLIP-seq
MIRT1168569	hsa-miR-561	CLIP-seq
MIRT1168571	hsa-miR-7	CLIP-seq
MIRT1168549	hsa-miR-3617	CLIP-seq
MIRT1168586	hsa-miR-382	CLIP-seq
MIRT1168560	hsa-miR-4699-5p	CLIP-seq
MIRT1168592	hsa-miR-4738-3p	CLIP-seq
MIRT1168569	hsa-miR-561	CLIP-seq
MIRT1168571	hsa-miR-7	CLIP-seq

Show/Hide all(7)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005509	Function	Calcium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	19328794, 32296183
GO:0005829	Component	Cytosol	TAS
GO:0006936	Process	Muscle contraction	TAS
GO:0016459	Component	Myosin complex	IEA
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0099738	Component	Cell cortex region	IDA	23870127

MIM	HGNC	e!Ensembl
609211	29827	ENSG00000118680

Protein

UniProt ID

O14950

Protein name

Myosin regulatory light chain 12B (MLC-2A) (MLC-2) (Myosin regulatory light chain 2-B, smooth muscle isoform) (Myosin regulatory light chain 20 kDa) (MLC20) (Myosin regulatory light chain MRLC2) (SHUJUN-1)

Protein function

Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cy

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13405	EF-hand_6	33 → 62	EF-hand domain	Domain
PF08976	EF-hand_11	92 → 168	EF-hand domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed in various hematopoietic cells. {ECO:0000269|PubMed:11436981, ECO:0000269|PubMed:18480596}.

Sequence

MSSKKAKTKTTKKRPQRATSNVFAMFDQSQIQEFKEAFNMIDQNRDGFIDKEDLHDMLAS
LGKNPTDAYLDAMMNEAPGPINFTMFLTMFGEKLNGTDPEDVIRNAFACFDEEATGTIQE
DYLRELLTTMGDRFTDEEVDELYREAPIDKKGNFNYIEFTRILKHGAKDKDD

Sequence length

172

Interactions

View interactions

MYL12B (myosin light chain 12B)