Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4609
Gene name Gene Name - the full gene name approved by the HGNC.
MYC proto-oncogene, bHLH transcription factor
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MYC
Synonyms (NCBI Gene) Gene synonyms aliases
MRTL, MYCC, bHLHe39, c-Myc
Chromosome Chromosome number
8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
8q24.21
Summary Summary of gene provided in NCBI Entrez Gene.
This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs28933407 C>T Pathogenic Coding sequence variant, missense variant
rs121918683 A>C Likely-pathogenic, pathogenic Missense variant, coding sequence variant
rs121918684 G>C Pathogenic Missense variant, coding sequence variant
rs121918685 C>G Pathogenic Missense variant, coding sequence variant
rs750664148 A>C,G Likely-pathogenic Missense variant, coding sequence variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT003748 hsa-let-7c-5p Luciferase reporter assay 17877811
MIRT003748 hsa-let-7c-5p Luciferase reporter assay 17877811
MIRT003748 hsa-let-7c-5p Luciferase reporter assay 17877811
MIRT003748 hsa-let-7c-5p Luciferase reporter assay 17877811
MIRT003748 hsa-let-7c-5p Luciferase reporter assay 17877811
Transcription factors
Transcription factor Regulation Reference
AATF Activation 20549547
AHR Unknown 11114727;16091746
APC Repression 16510874
AR Unknown 24512546
BCL6 Activation 21394099
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000082 Process G1/S transition of mitotic cell cycle TAS
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IDA 9924025, 19160485
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IMP 19786833
GO:0000165 Process MAPK cascade IMP 17873522
GO:0000785 Component Chromatin IMP 12837246
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
190080 7553 ENSG00000136997
Protein
UniProt ID P01106
Protein name Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Protein function Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3' (PubMed:24940000, PubMed:25956029). Activates the transcription of growth-related genes (PubMed:24940000, PubMed:259
PDB 1A93 , 1EE4 , 1MV0 , 1NKP , 2A93 , 2OR9 , 4Y7R , 5I4Z , 5I50 , 6C4U , 6E16 , 6E24 , 6G6J , 6G6K , 6G6L , 7T1Y , 7T1Z , 8J2Q , 8OTS , 8OTT , 8Q1N , 8WLG , 8X8S , 8X8V
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01056 Myc_N 1 345 Myc amino-terminal region Family
PF00010 HLH 355 407 Helix-loop-helix DNA-binding domain Domain
PF02344 Myc-LZ 408 438 Myc leucine zipper domain Coiled-coil
Sequence
Sequence length 439
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Eczema Eczema GWAS
Asthma Asthma GWAS
Associations from Text Mining
Disease Name Relationship Type References
Abnormalities Drug Induced Stimulate 25479599
Abnormalities Drug Induced Associate 27463019
Abortion Habitual Inhibit 28661480
Accessory Nerve Injuries Associate 35892263
Achalasia Addisonianism Alacrimia syndrome Associate 26892631, 26931436, 29785017, 29903764, 30210134, 31171907, 31288832, 31315646, 31518494, 32311849, 33168821, 34289655, 34698437, 36823603
Acidosis Inhibit 24152439
Acne Vulgaris Associate 24114350
Acquired Immunodeficiency Syndrome Associate 17405744, 20614267, 2840989, 3491176, 8043869
Acquired Immunodeficiency Syndrome Stimulate 8025268
Acute Aortic Syndrome Associate 33953793