Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4313
Gene name Gene Name - the full gene name approved by the HGNC.
Matrix metallopeptidase 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MMP2
Synonyms (NCBI Gene) Gene synonyms aliases
CLG4, CLG4A, MMP-2, MMP-II, MONA, TBE-1
Disease Acronyms (UniProt) Disease acronyms from UniProt database
MONA
Chromosome Chromosome number
16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
16q12.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelati
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs41459945 G>A,C Uncertain-significance, conflicting-interpretations-of-pathogenicity Missense variant, coding sequence variant
rs121912953 G>A Pathogenic Coding sequence variant, missense variant
rs121912954 C>A,G Pathogenic Coding sequence variant, stop gained
rs121912955 G>A Pathogenic Coding sequence variant, missense variant
rs140172728 G>A Conflicting-interpretations-of-pathogenicity, uncertain-significance Synonymous variant, coding sequence variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT005570 hsa-miR-29b-3p Luciferase reporter assay, qRT-PCR, Western blot 20657750
MIRT005570 hsa-miR-29b-3p Luciferase reporter assay, qRT-PCR, Western blot 20657750
MIRT005742 hsa-miR-451a qRT-PCR, Western blot 20816946
MIRT005570 hsa-miR-29b-3p Western blot 23254643
MIRT018099 hsa-miR-335-5p Microarray 18185580
Transcription factors
Transcription factor Regulation Reference
ATF2 Activation 17079470;17258390
ATF3 Repression 11792711;15102941
CEBPE Unknown 19853299
CREB1 Unknown 10506168
ETS2 Unknown 19939245;22108824
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001525 Process Angiogenesis IEA
GO:0001666 Process Response to hypoxia IBA 21873635
GO:0001955 Process Blood vessel maturation IEA
GO:0001957 Process Intramembranous ossification IEA
GO:0004175 Function Endopeptidase activity IDA 23845380
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
120360 7166 ENSG00000087245
Protein
UniProt ID P08253
Protein name 72 kDa type IV collagenase (EC 3.4.24.24) (72 kDa gelatinase) (Gelatinase A) (Matrix metalloproteinase-2) (MMP-2) (TBE-1) [Cleaved into: PEX]
Protein function Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix
PDB 1CK7 , 1CXW , 1EAK , 1GEN , 1GXD , 1HOV , 1J7M , 1KS0 , 1QIB , 1RTG , 3AYU , 7XGJ , 7XJO , 8H78
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01471 PG_binding_1 43 97 Putative peptidoglycan binding domain Domain
PF00413 Peptidase_M10 118 446 Matrixin Domain
PF00040 fn2 233 274 Fibronectin type II domain Domain
PF00040 fn2 291 332 Fibronectin type II domain Domain
PF00040 fn2 349 390 Fibronectin type II domain Domain
PF00045 Hemopexin 475 518 Hemopexin Repeat
PF00045 Hemopexin 520 563 Hemopexin Repeat
PF00045 Hemopexin 568 615 Hemopexin Repeat
PF00045 Hemopexin 617 660 Hemopexin Repeat
Tissue specificity TISSUE SPECIFICITY: Produced by normal skin fibroblasts. PEX is expressed in a number of tumors including gliomas, breast and prostate. {ECO:0000269|PubMed:11751392}.
Sequence
Sequence length 660
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Arthropathy multicentric osteolysis, nodulosis, and arthropathy GenCC
Multicentric Osteolysis, Nodulosis And Arthropathy multicentric osteolysis-nodulosis-arthropathy spectrum GenCC
Colorectal Cancer Colorectal Cancer In summary, our data strongly demonstrated that upregulation of GRB7 conferred MEKi resistance in CRC cells with KRAS mutations by mediating RTK signaling through the recruitment of PLK1. GWAS, CBGDA
Associations from Text Mining
Disease Name Relationship Type References
Abortion Spontaneous Stimulate 36564776
Abortion Spontaneous Associate 38581334
Achalasia Addisonianism Alacrimia syndrome Stimulate 23538006
Acne Vulgaris Associate 31032338
Actinic cheilitis Associate 26515234
Acute Coronary Syndrome Stimulate 21273668
Acute Coronary Syndrome Associate 34859099
Acute Kidney Injury Associate 25179305
Acute Lung Injury Associate 19159011
Adenocarcinoma Associate 11452866, 11786732, 19330734, 25337226, 27331624, 36938549, 37445754