MAPK8 (mitogen-activated protein kinase 8)

Gene Gene information from NCBI Gene database.
Gene SNPs Transcription factors Other IDs Associated diseases
Entrez ID 5599
Gene name Mitogen-activated protein kinase 8
Gene symbol MAPK8
Synonyms (NCBI Gene)
JNKJNK-46JNK1JNK1A2JNK21B1/2PRKM8SAPK1SAPK1c
Chromosome 10
Chromosome location 10q11.22
Summary The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription
miRNA miRNA information provided by mirtarbase database.
168
Gene SNPs Transcription factors Other IDs Associated diseases
Show/Hide all (168)
miRTarBase ID miRNA Experiments Reference
MIRT003985 hsa-miR-199a-3p Western blot 18456660
MIRT005427 hsa-miR-214-3p GFP reporter assayMicroarrayqRT-PCRWestern blot 19859982
MIRT005427 hsa-miR-214-3p GFP reporter assayMicroarrayqRT-PCRWestern blot 19859982
MIRT016104 hsa-miR-421 Sequencing 20371350
MIRT016510 hsa-miR-193b-3p Microarray 20304954
Transcription factors Transcription factors information provided by TRRUST V2 database.
5
Gene SNPs Transcription factors Other IDs Associated diseases
Show/Hide all (5)
Transcription factor Regulation Reference
E2F1 Unknown 20800677
E2F3 Unknown 20800677
HSF2 Repression 11557063
JUN Activation 19324081
JUN Unknown 16397260
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
78
Gene SNPs Transcription factors Other IDs Associated diseases
Show/Hide all (78)
GO ID Ontology Definition Evidence Reference
GO:0000165 Process MAPK cascade IDA 15850461
GO:0000165 Process MAPK cascade IEA
GO:0000166 Function Nucleotide binding IEA
GO:0004672 Function Protein kinase activity IEA
GO:0004674 Function Protein serine/threonine kinase activity IDA 14967141, 15850461, 20027304, 21095239, 22966201, 27568560, 28943315, 34048572
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene SNPs Transcription factors Other IDs Associated diseases
MIM HGNC e!Ensembl
601158 6881 ENSG00000107643
Protein Protein information from UniProt database.
Gene SNPs Transcription factors Other IDs Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P45983
Protein name Mitogen-activated protein kinase 8 (MAP kinase 8) (MAPK 8) (EC 2.7.11.24) (JNK-46) (Stress-activated protein kinase 1c) (SAPK1c) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1)
Protein function Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate
PDB 1UKH , 1UKI , 2G01 , 2GMX , 2H96 , 2NO3 , 2XRW , 2XS0 , 3ELJ , 3O17 , 3O2M , 3PZE , 3V3V , 3VUD , 3VUG , 3VUH , 3VUI , 3VUK , 3VUL , 3VUM , 4AWI , 4E73 , 4G1W , 4HYS , 4HYU , 4IZY , 4L7F , 4QTD , 4UX9 , 4YR8 , 5LW1 , 6F5E , 6ZR5 , 8PT8 , 8PT9 , 8PTA , 8R5E , 8X5M , 9FT9
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 26 → 321 Protein kinase domain Domain
Sequence
Sequence length 427
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
5
Gene SNPs Transcription factors Other IDs Associated diseases
Show/Hide Unknown Diseases (4)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Acute myeloid leukemia Benign rs1062225 RCV005920069
Gastric cancer Benign rs1062225 RCV005920070
MAPK8-related disorder Likely benign rs137900446, rs199940599 RCV003941444
RCV003954826
Uterine corpus endometrial carcinoma Benign rs1062225 RCV005920071
Show/Hide Text Mining Associations (339)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
3 methylcrotonyl CoA carboxylase 1 deficiency Associate 26655088
AA amyloidosis Inhibit 14997933
Acquired Immunodeficiency Syndrome Associate 37798121
Acute Coronary Syndrome Associate 25997853
Acute Kidney Injury Stimulate 34962918
Adenocarcinoma of Lung Associate 33299528, 33361736
Adenoma Associate 23082052
Adjustment Disorders Associate 15830375
Adrenoleukodystrophy Associate 37974207
Alexander Disease Associate 17038307