Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs Transcription factors Other IDs
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	5599
Gene name Gene Name - the full gene name approved by the HGNC.	Mitogen-activated protein kinase 8
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	MAPK8
Synonyms (NCBI Gene) Gene synonyms aliases	JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c
Chromosome Chromosome number	10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	10q11.22
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription

Show/Hide all(168)

miRTarBase ID	miRNA	Experiments	Reference
MIRT003985	hsa-miR-199a-3p	Western blot	18456660
MIRT005427	hsa-miR-214-3p	GFP reporter assay, Microarray, qRT-PCR, Western blot	19859982
MIRT005427	hsa-miR-214-3p	GFP reporter assay, Microarray, qRT-PCR, Western blot	19859982
MIRT016104	hsa-miR-421	Sequencing	20371350
MIRT016510	hsa-miR-193b-3p	Microarray	20304954
MIRT021289	hsa-miR-125a-5p	Sequencing	20371350
MIRT021678	hsa-miR-140-3p	Sequencing	20371350
MIRT005427	hsa-miR-214-3p	Reporter assay;qRT-PCR;Microarray;Other	19859982
MIRT025602	hsa-miR-10a-5p	Sequencing	20371350
MIRT028235	hsa-miR-33a-5p	Sequencing	20371350
MIRT016104	hsa-miR-421	CLASH	23622248
MIRT037323	hsa-miR-877-5p	CLASH	23622248
MIRT437964	hsa-miR-92a-3p	qRT-PCR, Luciferase reporter assay, Western blot	24705900
MIRT437964	hsa-miR-92a-3p	qRT-PCR, Luciferase reporter assay, Western blot	24705900
MIRT437964	hsa-miR-92a-3p	qRT-PCR, Luciferase reporter assay, Western blot	24705900
MIRT437964	hsa-miR-92a-3p	qRT-PCR, Luciferase reporter assay, Western blot	24705900
MIRT437964	hsa-miR-92a-3p	qRT-PCR, Luciferase reporter assay, Western blot	24705900
MIRT437964	hsa-miR-92a-3p	qRT-PCR, Luciferase reporter assay, Western blot	24705900
MIRT437964	hsa-miR-92a-3p	qRT-PCR, Luciferase reporter assay, Western blot	24705900
MIRT437964	hsa-miR-92a-3p	qRT-PCR, Luciferase reporter assay, Western blot	24705900
MIRT566821	hsa-miR-4282	PAR-CLIP	20371350
MIRT473694	hsa-miR-497-3p	PAR-CLIP	20371350
MIRT536128	hsa-miR-3613-3p	PAR-CLIP	20371350
MIRT566820	hsa-miR-548aj-5p	PAR-CLIP	20371350
MIRT566819	hsa-miR-548f-5p	PAR-CLIP	20371350
MIRT566818	hsa-miR-548g-5p	PAR-CLIP	20371350
MIRT566817	hsa-miR-548x-5p	PAR-CLIP	20371350
MIRT566816	hsa-miR-1468-3p	PAR-CLIP	20371350
MIRT566815	hsa-miR-548aw	PAR-CLIP	20371350
MIRT473699	hsa-miR-30a-5p	PAR-CLIP	21572407
MIRT473698	hsa-miR-30d-5p	PAR-CLIP	21572407
MIRT473697	hsa-miR-30c-5p	PAR-CLIP	21572407
MIRT473696	hsa-miR-30e-5p	PAR-CLIP	21572407
MIRT473695	hsa-miR-30b-5p	PAR-CLIP	21572407
MIRT473693	hsa-miR-193a-3p	PAR-CLIP	21572407
MIRT016510	hsa-miR-193b-3p	PAR-CLIP	21572407
MIRT473692	hsa-miR-892b	PAR-CLIP	21572407
MIRT473691	hsa-miR-4280	PAR-CLIP	21572407
MIRT473690	hsa-miR-3190-5p	PAR-CLIP	21572407
MIRT473689	hsa-miR-3926	PAR-CLIP	21572407
MIRT473688	hsa-miR-4524a-5p	PAR-CLIP	21572407
MIRT473687	hsa-miR-4524b-5p	PAR-CLIP	21572407
MIRT473686	hsa-miR-548s	PAR-CLIP	21572407
MIRT473685	hsa-miR-374b-3p	PAR-CLIP	21572407
MIRT441786	hsa-miR-3662	PAR-CLIP	22012620
MIRT441785	hsa-miR-1277-5p	PAR-CLIP	22012620
MIRT536130	hsa-miR-590-3p	PAR-CLIP	22012620
MIRT536129	hsa-miR-888-5p	PAR-CLIP	22012620
MIRT536128	hsa-miR-3613-3p	PAR-CLIP	22012620
MIRT536127	hsa-miR-371b-5p	PAR-CLIP	22012620
MIRT536126	hsa-miR-373-5p	PAR-CLIP	22012620
MIRT536125	hsa-miR-616-5p	PAR-CLIP	22012620
MIRT441784	hsa-miR-4480	PAR-CLIP	22012620
MIRT536124	hsa-miR-4775	PAR-CLIP	22012620
MIRT536123	hsa-miR-7703	PAR-CLIP	22012620
MIRT536122	hsa-miR-4325	PAR-CLIP	22012620
MIRT536121	hsa-miR-450b-5p	PAR-CLIP	22012620
MIRT536120	hsa-miR-507	PAR-CLIP	22012620
MIRT536119	hsa-miR-557	PAR-CLIP	22012620
MIRT501958	hsa-miR-3680-3p	PAR-CLIP	22012620
MIRT501966	hsa-miR-203a-3p	PAR-CLIP	24398324
MIRT501967	hsa-miR-33b-5p	PAR-CLIP	24398324
MIRT028235	hsa-miR-33a-5p	PAR-CLIP	24398324
MIRT501966	hsa-miR-203a-3p	PAR-CLIP	24398324
MIRT501965	hsa-miR-126-5p	PAR-CLIP	24398324
MIRT501964	hsa-miR-664a-3p	PAR-CLIP	24398324
MIRT501962	hsa-miR-8060	PAR-CLIP	24398324
MIRT501963	hsa-miR-496	PAR-CLIP	24398324
MIRT501961	hsa-miR-4795-3p	PAR-CLIP	24398324
MIRT501960	hsa-miR-7154-5p	PAR-CLIP	24398324
MIRT501959	hsa-miR-433-3p	PAR-CLIP	24398324
MIRT501958	hsa-miR-3680-3p	PAR-CLIP	24398324
MIRT473699	hsa-miR-30a-5p	PAR-CLIP	23592263
MIRT473698	hsa-miR-30d-5p	PAR-CLIP	23592263
MIRT473697	hsa-miR-30c-5p	PAR-CLIP	23592263
MIRT473696	hsa-miR-30e-5p	PAR-CLIP	23592263
MIRT473695	hsa-miR-30b-5p	PAR-CLIP	23592263
MIRT473694	hsa-miR-497-3p	PAR-CLIP	23592263
MIRT473693	hsa-miR-193a-3p	PAR-CLIP	23592263
MIRT016510	hsa-miR-193b-3p	PAR-CLIP	23592263
MIRT473692	hsa-miR-892b	PAR-CLIP	23592263
MIRT473691	hsa-miR-4280	PAR-CLIP	23592263
MIRT473690	hsa-miR-3190-5p	PAR-CLIP	23592263
MIRT473689	hsa-miR-3926	PAR-CLIP	23592263
MIRT473688	hsa-miR-4524a-5p	PAR-CLIP	23592263
MIRT473687	hsa-miR-4524b-5p	PAR-CLIP	23592263
MIRT473686	hsa-miR-548s	PAR-CLIP	23592263
MIRT473685	hsa-miR-374b-3p	PAR-CLIP	23592263
MIRT441786	hsa-miR-3662	PAR-CLIP	22100165
MIRT441785	hsa-miR-1277-5p	PAR-CLIP	22100165
MIRT441783	hsa-miR-3163	PAR-CLIP	22100165
MIRT441784	hsa-miR-4480	PAR-CLIP	22100165
MIRT736095	hsa-miR-141-3p	qRT-PCR	33133155
MIRT566821	hsa-miR-4282	PAR-CLIP	20371350
MIRT473694	hsa-miR-497-3p	PAR-CLIP	20371350
MIRT536128	hsa-miR-3613-3p	PAR-CLIP	20371350
MIRT566820	hsa-miR-548aj-5p	PAR-CLIP	20371350
MIRT566819	hsa-miR-548f-5p	PAR-CLIP	20371350
MIRT566818	hsa-miR-548g-5p	PAR-CLIP	20371350
MIRT566817	hsa-miR-548x-5p	PAR-CLIP	20371350
MIRT566816	hsa-miR-1468-3p	PAR-CLIP	20371350
MIRT566815	hsa-miR-548aw	PAR-CLIP	20371350
MIRT473699	hsa-miR-30a-5p	PAR-CLIP	21572407
MIRT473698	hsa-miR-30d-5p	PAR-CLIP	21572407
MIRT473697	hsa-miR-30c-5p	PAR-CLIP	21572407
MIRT473696	hsa-miR-30e-5p	PAR-CLIP	21572407
MIRT473695	hsa-miR-30b-5p	PAR-CLIP	21572407
MIRT473693	hsa-miR-193a-3p	PAR-CLIP	21572407
MIRT016510	hsa-miR-193b-3p	PAR-CLIP	21572407
MIRT473692	hsa-miR-892b	PAR-CLIP	21572407
MIRT473691	hsa-miR-4280	PAR-CLIP	21572407
MIRT473690	hsa-miR-3190-5p	PAR-CLIP	21572407
MIRT473689	hsa-miR-3926	PAR-CLIP	21572407
MIRT473688	hsa-miR-4524a-5p	PAR-CLIP	21572407
MIRT473687	hsa-miR-4524b-5p	PAR-CLIP	21572407
MIRT473686	hsa-miR-548s	PAR-CLIP	21572407
MIRT473685	hsa-miR-374b-3p	PAR-CLIP	21572407
MIRT441786	hsa-miR-3662	PAR-CLIP	22012620
MIRT441785	hsa-miR-1277-5p	PAR-CLIP	22012620
MIRT536130	hsa-miR-590-3p	PAR-CLIP	22012620
MIRT536129	hsa-miR-888-5p	PAR-CLIP	22012620
MIRT536128	hsa-miR-3613-3p	PAR-CLIP	22012620
MIRT536127	hsa-miR-371b-5p	PAR-CLIP	22012620
MIRT536126	hsa-miR-373-5p	PAR-CLIP	22012620
MIRT536125	hsa-miR-616-5p	PAR-CLIP	22012620
MIRT441784	hsa-miR-4480	PAR-CLIP	22012620
MIRT536124	hsa-miR-4775	PAR-CLIP	22012620
MIRT536123	hsa-miR-7703	PAR-CLIP	22012620
MIRT536122	hsa-miR-4325	PAR-CLIP	22012620
MIRT536121	hsa-miR-450b-5p	PAR-CLIP	22012620
MIRT536120	hsa-miR-507	PAR-CLIP	22012620
MIRT536119	hsa-miR-557	PAR-CLIP	22012620
MIRT501958	hsa-miR-3680-3p	PAR-CLIP	22012620
MIRT501966	hsa-miR-203a-3p	PAR-CLIP	24398324
MIRT501967	hsa-miR-33b-5p	PAR-CLIP	24398324
MIRT028235	hsa-miR-33a-5p	PAR-CLIP	24398324
MIRT501966	hsa-miR-203a-3p	PAR-CLIP	24398324
MIRT501965	hsa-miR-126-5p	PAR-CLIP	24398324
MIRT501964	hsa-miR-664a-3p	PAR-CLIP	24398324
MIRT501962	hsa-miR-8060	PAR-CLIP	24398324
MIRT501963	hsa-miR-496	PAR-CLIP	24398324
MIRT501961	hsa-miR-4795-3p	PAR-CLIP	24398324
MIRT501960	hsa-miR-7154-5p	PAR-CLIP	24398324
MIRT501959	hsa-miR-433-3p	PAR-CLIP	24398324
MIRT501958	hsa-miR-3680-3p	PAR-CLIP	24398324
MIRT473699	hsa-miR-30a-5p	PAR-CLIP	23592263
MIRT473698	hsa-miR-30d-5p	PAR-CLIP	23592263
MIRT473697	hsa-miR-30c-5p	PAR-CLIP	23592263
MIRT473696	hsa-miR-30e-5p	PAR-CLIP	23592263
MIRT473695	hsa-miR-30b-5p	PAR-CLIP	23592263
MIRT473694	hsa-miR-497-3p	PAR-CLIP	23592263
MIRT473693	hsa-miR-193a-3p	PAR-CLIP	23592263
MIRT016510	hsa-miR-193b-3p	PAR-CLIP	23592263
MIRT473692	hsa-miR-892b	PAR-CLIP	23592263
MIRT473691	hsa-miR-4280	PAR-CLIP	23592263
MIRT473690	hsa-miR-3190-5p	PAR-CLIP	23592263
MIRT473689	hsa-miR-3926	PAR-CLIP	23592263
MIRT473688	hsa-miR-4524a-5p	PAR-CLIP	23592263
MIRT473687	hsa-miR-4524b-5p	PAR-CLIP	23592263
MIRT473686	hsa-miR-548s	PAR-CLIP	23592263
MIRT473685	hsa-miR-374b-3p	PAR-CLIP	23592263
MIRT441786	hsa-miR-3662	PAR-CLIP	22100165
MIRT441785	hsa-miR-1277-5p	PAR-CLIP	22100165
MIRT441783	hsa-miR-3163	PAR-CLIP	22100165
MIRT441784	hsa-miR-4480	PAR-CLIP	22100165
MIRT473699	hsa-miR-30a-5p	Luciferase reporter assay, Western blotting, qRT-PCR	35001794
MIRT2037380	hsa-miR-1244	CLIP-seq
MIRT2037381	hsa-miR-3168	CLIP-seq

Transcription factors

Show/Hide all(5)

Transcription factor	Regulation	Reference
E2F1	Unknown	20800677
E2F3	Unknown	20800677
HSF2	Repression	11557063
JUN	Activation	19324081
JUN	Unknown	16397260

Show/Hide all(58)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004674	Function	Protein serine/threonine kinase activity	IBA	21873635
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	14967141, 15850461, 20027304, 21095239, 22966201
GO:0004705	Function	JUN kinase activity	IBA	21873635
GO:0004705	Function	JUN kinase activity	IDA	8654373, 21095239
GO:0004705	Function	JUN kinase activity	TAS
GO:0004707	Function	MAP kinase activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	10393177, 10490659, 10747973, 10856240, 11517249, 15334056, 15894542, 16291755, 16533805, 16840345, 16982329, 18003900, 18286207, 19234442, 19527717, 22966201, 23397142, 25241761, 25284480, 27043084
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005634	Component	Nucleus	IDA	20027304, 30878395
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005739	Component	Mitochondrion	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006468	Process	Protein phosphorylation	IDA	21856198
GO:0006468	Process	Protein phosphorylation	IMP	22441692
GO:0006979	Process	Response to oxidative stress	IDA	22966201
GO:0007254	Process	JNK cascade	IBA	21873635
GO:0007254	Process	JNK cascade	IDA	8654373
GO:0007254	Process	JNK cascade	TAS
GO:0007258	Process	JUN phosphorylation	IDA	14967141, 21095239
GO:0009411	Process	Response to UV	IDA	14967141
GO:0009612	Process	Response to mechanical stimulus	IBA	21873635
GO:0010628	Process	Positive regulation of gene expression	IMP	22065586
GO:0016241	Process	Regulation of macroautophagy	TAS	26546165
GO:0016301	Function	Kinase activity	TAS
GO:0018105	Process	Peptidyl-serine phosphorylation	IDA	15850461, 20027304, 21095239, 22966201
GO:0018107	Process	Peptidyl-threonine phosphorylation	IDA	21095239
GO:0018107	Process	Peptidyl-threonine phosphorylation	IMP	20027304
GO:0019899	Function	Enzyme binding	IPI	14615289
GO:0030424	Component	Axon	ISS	22683681
GO:0031063	Process	Regulation of histone deacetylation	IEA
GO:0031281	Process	Positive regulation of cyclase activity	IMP	22027397
GO:0032091	Process	Negative regulation of protein binding	IDA	21095239
GO:0032880	Process	Regulation of protein localization	IDA	20027304
GO:0034198	Process	Cellular response to amino acid starvation	IDA	11096076
GO:0034614	Process	Cellular response to reactive oxygen species	IMP	26514923
GO:0035033	Function	Histone deacetylase regulator activity	IMP	20027304
GO:0035556	Process	Intracellular signal transduction	IBA	21873635
GO:0038095	Process	Fc-epsilon receptor signaling pathway	TAS
GO:0042752	Process	Regulation of circadian rhythm	ISS
GO:0042826	Function	Histone deacetylase binding	IPI	20027304
GO:0043065	Process	Positive regulation of apoptotic process	IBA	21873635
GO:0043065	Process	Positive regulation of apoptotic process	TAS
GO:0043066	Process	Negative regulation of apoptotic process	IDA	14967141, 21095239
GO:0045202	Component	Synapse	ISS
GO:0048511	Process	Rhythmic process	IEA
GO:0051090	Process	Regulation of DNA-binding transcription factor activity	TAS
GO:0051247	Process	Positive regulation of protein metabolic process	IMP	22027397
GO:0051403	Process	Stress-activated MAPK cascade	IDA	11096076
GO:0071222	Process	Cellular response to lipopolysaccharide	IDA	23776175
GO:0071260	Process	Cellular response to mechanical stimulus	IEP	19593445
GO:0071276	Process	Cellular response to cadmium ion	IMP	26514923
GO:0071345	Process	Cellular response to cytokine stimulus	TAS
GO:0090045	Process	Positive regulation of deacetylase activity	IMP	20027304
GO:0097441	Component	Basal dendrite	ISS	22683681
GO:1900740	Process	Positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	TAS
GO:1902595	Process	Regulation of DNA replication origin binding	IMP	21856198

MIM	HGNC	e!Ensembl
601158	6881	ENSG00000107643

Protein

UniProt ID

P45983

Protein name

Mitogen-activated protein kinase 8 (MAP kinase 8) (MAPK 8) (EC 2.7.11.24) (JNK-46) (Stress-activated protein kinase 1c) (SAPK1c) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1)

Protein function

Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate

PDB

1UKH , 1UKI , 2G01 , 2GMX , 2H96 , 2NO3 , 2XRW , 2XS0 , 3ELJ , 3O17 , 3O2M , 3PZE , 3V3V , 3VUD , 3VUG , 3VUH , 3VUI , 3VUK , 3VUL , 3VUM , 4AWI , 4E73 , 4G1W , 4HYS , 4HYU , 4IZY , 4L7F , 4QTD , 4UX9 , 4YR8 , 5LW1 , 6F5E , 6ZR5 , 8PT8 , 8PT9 , 8PTA , 8R5E , 8X5M , 9FT9

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	26 → 321	Protein kinase domain	Domain

Sequence

MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ
LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA
GPLGCCR

Sequence length

427

Interactions

View interactions

MAPK8 (mitogen-activated protein kinase 8)