MAPK10 (mitogen-activated protein kinase 10)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 5602 |
| Gene name | Mitogen-activated protein kinase 10 |
| Gene symbol | MAPK10 |
| Synonyms (NCBI Gene) |
JNK3JNK3APRKM10SAPK1bp493F12p54bSAPK
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| Chromosome | 4 |
| Chromosome location | 4q21.3 |
| Summary | The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcrip |
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miRNA
miRNA information provided by mirtarbase database.
246
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
38
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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P53779 | ||||||||||
| Protein name | Mitogen-activated protein kinase 10 (MAP kinase 10) (MAPK 10) (EC 2.7.11.24) (MAP kinase p49 3F12) (Stress-activated protein kinase 1b) (SAPK1b) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) | ||||||||||
| Protein function | Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress- | ||||||||||
| PDB | 1JNK , 1PMN , 1PMU , 1PMV , 2B1P , 2EXC , 2O0U , 2O2U , 2OK1 , 2P33 , 2R9S , 2WAJ , 2ZDT , 2ZDU , 3CGF , 3CGO , 3DA6 , 3FI2 , 3FI3 , 3FV8 , 3G90 , 3G9L , 3G9N , 3KVX , 3OXI , 3OY1 , 3PTG , 3RTP , 3TTI , 3TTJ , 3V6R , 3V6S , 4H36 , 4H39 , 4H3B , 4KKE , 4KKG , 4KKH , 4U79 , 4W4V , 4W4W , 4W4X , 4W4Y , 4WHZ , 4X21 , 4Y46 , 4Y5H , 4Z9L , 6EKD , 6EMH , 6EQ9 | ||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Specific to a subset of neurons in the nervous system. Present in the hippocampus and areas, cerebellum, striatum, brain stem, and weakly in the spinal cord. Very weak expression in testis and kidney. | ||||||||||
| Sequence |
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| Sequence length | 464 | ||||||||||
| Interactions | View interactions | ||||||||||
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Associated diseases
Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
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