Gene Gene information from NCBI Gene database.
Entrez ID 5602
Gene name Mitogen-activated protein kinase 10
Gene symbol MAPK10
Synonyms (NCBI Gene)
JNK3JNK3APRKM10SAPK1bp493F12p54bSAPK
Chromosome 4
Chromosome location 4q21.3
Summary The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcrip
miRNA miRNA information provided by mirtarbase database.
246
miRTarBase ID miRNA Experiments Reference
MIRT053727 hsa-miR-221-3p Microarray 22942087
MIRT667467 hsa-miR-3617-5p HITS-CLIP 23824327
MIRT667466 hsa-miR-641 HITS-CLIP 23824327
MIRT607689 hsa-miR-6867-5p HITS-CLIP 23824327
MIRT667465 hsa-miR-3152-3p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
38
GO ID Ontology Definition Evidence Reference
GO:0000165 Process MAPK cascade IEA
GO:0000166 Function Nucleotide binding IEA
GO:0004672 Function Protein kinase activity IEA
GO:0004674 Function Protein serine/threonine kinase activity IEA
GO:0004705 Function JUN kinase activity IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
602897 6872 ENSG00000109339
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P53779
Protein name Mitogen-activated protein kinase 10 (MAP kinase 10) (MAPK 10) (EC 2.7.11.24) (MAP kinase p49 3F12) (Stress-activated protein kinase 1b) (SAPK1b) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3)
Protein function Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-
PDB 1JNK , 1PMN , 1PMU , 1PMV , 2B1P , 2EXC , 2O0U , 2O2U , 2OK1 , 2P33 , 2R9S , 2WAJ , 2ZDT , 2ZDU , 3CGF , 3CGO , 3DA6 , 3FI2 , 3FI3 , 3FV8 , 3G90 , 3G9L , 3G9N , 3KVX , 3OXI , 3OY1 , 3PTG , 3RTP , 3TTI , 3TTJ , 3V6R , 3V6S , 4H36 , 4H39 , 4H3B , 4KKE , 4KKG , 4KKH , 4U79 , 4W4V , 4W4W , 4W4X , 4W4Y , 4WHZ , 4X21 , 4Y46 , 4Y5H , 4Z9L , 6EKD , 6EMH , 6EQ9
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 64 359 Protein kinase domain Domain
Tissue specificity TISSUE SPECIFICITY: Specific to a subset of neurons in the nervous system. Present in the hippocampus and areas, cerebellum, striatum, brain stem, and weakly in the spinal cord. Very weak expression in testis and kidney.
Sequence
Sequence length 464
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
14
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Epileptic encephalopathy Likely benign; Uncertain significance rs574058049, rs757219361, rs748962891 RCV000305749
RCV000403139
RCV000280468
Epileptic encephalopathy with cognitive deficit Uncertain significance rs775333978 RCV003225262
Familial cancer of breast Benign rs55663953 RCV005889130
Gastric cancer Benign rs55663953 RCV005889132
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma Associate 30170437
Alzheimer Disease Associate 21811019, 37236204, 7826642
Beckwith Wiedemann Syndrome Associate 35507738
Breast Neoplasms Associate 30670769, 32947764
Burkitt Lymphoma Associate 12967475
Carcinogenesis Associate 32987560
Carcinoma Hepatocellular Associate 32572915
Carcinoma Non Small Cell Lung Associate 32468043
Carcinoma Pancreatic Ductal Associate 32119844
Cognition Disorders Stimulate 37236204