MAPK1 (mitogen-activated protein kinase 1)

Gene
Gene SNPs Transcription factors Other IDs Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5594
Gene name Gene Name - the full gene name approved by the HGNC.
Mitogen-activated protein kinase 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MAPK1
Synonyms (NCBI Gene) Gene synonyms aliases
ERK, ERK-2, ERK2, ERT1, MAPK2, NS13, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk, p42-MAPK
Chromosome Chromosome number
22
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
22q11.22
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as p
SNPs SNP information provided by dbSNP.
Gene SNPs Transcription factors Other IDs Associated diseases
Show/Hide all(2)
SNP ID Visualize variation Clinical significance Consequence
rs797044892 C>G Pathogenic Missense variant, coding sequence variant
rs1057519911 C>T Likely-pathogenic Coding sequence variant, missense variant
miRNA miRNA information provided by mirtarbase database.
Gene SNPs Transcription factors Other IDs Associated diseases
Show/Hide all(2128)
miRTarBase ID miRNA Experiments Reference
MIRT003983 hsa-miR-199a-3p Western blot 18456660
MIRT003983 hsa-miR-199a-3p Luciferase reporter assay 18456660
MIRT006418 hsa-miR-28-5p Luciferase reporter assay 20445018
MIRT006447 hsa-miR-335-5p Immunofluorescence, Immunoprecipitaion, Luciferase reporter assay, Microarray, qRT-PCR, Western blot 22382496
MIRT006447 hsa-miR-335-5p Immunofluorescence, Immunoprecipitaion, Luciferase reporter assay, Microarray, qRT-PCR, Western blot 22382496
Transcription factors
Gene SNPs Transcription factors Other IDs Associated diseases
Show/Hide all(3)
Transcription factor Regulation Reference
MYC Unknown 21933022
SPI1 Repression 22075620
TWIST1 Activation 23222305
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs Transcription factors Other IDs Associated diseases
Show/Hide all(145)
GO ID Ontology Definition Evidence Reference
GO:0000165 Process MAPK cascade IDA 15850461, 24854121
GO:0000165 Process MAPK cascade IEA
GO:0000166 Function Nucleotide binding IEA
GO:0001784 Function Phosphotyrosine residue binding IEA
GO:0003677 Function DNA binding IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs Transcription factors Other IDs Associated diseases
MIM HGNC e!Ensembl
176948 6871 ENSG00000100030
Protein
Gene SNPs Transcription factors Other IDs Associated diseases
UniProt ID P28482
Protein name Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
Protein function Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling casc
PDB 1PME , 1TVO , 1WZY , 2OJG , 2OJI , 2OJJ , 2Y9Q , 3D42 , 3D44 , 3I5Z , 3I60 , 3SA0 , 3TEI , 3W55 , 4FMQ , 4FUX , 4FUY , 4FV0 , 4FV1 , 4FV2 , 4FV3 , 4FV4 , 4FV5 , 4FV6 , 4FV7 , 4FV8 , 4FV9 , 4G6N , 4G6O , 4H3P , 4H3Q , 4IZ5 , 4IZ7 , 4IZA , 4N0S , 4NIF , 4O6E , 4QP1 , 4QP2 , 4QP3 , 4QP4 , 4QP6 , 4QP7 , 4QP8 , 4QP9 , 4QPA , 4QTA , 4QTE , 4XJ0 , 4ZXT , 4ZZM
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 25 → 313 Protein kinase domain Domain
Sequence
Sequence length 360
Interactions View interactions
<
Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene SNPs Transcription factors Other IDs Associated diseases
Show/Hide Unknown Diseases (5)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Amyotrophic Lateral Sclerosis Amyotrophic lateral sclerosis N/A N/A GWAS
Bipolar Disorder Bipolar disorder N/A N/A GWAS
Multiple Sclerosis Multiple sclerosis N/A N/A GWAS
neoplasm Neoplasm N/A N/A ClinVar
Show/Hide Text Mining Associations (554)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Abnormalities Drug Induced Associate 35966064
Acrocephalosyndactylia Stimulate 23404329
Acute Coronary Syndrome Associate 25997853, 34239024
Acute Disease Associate 17351113
Acute Kidney Injury Associate 33436543
Adenoameloblastoma Associate 30643167
Adenocarcinoma Associate 19445727, 21143918, 21390183, 27036313, 27763636, 34684639, 37894790
Adenocarcinoma Stimulate 26986830
Adenocarcinoma of Lung Associate 11891209, 17201164, 24374773, 25351745, 25763322, 26402252, 26556867, 26840709, 26986830, 28451792, 30195659, 30321617, 30475204, 30815935, 30838797
View all (11 more)
Adenoma Inhibit 10323886