Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs Transcription factors Other IDs
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	4217
Gene name Gene Name - the full gene name approved by the HGNC.	Mitogen-activated protein kinase kinase kinase 5
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	MAP3K5
Synonyms (NCBI Gene) Gene synonyms aliases	ASK1, MAPKKK5, MEKK5
Chromosome Chromosome number	6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	6q23.3
Summary Summary of gene provided in NCBI Entrez Gene.	Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protei

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miRTarBase ID	miRNA	Experiments	Reference
MIRT039091	hsa-miR-769-3p	CLASH	23622248
MIRT053208	hsa-miR-20a-5p	Luciferase reporter assay, qRT-PCR, Western blot	23087182
MIRT556297	hsa-miR-425-5p	PAR-CLIP	21572407
MIRT556296	hsa-miR-4517	PAR-CLIP	21572407
MIRT556295	hsa-miR-208a-5p	PAR-CLIP	21572407
MIRT556294	hsa-miR-208b-5p	PAR-CLIP	21572407
MIRT556293	hsa-miR-130b-5p	PAR-CLIP	21572407
MIRT556292	hsa-miR-302b-5p	PAR-CLIP	21572407
MIRT556291	hsa-miR-302d-5p	PAR-CLIP	21572407
MIRT556290	hsa-miR-642a-3p	PAR-CLIP	21572407
MIRT556289	hsa-miR-642b-3p	PAR-CLIP	21572407
MIRT556287	hsa-miR-5191	PAR-CLIP	21572407
MIRT556288	hsa-miR-4753-3p	PAR-CLIP	21572407
MIRT556286	hsa-miR-1303	PAR-CLIP	21572407
MIRT440282	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440282	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT556286	hsa-miR-1303	PAR-CLIP	27292025
MIRT556286	hsa-miR-1303	PAR-CLIP	27292025
MIRT556293	hsa-miR-130b-5p	PAR-CLIP	27292025
MIRT556293	hsa-miR-130b-5p	PAR-CLIP	27292025
MIRT556295	hsa-miR-208a-5p	PAR-CLIP	27292025
MIRT556295	hsa-miR-208a-5p	PAR-CLIP	27292025
MIRT556294	hsa-miR-208b-5p	PAR-CLIP	27292025
MIRT556294	hsa-miR-208b-5p	PAR-CLIP	27292025
MIRT556292	hsa-miR-302b-5p	PAR-CLIP	27292025
MIRT556292	hsa-miR-302b-5p	PAR-CLIP	27292025
MIRT556291	hsa-miR-302d-5p	PAR-CLIP	27292025
MIRT556291	hsa-miR-302d-5p	PAR-CLIP	27292025
MIRT556297	hsa-miR-425-5p	PAR-CLIP	27292025
MIRT556297	hsa-miR-425-5p	PAR-CLIP	27292025
MIRT556296	hsa-miR-4517	PAR-CLIP	27292025
MIRT556296	hsa-miR-4517	PAR-CLIP	27292025
MIRT556288	hsa-miR-4753-3p	PAR-CLIP	27292025
MIRT556288	hsa-miR-4753-3p	PAR-CLIP	27292025
MIRT556287	hsa-miR-5191	PAR-CLIP	27292025
MIRT556287	hsa-miR-5191	PAR-CLIP	27292025
MIRT556290	hsa-miR-642a-3p	PAR-CLIP	27292025
MIRT556290	hsa-miR-642a-3p	PAR-CLIP	27292025
MIRT556289	hsa-miR-642b-3p	PAR-CLIP	27292025
MIRT556289	hsa-miR-642b-3p	PAR-CLIP	27292025
MIRT556297	hsa-miR-425-5p	qRT-PCR	31673240
MIRT556297	hsa-miR-425-5p	PAR-CLIP	21572407
MIRT556296	hsa-miR-4517	PAR-CLIP	21572407
MIRT556295	hsa-miR-208a-5p	PAR-CLIP	21572407
MIRT556294	hsa-miR-208b-5p	PAR-CLIP	21572407
MIRT556293	hsa-miR-130b-5p	PAR-CLIP	21572407
MIRT556292	hsa-miR-302b-5p	PAR-CLIP	21572407
MIRT556291	hsa-miR-302d-5p	PAR-CLIP	21572407
MIRT556290	hsa-miR-642a-3p	PAR-CLIP	21572407
MIRT556289	hsa-miR-642b-3p	PAR-CLIP	21572407
MIRT556287	hsa-miR-5191	PAR-CLIP	21572407
MIRT556288	hsa-miR-4753-3p	PAR-CLIP	21572407
MIRT556286	hsa-miR-1303	PAR-CLIP	21572407
MIRT1129016	hsa-miR-199a-3p	CLIP-seq
MIRT1129017	hsa-miR-199b-3p	CLIP-seq
MIRT1129018	hsa-miR-3129-5p	CLIP-seq
MIRT1129019	hsa-miR-371-5p	CLIP-seq
MIRT1129020	hsa-miR-582-5p	CLIP-seq
MIRT1129021	hsa-miR-888	CLIP-seq
MIRT1129022	hsa-miR-936	CLIP-seq
MIRT2036721	hsa-miR-30a	CLIP-seq
MIRT2036722	hsa-miR-30b	CLIP-seq
MIRT2036723	hsa-miR-30c	CLIP-seq
MIRT2036724	hsa-miR-30d	CLIP-seq
MIRT2036725	hsa-miR-30e	CLIP-seq
MIRT2036726	hsa-miR-3143	CLIP-seq
MIRT2036727	hsa-miR-3919	CLIP-seq
MIRT2036728	hsa-miR-4773	CLIP-seq
MIRT1129020	hsa-miR-582-5p	CLIP-seq
MIRT2390563	hsa-miR-130a	CLIP-seq
MIRT2390564	hsa-miR-130b	CLIP-seq
MIRT2390565	hsa-miR-22	CLIP-seq
MIRT2390566	hsa-miR-301a	CLIP-seq
MIRT2390567	hsa-miR-301b	CLIP-seq
MIRT2390568	hsa-miR-3616-5p	CLIP-seq
MIRT2390569	hsa-miR-3647-5p	CLIP-seq
MIRT2390570	hsa-miR-3666	CLIP-seq
MIRT2390571	hsa-miR-4295	CLIP-seq
MIRT2390572	hsa-miR-454	CLIP-seq
MIRT2390573	hsa-miR-4795-5p	CLIP-seq
MIRT2390574	hsa-miR-519a	CLIP-seq
MIRT2390575	hsa-miR-519b-3p	CLIP-seq
MIRT2390576	hsa-miR-519c-3p	CLIP-seq
MIRT2390577	hsa-miR-573	CLIP-seq
MIRT2438507	hsa-miR-139-5p	CLIP-seq
MIRT2036726	hsa-miR-3143	CLIP-seq
MIRT2438508	hsa-miR-323-3p	CLIP-seq
MIRT2036728	hsa-miR-4773	CLIP-seq
MIRT2438509	hsa-miR-498	CLIP-seq
MIRT2438510	hsa-miR-543	CLIP-seq
MIRT1129020	hsa-miR-582-5p	CLIP-seq
MIRT2438511	hsa-miR-642b	CLIP-seq
MIRT2438507	hsa-miR-139-5p	CLIP-seq
MIRT1129016	hsa-miR-199a-3p	CLIP-seq
MIRT1129017	hsa-miR-199b-3p	CLIP-seq
MIRT2566458	hsa-miR-19a	CLIP-seq
MIRT2566459	hsa-miR-19b	CLIP-seq
MIRT2566460	hsa-miR-3121-3p	CLIP-seq
MIRT1129018	hsa-miR-3129-5p	CLIP-seq
MIRT2566461	hsa-miR-3130-3p	CLIP-seq
MIRT2036726	hsa-miR-3143	CLIP-seq
MIRT2438508	hsa-miR-323-3p	CLIP-seq
MIRT2036727	hsa-miR-3919	CLIP-seq
MIRT2566462	hsa-miR-4330	CLIP-seq
MIRT2036728	hsa-miR-4773	CLIP-seq
MIRT2566463	hsa-miR-4793-3p	CLIP-seq
MIRT2438509	hsa-miR-498	CLIP-seq
MIRT2566464	hsa-miR-520d-5p	CLIP-seq
MIRT2566465	hsa-miR-524-5p	CLIP-seq
MIRT2438510	hsa-miR-543	CLIP-seq
MIRT2566466	hsa-miR-544	CLIP-seq
MIRT2566467	hsa-miR-548aa	CLIP-seq
MIRT2566468	hsa-miR-548ac	CLIP-seq
MIRT2566469	hsa-miR-548ae	CLIP-seq
MIRT2566470	hsa-miR-548aj	CLIP-seq
MIRT2566471	hsa-miR-548am	CLIP-seq
MIRT2566472	hsa-miR-548d-3p	CLIP-seq
MIRT2566473	hsa-miR-548x	CLIP-seq
MIRT2566474	hsa-miR-548z	CLIP-seq
MIRT2566475	hsa-miR-582-3p	CLIP-seq
MIRT1129020	hsa-miR-582-5p	CLIP-seq
MIRT2438511	hsa-miR-642b	CLIP-seq
MIRT2566476	hsa-miR-891b	CLIP-seq
MIRT1129022	hsa-miR-936	CLIP-seq
MIRT2438507	hsa-miR-139-5p	CLIP-seq
MIRT1129016	hsa-miR-199a-3p	CLIP-seq
MIRT1129017	hsa-miR-199b-3p	CLIP-seq
MIRT2566458	hsa-miR-19a	CLIP-seq
MIRT2566459	hsa-miR-19b	CLIP-seq
MIRT2566460	hsa-miR-3121-3p	CLIP-seq
MIRT1129018	hsa-miR-3129-5p	CLIP-seq
MIRT2036726	hsa-miR-3143	CLIP-seq
MIRT2438508	hsa-miR-323-3p	CLIP-seq
MIRT1129019	hsa-miR-371-5p	CLIP-seq
MIRT2036727	hsa-miR-3919	CLIP-seq
MIRT2566462	hsa-miR-4330	CLIP-seq
MIRT2036728	hsa-miR-4773	CLIP-seq
MIRT2438509	hsa-miR-498	CLIP-seq
MIRT2566464	hsa-miR-520d-5p	CLIP-seq
MIRT2566465	hsa-miR-524-5p	CLIP-seq
MIRT2438510	hsa-miR-543	CLIP-seq
MIRT2566467	hsa-miR-548aa	CLIP-seq
MIRT2566468	hsa-miR-548ac	CLIP-seq
MIRT2566469	hsa-miR-548ae	CLIP-seq
MIRT2566470	hsa-miR-548aj	CLIP-seq
MIRT2566471	hsa-miR-548am	CLIP-seq
MIRT2566472	hsa-miR-548d-3p	CLIP-seq
MIRT2566473	hsa-miR-548x	CLIP-seq
MIRT2566474	hsa-miR-548z	CLIP-seq
MIRT2566475	hsa-miR-582-3p	CLIP-seq
MIRT1129020	hsa-miR-582-5p	CLIP-seq
MIRT2438511	hsa-miR-642b	CLIP-seq
MIRT1129021	hsa-miR-888	CLIP-seq
MIRT2566476	hsa-miR-891b	CLIP-seq
MIRT1129022	hsa-miR-936	CLIP-seq

Transcription factors

Show/Hide all(6)

Transcription factor	Regulation	Reference
E2F1	Activation	16476732;17287612
E2F1	Unknown	16512785;19610065
E2F2	Unknown	16512785
E2F3	Unknown	16512785
E2F4	Unknown	16512785
RB1	Unknown	19610065

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000165	Process	MAPK cascade	IDA	17210579, 21771788
GO:0000165	Process	MAPK cascade	IEA
GO:0000165	Process	MAPK cascade	TAS	8974401
GO:0000166	Function	Nucleotide binding	IEA
GO:0000287	Function	Magnesium ion binding	IDA	17210579
GO:0002376	Process	Immune system process	IEA
GO:0002931	Process	Response to ischemia	IEA
GO:0004672	Function	Protein kinase activity	IDA	11096076, 21771788
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	TAS
GO:0004706	Function	JUN kinase kinase kinase activity	IDA	11959862
GO:0004709	Function	MAP kinase kinase kinase activity	IBA
GO:0004709	Function	MAP kinase kinase kinase activity	IDA	15983381, 17210579
GO:0004709	Function	MAP kinase kinase kinase activity	IEA
GO:0004709	Function	MAP kinase kinase kinase activity	TAS	8974401
GO:0005515	Function	Protein binding	IPI	9743501, 11003656, 11154276, 11298454, 11495919, 12556535, 12813029, 14557248, 14761963, 15023544, 15246877, 16449798, 16636664, 16648474, 17210579, 17389591, 17700517, 17761141, 19590015, 19782076, 19805025, 19935702, 21496457, 21771788, 22095282, 22609355, 25241761, 25852190, 2609
GO:0005524	Function	ATP binding	IDA	17210579
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IDA	26095851
GO:0005737	Component	Cytoplasm	IEA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006915	Process	Apoptotic process	IEA
GO:0007254	Process	JNK cascade	IBA
GO:0007254	Process	JNK cascade	IDA	11959862, 21771788
GO:0007254	Process	JNK cascade	IEA
GO:0007254	Process	JNK cascade	IMP	22095282
GO:0008631	Process	Intrinsic apoptotic signaling pathway in response to oxidative stress	IBA
GO:0008631	Process	Intrinsic apoptotic signaling pathway in response to oxidative stress	IDA	21771788, 26095851
GO:0008631	Process	Intrinsic apoptotic signaling pathway in response to oxidative stress	IEA
GO:0009897	Component	External side of plasma membrane	IEA
GO:0010666	Process	Positive regulation of cardiac muscle cell apoptotic process	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0019901	Function	Protein kinase binding	IEA
GO:0019903	Function	Protein phosphatase binding	IPI	11959862, 20674765
GO:0019904	Function	Protein domain specific binding	IPI	11096076
GO:0032991	Component	Protein-containing complex	IMP	11096076
GO:0034198	Process	Cellular response to amino acid starvation	IDA	11096076
GO:0034976	Process	Response to endoplasmic reticulum stress	IEA
GO:0034976	Process	Response to endoplasmic reticulum stress	IMP	23000344
GO:0036480	Process	Neuron intrinsic apoptotic signaling pathway in response to oxidative stress	IGI	15983381
GO:0038066	Process	P38MAPK cascade	IBA
GO:0038066	Process	P38MAPK cascade	IEA
GO:0042802	Function	Identical protein binding	IPI	9743501, 17937911, 19805025
GO:0042803	Function	Protein homodimerization activity	IDA	11920685
GO:0043065	Process	Positive regulation of apoptotic process	IDA	21771788
GO:0043065	Process	Positive regulation of apoptotic process	IEA
GO:0043067	Process	Regulation of programmed cell death	IEA
GO:0043410	Process	Positive regulation of MAPK cascade	IEA
GO:0045087	Process	Innate immune response	IEA
GO:0045663	Process	Positive regulation of myoblast differentiation	IEA
GO:0045893	Process	Positive regulation of DNA-templated transcription	IDA	11096076
GO:0046330	Process	Positive regulation of JNK cascade	IEA
GO:0046330	Process	Positive regulation of JNK cascade	IMP	23000344
GO:0046330	Process	Positive regulation of JNK cascade	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0051402	Process	Neuron apoptotic process	IBA
GO:0051402	Process	Neuron apoptotic process	IEA
GO:0051402	Process	Neuron apoptotic process	ISS
GO:0051403	Process	Stress-activated MAPK cascade	IDA	11096076
GO:0070059	Process	Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IBA
GO:0070059	Process	Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IEA
GO:0070059	Process	Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	ISS
GO:0070301	Process	Cellular response to hydrogen peroxide	IDA	20674765
GO:0070301	Process	Cellular response to hydrogen peroxide	IEA
GO:0071356	Process	Cellular response to tumor necrosis factor	IEA
GO:0072577	Process	Endothelial cell apoptotic process	IEA
GO:0090398	Process	Cellular senescence	TAS
GO:0097190	Process	Apoptotic signaling pathway	IDA	20674765
GO:0097190	Process	Apoptotic signaling pathway	TAS	8974401
GO:0097300	Process	Programmed necrotic cell death	IEA
GO:0106310	Function	Protein serine kinase activity	IEA
GO:1900745	Process	Positive regulation of p38MAPK cascade	IEA
GO:1902170	Process	Cellular response to reactive nitrogen species	IEA
GO:1902911	Component	Protein kinase complex	IDA	15983381
GO:1904707	Process	Positive regulation of vascular associated smooth muscle cell proliferation	IEA
GO:1990604	Component	IRE1-TRAF2-ASK1 complex	IDA	12050113, 23000344

MIM	HGNC	e!Ensembl
602448	6857	ENSG00000197442

Protein

UniProt ID

Q99683

Protein name

Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 1) (ASK-1) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5)

Protein function

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination

PDB

2CLQ , 3VW6 , 4BF2 , 4BHN , 4BIB , 4BIC , 4BID , 4BIE , 5ULM , 5UOR , 5UOX , 5UP3 , 5V19 , 5V24 , 5VIL , 5VIO , 6E2M , 6E2N , 6E2O , 6EJL , 6OYT , 6OYW , 6VRE , 6XIH , 7MU6 , 7MU7 , 8QGY

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13281	DUF4071	165 → 545	Domain of unknown function (DUF4071)	Family
PF19039	ASK_PH	555 → 654	ASK kinase PH domain	Domain
PF00069	Pkinase	682 → 938	Protein kinase domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Abundantly expressed in heart and pancreas.

Sequence

MSTEADEGITFSVPPFAPSGFCTIPEGGICRRGGAAAVGEGEEHQLPPPPPGSFWNVESA
AAPGIGCPAATSSSSATRGRGSSVGGGSRRTTVAYVINEASQGQLVVAESEALQSLREAC
ETVGATLETLHFGKLDFGETTVLDRFYNADIAVVEMSDAFRQPSLFYHLGVRESFSMANN
IILYCDTNSDSLQSLKEIICQKNTMCTGNYTFVPYMITPHNKVYCCDSSFMKGLTELMQP
NFELLLGPICLPLVDRFIQLLKVAQASSSQYFRESILNDIRKARNLYTGKELAAELARIR
QRVDNIEVLTADIVINLLLSYRDIQDYDSIVKLVETLEKLPTFDLASHHHVKFHYAFALN
RRNLPGDRAKALDIMIPMVQSEGQVASDMYCLVGRIYKDMFLDSNFTDTESRDHGASWFK
KAFESEPTLQSGINYAVLLLAAGHQFESSFELRKVGVKLSSLLGKKGNLEKLQSYWEVGF
FLGASVLANDHMRVIQASEKLFKLKTPAWYLKSIVETILIYKHFVKLTTEQPVAKQELVD
FWMDFLVEATKTDVTVVRFPVLILEPTKIYQPSYLSINNEVEEKTISIWHVLPDDKKGIH
EWNFSASSVRGVSISKFEERCCFLYVLHNSDDFQIYFCTELHCKKFFEMVNTITEEKGRS
TEEGDCESDLLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQ
PLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTI
GFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFT
GTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVH
PEIPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFLKVSSKKKKTQPKLSALSAGSNE
YLRSISLPVPVLVEDTSSSSEYGSVSPDTELKVDPFSFKTRAKSCGERDVKGIRTLFLGI
PDENFEDHSAPPSPEEKDSGFFMLRKDSERRATLHRILTEDQDKIVRNLMESLAQGAEEP
KLKWEHITTLIASLREFVRSTDRKIIATTLSKLKLELDFDSHGISQVQVVLFGFQDAVNK
VLRNHNIKPHWMFALDSIIRKAVQTAITILVPELRPHFSLASESDTADQEDLDVEDDHEE
QPSNQTVRRPQAVIEDAVATSGVSTLSSTVSHDSQSAHRSLNVQLGRMKIETNRLLEELV
RKEKELQALLHRAIEEKDQEIKHLKLKSQPIEIPELPVFHLNSSGTNTEDSELTDWLRVN
GADEDTISRFLAEDYTLLDVLYYVTRDDLKCLRLRGGMLCTLWKAIIDFRNKQT

Sequence length

1374

Interactions

View interactions

MAP3K5 (mitogen-activated protein kinase kinase kinase 5)