Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs Other IDs
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	5608
Gene name Gene Name - the full gene name approved by the HGNC.	Mitogen-activated protein kinase kinase 6
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	MAP2K6
Synonyms (NCBI Gene) Gene synonyms aliases	CRCMSL, MAPKK6, MEK6, MKK6, PRKMK6, SAPKK-3, SAPKK3
Chromosome Chromosome number	17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	17q24.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multipl

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miRTarBase ID	miRNA	Experiments	Reference
MIRT016670	hsa-miR-425-5p	Sequencing	20371350
MIRT021513	hsa-miR-145-5p	Reporter assay;Microarray	21351259
MIRT053745	hsa-miR-29b-3p	Microarray	22942087
MIRT720403	hsa-miR-6769a-3p	HITS-CLIP	19536157
MIRT720402	hsa-miR-5587-5p	HITS-CLIP	19536157
MIRT573371	hsa-miR-1178-5p	PAR-CLIP	20371350
MIRT573370	hsa-miR-1324	PAR-CLIP	20371350
MIRT573369	hsa-miR-922	PAR-CLIP	20371350
MIRT573368	hsa-miR-6804-5p	PAR-CLIP	20371350
MIRT573367	hsa-miR-3166	PAR-CLIP	20371350
MIRT573366	hsa-miR-6834-5p	PAR-CLIP	20371350
MIRT573365	hsa-miR-1226-5p	PAR-CLIP	20371350
MIRT573364	hsa-miR-6734-5p	PAR-CLIP	20371350
MIRT573363	hsa-miR-1304-5p	PAR-CLIP	20371350
MIRT573362	hsa-miR-8055	PAR-CLIP	20371350
MIRT473850	hsa-miR-590-3p	PAR-CLIP	23592263
MIRT473845	hsa-miR-411-5p	PAR-CLIP	23592263
MIRT473849	hsa-miR-6872-3p	PAR-CLIP	23592263
MIRT473847	hsa-miR-4735-5p	PAR-CLIP	23592263
MIRT473848	hsa-miR-6832-5p	PAR-CLIP	23592263
MIRT473846	hsa-miR-4775	PAR-CLIP	23592263
MIRT473845	hsa-miR-411-5p	PAR-CLIP	23592263
MIRT473844	hsa-miR-3149	PAR-CLIP	23592263
MIRT732300	hsa-miR-625-3p	Luciferase reporter assay, qRT-PCR, Western blot	27526785
MIRT732300	hsa-miR-625-3p	Luciferase reporter assay, qRT-PCR, Western blot	27526785
MIRT732300	hsa-miR-625-3p	Luciferase reporter assay, qRT-PCR, Western blot	27526785
MIRT735799	hsa-miR-10a-5p	Luciferase reporter assay, Western blotting, qRT-PCR	33128541
MIRT720403	hsa-miR-6769a-3p	HITS-CLIP	19536157
MIRT720402	hsa-miR-5587-5p	HITS-CLIP	19536157
MIRT573371	hsa-miR-1178-5p	PAR-CLIP	20371350
MIRT573370	hsa-miR-1324	PAR-CLIP	20371350
MIRT573369	hsa-miR-922	PAR-CLIP	20371350
MIRT573368	hsa-miR-6804-5p	PAR-CLIP	20371350
MIRT573367	hsa-miR-3166	PAR-CLIP	20371350
MIRT573366	hsa-miR-6834-5p	PAR-CLIP	20371350
MIRT573365	hsa-miR-1226-5p	PAR-CLIP	20371350
MIRT573364	hsa-miR-6734-5p	PAR-CLIP	20371350
MIRT573363	hsa-miR-1304-5p	PAR-CLIP	20371350
MIRT573362	hsa-miR-8055	PAR-CLIP	20371350
MIRT473850	hsa-miR-590-3p	PAR-CLIP	23592263
MIRT473845	hsa-miR-411-5p	PAR-CLIP	23592263
MIRT473849	hsa-miR-6872-3p	PAR-CLIP	23592263
MIRT473847	hsa-miR-4735-5p	PAR-CLIP	23592263
MIRT473848	hsa-miR-6832-5p	PAR-CLIP	23592263
MIRT473846	hsa-miR-4775	PAR-CLIP	23592263
MIRT473845	hsa-miR-411-5p	PAR-CLIP	23592263
MIRT473844	hsa-miR-3149	PAR-CLIP	23592263
MIRT755867	hsa-miR-643	Luciferase reporter assay, Western blotting, qRT-PCR, In situ hybridization, RNA pull down assay	34581623
MIRT1920611	hsa-miR-34c-3p	CLIP-seq
MIRT1920612	hsa-miR-374a	CLIP-seq
MIRT1920613	hsa-miR-374b	CLIP-seq
MIRT1920611	hsa-miR-34c-3p	CLIP-seq
MIRT1920612	hsa-miR-374a	CLIP-seq
MIRT1920613	hsa-miR-374b	CLIP-seq
MIRT2266661	hsa-miR-4305	CLIP-seq
MIRT2266662	hsa-miR-664	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000165	Process	MAPK cascade	IEA
GO:0000187	Process	Activation of MAPK activity	IBA	21873635
GO:0000187	Process	Activation of MAPK activity	IDA	8663524, 9218798
GO:0000187	Process	Activation of MAPK activity	TAS
GO:0002931	Process	Response to ischemia	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	TAS
GO:0004708	Function	MAP kinase kinase activity	IBA	21873635
GO:0004708	Function	MAP kinase kinase activity	IDA	8663524, 9218798
GO:0004708	Function	MAP kinase kinase activity	TAS
GO:0004713	Function	Protein tyrosine kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	11035004, 12052864, 15229216, 20067578, 25241761, 32296183, 32814053, 32911434
GO:0005524	Function	ATP binding	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0006915	Process	Apoptotic process	IEA
GO:0006975	Process	DNA damage induced protein phosphorylation	TAS	10848581
GO:0007050	Process	Cell cycle arrest	TAS	10848581
GO:0007165	Process	Signal transduction	TAS	8621675
GO:0018108	Process	Peptidyl-tyrosine phosphorylation	IEA
GO:0019901	Function	Protein kinase binding	IPI	11279118
GO:0022602	Process	Ovulation cycle process	IEA
GO:0032308	Process	Positive regulation of prostaglandin secretion	IEA
GO:0042493	Process	Response to drug	IEA
GO:0043065	Process	Positive regulation of apoptotic process	IEA
GO:0051770	Process	Positive regulation of nitric-oxide synthase biosynthetic process	IEA
GO:0060048	Process	Cardiac muscle contraction	IEA
GO:0070423	Process	Nucleotide-binding oligomerization domain containing signaling pathway	TAS
GO:0072709	Process	Cellular response to sorbitol	IEA
GO:0120163	Process	Negative regulation of cold-induced thermogenesis	ISS	29021624

MIM	HGNC	e!Ensembl
601254	6846	ENSG00000108984

Protein

UniProt ID

P52564

Protein name

Dual specificity mitogen-activated protein kinase kinase 6 (MAP kinase kinase 6) (MAPKK 6) (EC 2.7.12.2) (MAPK/ERK kinase 6) (MEK 6) (Stress-activated protein kinase kinase 3) (SAPK kinase 3) (SAPKK-3) (SAPKK3)

Protein function

Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 MAPK11,

PDB

2Y8O , 3ENM , 3FME , 3VN9 , 5ETF , 8A8M , 8P7J , 8PM3

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	53 → 314	Protein kinase domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Isoform 2 is only expressed in skeletal muscle. Isoform 1 is expressed in skeletal muscle, heart, and in lesser extent in liver or pancreas. {ECO:0000269|PubMed:8621675}.

Sequence

MSQSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELG
RGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALF
REGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDV
KPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDI
WSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSK
ERPTYPELMQHPFFTLHESKGTDVASFVKLILGD

Sequence length

334

Interactions

View interactions

MAP2K6 (mitogen-activated protein kinase kinase 6)