Gene Gene information from NCBI Gene database.
Entrez ID 6416
Gene name Mitogen-activated protein kinase kinase 4
Gene symbol MAP2K4
Synonyms (NCBI Gene)
JNKKJNKK1MAPKK4MEK4MKK4PRKMK4SAPKK-1SAPKK1SEK1SERK1SKK1
Chromosome 17
Chromosome location 17p12
Summary This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, different
miRNA miRNA information provided by mirtarbase database.
616
miRTarBase ID miRNA Experiments Reference
MIRT019756 hsa-miR-375 Microarray 20215506
MIRT028937 hsa-miR-26b-5p Microarray 19088304
MIRT023483 hsa-miR-15b-5p CLASH 23622248
MIRT053655 hsa-miR-145-5p Microarray 22942087
MIRT053698 hsa-miR-188-5p Microarray 22942087
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
HSF2 Repression 11557063
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
32
GO ID Ontology Definition Evidence Reference
GO:0000165 Process MAPK cascade IBA
GO:0000165 Process MAPK cascade IEA
GO:0000165 Process MAPK cascade IEA
GO:0000166 Function Nucleotide binding IEA
GO:0004672 Function Protein kinase activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
601335 6844 ENSG00000065559
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P45985
Protein name Dual specificity mitogen-activated protein kinase kinase 4 (MAP kinase kinase 4) (MAPKK 4) (EC 2.7.12.2) (JNK-activating kinase 1) (MAPK/ERK kinase 4) (MEK 4) (SAPK/ERK kinase 1) (SEK1) (Stress-activated protein kinase kinase 1) (SAPK kinase 1) (SAPKK-1)
Protein function Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7,
PDB 3ALN , 3ALO , 3VUT , 8YP5
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 102 367 Protein kinase domain Domain
Tissue specificity TISSUE SPECIFICITY: Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.
Sequence
Sequence length 399
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
3
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Familial cancer of breast - rs2151599700 RCV005922736
Neuroblastoma other rs1555550018 RCV000505661
Neurodevelopmental disorder Uncertain significance rs2508394673 RCV004586507
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Adenoma Associate 28423721
Alzheimer Disease Associate 26080319
Arthritis Rheumatoid Associate 13130464, 16802349, 25732927
Atrial Fibrillation Associate 32510852
Brain Neoplasms Inhibit 15592684
Breast Neoplasms Associate 15592684, 22522925, 22722193, 28027327, 35589867, 36656864, 39264897
Breast Neoplasms Male Associate 24194916
Calcinosis Cutis Associate 15592684, 24466137
Carcinogenesis Associate 21518142, 22335172
Carcinoma Endometrioid Associate 21575258