Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
64900
Gene name Gene Name - the full gene name approved by the HGNC.
Lipin 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
LPIN3
Synonyms (NCBI Gene) Gene synonyms aliases
LIPN3L, SMP2, dJ620E11.2
Chromosome Chromosome number
20
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
20q12
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the lipin family of proteins, and all family members share strong homology in their C-terminal region. This protein is thought to form hetero-oligomers with other lipin family members, while one family membe
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT018816 hsa-miR-335-5p Microarray 18185580
MIRT1116408 hsa-miR-1231 CLIP-seq
MIRT1116409 hsa-miR-1236 CLIP-seq
MIRT1116410 hsa-miR-125a-3p CLIP-seq
MIRT1116411 hsa-miR-1275 CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003713 Function Transcription coactivator activity IBA 21873635
GO:0005634 Component Nucleus IBA 21873635
GO:0005789 Component Endoplasmic reticulum membrane TAS
GO:0006646 Process Phosphatidylethanolamine biosynthetic process TAS
GO:0006656 Process Phosphatidylcholine biosynthetic process TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
605520 14451 ENSG00000132793
Protein
UniProt ID Q9BQK8
Protein name Phosphatidate phosphatase LPIN3 (EC 3.1.3.4) (Lipin-3) (Lipin-3-like)
Protein function Magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis therefore regulates fatty acid metaboli
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF04571 Lipin_N 1 107 lipin, N-terminal conserved region Family
PF16876 Lipin_mid 438 531 Lipin/Ned1/Smp2 multi-domain protein middle domain Family
PF08235 LNS2 592 817 LNS2 (Lipin/Ned1/Smp2) Domain
Tissue specificity TISSUE SPECIFICITY: Significant expression in intestine and other regions of the gastrointestinal tract. {ECO:0000269|PubMed:17158099}.
Sequence
MNYVGQLAETVFGTVKELYRGLNPATLSGGIDVLVVKQVDGSFRCSPFHVRFGKLGVLRS
REKVVDIELNGEPVDLHMKLGDSGEAFFVQELESDDEHVPPGLCTSP
IPWGGLSGFPSDS
QLGTASEPEGLVMAGTASTGRRKRRRRRKPKQKEDAVATDSSPEELEAGAESELSLPEKL
RPEPPGVQLEEKSSLQPKDIYPYSDGEWPPQASLSAGELTSPKSDSELEVRTPEPSPLRA
ESHMQWAWGRLPKVARAERPESSVVLEGRAGATSPPRGGPSTPSTSVAGGVDPLGLPIQQ
TEAGADLQPDTEDPTLVGPPLHTPETEESKTQSSGDMGLPPASKSWSWATLEVPVPTGQP
ERVSRGKGSPKRSQHLGPSDIYLDDLPSLDSENAALYFPQSDSGLGARRWSEPSSQKSLR
DPNPEHEPEPTLDTVDTIALSLCGGLADSRDISLEKFNQHSVSYQDLTKNPGLLDDPNLV
VKINGKHYNWAVAAPMILSLQAFQKNLPKSTMDKLEREKMPRKGGRWWFSW
RRRDFLAEE
RSAQKEKTAAKEQQGEKTEVLSSDDDAPDSPVILEIPSLPPSTPPSTPTYKKSLRLSSDQ
IRRLNLQEGANDVVFSVTTQYQGTCRCKATIYLWKWDDKVVISDIDGTITKSDALGHILP
QLGKDWTHQGITSLYHKIQLNGYKFLYCSARAIGMADLTKGYLQWVSEGGCSLPKGPILL
SPSSLFSALHREVIEKKPEVFKVACLSDIQQLFLPHGQPFYAAFGNRPNDVFAYRQVGLP
ESRIFTVNPRGELIQELIKNHKSTYERLGEVVELLFP
PVARGPSTDLANPEYSNFCYWRE
PLPAVDLDTLD
Sequence length 851
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Multiple Sclerosis Multiple Sclerosis GWAS
Associations from Text Mining
Disease Name Relationship Type References
Alzheimer Disease Associate 35675752
Atherosclerosis Associate 35675752
Dementia Associate 35675752
Prostatic Neoplasms Associate 33596934