Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs Transcription factors Other IDs Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	4008
Gene name Gene Name - the full gene name approved by the HGNC.	LIM domain 7
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	LMO7
Synonyms (NCBI Gene) Gene synonyms aliases	FBX20, FBXO20, LMO7b, LOMP
Chromosome Chromosome number	13
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	13q22.2
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a protein containing a calponin homology (CH) domain, a PDZ domain, and a LIM domain, and may be involved in protein-protein interactions. Several alternatively spliced transcript variants encoding different isoforms have been found for

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miRTarBase ID	miRNA	Experiments	Reference
MIRT027702	hsa-miR-98-5p	Microarray	19088304
MIRT031907	hsa-miR-16-5p	Proteomics	18668040
MIRT732828	hsa-miR-30a-3p	Immunofluorescence, Luciferase reporter assay, RNA-seq, Western blotting	33397440
MIRT732828	hsa-miR-30a-3p	Immunofluorescence, Luciferase reporter assay, RNA-seq, Western blotting	33397440
MIRT1111953	hsa-miR-1252	CLIP-seq
MIRT1111954	hsa-miR-196a	CLIP-seq
MIRT1111955	hsa-miR-196b	CLIP-seq
MIRT1111956	hsa-miR-3154	CLIP-seq
MIRT1111957	hsa-miR-3655	CLIP-seq
MIRT1111958	hsa-miR-3673	CLIP-seq
MIRT1111959	hsa-miR-3927	CLIP-seq
MIRT1111960	hsa-miR-4476	CLIP-seq
MIRT1111961	hsa-miR-4533	CLIP-seq
MIRT1111962	hsa-miR-4650-3p	CLIP-seq
MIRT1111963	hsa-miR-4797-5p	CLIP-seq
MIRT1111964	hsa-miR-511	CLIP-seq
MIRT1111965	hsa-miR-578	CLIP-seq
MIRT1111966	hsa-miR-9	CLIP-seq
MIRT1550759	hsa-miR-1226	CLIP-seq
MIRT1550760	hsa-miR-300	CLIP-seq
MIRT1550761	hsa-miR-3185	CLIP-seq
MIRT1550762	hsa-miR-325	CLIP-seq
MIRT1550763	hsa-miR-381	CLIP-seq
MIRT1550764	hsa-miR-4666-3p	CLIP-seq
MIRT1550765	hsa-miR-4733-3p	CLIP-seq
MIRT1550766	hsa-miR-4762-3p	CLIP-seq
MIRT1550767	hsa-miR-628-3p	CLIP-seq
MIRT2031251	hsa-miR-3122	CLIP-seq
MIRT2031252	hsa-miR-3133	CLIP-seq
MIRT2031253	hsa-miR-3913-5p	CLIP-seq
MIRT2031254	hsa-miR-4452	CLIP-seq
MIRT2262161	hsa-miR-105	CLIP-seq
MIRT2262162	hsa-miR-1324	CLIP-seq
MIRT2262163	hsa-miR-217	CLIP-seq
MIRT2262164	hsa-miR-3616-3p	CLIP-seq
MIRT2262165	hsa-miR-4260	CLIP-seq
MIRT2262166	hsa-miR-4446-3p	CLIP-seq
MIRT2262167	hsa-miR-4721	CLIP-seq
MIRT2262168	hsa-miR-544b	CLIP-seq
MIRT2262161	hsa-miR-105	CLIP-seq
MIRT1550759	hsa-miR-1226	CLIP-seq
MIRT2430749	hsa-miR-186	CLIP-seq
MIRT2430750	hsa-miR-200b	CLIP-seq
MIRT2430751	hsa-miR-200c	CLIP-seq
MIRT2430752	hsa-miR-205	CLIP-seq
MIRT1550760	hsa-miR-300	CLIP-seq
MIRT2430753	hsa-miR-3121-3p	CLIP-seq
MIRT2031252	hsa-miR-3133	CLIP-seq
MIRT1550761	hsa-miR-3185	CLIP-seq
MIRT2430754	hsa-miR-323-3p	CLIP-seq
MIRT1550762	hsa-miR-325	CLIP-seq
MIRT2430755	hsa-miR-338-5p	CLIP-seq
MIRT1550763	hsa-miR-381	CLIP-seq
MIRT2430756	hsa-miR-3924	CLIP-seq
MIRT2430757	hsa-miR-4284	CLIP-seq
MIRT2430758	hsa-miR-4287	CLIP-seq
MIRT2430759	hsa-miR-429	CLIP-seq
MIRT2430760	hsa-miR-4490	CLIP-seq
MIRT1550764	hsa-miR-4666-3p	CLIP-seq
MIRT2430761	hsa-miR-4685-3p	CLIP-seq
MIRT2430762	hsa-miR-4699-3p	CLIP-seq
MIRT1550765	hsa-miR-4733-3p	CLIP-seq
MIRT1550766	hsa-miR-4762-3p	CLIP-seq
MIRT2430763	hsa-miR-4766-3p	CLIP-seq
MIRT2430764	hsa-miR-4774-5p	CLIP-seq
MIRT2430765	hsa-miR-4775	CLIP-seq
MIRT2430766	hsa-miR-520d-5p	CLIP-seq
MIRT2430767	hsa-miR-524-5p	CLIP-seq
MIRT1550767	hsa-miR-628-3p	CLIP-seq
MIRT2561867	hsa-miR-1273f	CLIP-seq
MIRT2561868	hsa-miR-143	CLIP-seq
MIRT2561869	hsa-miR-4708-5p	CLIP-seq
MIRT2561870	hsa-miR-4770	CLIP-seq

Transcription factors

Show/Hide all(1)

Transcription factor	Regulation	Reference
SRF	Unknown	21670154

Show/Hide all(20)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000151	Component	Ubiquitin ligase complex	NAS	10531035
GO:0004842	Function	Ubiquitin-protein transferase activity	NAS	10531035
GO:0005515	Function	Protein binding	IPI	15161933, 30429017, 35271311
GO:0005634	Component	Nucleus	IDA	17067998
GO:0005634	Component	Nucleus	TAS	9826547
GO:0005635	Component	Nuclear envelope	IDA	17067998
GO:0005737	Component	Cytoplasm	IDA	17067998
GO:0005737	Component	Cytoplasm	TAS	9826547
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005829	Component	Cytosol	TAS
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0009986	Component	Cell surface	IDA	17067998
GO:0010604	Process	Positive regulation of macromolecule metabolic process	IEA
GO:0016324	Component	Apical plasma membrane	ISS
GO:0016567	Process	Protein ubiquitination	NAS	10531035
GO:0023051	Process	Regulation of signaling	IEA
GO:0030155	Process	Regulation of cell adhesion	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	17067998
GO:0046872	Function	Metal ion binding	IEA
GO:0080090	Process	Regulation of primary metabolic process	IEA

MIM	HGNC	e!Ensembl
604362	6646	ENSG00000136153

Protein

UniProt ID

Q8WWI1

Protein name

LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP)

PDB

2EAQ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00307	CH	71 → 179	Calponin homology (CH) domain	Domain
PF15949	DUF4757	294 → 375	Domain of unknown function (DUF4757)	Family
PF15949	DUF4757	635 → 787	Domain of unknown function (DUF4757)	Family
PF00595	PDZ	1043 → 1119	PDZ domain	Domain
PF00412	LIM	1614 → 1676	LIM domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. Isoform 2 and isoform 4 are predominantly expressed in brain. {ECO:0000269|PubMed:11935316, ECO:0000269|PubMed:9826547}.

Sequence

MKKIRICHIFTFYSWMSYDVLFQRTELGALEIWRQLICAHVCICVGWLYLRDRVCSKKDI
ILRTEQNSGRTILIKAVTEKNFETKDFRASLENGVLLCDLINKLKPGVIKKINRLSTPIA
GLDNINVFLKACEQIGLKEAQLFHPGDLQDLSNRVTVKQEETDRRVKNVLITLYWLGRKA
QSNPYYNGPHLNLKAFENLLGQALTKALEDSSFLKRSGRDSGYGDIWCPERGEFLAPPRH
HKREDSFESLDSLGSRSLTSCSSDITLRGGREGFESDTDSEFTFKMQDYNKDDMSYRRIS
AVEPKTALPFNRFLPNKSRQPSYVPAPLRKKKPDKHEDNRRSWASPVYTEADGTFSSNQR
RIWGTNVENWPTVQGTSKSSCYLEEEKAKTRSIPNIVKDDLYVRKLSPVMPNPGNAFDQF
LPKCWTPEDVNWKRIKRETYKPWYKEFQGFSQFLLLQALQTYSDDILSSETHTKIDPTSG
PRLITRRKNLSYAPGYRRDDLEMAALDPDLENDDFFVRKTGVFHANPYVLRAFEDFRKFS
EQDDSVERDIILQCREGELVLPDLEKDDMIVRRIPAQKKEVPLSGAPDRYHPVPFPEPWT
LPPEIQAKFLCVFERTCPSKEKSNSCRILVPSYRQKKDDMLTRKIQSWKLGTTVPPISFT
PGPCSEADLKRWEAIREASRLRHKKRLMVERLFQKIYGENGSKSMSDVSAEDVQNLRQLR
YEEMQKIKSQLKEQDQKWQDDLAKWKDRRKSYTSDLQKKKEEREEIEKQALEKSKRSSKT
FKEMLQDRESQNQKSTVPSRRRMYSFDDVLEEGKRPPTMTVSEASYQSERVEEKGATYPS
EIPKEDSTTFAKREDRVTTEIQLPSQSPVEEQSPASLSSLRSRSTQMESTRVSASLPRSY
RKTDTVRLTSVVTPRPFGSQTRGISSLPRSYTMDDAWKYNGDVEDIKRTPNNVVSTPAPS
PDASQLASSLSSQKEVAATEEDVTRLPSPTSPFSSLSQDQAATSKATLSSTSGLDLMSES
GEGEISPQREVSRSQDQFSDMRISINQTPGKSLDFGFTIKWDIPGIFVASVEAGSPAEFS
QLQVDDEIIAINNTKFSYNDSKEWEEAMAKAQETGHLVMDVRRYGKAGSPETKWIDATSG
IYNSEKSSNLSVTTDFSESLQSSNIESKEINGIHDESNAFESKASESISLKNLKRRSQFF
EQGSSDSVVPDLPVPTISAPSRWVWDQEEERKRQERWQKEQDRLLQEKYQREQEKLREEW
QRAKQEAERENSKYLDEELMVLSSNSMSLTTREPSLATWEATWSEGSKSSDREGTRAGEE
ERRQPQEEVVHEDQGKKPQDQLVIERERKWEQQLQEEQEQKRLQAEAEEQKRPAEEQKRQ
AEIERETSVRIYQYRRPVDSYDIPKTEEASSGFLPGDRNKSRSTTELDDYSTNKNGNNKY
LDQIGNMTSSQRRSKKEQVPSGAELERQQILQEMRKRTPLHNDNSWIRQRSASVNKEPVS
LPGIMRRGESLDNLDSPRSNSWRQPPWLNQPTGFYASSSVQDFSRPPPQLVSTSNRAYMR
NPSSSVPPPSAGSVKTSTTGVATTQSPTPRSHSPSASQSGSQLRNRSVSGKRICSYCNNI
LGKGAAMIIESLGLCYHLHCFKCVACECDLGGSSSGAEVRIRNHQLYCNDCYLRFKSGRP
TAM

Sequence length

1683

Interactions

View interactions

Show/Hide Unknown Diseases (7)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Astrocytoma	Astrocytoma	N/A	N/A	GWAS
Glaucoma	Glaucoma	N/A	N/A	GWAS
Glioblastoma	Glioblastoma	N/A	N/A	GWAS
Hemorrhoids	Hemorrhoids	N/A	N/A	GWAS
Metabolic Syndrome	Metabolic syndrome	N/A	N/A	GWAS
Obsessive-Compulsive Disorder	Obsessive-compulsive disorder	N/A	N/A	GWAS
Prostate cancer	Prostate cancer	N/A	N/A	GWAS

Show/Hide Text Mining Associations (19)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Bardet Biedl Syndrome	Associate	28800606
Breast Neoplasms	Associate	21670154
Carcinoma Pancreatic Ductal	Stimulate	35046938
Ciliopathies	Associate	28800606
Dry Eye Syndromes	Associate	30312344
Encephalitis Tick Borne	Associate	31122248
Glaucoma	Associate	29449654
Glaucoma Open Angle	Associate	29449654
LEOPARD Syndrome	Associate	21179469
Lung Neoplasms	Associate	28026121
Muscular Diseases	Associate	21179469
Neoplasms	Associate	21999571
Neoplasms	Inhibit	32149111
Psychotic Disorders	Associate	29064472
Pulmonary Disease Chronic Obstructive	Associate	31952466
Retinal Degeneration	Associate	29064472
Sjogren's Syndrome	Associate	30312344
Sjogren's Syndrome	Stimulate	31366407
Wilms Tumor	Associate	32149111

LMO7 (LIM domain 7)