Gene Gene information from NCBI Gene database.
Entrez ID 3845
Gene name KRAS proto-oncogene, GTPase
Gene symbol KRAS
Synonyms (NCBI Gene)
'C-K-RASC-K-RASCFC2K-RAS2AK-RAS2BK-RAS4AK-RAS4BK-RasK-Ras 2KI-RASKRAS1KRAS2NSNS3OESRALDRASK2c-Ki-rasc-Ki-ras2
Chromosome 12
Chromosome location 12p12.1
Summary This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that res
SNPs SNP information provided by dbSNP.
46
SNP ID Visualize variation Clinical significance Consequence
rs17851045 T>A,G Likely-pathogenic, pathogenic Missense variant, coding sequence variant
rs104894359 C>G,T Pathogenic Coding sequence variant, missense variant
rs104894360 T>A,C Pathogenic, likely-pathogenic Missense variant, coding sequence variant, 3 prime UTR variant
rs104894361 T>A,C,G Pathogenic, uncertain-significance Coding sequence variant, synonymous variant, missense variant
rs104894362 G>C Pathogenic Missense variant, coding sequence variant, 3 prime UTR variant
miRNA miRNA information provided by mirtarbase database.
884
miRTarBase ID miRNA Experiments Reference
MIRT000312 hsa-miR-143-3p qRT-PCRLuciferase reporter assayMicroarray 19137007
MIRT000312 hsa-miR-143-3p qRT-PCRLuciferase reporter assayMicroarray 19137007
MIRT000399 hsa-let-7g-5p Luciferase reporter assay 18308936
MIRT000312 hsa-miR-143-3p Luciferase reporter assay 19137007
MIRT000312 hsa-miR-143-3p Luciferase reporter assay 19137007
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
MYC Activation 21252116
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
69
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane TAS
GO:0000165 Process MAPK cascade IEA
GO:0000165 Process MAPK cascade TAS
GO:0000166 Function Nucleotide binding IEA
GO:0001889 Process Liver development IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
190070 6407 ENSG00000133703
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P01116
Protein name GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Protein function Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:20949621, PubMed:39809765). Plays an important role in the regulation of cell proliferation (PubMed:22711838, PubMed:23698361). Plays a role in promoting oncogenic events by
PDB 1D8D , 1D8E , 1KZO , 1KZP , 1N4P , 1N4Q , 1N4R , 1N4S , 2MSC , 2MSD , 2MSE , 3GFT , 4DSN , 4DSO , 4EPR , 4EPT , 4EPV , 4EPW , 4EPX , 4EPY , 4L8G , 4LDJ , 4LPK , 4LRW , 4LUC , 4LV6 , 4LYF , 4LYH , 4LYJ , 4M1O , 4M1S , 4M1T , 4M1W , 4M1Y , 4M21 , 4M22 , 4NMM , 4OBE , 4PZY , 4PZZ , 4Q01 , 4Q02 , 4Q03 , 4QL3 , 4TQ9 , 4TQA , 4WA7 , 5F2E , 5KYK , 5MLA , 5MLB
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00071 Ras 5 165 Ras family Domain
Sequence
Sequence length 189
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
779
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Acute myeloid leukemia Pathogenic; Likely pathogenic rs112445441, rs121913529, rs606231202, rs104894366, rs730880471 RCV005887479
RCV000433573
RCV000013415
RCV000850569
RCV000850568
Adenocarcinoma of the large intestine Likely pathogenic; Pathogenic rs121913530, rs112445441, rs121913529 RCV006253513
RCV006253517
RCV006253525
RCV006253529
Adenoid cystic carcinoma Likely pathogenic; Pathogenic rs121913530 RCV004813033
Alveolar rhabdomyosarcoma Likely pathogenic; Pathogenic rs121913529 RCV006253520
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Classic Hodgkin lymphoma Conflicting classifications of pathogenicity rs121913527 RCV002227934
Familial cancer of breast not provided rs104886029 RCV000119371
Non-immune hydrops fetalis Conflicting classifications of pathogenicity rs770020203 RCV001375978
Primary familial hypertrophic cardiomyopathy Uncertain significance rs397517043 RCV000143908
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
3 methylcrotonyl CoA carboxylase 1 deficiency Associate 35794233
Aberrant Crypt Foci Associate 12000733, 17487400, 29222172
Abnormalities Drug Induced Associate 15923430
Abortion Spontaneous Associate 34787849
Achondroplasia Associate 30355600
Acrospiroma Associate 10543256
Acute erythroleukemia Associate 30385823
Adenoameloblastoma Associate 30643167, 37093491
Adenocarcinoma Associate 10517904, 10945494, 11461083, 11592777, 11882817, 12163385, 12606951, 12673679, 14511407, 1486847, 15492756, 16533793, 16598760, 1685441, 16896030
View all (171 more)
Adenocarcinoma Stimulate 9460997