Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3845
Gene name Gene Name - the full gene name approved by the HGNC.
KRAS proto-oncogene, GTPase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
KRAS
Synonyms (NCBI Gene) Gene synonyms aliases
'C-K-RAS, C-K-RAS, CFC2, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, K-Ras, K-Ras 2, KI-RAS, KRAS1, KRAS2, NS, NS3, OES, RALD, RASK2, c-Ki-ras, c-Ki-ras2
Disease Acronyms (UniProt) Disease acronyms from UniProt database
CFC2, NS3, OES, RALD
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12p12.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that res
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs17851045 T>A,G Likely-pathogenic, pathogenic Missense variant, coding sequence variant
rs104894359 C>G,T Pathogenic Coding sequence variant, missense variant
rs104894360 T>A,C Pathogenic, likely-pathogenic Missense variant, coding sequence variant, 3 prime UTR variant
rs104894361 T>A,C,G Pathogenic, uncertain-significance Coding sequence variant, synonymous variant, missense variant
rs104894362 G>C Pathogenic Missense variant, coding sequence variant, 3 prime UTR variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT000312 hsa-miR-143-3p qRT-PCR, Luciferase reporter assay, Microarray 19137007
MIRT000312 hsa-miR-143-3p qRT-PCR, Luciferase reporter assay, Microarray 19137007
MIRT000399 hsa-let-7g-5p Luciferase reporter assay 18308936
MIRT000312 hsa-miR-143-3p Luciferase reporter assay 19137007
MIRT000312 hsa-miR-143-3p Luciferase reporter assay 19137007
Transcription factors
Transcription factor Regulation Reference
MYC Activation 21252116
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000165 Process MAPK cascade TAS
GO:0001889 Process Liver development IEA
GO:0001934 Process Positive regulation of protein phosphorylation IMP 22065586
GO:0002223 Process Stimulatory C-type lectin receptor signaling pathway TAS
GO:0003924 Function GTPase activity IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
190070 6407 ENSG00000133703
Protein
UniProt ID P01116
Protein name GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Protein function Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:20949621, PubMed:39809765). Plays an important role in the regulation of cell proliferation (PubMed:22711838, PubMed:23698361). Plays a role in promoting oncogenic events by
PDB 1D8D , 1D8E , 1KZO , 1KZP , 1N4P , 1N4Q , 1N4R , 1N4S , 2MSC , 2MSD , 2MSE , 3GFT , 4DSN , 4DSO , 4EPR , 4EPT , 4EPV , 4EPW , 4EPX , 4EPY , 4L8G , 4LDJ , 4LPK , 4LRW , 4LUC , 4LV6 , 4LYF , 4LYH , 4LYJ , 4M1O , 4M1S , 4M1T , 4M1W , 4M1Y , 4M21 , 4M22 , 4NMM , 4OBE , 4PZY , 4PZZ , 4Q01 , 4Q02 , 4Q03 , 4QL3 , 4TQ9 , 4TQA , 4WA7 , 5F2E , 5KYK , 5MLA , 5MLB
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00071 Ras 5 165 Ras family Domain
Sequence
Sequence length 189
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Epidermal nevus syndrome linear nevus sebaceous syndrome GenCC
Noonan Syndrome Noonan syndrome GenCC
Cardiofaciocutaneous Syndrome cardiofaciocutaneous syndrome GenCC
Costello Syndrome Costello syndrome GenCC
Associations from Text Mining
Disease Name Relationship Type References
3 methylcrotonyl CoA carboxylase 1 deficiency Associate 35794233
Aberrant Crypt Foci Associate 12000733, 17487400, 29222172
Abnormalities Drug Induced Associate 15923430
Abortion Spontaneous Associate 34787849
Achondroplasia Associate 30355600
Acrospiroma Associate 10543256
Acute erythroleukemia Associate 30385823
Adenoameloblastoma Associate 30643167, 37093491
Adenocarcinoma Associate 10517904, 10945494, 11461083, 11592777, 11882817, 12163385, 12606951, 12673679, 14511407, 1486847, 15492756, 16533793, 16598760, 1685441, 16896030
View all (171 more)
Adenocarcinoma Stimulate 9460997