ITGAM (integrin subunit alpha M)

Gene Gene information from NCBI Gene database.
Gene SNPs Transcription factors Other IDs Associated diseases
Entrez ID 3684
Gene name Integrin subunit alpha M
Gene symbol ITGAM
Synonyms (NCBI Gene)
CD11BCR3AMAC-1MAC1AMO1ASLEB6
Chromosome 16
Chromosome location 16p11.2
Summary This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific i
miRNA miRNA information provided by mirtarbase database.
23
Gene SNPs Transcription factors Other IDs Associated diseases
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miRTarBase ID miRNA Experiments Reference
MIRT1073816 hsa-miR-203 CLIP-seq
MIRT1073817 hsa-miR-224 CLIP-seq
MIRT1073818 hsa-miR-23a CLIP-seq
MIRT1073819 hsa-miR-23b CLIP-seq
MIRT1073820 hsa-miR-23c CLIP-seq
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Gene SNPs Transcription factors Other IDs Associated diseases
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Transcription factor Regulation Reference
SPI1 Activation 15163413;8095266;9295016
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
64
Gene SNPs Transcription factors Other IDs Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0001540 Function Amyloid-beta binding IC
GO:0001774 Process Microglial cell activation ISS
GO:0001851 Function Complement component C3b binding ISS
GO:0002376 Process Immune system process IEA
GO:0002430 Process Complement receptor mediated signaling pathway ISS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene SNPs Transcription factors Other IDs Associated diseases
MIM HGNC e!Ensembl
120980 6149 ENSG00000169896
Protein Protein information from UniProt database.
Gene SNPs Transcription factors Other IDs Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P11215
Protein name Integrin alpha-M (CD11 antigen-like family member B) (CR-3 alpha chain) (Cell surface glycoprotein MAC-1 subunit alpha) (Leukocyte adhesion receptor MO1) (Neutrophil adherence receptor) (CD antigen CD11b)
Protein function Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (PubMed:20008295, PubMed:9558116). It is identical wit
PDB 1BHO , 1BHQ , 1IDN , 1IDO , 1JLM , 1M1U , 1MF7 , 1N9Z , 1NA5 , 2LKE , 2LKJ , 3Q3G , 3QA3 , 4M76 , 4XW2 , 6RHW , 7AKK , 7P2D , 7USL , 7USM , 8CE6 , 8CE9 , 8VOH , 8VOI
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00092 VWA 150 → 327 von Willebrand factor type A domain Domain
PF01839 FG-GAP 520 → 555 FG-GAP repeat Repeat
PF08441 Integrin_alpha2 614 → 1005 Integrin alpha Family
PF00357 Integrin_alpha 1129 → 1143 Integrin alpha cytoplasmic region Family
Tissue specificity TISSUE SPECIFICITY: Predominantly expressed in monocytes and granulocytes (PubMed:1346576). Expressed in neutrophils (at protein level) (PubMed:21193407). {ECO:0000269|PubMed:1346576, ECO:0000269|PubMed:21193407}.
Sequence 
MALRVLLLTALTLCHGFNLDTENAMTFQENARGFGQSVVQLQGSRVVVGAPQEIVAANQR
GSLYQCDYSTGSCEPIRLQVPVEAVNMSLGLSLAATTSPPQLLACGPTVHQTCSENTYVK
GLCFLFGSNLRQQPQKFPEALRGCPQEDSDIAFLIDGSGSIIPHDFRRMKEFVSTVMEQL
KKSKTLFSLMQYSEEFRIHFTFKEFQNNPNPRSLVKPITQLLGRTHTATGIRKVVRELFN
ITNGARKNAFKILVVITDGEKFGDPLGYEDVIPEADREGVIRYVIGVGDAFRSEKSRQEL
NTIASKPPRDHVFQVNNFEALKTIQNQLREKIFAIEGTQTGSSSSFEHEMSQEGFSAAIT
SNGPLLSTVGSYDWAGGVFLYTSKEKSTFINMTRVDSDMNDAYLGYAAAIILRNRVQSLV
LGAPRYQHIGLVAMFRQNTGMWESNANVKGTQIGAYFGASLCSVDVDSNGSTDLVLIGAP
HYYEQTRGGQVSVCPLPRGRARWQCDAVLYGEQGQPWGRFGAALTVLGDVNGDKLTDVAI
GAPGEEDNRGAVYLFHGTSGSGISPSHSQRIAGSKLSPRLQYFGQSLSGGQDLTMDGLVD
LTVGAQGHVLLLRSQPVLRVKAIMEFNPREVARNVFECNDQVVKGKEAGEVRVCLHVQKS
TRDRLREGQIQSVVTYDLALDSGRPHSRAVFNETKNSTRRQTQVLGLTQTCETLKLQLPN
CIEDPVSPIVLRLNFSLVGTPLSAFGNLRPVLAEDAQRLFTALFPFEKNCGNDNICQDDL
SITFSFMSLDCLVVGGPREFNVTVTVRNDGEDSYRTQVTFFFPLDLSYRKVSTLQNQRSQ
RSWRLACESASSTEVSGALKSTSCSINHPIFPENSEVTFNITFDVDSKASLGNKLLLKAN
VTSENNMPRTNKTEFQLELPVKYAVYMVVTSHGVSTKYLNFTASENTSRVMQHQYQVSNL
GQRSLPISLVFLVPVRLNQTVIWDRPQVTFSENLSSTCHTKERLPSHSDFLAELRKAPVV
NCSIAVCQRIQCDIPFFGIQEEFNATLKGNLSFDWYIKTSHNHLLIVSTAEILFNDSVFT
LLPGQGAFVRSQTETKVEPFEVPNPLPLIVGSSVGGLLLLALITAALYKLGFFKRQYKDM
MSEGGPPGAEPQ
Sequence length 1152
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
33
Gene SNPs Transcription factors Other IDs Associated diseases
Show/Hide Unknown Diseases (5)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Cervical cancer Benign rs189988398 RCV005909492
Familial cancer of breast Benign rs189988398 RCV005909491
ITGAM-related disorder Likely benign; Benign; Uncertain significance rs192388678, rs1143679, rs35314490, rs35472514, rs61755177, rs1143680, rs1143682, rs1143683, rs1143678, rs763736373, rs754605580, rs1310395965, rs772703244, rs140927329, rs747384775
View all (13 more)		 RCV004753348
RCV003980488
RCV003983926
RCV003980489
RCV003956193
RCV003966115
RCV003980467
RCV003980490
RCV003983927
RCV004753406
RCV003401958
RCV003948860
RCV003933687
RCV003923512
RCV003968787
RCV003978834
RCV003978531
RCV003958480
RCV003906532
RCV003963331
RCV004753600
RCV003402098
RCV003394396
RCV003954744
RCV003961885
RCV003976309
RCV003925881
RCV003905955
Sarcoma Benign rs189988398 RCV005909493
Show/Hide Text Mining Associations (286)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Accessory Nerve Injuries Associate 35892263
Acute Coronary Syndrome Stimulate 11132167
Acute Lung Injury Associate 33949285
Acute On Chronic Liver Failure Associate 28592438
Adenocarcinoma Associate 32509861
Adenocarcinoma of Lung Associate 35291954
Agranulocytosis Associate 1372668
Albuminuria Associate 31023084
Alzheimer Disease Associate 23134465, 40465637
Amyotrophic Lateral Sclerosis Associate 35328793