Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
8826
Gene name Gene Name - the full gene name approved by the HGNC.
IQ motif containing GTPase activating protein 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
IQGAP1
Synonyms (NCBI Gene) Gene synonyms aliases
HUMORFA01, SAR1, p195
Chromosome Chromosome number
15
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
15q26.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several sign
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT002697 hsa-miR-124-3p Luciferase reporter assay, qRT-PCR, Western blot 19843643
MIRT002697 hsa-miR-124-3p Luciferase reporter assay, qRT-PCR, Western blot 19843643
MIRT002697 hsa-miR-124-3p Luciferase reporter assay, qRT-PCR, Western blot 19843643
MIRT002697 hsa-miR-124-3p Luciferase reporter assay, qRT-PCR, Western blot 19843643
MIRT002697 hsa-miR-124-3p Luciferase reporter assay, Microarray 15685193
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001726 Component Ruffle IDA 25554515, 26242911
GO:0005078 Function MAP-kinase scaffold activity IPI 18567582
GO:0005095 Function GTPase inhibitor activity TAS 8670801
GO:0005096 Function GTPase activator activity IBA 21873635
GO:0005509 Function Calcium ion binding IDA 18567582
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
603379 6110 ENSG00000140575
Protein
UniProt ID P46940
Protein name Ras GTPase-activating-like protein IQGAP1 (p195)
Protein function Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Recruited to the cell cortex by interaction with ILK which allows it to cooperate with its effector DIAPH1 to locally stabilize microtubules and allow stable
PDB 1X0H , 2RR8 , 3FAY , 3I6X , 5L0O
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00307 CH 44 161 Calponin homology (CH) domain Domain
PF00612 IQ 747 766 IQ calmodulin-binding motif Motif
PF00612 IQ 776 796 IQ calmodulin-binding motif Motif
PF00612 IQ 806 826 IQ calmodulin-binding motif Motif
PF00612 IQ 837 856 IQ calmodulin-binding motif Motif
PF00616 RasGAP 1025 1237 GTPase-activator protein for Ras-like GTPase Family
PF03836 RasGAP_C 1452 1580 RasGAP C-terminus Family
Tissue specificity TISSUE SPECIFICITY: Expressed in the placenta, lung, and kidney (PubMed:8051149). A lower level expression is seen in the heart, liver, skeletal muscle and pancreas (PubMed:8051149). {ECO:0000269|PubMed:8051149}.
Sequence
MSAADEVDGLGVARPHYGSVLDNERLTAEEMDERRRQNVAYEYLCHLEEAKRWMEACLGE
DLPPTTELEEGLRNGVYLAKLGNFFSPKVVSLKKIYDREQTRYKATGLHFRHTDNVIQWL
NAMDEIGLPKIFYPETTDIYDRKNMPRCIYCIHALSLYLFK
LGLAPQIQDLYGKVDFTEE
EINNMKTELEKYGIQMPAFSKIGGILANELSVDEAALHAAVIAINEAIDRRIPADTFAAL
KNPNAMLVNLEEPLASTYQDILYQAKQDKMTNAKNRTENSERERDVYEELLTQAEIQGNI
NKVNTFSALANIDLALEQGDALALFRALQSPALGLRGLQQQNSDWYLKQLLSDKQQKRQS
GQTDPLQKEELQSGVDAANSAAQQYQRRLAAVALINAAIQKGVAEKTVLELMNPEAQLPQ
VYPFAADLYQKELATLQRQSPEHNLTHPELSVAVEMLSSVALINRALESGDVNTVWKQLS
SSVTGLTNIEEENCQRYLDELMKLKAQAHAENNEFITWNDIQACVDHVNLVVQEEHERIL
AIGLINEALDEGDAQKTLQALQIPAAKLEGVLAEVAQHYQDTLIRAKREKAQEIQDESAV
LWLDEIQGGIWQSNKDTQEAQKFALGIFAINEAVESGDVGKTLSALRSPDVGLYGVIPEC
GETYHSDLAEAKKKKLAVGDNNSKWVKHWVKGGYYYYHNLETQEGGWDEPPNFVQNSMQL
SREEIQSSISGVTAAYNREQLWLANEGLITRLQARCRGYLVRQEFRSRMNFLKKQIPAIT
CIQSQWRGYKQKKAYQ
DRLAYLRSHKDEVVKIQSLARMHQARKRYRDRLQYFRDHINDII
KIQAFIRANKARDDYK
TLINAEDPPMVVVRKFVHLLDQSDQDFQEELDLMKMREEVITLI
RSNQQLENDLNLMDIKIGLLVKNKITLQDVVSHSKKLTKKNKEQLSDMMMINKQKGGLKA
LSKEKREKLEAYQHLFYLLQTNPTYLAKLIFQMPQNKSTKFMDSVIFTLYNYASNQREEY
LLLRLFKTALQEEIKSKVDQIQEIVTGNPTVIKMVVSFNRGARGQNALRQILAPVVKEIM
DDKSLNIKTDPVDIYKSWVNQMESQTGEASKLPYDVTPEQALAHEEVKTRLDSSIRNMRA
VTDKFLSAIVSSVDKIPYGMRFIAKVLKDSLHEKFPDAGEDELLKIIGNLLYYRYMNPAI
VAPDAFDIIDLSAGGQLTTDQRRNLGSIAKMLQHAAS
NKMFLGDNAHLSIINEYLSQSYQ
KFRRFFQTACDVPELQDKFNVDEYSDLVTLTKPVIYISIGEIINTHTLLLDHQDAIAPEH
NDPIHELLDDLGEVPTIESLIGESSGNLNDPNKEALAKTEVSLTLTNKFDVPGDENAEMD
ARTILLNTKRLIVDVIRFQPGETLTEILETPATSEQEAEHQRAMQRRAIRDAKTPDKMKK
SKSVKEDSNLTLQEKKEKIQTGLKKLTELGTVDPKNKYQELINDIARDIRNQRRYRQRRK
AELVKLQQTYAALNSKATFYGEQVDYYKSYIKTCLDNLASKGKVSKKPREMKGKKSKKIS
LKYTAARLHEKGVLLEIEDL
QVNQFKNVIFEISPTEEVGDFEVKAKFMGVQMETFMLHYQ
DLLQLQYEGVAVMKLFDRAKVNVNLLIFLLNKKFYGK
Sequence length 1657
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Eczema Eczema GWAS
Multiple Sclerosis Multiple Sclerosis GWAS
Rheumatoid arthritis Rheumatoid arthritis GWAS
Dermatitis Dermatitis GWAS
Associations from Text Mining
Disease Name Relationship Type References
Annular pancreas Associate 37635636
Anophthalmia with pulmonary hypoplasia Associate 32799327
Arthritis Rheumatoid Associate 36614150
Astrocytoma Associate 24252689
Breast Neoplasms Associate 17981797, 22992742, 23405264, 32051509
Breast Neoplasms Stimulate 21724847, 29779034
Calcinosis Cutis Associate 30367951
Carcinogenesis Stimulate 17981797
Carcinogenesis Inhibit 25848980
Carcinogenesis Associate 26252773, 26934121, 27100492, 28035419, 28282856, 28708206