Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3569
Gene name Gene Name - the full gene name approved by the HGNC.
Interleukin 6
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
IL6
Synonyms (NCBI Gene) Gene synonyms aliases
BSF-2, BSF2, CDF, HGF, HSF, IFN-beta-2, IFNB2, IL-6
Chromosome Chromosome number
7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
7p15.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT005420 hsa-let-7a-5p Luciferase reporter assay, qRT-PCR, Western blot 19878981
MIRT006061 hsa-miR-203a-3p ELISA, qRT-PCR 21279994
MIRT006061 hsa-miR-203a-3p ELISA, qRT-PCR 21279994
MIRT006061 hsa-miR-203a-3p ELISA, qRT-PCR 21279994
MIRT006790 hsa-miR-142-3p ELISA, Immunoblot, Microarray, qRT-PCR 21474672
Transcription factors
Transcription factor Regulation Reference
AHR Activation 20511231
AHR Unknown 18483242;23349129
ATF4 Unknown 16931790
CEBPA Unknown 11975924
CEBPB Activation 10903137;8725624
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001781 Process Neutrophil apoptotic process IDA 7595060
GO:0002314 Process Germinal center B cell differentiation ISS
GO:0002377 Process Immunoglobulin production ISS
GO:0002384 Process Hepatic immune response IDA 2444978
GO:0002384 Process Hepatic immune response TAS 12832423
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
147620 6018 ENSG00000136244
Protein
UniProt ID P05231
Protein name Interleukin-6 (IL-6) (B-cell stimulatory factor 2) (BSF-2) (CTL differentiation factor) (CDF) (Hybridoma growth factor) (Interferon beta-2) (IFN-beta-2)
Protein function Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway (Probable).
PDB 1ALU , 1IL6 , 1P9M , 2IL6 , 4CNI , 4J4L , 4NI7 , 4NI9 , 4O9H , 4ZS7 , 5FUC , 7NXZ , 8D82 , 8QY5 , 8QY6 , 8YWQ , 8YWR
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00489 IL6 27 212 Interleukin-6/G-CSF/MGF family Domain
Tissue specificity TISSUE SPECIFICITY: Produced by skeletal muscle. {ECO:0000269|PubMed:11080265}.
Sequence
Sequence length 212
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Kaposi Sarcoma Kaposi sarcoma, susceptibility to GenCC
Asthma Asthma GWAS
Multiple Sclerosis Multiple Sclerosis GWAS
Systemic lupus erythematosus Systemic lupus erythematosus GWAS
Associations from Text Mining
Disease Name Relationship Type References
AA amyloidosis Associate 1616367
Abdominal Pain Associate 30918467
Abortion Habitual Associate 24975966, 29017513
Abortion Spontaneous Inhibit 10632428
Abortion Spontaneous Associate 35090453, 35955896
Abscess Associate 37091905
Achalasia Addisonianism Alacrimia syndrome Associate 17194638
Acidemia isovaleric Associate 33166496
Acidosis Associate 40217316
Acne Vulgaris Associate 25153527, 29771405, 32627753