IL4I1 (interleukin 4 induced 1)

Gene
Gene SNPs Other IDs
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
259307
Gene name Gene Name - the full gene name approved by the HGNC.
Interleukin 4 induced 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
IL4I1
Synonyms (NCBI Gene) Gene synonyms aliases
FIG1, LAAO, LAO, hIL4I1
Chromosome Chromosome number
19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19q13.33
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a secreted L-amino acid oxidase protein which primarily catabolizes L-phenylalanine and, to a lesser extent, L-arginine. The expression of this gene is induced by the cytokine interleukin 4 in B cells. This gene is also expressed in macr
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs Other IDs
Show/Hide all(10)
GO ID Ontology Definition Evidence Reference
GO:0001669 Component Acrosomal vesicle IEA
GO:0001716 Function L-amino-acid oxidase activity IBA 21873635
GO:0002250 Process Adaptive immune response IEA
GO:0005515 Function Protein binding IPI 32814053
GO:0005576 Component Extracellular region TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs Other IDs
MIM HGNC e!Ensembl
609742 19094 ENSG00000104951
Protein
Gene SNPs Other IDs
UniProt ID Q96RQ9
Protein name L-amino-acid oxidase (LAAO) (LAO) (EC 1.4.3.2) (EC 1.4.3.25) (Interleukin-4-induced protein 1) (IL4-induced protein 1) (hIL4I1) (Protein Fig-1) (hFIG1)
Protein function Secreted L-amino-acid oxidase that acts as a key immunoregulator (PubMed:17356132, PubMed:32818467, PubMed:32866000). Has preference for L-aromatic amino acids: converts phenylalanine (Phe), tyrosine (Tyr) and tryptophan (Trp) to phenylpyruvic a
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01593 Amino_oxidase 69 → 505 Flavin containing amine oxidoreductase Domain
Tissue specificity TISSUE SPECIFICITY: Primarily found in immune tissues, with the highest expression in lymph nodes and spleen (PubMed:12031486, PubMed:12446450). Present in germinal center macrophages and inflammatory myeloid cells and antigen-presenting cells (at protein
Sequence
Sequence length 567
Interactions View interactions