IL1A (interleukin 1 alpha)

Gene
Gene SNPs Transcription factors Other IDs Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3552
Gene name Gene Name - the full gene name approved by the HGNC.
Interleukin 1 alpha
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
IL1A
Synonyms (NCBI Gene) Gene synonyms aliases
IL-1 alpha, IL-1A, IL1, IL1-ALPHA, IL1F1
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2q14.1
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macropha
miRNA miRNA information provided by mirtarbase database.
Gene SNPs Transcription factors Other IDs Associated diseases
Show/Hide all(33)
miRTarBase ID miRNA Experiments Reference
MIRT004689 hsa-miR-191-5p Immunohistochemistry, Immunoprecipitaion, Luciferase reporter assay, Microarray, qRT-PCR 20924108
MIRT004689 hsa-miR-191-5p Immunohistochemistry, Immunoprecipitaion, Luciferase reporter assay, Microarray, qRT-PCR 20924108
MIRT017051 hsa-miR-335-5p Microarray 18185580
MIRT054374 hsa-miR-142-3p Luciferase reporter assay, Western blot 22870299
MIRT054374 hsa-miR-142-3p Luciferase reporter assay, Western blot 22870299
Transcription factors
Gene SNPs Transcription factors Other IDs Associated diseases
Show/Hide all(4)
Transcription factor Regulation Reference
FOS Unknown 8688489
JUN Unknown 8688489
NFKB1 Repression 17612514
RELA Repression 17612514
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs Transcription factors Other IDs Associated diseases
Show/Hide all(41)
GO ID Ontology Definition Evidence Reference
GO:0001660 Process Fever generation IEA
GO:0001819 Process Positive regulation of cytokine production IDA 1739124
GO:0002248 Process Connective tissue replacement involved in inflammatory response wound healing IEA
GO:0005125 Function Cytokine activity IMP 2989698
GO:0005149 Function Interleukin-1 receptor binding IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs Transcription factors Other IDs Associated diseases
MIM HGNC e!Ensembl
147760 5991 ENSG00000115008
Protein
Gene SNPs Transcription factors Other IDs Associated diseases
UniProt ID P01583
Protein name Interleukin-1 alpha (IL-1 alpha) (Hematopoietin-1)
Protein function Cytokine constitutively present intracellularly in nearly all resting non-hematopoietic cells that plays an important role in inflammation and bridges the innate and adaptive immune systems (PubMed:26439902). After binding to its receptor IL1R1
PDB 2ILA , 2KKI , 2L5X , 5UC6
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02394 IL1_propep 1 → 109 Interleukin-1 propeptide Family
PF00340 IL1 155 → 266 Interleukin-1 / 18 Domain
Sequence
Sequence length 271
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene SNPs Transcription factors Other IDs Associated diseases
Show/Hide Unknown Diseases (1)
Unknown
Disease term Disease name Evidence References Source
Endometriosis Endometriosis GWAS
Show/Hide Text Mining Associations (563)
Associations from Text Mining
Disease Name Relationship Type References
AA amyloidosis Associate 1616367, 26268530, 37747561
Abortion Habitual Associate 22505054, 30893922
Achlorhydria Associate 10746728
Acidosis Associate 23144702
Acne Vulgaris Associate 29771405, 32627753
Acquired Immunodeficiency Syndrome Associate 15327898, 2789293, 3159524
Acro Osteolysis Associate 2844218
Acute Disease Stimulate 22674409
Acute Disease Associate 26559268
Acute Lung Injury Associate 21126389