Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
23765
Gene name Gene Name - the full gene name approved by the HGNC.
Interleukin 17 receptor A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
IL17RA
Synonyms (NCBI Gene) Gene synonyms aliases
CANDF5, CD217, CDw217, IL-17RA, IL17R, IMD51, hIL-17R
Disease Acronyms (UniProt) Disease acronyms from UniProt database
IMD51
Chromosome Chromosome number
22
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
22q11.1
Summary Summary of gene provided in NCBI Entrez Gene.
Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs201128237 T>C Likely-pathogenic Splice donor variant
rs387906913 C>T Pathogenic Stop gained, coding sequence variant
rs778624945 C>A,T Pathogenic Synonymous variant, coding sequence variant, stop gained
rs1057518744 ->GGAGATGGTGGAGAGCA Pathogenic Frameshift variant, coding sequence variant
rs1057518745 C>G,T Pathogenic Coding sequence variant, stop gained, missense variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT019991 hsa-miR-375 Microarray 20215506
MIRT049271 hsa-miR-92a-3p CLASH 23622248
MIRT631783 hsa-miR-5571-5p HITS-CLIP 23824327
MIRT631782 hsa-miR-10b-3p HITS-CLIP 23824327
MIRT631781 hsa-miR-3653-5p HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0002250 Process Adaptive immune response IEA
GO:0005515 Function Protein binding IPI 21993848, 23695682, 24120361, 28827714, 32353859, 33060197
GO:0005576 Component Extracellular region IEA
GO:0005886 Component Plasma membrane TAS
GO:0005887 Component Integral component of plasma membrane NAS 9367539
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
605461 5985 ENSG00000177663
Protein
UniProt ID Q96F46
Protein name Interleukin-17 receptor A (IL-17 receptor A) (IL-17RA) (CDw217) (CD antigen CD217)
Protein function Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Receptor for IL17A (PubMed:17911633, PubMed:9367539). Receptor for IL17F (Pub
PDB 3JVF , 4HSA , 4NUX , 5N9B , 5NAN , 7UWL , 7UWM , 7UWN , 7ZAN
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF16556 IL17R_fnIII_D1 48 198 Interleukin-17 receptor, fibronectin-III-like domain 1 Domain
PF16578 IL17R_fnIII_D2 199 303 Domain
PF08357 SEFIR 378 536 SEFIR domain Family
Tissue specificity TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:21993848}.
Sequence
MGAARSPPSAVPGPLLGLLLLLLGVLAPGGASLRLLDHRALVCSQPGLNCTVKNSTCLDD
SWIHPRNLTPSSPKDLQIQLHFAHTQQGDLFPVAHIEWTLQTDASILYLEGAELSVLQLN
TNERLCVRFEFLSKLRHHHRRWRFTFSHFVVDPDQEYEVTVHHLPKPIPDGDPNHQSKNF
LVPDCEHARMKVTTPCMS
SGSLWDPNITVETLEAHQLRVSFTLWNESTHYQILLTSFPHM
ENHSCFEHMHHIPAPRPEEFHQRSNVTLTLRNLKGCCRHQVQIQPFFSSCLNDCLRHSAT
VSC
PEMPDTPEPIPDYMPLWVYWFITGISILLVGSVILLIVCMTWRLAGPGSEKYSDDTK
YTDGLPAADLIPPPLKPRKVWIIYSADHPLYVDVVLKFAQFLLTACGTEVALDLLEEQAI
SEAGVMTWVGRQKQEMVESNSKIIVLCSRGTRAKWQALLGRGAPVRLRCDHGKPVGDLFT
AAMNMILPDFKRPACFGTYVVCYFSEVSCDGDVPDLFGAAPRYPLMDRFEEVYFRI
QDLE
MFQPGRMHRVGELSGDNYLRSPGGRQLRAALDRFRDWQVRCPDWFECENLYSADDQDAPS
LDEEVFEEPLLPPGTGIVKRAPLVREPGSQACLAIDPLVGEEGGAAVAKLEPHLQPRGQP
APQPLHTLVLAAEEGALVAAVEPGPLADGAAVRLALAGEGEACPLLGSPGAGRNSVLFLP
VDPEDSPLGSSTPMASPDLLPEDVREHLEGLMLSLFEQSLSCQAQGGCSRPAMVLTDPHT
PYEEEQRQSVQSDQGYISRSSPQPPEGLTEMEEEEEEEQDPGKPALPLSPEDLESLRSLQ
RQLLFRQLQKNSGWDTMGSESEGPSA
Sequence length 866
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Psoriasis Psoriasis GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Stimulate 21785272
Adenocarcinoma of Lung Associate 33802737
Adenomyosis Associate 39456936
Aneurysm Associate 30686933
Aortic Aneurysm Abdominal Associate 30686933
Arthritis Rheumatoid Associate 11966773, 15059275, 15879699, 30604628, 37926850
Asthma Stimulate 32302698, 33840588
Bacterial Infections Associate 27930337
Balkan Nephropathy Associate 24131581
Borderline Personality Disorder Associate 25612291