IFNG (interferon gamma)

Gene
Gene SNPs Transcription factors Other IDs Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3458
Gene name Gene Name - the full gene name approved by the HGNC.
Interferon gamma
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
IFNG
Synonyms (NCBI Gene) Gene synonyms aliases
IFG, IFI, IMD69
Disease Acronyms (UniProt) Disease acronyms from UniProt database
IMD69
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12q15
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor w
SNPs SNP information provided by dbSNP.
Gene SNPs Transcription factors Other IDs Associated diseases
Show/Hide all(2)
SNP ID Visualize variation Clinical significance Consequence
rs2069707 G>A,C Drug-response Upstream transcript variant
rs34079299 TGTGTGTGTGTG>-,TG,TGTG,TGTGTG,TGTGTGTG,TGTGTGTGTG,TGTGTGTGTGTGTG,TGTGTGTGTGTGTGTG,TGTGTGTGTGTGTGTGTG,TGTGTGTGTGTGTGTGTGTG,TGTGTGTGTGTGTGTGTGTGTG,TGTGTGTGTGTGTGTGTGTGTGTG,TGTGTGTGTGTGTGTGTGTGTGTGTG Risk-factor Intron variant
miRNA miRNA information provided by mirtarbase database.
Gene SNPs Transcription factors Other IDs Associated diseases
Show/Hide all(34)
miRTarBase ID miRNA Experiments Reference
MIRT006912 hsa-miR-16-5p Luciferase reporter assay, qRT-PCR 22379033
MIRT006913 hsa-miR-15a-5p Luciferase reporter assay, qRT-PCR 22379033
MIRT006914 hsa-miR-15b-5p Luciferase reporter assay, qRT-PCR 22379033
MIRT006914 hsa-miR-15b-5p Luciferase reporter assay, qRT-PCR 22379033
MIRT006914 hsa-miR-15b-5p Luciferase reporter assay, qRT-PCR 22379033
Transcription factors
Gene SNPs Transcription factors Other IDs Associated diseases
Show/Hide all(39)
Transcription factor Regulation Reference
ATF2 Activation 12836278;18641343;20006311;20304822
ATF3 Activation 20304822
CREB1 Activation 20006311;20685939
CREB1 Repression 11907114
CREB1 Unknown 7759501
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs Transcription factors Other IDs Associated diseases
Show/Hide all(90)
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II ISS
GO:0001774 Process Microglial cell activation IGI 7715705, 19808651
GO:0001774 Process Microglial cell activation ISS
GO:0001819 Process Positive regulation of cytokine production IDA 30634164
GO:0001934 Process Positive regulation of protein phosphorylation IDA 22504299
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs Transcription factors Other IDs Associated diseases
MIM HGNC e!Ensembl
147570 5438 ENSG00000111537
Protein
Gene SNPs Transcription factors Other IDs Associated diseases
UniProt ID P01579
Protein name Interferon gamma (IFN-gamma) (Immune interferon)
Protein function Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation (PubMed:16914093, PubMe
PDB 1EKU , 1FG9 , 1FYH , 1HIG , 3BES , 6E3K , 6E3L
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00714 IFN-gamma 15 → 153 Interferon gamma Domain
Tissue specificity TISSUE SPECIFICITY: Released primarily from activated T lymphocytes.
Sequence
Sequence length 166
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene SNPs Transcription factors Other IDs Associated diseases
Show/Hide Unknown Diseases (8)
Unknown
Disease term Disease name Evidence References Source
Immunodeficiency immunodeficiency 69 GenCC
Alopecia Areata Alopecia Areata GWAS
Hypothyroidism Hypothyroidism GWAS
Ulcerative colitis Ulcerative colitis GWAS
Show/Hide Text Mining Associations (1195)
Associations from Text Mining
Disease Name Relationship Type References
3 Hydroxyacyl CoA Dehydrogenase Deficiency Stimulate 17392368
3 Hydroxyacyl CoA Dehydrogenase Deficiency Associate 18569454
3C syndrome Associate 19753481
3C syndrome Stimulate 34867990
Ablepharon macrostomia syndrome Associate 26110930
Abortion Habitual Associate 29017513
Abortion Habitual Stimulate 9093132
Abortion Spontaneous Stimulate 17482605, 33731680
Abortion Spontaneous Associate 25963913, 33565696, 36096448
Acquired Immunodeficiency Syndrome Inhibit 10602033, 8450057