IFNA2 (interferon alpha 2)

Gene

• Entrez ID: 3440
• Gene name: Interferon alpha 2
• Gene symbol: IFNA2
• Synonyms (NCBI Gene): IFN-alpha-2, IFN-alphaA, IFNA, IFNA2B, leIF A
• Chromosome: 9
• Chromosome location: 9p21.3
• Summary: This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded cytokine is a member of the type I interferon family that is produced in response to viral infection as a key part of the innate immune response with potent antiviral,

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT736417	hsa-miR-491-3p	qRT-PCR, Flow cytometry	33679688
MIRT1060630	hsa-miR-103b	CLIP-seq
MIRT1060631	hsa-miR-19a	CLIP-seq
MIRT1060632	hsa-miR-19b	CLIP-seq
MIRT1060633	hsa-miR-203	CLIP-seq
MIRT1060634	hsa-miR-323-3p	CLIP-seq
MIRT1060635	hsa-miR-494	CLIP-seq
MIRT1060636	hsa-miR-518a-5p	CLIP-seq
MIRT1060637	hsa-miR-527	CLIP-seq
MIRT1549737	hsa-miR-3607-3p	CLIP-seq
MIRT1549738	hsa-miR-3686	CLIP-seq
MIRT1549739	hsa-miR-3909	CLIP-seq
MIRT1549740	hsa-miR-4310	CLIP-seq
MIRT1549741	hsa-miR-4704-3p	CLIP-seq
MIRT1549739	hsa-miR-3909	CLIP-seq
MIRT1549740	hsa-miR-4310	CLIP-seq
MIRT1549741	hsa-miR-4704-3p	CLIP-seq
MIRT1060633	hsa-miR-203	CLIP-seq
MIRT2451618	hsa-miR-627	CLIP-seq
MIRT2451619	hsa-miR-924	CLIP-seq
MIRT2549837	hsa-miR-3121-3p	CLIP-seq
MIRT2549838	hsa-miR-548c-3p	CLIP-seq
MIRT2549838	hsa-miR-548c-3p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
IRF7	Activation	17236232

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002250	Process	Adaptive immune response	IBA	21873635
GO:0002286	Process	T cell activation involved in immune response	IBA	21873635
GO:0002323	Process	Natural killer cell activation involved in immune response	IBA	21873635
GO:0005125	Function	Cytokine activity	IBA	21873635
GO:0005132	Function	Type I interferon receptor binding	IBA	21873635
GO:0005515	Function	Protein binding	IPI	7759950, 21854986, 32296183
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0006915	Process	Apoptotic process	TAS	10477584
GO:0006954	Process	Inflammatory response	TAS	10477584
GO:0006959	Process	Humoral immune response	IBA	21873635
GO:0007166	Process	Cell surface receptor signaling pathway	TAS	6158094
GO:0007267	Process	Cell-cell signaling	TAS	10477584
GO:0007596	Process	Blood coagulation	TAS
GO:0010629	Process	Negative regulation of gene expression	IDA	20554961
GO:0019221	Process	Cytokine-mediated signaling pathway	IBA	21873635
GO:0030183	Process	B cell differentiation	IBA	21873635
GO:0032696	Process	Negative regulation of interleukin-13 production	IDA	20554961
GO:0032714	Process	Negative regulation of interleukin-5 production	IDA	20554961
GO:0033141	Process	Positive regulation of peptidyl-serine phosphorylation of STAT protein	IBA	21873635
GO:0042100	Process	B cell proliferation	IBA	21873635
GO:0042327	Process	Positive regulation of phosphorylation	IMP	17275127
GO:0042531	Process	Positive regulation of tyrosine phosphorylation of STAT protein	IDA	22783022
GO:0043330	Process	Response to exogenous dsRNA	IBA	21873635
GO:0045581	Process	Negative regulation of T cell differentiation	IDA	20554961
GO:0045892	Process	Negative regulation of transcription, DNA-templated	IDA	20554961
GO:0045893	Process	Positive regulation of transcription, DNA-templated	IMP	17275127
GO:0046597	Process	Negative regulation of viral entry into host cell	IDA	22783022
GO:0051607	Process	Defense response to virus	IDA	22783022
GO:0060337	Process	Type I interferon signaling pathway	TAS
GO:0062023	Component	Collagen-containing extracellular matrix	HDA	28675934
GO:0062023	Component	Collagen-containing extracellular matrix	HDA	28327460
GO:2000552	Process	Negative regulation of T-helper 2 cell cytokine production	IDA	20554961

Other IDs

• MIM: 147562
• HGNC: 5423
• e!Ensembl: ENSG00000188379

Protein

• UniProt ID: P01563
• Protein name: Interferon alpha-2 (IFN-alpha-2) (Interferon alpha-A) (LeIF A)
• Protein function: Produced by macrophages, IFN-alpha have antiviral activities.
• PDB: 1ITF, 1RH2, 2HYM, 2KZ1, 2LAG, 2LMS, 3S9D, 3SE3, 4YPG, 4Z5R
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00143	Interferon	26 → 184	Interferon alpha/beta domain	Domain

• Sequence:

  MALTFALLVALLVLSCKSSCSVGCDLPQTHSLGSRRTLMLLAQMRKISLFSCLKDRHDFG
  FPQEEFGNQFQKAETIPVLHEMIQQIFNLFSTKDSSAAWDETLLDKFYTELYQQLNDLEA
  CVIQGVGVTETPLMKEDSILAVRKYFQRITLYLKEKKYSPCAWEVVRAEIMRSFSLSTNL
  QESLRSKE

• Sequence length: 188