IDO2 (indoleamine 2,3-dioxygenase 2)

Gene

• Entrez ID: 169355
• Gene name: Indoleamine 2,3-dioxygenase 2
• Gene symbol: IDO2
• Synonyms (NCBI Gene): INDOL1
• Chromosome: 8
• Chromosome location: 8p11.21
• Summary: Along with the enzymes encoded by the INDO (MIM 147435) and TDO2 (MIM 191070) genes, the enzyme encoded by the INDOL1 gene metabolizes tryptophan in the kynurenine pathway (Ball et al., 2007 [PubMed 17499941]).[supplied by OMIM, Feb 2011]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1059539	hsa-miR-1827	CLIP-seq
MIRT1059540	hsa-miR-2682	CLIP-seq
MIRT1059541	hsa-miR-34a	CLIP-seq
MIRT1059542	hsa-miR-34c-5p	CLIP-seq
MIRT1059543	hsa-miR-3612	CLIP-seq
MIRT1059544	hsa-miR-432	CLIP-seq
MIRT1059545	hsa-miR-4443	CLIP-seq
MIRT1059546	hsa-miR-449a	CLIP-seq
MIRT1059547	hsa-miR-449b	CLIP-seq
MIRT1059548	hsa-miR-449c	CLIP-seq
MIRT1059549	hsa-miR-4797-3p	CLIP-seq
MIRT1059550	hsa-miR-650	CLIP-seq
MIRT2013861	hsa-miR-489	CLIP-seq
MIRT2013862	hsa-miR-514	CLIP-seq
MIRT2013863	hsa-miR-514b-3p	CLIP-seq
MIRT2246042	hsa-miR-579	CLIP-seq
MIRT2246043	hsa-miR-664	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
PTMA	Activation	21176371;21575365

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002376	Process	Immune system process	IEA
GO:0004833	Function	Tryptophan 2,3-dioxygenase activity	IBA
GO:0004833	Function	Tryptophan 2,3-dioxygenase activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS	17499941
GO:0005829	Component	Cytosol	TAS
GO:0006569	Process	L-tryptophan catabolic process	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0019441	Process	L-tryptophan catabolic process to kynurenine	IBA
GO:0019441	Process	L-tryptophan catabolic process to kynurenine	IDA	17671174
GO:0019441	Process	L-tryptophan catabolic process to kynurenine	IEA
GO:0019441	Process	L-tryptophan catabolic process to kynurenine	IEA
GO:0019441	Process	L-tryptophan catabolic process to kynurenine	ISS	17499941
GO:0020037	Function	Heme binding	IEA
GO:0033754	Function	Indoleamine 2,3-dioxygenase activity	IBA
GO:0033754	Function	Indoleamine 2,3-dioxygenase activity	IDA	17671174
GO:0033754	Function	Indoleamine 2,3-dioxygenase activity	IEA
GO:0033754	Function	Indoleamine 2,3-dioxygenase activity	ISS	17499941
GO:0034354	Process	'de novo' NAD+ biosynthetic process from L-tryptophan	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:0051213	Function	Dioxygenase activity	IEA

Other IDs

• MIM: 612129
• HGNC: 27269
• e!Ensembl: ENSG00000188676

Protein

• UniProt ID: Q6ZQW0
• Protein name: Indoleamine 2,3-dioxygenase 2 (IDO-2) (EC 1.13.11.-) (Indoleamine 2,3-dioxygenase-like protein 1) (Indoleamine-pyrrole 2,3-dioxygenase-like protein 1)
• Protein function: Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174). Involved in immune regulation. May not play a significant role in tryptophan-related tumoral resi
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01231	IDO	28 → 414	Indoleamine 2,3-dioxygenase	Family

• Tissue specificity: TISSUE SPECIFICITY: Detected in liver, small intestine, spleen, placenta, thymus, lung, brain, kidney, and colon (PubMed:17671174). Also expressed at low level in testis and thyroid. Not expressed in the majority of human tumor samples (>99%) (PubMed:2569
• Sequence:

  MLHFHYYDTSNKIMEPHRPNVKTAVPLSLESYHISEEYGFLLPDSLKELPDHYRPWMEIA
  NKLPQLIDAHQLQAHVDKMPLLSCQFLKGHREQRLAHLVLSFLTMGYVWQEGEAQPAEVL
  PRNLALPFVEVSRNLGLPPILVHSDLVLTNWTKKDPDGFLEIGNLETIISFPGGESLHGF
  ILVTALVEKEAVPGIKALVQATNAILQPNQEALLQALQRLRLSIQDITKTLGQMHDYVDP
  DIFYAGIRIFLSGWKDNPAMPAGLMYEGVSQEPLKYSGGSAAQSTVLHAFDEFLGIRHSK
  ESGDFLYRMRDYMPPSHKAFIEDIHSAPSLRDYILSSGQDHLLTAYNQCVQALAELRSYH
  ITMVTKYLITAAAKAKHGKPNHLPGPPQALKDRGTGGTAVMSFLKSVRDKTLESILHPRG
  

• Sequence length: 420