Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs Transcription factors Other IDs
Entrez ID	3620
Gene name	Indoleamine 2,3-dioxygenase 1
Gene symbol	IDO1
Synonyms (NCBI Gene)	IDOIDO-1INDO
Chromosome	8
Chromosome location	8p11.21
Summary	This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5

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Show/Hide all (268)

miRTarBase ID	miRNA	Experiments
MIRT1059501	hsa-miR-106a	CLIP-seq
MIRT1059502	hsa-miR-106b	CLIP-seq
MIRT1059503	hsa-miR-1234	CLIP-seq
MIRT1059504	hsa-miR-150	CLIP-seq
MIRT1059505	hsa-miR-17	CLIP-seq
MIRT1059506	hsa-miR-1976	CLIP-seq
MIRT1059507	hsa-miR-20a	CLIP-seq
MIRT1059508	hsa-miR-20b	CLIP-seq
MIRT1059509	hsa-miR-302a	CLIP-seq
MIRT1059510	hsa-miR-302b	CLIP-seq
MIRT1059511	hsa-miR-302c	CLIP-seq
MIRT1059512	hsa-miR-302d	CLIP-seq
MIRT1059513	hsa-miR-302e	CLIP-seq
MIRT1059514	hsa-miR-3199	CLIP-seq
MIRT1059515	hsa-miR-372	CLIP-seq
MIRT1059516	hsa-miR-373	CLIP-seq
MIRT1059517	hsa-miR-4258	CLIP-seq
MIRT1059518	hsa-miR-4438	CLIP-seq
MIRT1059519	hsa-miR-4454	CLIP-seq
MIRT1059520	hsa-miR-4707-3p	CLIP-seq
MIRT1059521	hsa-miR-4731-5p	CLIP-seq
MIRT1059522	hsa-miR-4735-5p	CLIP-seq
MIRT1059523	hsa-miR-4740-3p	CLIP-seq
MIRT1059524	hsa-miR-4775	CLIP-seq
MIRT1059525	hsa-miR-5095	CLIP-seq
MIRT1059526	hsa-miR-512-3p	CLIP-seq
MIRT1059527	hsa-miR-519d	CLIP-seq
MIRT1059528	hsa-miR-520a-3p	CLIP-seq
MIRT1059529	hsa-miR-520b	CLIP-seq
MIRT1059530	hsa-miR-520c-3p	CLIP-seq
MIRT1059531	hsa-miR-520d-3p	CLIP-seq
MIRT1059532	hsa-miR-520e	CLIP-seq
MIRT1059533	hsa-miR-520g	CLIP-seq
MIRT1059534	hsa-miR-520h	CLIP-seq
MIRT1059535	hsa-miR-552	CLIP-seq
MIRT1059536	hsa-miR-590-3p	CLIP-seq
MIRT1059537	hsa-miR-764	CLIP-seq
MIRT1059538	hsa-miR-93	CLIP-seq
MIRT1549732	hsa-miR-1281	CLIP-seq
MIRT1549733	hsa-miR-1915	CLIP-seq
MIRT1549734	hsa-miR-2276	CLIP-seq
MIRT1549735	hsa-miR-4726-3p	CLIP-seq
MIRT1922115	hsa-miR-129-5p	CLIP-seq
MIRT1059506	hsa-miR-1976	CLIP-seq
MIRT1922116	hsa-miR-3149	CLIP-seq
MIRT1922117	hsa-miR-3152-3p	CLIP-seq
MIRT1922118	hsa-miR-411	CLIP-seq
MIRT1922119	hsa-miR-4426	CLIP-seq
MIRT1059519	hsa-miR-4454	CLIP-seq
MIRT1922120	hsa-miR-4647	CLIP-seq
MIRT1922121	hsa-miR-4662a-5p	CLIP-seq
MIRT1922122	hsa-miR-4662b	CLIP-seq
MIRT1059520	hsa-miR-4707-3p	CLIP-seq
MIRT1922123	hsa-miR-483-5p	CLIP-seq
MIRT1922124	hsa-miR-5096	CLIP-seq
MIRT1922115	hsa-miR-129-5p	CLIP-seq
MIRT1059506	hsa-miR-1976	CLIP-seq
MIRT1922116	hsa-miR-3149	CLIP-seq
MIRT1922117	hsa-miR-3152-3p	CLIP-seq
MIRT1922118	hsa-miR-411	CLIP-seq
MIRT1922119	hsa-miR-4426	CLIP-seq
MIRT1059519	hsa-miR-4454	CLIP-seq
MIRT1922120	hsa-miR-4647	CLIP-seq
MIRT1922121	hsa-miR-4662a-5p	CLIP-seq
MIRT1922122	hsa-miR-4662b	CLIP-seq
MIRT1059520	hsa-miR-4707-3p	CLIP-seq
MIRT1922123	hsa-miR-483-5p	CLIP-seq
MIRT1922124	hsa-miR-5096	CLIP-seq
MIRT1059501	hsa-miR-106a	CLIP-seq
MIRT1059502	hsa-miR-106b	CLIP-seq
MIRT1059503	hsa-miR-1234	CLIP-seq
MIRT1549732	hsa-miR-1281	CLIP-seq
MIRT1922115	hsa-miR-129-5p	CLIP-seq
MIRT1059504	hsa-miR-150	CLIP-seq
MIRT1059505	hsa-miR-17	CLIP-seq
MIRT1549733	hsa-miR-1915	CLIP-seq
MIRT1059506	hsa-miR-1976	CLIP-seq
MIRT1059507	hsa-miR-20a	CLIP-seq
MIRT1059508	hsa-miR-20b	CLIP-seq
MIRT1549734	hsa-miR-2276	CLIP-seq
MIRT2013857	hsa-miR-24	CLIP-seq
MIRT1059509	hsa-miR-302a	CLIP-seq
MIRT1059510	hsa-miR-302b	CLIP-seq
MIRT1059511	hsa-miR-302c	CLIP-seq
MIRT1059512	hsa-miR-302d	CLIP-seq
MIRT1059513	hsa-miR-302e	CLIP-seq
MIRT1922116	hsa-miR-3149	CLIP-seq
MIRT1059514	hsa-miR-3199	CLIP-seq
MIRT1059515	hsa-miR-372	CLIP-seq
MIRT1059516	hsa-miR-373	CLIP-seq
MIRT1922118	hsa-miR-411	CLIP-seq
MIRT1059517	hsa-miR-4258	CLIP-seq
MIRT2013858	hsa-miR-4279	CLIP-seq
MIRT2013859	hsa-miR-4284	CLIP-seq
MIRT1922119	hsa-miR-4426	CLIP-seq
MIRT1059519	hsa-miR-4454	CLIP-seq
MIRT1922120	hsa-miR-4647	CLIP-seq
MIRT1922122	hsa-miR-4662b	CLIP-seq
MIRT1059520	hsa-miR-4707-3p	CLIP-seq
MIRT2013860	hsa-miR-4722-3p	CLIP-seq
MIRT1549735	hsa-miR-4726-3p	CLIP-seq
MIRT1059522	hsa-miR-4735-5p	CLIP-seq
MIRT1059523	hsa-miR-4740-3p	CLIP-seq
MIRT1059524	hsa-miR-4775	CLIP-seq
MIRT1922123	hsa-miR-483-5p	CLIP-seq
MIRT1922124	hsa-miR-5096	CLIP-seq
MIRT1059526	hsa-miR-512-3p	CLIP-seq
MIRT1059527	hsa-miR-519d	CLIP-seq
MIRT1059528	hsa-miR-520a-3p	CLIP-seq
MIRT1059529	hsa-miR-520b	CLIP-seq
MIRT1059530	hsa-miR-520c-3p	CLIP-seq
MIRT1059531	hsa-miR-520d-3p	CLIP-seq
MIRT1059532	hsa-miR-520e	CLIP-seq
MIRT1059533	hsa-miR-520g	CLIP-seq
MIRT1059534	hsa-miR-520h	CLIP-seq
MIRT1059535	hsa-miR-552	CLIP-seq
MIRT1059536	hsa-miR-590-3p	CLIP-seq
MIRT1059537	hsa-miR-764	CLIP-seq
MIRT1059538	hsa-miR-93	CLIP-seq
MIRT1059501	hsa-miR-106a	CLIP-seq
MIRT1059502	hsa-miR-106b	CLIP-seq
MIRT1059503	hsa-miR-1234	CLIP-seq
MIRT1549732	hsa-miR-1281	CLIP-seq
MIRT1059504	hsa-miR-150	CLIP-seq
MIRT1059505	hsa-miR-17	CLIP-seq
MIRT1549733	hsa-miR-1915	CLIP-seq
MIRT1059506	hsa-miR-1976	CLIP-seq
MIRT1059507	hsa-miR-20a	CLIP-seq
MIRT1059508	hsa-miR-20b	CLIP-seq
MIRT1549734	hsa-miR-2276	CLIP-seq
MIRT2013857	hsa-miR-24	CLIP-seq
MIRT1059509	hsa-miR-302a	CLIP-seq
MIRT1059510	hsa-miR-302b	CLIP-seq
MIRT1059511	hsa-miR-302c	CLIP-seq
MIRT1059512	hsa-miR-302d	CLIP-seq
MIRT1059513	hsa-miR-302e	CLIP-seq
MIRT1059514	hsa-miR-3199	CLIP-seq
MIRT1059515	hsa-miR-372	CLIP-seq
MIRT1059516	hsa-miR-373	CLIP-seq
MIRT1059517	hsa-miR-4258	CLIP-seq
MIRT2013858	hsa-miR-4279	CLIP-seq
MIRT2013859	hsa-miR-4284	CLIP-seq
MIRT1059519	hsa-miR-4454	CLIP-seq
MIRT1059520	hsa-miR-4707-3p	CLIP-seq
MIRT2013860	hsa-miR-4722-3p	CLIP-seq
MIRT1549735	hsa-miR-4726-3p	CLIP-seq
MIRT1059522	hsa-miR-4735-5p	CLIP-seq
MIRT1059523	hsa-miR-4740-3p	CLIP-seq
MIRT1059524	hsa-miR-4775	CLIP-seq
MIRT1059527	hsa-miR-519d	CLIP-seq
MIRT1059528	hsa-miR-520a-3p	CLIP-seq
MIRT1059529	hsa-miR-520b	CLIP-seq
MIRT1059530	hsa-miR-520c-3p	CLIP-seq
MIRT1059531	hsa-miR-520d-3p	CLIP-seq
MIRT1059532	hsa-miR-520e	CLIP-seq
MIRT1059533	hsa-miR-520g	CLIP-seq
MIRT1059534	hsa-miR-520h	CLIP-seq
MIRT1059535	hsa-miR-552	CLIP-seq
MIRT1059536	hsa-miR-590-3p	CLIP-seq
MIRT1059537	hsa-miR-764	CLIP-seq
MIRT1059538	hsa-miR-93	CLIP-seq
MIRT1059517	hsa-miR-4258	CLIP-seq
MIRT1059520	hsa-miR-4707-3p	CLIP-seq
MIRT1059522	hsa-miR-4735-5p	CLIP-seq
MIRT1059524	hsa-miR-4775	CLIP-seq
MIRT1059536	hsa-miR-590-3p	CLIP-seq
MIRT1549732	hsa-miR-1281	CLIP-seq
MIRT2451588	hsa-miR-1289	CLIP-seq
MIRT1922115	hsa-miR-129-5p	CLIP-seq
MIRT2451589	hsa-miR-139-3p	CLIP-seq
MIRT1549733	hsa-miR-1915	CLIP-seq
MIRT1059506	hsa-miR-1976	CLIP-seq
MIRT1922116	hsa-miR-3149	CLIP-seq
MIRT1922118	hsa-miR-411	CLIP-seq
MIRT1059517	hsa-miR-4258	CLIP-seq
MIRT2013858	hsa-miR-4279	CLIP-seq
MIRT1059520	hsa-miR-4707-3p	CLIP-seq
MIRT2013860	hsa-miR-4722-3p	CLIP-seq
MIRT1549735	hsa-miR-4726-3p	CLIP-seq
MIRT1059522	hsa-miR-4735-5p	CLIP-seq
MIRT1059523	hsa-miR-4740-3p	CLIP-seq
MIRT1059524	hsa-miR-4775	CLIP-seq
MIRT1922123	hsa-miR-483-5p	CLIP-seq
MIRT1059536	hsa-miR-590-3p	CLIP-seq
MIRT1922115	hsa-miR-129-5p	CLIP-seq
MIRT1922116	hsa-miR-3149	CLIP-seq
MIRT1922118	hsa-miR-411	CLIP-seq
MIRT1059522	hsa-miR-4735-5p	CLIP-seq
MIRT1059524	hsa-miR-4775	CLIP-seq
MIRT1922123	hsa-miR-483-5p	CLIP-seq
MIRT1059536	hsa-miR-590-3p	CLIP-seq
MIRT1059501	hsa-miR-106a	CLIP-seq
MIRT1059502	hsa-miR-106b	CLIP-seq
MIRT1059503	hsa-miR-1234	CLIP-seq
MIRT1549732	hsa-miR-1281	CLIP-seq
MIRT1922115	hsa-miR-129-5p	CLIP-seq
MIRT1059504	hsa-miR-150	CLIP-seq
MIRT1059505	hsa-miR-17	CLIP-seq
MIRT1549733	hsa-miR-1915	CLIP-seq
MIRT1059506	hsa-miR-1976	CLIP-seq
MIRT1059507	hsa-miR-20a	CLIP-seq
MIRT1059508	hsa-miR-20b	CLIP-seq
MIRT1549734	hsa-miR-2276	CLIP-seq
MIRT2013857	hsa-miR-24	CLIP-seq
MIRT1059509	hsa-miR-302a	CLIP-seq
MIRT1059510	hsa-miR-302b	CLIP-seq
MIRT1059511	hsa-miR-302c	CLIP-seq
MIRT1059512	hsa-miR-302d	CLIP-seq
MIRT1059513	hsa-miR-302e	CLIP-seq
MIRT1922116	hsa-miR-3149	CLIP-seq
MIRT1922117	hsa-miR-3152-3p	CLIP-seq
MIRT1059514	hsa-miR-3199	CLIP-seq
MIRT1059515	hsa-miR-372	CLIP-seq
MIRT1059516	hsa-miR-373	CLIP-seq
MIRT1922118	hsa-miR-411	CLIP-seq
MIRT1059517	hsa-miR-4258	CLIP-seq
MIRT2013858	hsa-miR-4279	CLIP-seq
MIRT2013859	hsa-miR-4284	CLIP-seq
MIRT1922121	hsa-miR-4662a-5p	CLIP-seq
MIRT1059520	hsa-miR-4707-3p	CLIP-seq
MIRT2013860	hsa-miR-4722-3p	CLIP-seq
MIRT1549735	hsa-miR-4726-3p	CLIP-seq
MIRT1059521	hsa-miR-4731-5p	CLIP-seq
MIRT1059522	hsa-miR-4735-5p	CLIP-seq
MIRT1059523	hsa-miR-4740-3p	CLIP-seq
MIRT1059524	hsa-miR-4775	CLIP-seq
MIRT1922123	hsa-miR-483-5p	CLIP-seq
MIRT1922124	hsa-miR-5096	CLIP-seq
MIRT1059526	hsa-miR-512-3p	CLIP-seq
MIRT1059527	hsa-miR-519d	CLIP-seq
MIRT1059528	hsa-miR-520a-3p	CLIP-seq
MIRT1059529	hsa-miR-520b	CLIP-seq
MIRT1059530	hsa-miR-520c-3p	CLIP-seq
MIRT1059531	hsa-miR-520d-3p	CLIP-seq
MIRT1059532	hsa-miR-520e	CLIP-seq
MIRT1059533	hsa-miR-520g	CLIP-seq
MIRT1059534	hsa-miR-520h	CLIP-seq
MIRT1059535	hsa-miR-552	CLIP-seq
MIRT1059536	hsa-miR-590-3p	CLIP-seq
MIRT1059537	hsa-miR-764	CLIP-seq
MIRT1059538	hsa-miR-93	CLIP-seq
MIRT1059503	hsa-miR-1234	CLIP-seq
MIRT1549732	hsa-miR-1281	CLIP-seq
MIRT1922115	hsa-miR-129-5p	CLIP-seq
MIRT1549733	hsa-miR-1915	CLIP-seq
MIRT1059506	hsa-miR-1976	CLIP-seq
MIRT1549734	hsa-miR-2276	CLIP-seq
MIRT2013857	hsa-miR-24	CLIP-seq
MIRT1922116	hsa-miR-3149	CLIP-seq
MIRT1922117	hsa-miR-3152-3p	CLIP-seq
MIRT1059514	hsa-miR-3199	CLIP-seq
MIRT1922118	hsa-miR-411	CLIP-seq
MIRT1059517	hsa-miR-4258	CLIP-seq
MIRT2013858	hsa-miR-4279	CLIP-seq
MIRT2013859	hsa-miR-4284	CLIP-seq
MIRT1059519	hsa-miR-4454	CLIP-seq
MIRT1922121	hsa-miR-4662a-5p	CLIP-seq
MIRT1059520	hsa-miR-4707-3p	CLIP-seq
MIRT2013860	hsa-miR-4722-3p	CLIP-seq
MIRT1549735	hsa-miR-4726-3p	CLIP-seq
MIRT1059522	hsa-miR-4735-5p	CLIP-seq
MIRT1059523	hsa-miR-4740-3p	CLIP-seq
MIRT1059524	hsa-miR-4775	CLIP-seq
MIRT1922123	hsa-miR-483-5p	CLIP-seq
MIRT1922124	hsa-miR-5096	CLIP-seq
MIRT1059535	hsa-miR-552	CLIP-seq
MIRT1059536	hsa-miR-590-3p	CLIP-seq
MIRT1059537	hsa-miR-764	CLIP-seq

Show/Hide all (2)

Transcription factor	Regulation	Reference
EGR2	Unknown	24007274
PTMA	Activation	21176371;21575365

Show/Hide all (41)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002376	Process	Immune system process	IEA
GO:0002666	Process	Positive regulation of T cell tolerance induction	IEA
GO:0002678	Process	Positive regulation of chronic inflammatory response	IEA
GO:0002830	Process	Positive regulation of type 2 immune response	IEA
GO:0004833	Function	Tryptophan 2,3-dioxygenase activity	IBA
GO:0004833	Function	Tryptophan 2,3-dioxygenase activity	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006569	Process	L-tryptophan catabolic process	IEA
GO:0006569	Process	L-tryptophan catabolic process	TAS	2109605
GO:0006954	Process	Inflammatory response	IEA
GO:0007565	Process	Female pregnancy	TAS	9712583
GO:0009055	Function	Electron transfer activity	TAS	2109605
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0019441	Process	L-tryptophan catabolic process to kynurenine	IBA
GO:0019441	Process	L-tryptophan catabolic process to kynurenine	IEA
GO:0019441	Process	L-tryptophan catabolic process to kynurenine	IEA
GO:0019805	Process	Quinolinate biosynthetic process	IEA
GO:0020037	Function	Heme binding	IEA
GO:0030485	Component	Smooth muscle contractile fiber	IEA
GO:0032421	Component	Stereocilium bundle	IEA
GO:0032496	Process	Response to lipopolysaccharide	IEA
GO:0032693	Process	Negative regulation of interleukin-10 production	IEA
GO:0032735	Process	Positive regulation of interleukin-12 production	IEA
GO:0033555	Process	Multicellular organismal response to stress	IEA
GO:0033754	Function	Indoleamine 2,3-dioxygenase activity	IBA
GO:0033754	Function	Indoleamine 2,3-dioxygenase activity	IEA
GO:0033754	Function	Indoleamine 2,3-dioxygenase activity	IMP	25310899
GO:0034276	Process	Kynurenic acid biosynthetic process	IEA
GO:0034354	Process	'de novo' NAD+ biosynthetic process from L-tryptophan	IBA
GO:0036269	Process	Swimming behavior	IEA
GO:0042098	Process	T cell proliferation	IEA
GO:0042130	Process	Negative regulation of T cell proliferation	IEA
GO:0043065	Process	Positive regulation of apoptotic process	IEA
GO:0046006	Process	Regulation of activated T cell proliferation	IMP	25310899
GO:0046872	Function	Metal ion binding	IEA
GO:0051213	Function	Dioxygenase activity	IEA
GO:0070233	Process	Negative regulation of T cell apoptotic process	IEA
GO:0070234	Process	Positive regulation of T cell apoptotic process	IMP	25310899

MIM	HGNC	e!Ensembl
147435	6059	ENSG00000131203

P14902

Protein name

Indoleamine 2,3-dioxygenase 1 (IDO-1) (EC 1.13.11.52) (Indoleamine-pyrrole 2,3-dioxygenase)

Protein function

Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174). Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing a

PDB

2D0T , 2D0U , 4PK5 , 4PK6 , 4U72 , 4U74 , 5EK2 , 5EK3 , 5EK4 , 5ETW , 5WHR , 5WMU , 5WMV , 5WMW , 5WMX , 5WN8 , 5XE1 , 6AZU , 6AZV , 6AZW , 6CXU , 6CXV , 6DPQ , 6DPR , 6E35 , 6E40 , 6E41 , 6E42 , 6E43 , 6E44 , 6E45 , 6E46 , 6F0A , 6KOF , 6KPS , 6KW7 , 6MQ6 , 6O3I , 6PU7 , 6PZ1 , 6R63 , 6UBP , 6V52 , 6WJY , 6WPE , 6X5Y , 7A62 , 7AH4 , 7AH5 , 7AH6 , 7B1O

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01231	IDO	11 → 398	Indoleamine 2,3-dioxygenase	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in mature dendritic cells located in lymphoid organs (including lymph nodes, spleen, tonsils, Peyers's patches, the gut lamina propria, and the thymic medulla), in some epithelial cells of the female genital tract, as well as

Sequence

MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE
KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL
PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV
IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN
PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP
PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ
QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG

Sequence length

403

Interactions

View interactions

IDO1 (indoleamine 2,3-dioxygenase 1)