HRAS (HRas proto-oncogene, GTPase)

Gene
Gene SNPs Transcription factors Other IDs Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3265
Gene name Gene Name - the full gene name approved by the HGNC.
HRas proto-oncogene, GTPase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
HRAS
Synonyms (NCBI Gene) Gene synonyms aliases
C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, RASH1, p21ras
Chromosome Chromosome number
11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11p15.5
Summary Summary of gene provided in NCBI Entrez Gene.
This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and the
miRNA miRNA information provided by mirtarbase database.
Gene SNPs Transcription factors Other IDs Associated diseases
Show/Hide all(95)
miRTarBase ID miRNA Experiments Reference
MIRT004471 hsa-let-7a-5p Luciferase reporter assay 18083101
MIRT005644 hsa-miR-143-3p Luciferase reporter assay, Northern blot, qRT-PCR 21276449
MIRT005880 hsa-miR-181a-5p Luciferase reporter assay, qRT-PCR, Western blot 21167132
MIRT005880 hsa-miR-181a-5p Luciferase reporter assay, qRT-PCR, Western blot 21167132
MIRT004471 hsa-let-7a-5p Immunoblot, qRT-PCR, Western blot 21252116
Transcription factors
Gene SNPs Transcription factors Other IDs Associated diseases
Show/Hide all(5)
Transcription factor Regulation Reference
BTG2 Repression 20197462
MAZ Activation 21931711
SP1 Activation 21931711
SP1 Unknown 3012774
TP53 Unknown 11127813
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs Transcription factors Other IDs Associated diseases
Show/Hide all(90)
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IEA
GO:0000139 Component Golgi membrane TAS
GO:0000165 Process MAPK cascade IEA
GO:0000165 Process MAPK cascade TAS
GO:0000166 Function Nucleotide binding IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs Transcription factors Other IDs Associated diseases
MIM HGNC e!Ensembl
190020 5173 ENSG00000174775
Protein
Gene SNPs Transcription factors Other IDs Associated diseases
UniProt ID P01112
Protein name GTPase HRas (EC 3.6.5.2) (H-Ras-1) (Ha-Ras) (Transforming protein p21) (c-H-ras) (p21ras) [Cleaved into: GTPase HRas, N-terminally processed]
Protein function Involved in the activation of Ras protein signal transduction (PubMed:22821884). Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:12740440, PubMed:14500341, PubMed:9020151). {ECO:0000269|PubMed:12740440, ECO:0000269|PubMed
PDB 121P , 1AA9 , 1AGP , 1BKD , 1CLU , 1CRP , 1CRQ , 1CRR , 1CTQ , 1GNP , 1GNQ , 1GNR , 1HE8 , 1IAQ , 1IOZ , 1JAH , 1JAI , 1K8R , 1LF0 , 1LF5 , 1LFD , 1NVU , 1NVV , 1NVW , 1NVX , 1P2S , 1P2T , 1P2U , 1P2V , 1PLJ , 1PLK , 1PLL , 1Q21 , 1QRA , 1RVD , 1WQ1 , 1XCM , 1XD2 , 1XJ0 , 1ZVQ , 1ZW6 , 221P , 2C5L , 2CE2 , 2CL0 , 2CL6 , 2CL7 , 2CLC , 2CLD , 2EVW , 2LCF
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00071 Ras 5 → 165 Ras family Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:14500341}.
Sequence
Sequence length 189
Interactions View interactions
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene SNPs Transcription factors Other IDs Associated diseases
Show/Hide Causal Diseases (7)
Causal Diseases caused by PATHOGENIC or LIKELY PATHOGENIC variants from ClinVar only
Disease merge term Disease name dbSNP ID References
Costello Syndrome costello syndrome rs121917756, rs104894229, rs121917757, rs104894228, rs121917758, rs104894226, rs121917759, rs1554884966, rs104894230, rs727503093, rs727503094, rs730880460, rs1589792804, rs104894227, rs587777239
View all (4 more)		 N/A
Lip and Oral Cavity Carcinoma lip and oral cavity carcinoma rs104894226, rs104894230, rs28933406, rs104894229, rs104894228 N/A
Noonan Syndrome Noonan syndrome and Noonan-related syndrome, noonan syndrome 3, noonan syndrome rs104894230, rs121913496, rs104894228, rs104894226, rs28933406, rs121913233 N/A
Lung carcinoma non-small cell lung carcinoma rs727503093 N/A
Show/Hide Unknown Diseases (3)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Mental retardation intellectual disability N/A N/A ClinVar
neoplasm Neoplasm N/A N/A ClinVar
Noonan-Like Syndrome With Loose Anagen Hair Noonan syndrome-like disorder with loose anagen hair N/A N/A GenCC
Show/Hide Text Mining Associations (245)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Achondroplasia Associate 30355600
Adenocarcinoma Associate 12673679
Adenocarcinoma Stimulate 33549031
Adenocarcinoma Bronchiolo Alveolar Associate 29846186
Adenocarcinoma Follicular Associate 23150177, 24820091
Adenocarcinoma of Lung Associate 26066407, 27151654, 36853323, 37000102
Adenoma Associate 1452458, 36480093
Adenoma Oxyphilic Associate 33045146
Adenomyoepithelioma Associate 29739933, 31887226, 34496925
Alcoholism Associate 28799801