HPR (haptoglobin-related protein)

Gene

• Entrez ID: 3250
• Gene name: Haptoglobin-related protein
• Gene symbol: HPR
• Synonyms (NCBI Gene): A-259H10.2, HP
• Chromosome: 16
• Chromosome location: 16q22.2
• Summary: This gene encodes a haptoglobin-related protein that binds hemoglobin as efficiently as haptoglobin. Unlike haptoglobin, plasma concentration of this protein is unaffected in patients with sickle cell anemia and extensive intravascular hemolysis, suggesti

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT525361	hsa-miR-483-3p	PAR-CLIP	22012620
MIRT525360	hsa-miR-6777-3p	PAR-CLIP	22012620
MIRT525359	hsa-miR-1247-5p	PAR-CLIP	22012620
MIRT525358	hsa-miR-6748-3p	PAR-CLIP	22012620
MIRT525357	hsa-miR-4421	PAR-CLIP	22012620
MIRT525356	hsa-miR-5699-3p	PAR-CLIP	22012620
MIRT525355	hsa-miR-4290	PAR-CLIP	22012620
MIRT525354	hsa-miR-4436b-5p	PAR-CLIP	22012620
MIRT525353	hsa-miR-3157-3p	PAR-CLIP	22012620
MIRT525352	hsa-miR-874-3p	PAR-CLIP	22012620
MIRT525361	hsa-miR-483-3p	PAR-CLIP	22012620
MIRT525360	hsa-miR-6777-3p	PAR-CLIP	22012620
MIRT525359	hsa-miR-1247-5p	PAR-CLIP	22012620
MIRT525358	hsa-miR-6748-3p	PAR-CLIP	22012620
MIRT525357	hsa-miR-4421	PAR-CLIP	22012620
MIRT525356	hsa-miR-5699-3p	PAR-CLIP	22012620
MIRT525355	hsa-miR-4290	PAR-CLIP	22012620
MIRT525354	hsa-miR-4436b-5p	PAR-CLIP	22012620
MIRT525353	hsa-miR-3157-3p	PAR-CLIP	22012620
MIRT525352	hsa-miR-874-3p	PAR-CLIP	22012620
MIRT1054162	hsa-miR-4492	CLIP-seq
MIRT1054163	hsa-miR-4498	CLIP-seq
MIRT1054164	hsa-miR-762	CLIP-seq
MIRT2012280	hsa-miR-1236	CLIP-seq
MIRT2012281	hsa-miR-3929	CLIP-seq
MIRT2012282	hsa-miR-4419b	CLIP-seq
MIRT2012283	hsa-miR-4478	CLIP-seq
MIRT2012284	hsa-miR-4645-5p	CLIP-seq
MIRT2012285	hsa-miR-4673	CLIP-seq
MIRT2012286	hsa-miR-874	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
SP1	Activation	12088866

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004252	Function	Serine-type endopeptidase activity	IBA
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA
GO:0030492	Function	Hemoglobin binding	IEA
GO:0030492	Function	Hemoglobin binding	NAS	2987228
GO:0031638	Process	Zymogen activation	IBA
GO:0034366	Component	Spherical high-density lipoprotein particle	IDA	16682745
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:0072562	Component	Blood microparticle	HDA	22516433
GO:0072562	Component	Blood microparticle	IBA

Other IDs

• MIM: 140210
• HGNC: 5156
• e!Ensembl: ENSG00000261701

Protein

• UniProt ID: P00739
• Protein name: Haptoglobin-related protein
• Protein function: Primate-specific plasma protein associated with apolipoprotein L-I (apoL-I)-containing high-density lipoprotein (HDL). This HDL particle, termed trypanosome lytic factor-1 (TLF-1), mediates human innate immune protection against many species of
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00089	Trypsin	104 → 341	Trypsin	Domain

• Tissue specificity: TISSUE SPECIFICITY: In adult liver the amount of HPR mRNA is at the lower limit of detection, therefore the extent of its expression is at most less than 1000-fold that of the HP1F gene. No HPR mRNA can be detected in fetal liver. Expressed in Hep-G2 and
• Sequence:

  MSDLGAVISLLLWGRQLFALYSGNDVTDISDDRFPKPPEIANGYVEHLFRYQCKNYYRLR
  TEGDGVYTLNDKKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAK
  MVSHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVL
  HPNYHQVDIGLIKLKQKVLVNERVMPICLPSKNYAEVGRVGYVSGWGQSDNFKLTDHLKY
  VMLPVADQYDCITHYEGSTCPKWKAPKSPVGVQPILNEHTFCVGMSKYQEDTCYGDAGSA
  FAVHDLEEDTWYAAGILSFDKSCAVAEYGVYVKVTSIQHWVQKTIAEN

• Sequence length: 348