Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2885
Gene name Gene Name - the full gene name approved by the HGNC.
Growth factor receptor bound protein 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
GRB2
Synonyms (NCBI Gene) Gene synonyms aliases
ASH, EGFRBP-GRB2, Grb3-3, MST084, MSTP084, NCKAP2
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17q25.1
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosph
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT001201 hsa-miR-433-3p Luciferase reporter assay, Western blot 19531230
MIRT007278 hsa-miR-378a-3p Luciferase reporter assay 23447532
MIRT022221 hsa-miR-124-3p Microarray 18668037
MIRT025255 hsa-miR-34a-5p Sequencing 20371350
MIRT025709 hsa-miR-7-5p Sequencing 20371350
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000165 Process MAPK cascade TAS
GO:0001784 Function Phosphotyrosine residue binding IPI 20624904
GO:0003723 Function RNA binding HDA 22658674
GO:0005154 Function Epidermal growth factor receptor binding IPI 12577067
GO:0005168 Function Neurotrophin TRKA receptor binding IPI 15488758
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
108355 4566 ENSG00000177885
Protein
UniProt ID P62993
Protein name Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Protein function Non-enzymatic adapter protein that plays a pivotal role in precisely regulated signaling cascades from cell surface receptors to cellular responses, including signaling transduction and gene expression (PubMed:11726515, PubMed:37626338). Thus, p
PDB 1AZE , 1BM2 , 1BMB , 1CJ1 , 1FHS , 1FYR , 1GCQ , 1GFC , 1GFD , 1GHU , 1GRI , 1IO6 , 1JYQ , 1JYR , 1JYU , 1QG1 , 1TZE , 1X0N , 1ZFP , 2AOA , 2AOB , 2H46 , 2H5K , 2HUW , 2VVK , 2VWF , 2W0Z , 3C7I , 3IMD , 3IMJ , 3IN7 , 3IN8 , 3KFJ , 3MXC , 3MXY , 3N7Y , 3N84 , 3N8M , 3OV1 , 3OVE , 3S8L , 3S8N , 3S8O , 3WA4 , 4P9V , 4P9Z , 5CDW , 6ICG , 6ICH , 6SDF , 6VK2
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00018 SH3_1 4 50 SH3 domain Domain
PF00017 SH2 60 135 SH2 domain Domain
PF00018 SH3_1 162 207 SH3 domain Domain
Sequence
Sequence length 217
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Systemic lupus erythematosus Systemic lupus erythematosus GWAS
Multiple Sclerosis Multiple Sclerosis GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 26402252, 27449805, 32160453
Alzheimer Disease Associate 33804025
Bipolar Disorder Associate 29197740
Breast Neoplasms Associate 26458823, 40384436
Carcinogenesis Associate 10995035
Carcinoma Hepatocellular Associate 24391994, 26204832, 32298608, 34348664, 37626338
Carcinoma Non Small Cell Lung Associate 27418131, 30069987
Carcinoma Ovarian Epithelial Associate 26637171
Colorectal Neoplasms Associate 21622897, 29693170
Dementia Associate 35327643