Gene Gene information from NCBI Gene database.
Entrez ID 2885
Gene name Growth factor receptor bound protein 2
Gene symbol GRB2
Synonyms (NCBI Gene)
ASHEGFRBP-GRB2Grb3-3MST084MSTP084NCKAP2
Chromosome 17
Chromosome location 17q25.1
Summary The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosph
miRNA miRNA information provided by mirtarbase database.
874
miRTarBase ID miRNA Experiments Reference
MIRT001201 hsa-miR-433-3p Luciferase reporter assayWestern blot 19531230
MIRT007278 hsa-miR-378a-3p Luciferase reporter assay 23447532
MIRT022221 hsa-miR-124-3p Microarray 18668037
MIRT025255 hsa-miR-34a-5p Sequencing 20371350
MIRT025709 hsa-miR-7-5p Sequencing 20371350
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
77
GO ID Ontology Definition Evidence Reference
GO:0001784 Function Phosphotyrosine residue binding IBA
GO:0001784 Function Phosphotyrosine residue binding IPI 20624904
GO:0003723 Function RNA binding HDA 22658674
GO:0005068 Function Transmembrane receptor protein tyrosine kinase adaptor activity IEA
GO:0005091 Function Guanyl-nucleotide exchange factor adaptor activity IDA 8386805
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
108355 4566 ENSG00000177885
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P62993
Protein name Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Protein function Non-enzymatic adapter protein that plays a pivotal role in precisely regulated signaling cascades from cell surface receptors to cellular responses, including signaling transduction and gene expression (PubMed:11726515, PubMed:37626338). Thus, p
PDB 1AZE , 1BM2 , 1BMB , 1CJ1 , 1FHS , 1FYR , 1GCQ , 1GFC , 1GFD , 1GHU , 1GRI , 1IO6 , 1JYQ , 1JYR , 1JYU , 1QG1 , 1TZE , 1X0N , 1ZFP , 2AOA , 2AOB , 2H46 , 2H5K , 2HUW , 2VVK , 2VWF , 2W0Z , 3C7I , 3IMD , 3IMJ , 3IN7 , 3IN8 , 3KFJ , 3MXC , 3MXY , 3N7Y , 3N84 , 3N8M , 3OV1 , 3OVE , 3S8L , 3S8N , 3S8O , 3WA4 , 4P9V , 4P9Z , 5CDW , 6ICG , 6ICH , 6SDF , 6VK2
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00018 SH3_1 4 50 SH3 domain Domain
PF00017 SH2 60 135 SH2 domain Domain
PF00018 SH3_1 162 207 SH3 domain Domain
Sequence
Sequence length 217
Interactions View interactions