GPT (glutamic--pyruvic transaminase)

Gene

• Entrez ID: 2875
• Gene name: Glutamic--pyruvic transaminase
• Gene symbol: GPT
• Synonyms (NCBI Gene): AAT1, ALT, ALT1, GPT1, SGPT
• Chromosome: 8
• Chromosome location: 8q24.3
• Summary: This gene encodes cytosolic alanine aminotransaminase 1 (ALT1); also known as glutamate-pyruvate transaminase 1. This enzyme catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate and, therefore, play

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1032467	hsa-miR-3065-3p	CLIP-seq
MIRT1032468	hsa-miR-455-3p	CLIP-seq
MIRT1032469	hsa-miR-4685-5p	CLIP-seq
MIRT1032470	hsa-miR-551a	CLIP-seq
MIRT1032471	hsa-miR-551b	CLIP-seq
MIRT2006294	hsa-miR-3064-3p	CLIP-seq
MIRT2006295	hsa-miR-3162-5p	CLIP-seq
MIRT2006296	hsa-miR-3649	CLIP-seq
MIRT2006297	hsa-miR-492	CLIP-seq
MIRT2542635	hsa-miR-1207-3p	CLIP-seq
MIRT2542636	hsa-miR-342-5p	CLIP-seq
MIRT2542637	hsa-miR-4651	CLIP-seq
MIRT2542638	hsa-miR-4664-5p	CLIP-seq
MIRT2542639	hsa-miR-4731-5p	CLIP-seq
MIRT2542640	hsa-miR-608	CLIP-seq
MIRT2542635	hsa-miR-1207-3p	CLIP-seq
MIRT2542636	hsa-miR-342-5p	CLIP-seq
MIRT2542637	hsa-miR-4651	CLIP-seq
MIRT2542638	hsa-miR-4664-5p	CLIP-seq
MIRT2542639	hsa-miR-4731-5p	CLIP-seq
MIRT2542640	hsa-miR-608	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004021	Function	L-alanine:2-oxoglutarate aminotransferase activity	IEA
GO:0004021	Function	L-alanine:2-oxoglutarate aminotransferase activity	NAS	1931970
GO:0005615	Component	Extracellular space	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0008483	Function	Transaminase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0030170	Function	Pyridoxal phosphate binding	IEA
GO:0042853	Process	L-alanine catabolic process	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867

Other IDs

• MIM: 138200
• HGNC: 4552
• e!Ensembl: ENSG00000167701

Protein

• UniProt ID: P24298
• Protein name: Alanine aminotransferase 1 (ALT1) (EC 2.6.1.2) (Glutamate pyruvate transaminase 1) (GPT 1) (Glutamic--alanine transaminase 1) (Glutamic--pyruvic transaminase 1)
• Protein function: Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00155	Aminotran_1_2	83 → 484	Aminotransferase class I and II	Domain

• Tissue specificity: TISSUE SPECIFICITY: Liver, kidney, heart, and skeletal muscles. Expressed at moderate levels in the adipose tissue. {ECO:0000269|PubMed:11863375}.
• Sequence:

  MASSTGDRSQAVRHGLRAKVLTLDGMNPRVRRVEYAVRGPIVQRALELEQELRQGVKKPF
  TEVIRANIGDAQAMGQRPITFLRQVLALCVNPDLLSSPNFPDDAKKRAERILQACGGHSL
  GAYSVSSGIQLIREDVARYIERRDGGIPADPNNVFLSTGASDAIVTVLKLLVAGEGHTRT
  GVLIPIPQYPLYSATLAELGAVQVDYYLDEERAWALDVAELHRALGQARDHCRPRALCVI
  NPGNPTGQVQTRECIEAVIRFAFEERLFLLADEVYQDNVYAAGSQFHSFKKVLMEMGPPY
  AGQQELASFHSTSKGYMGECGFRGGYVEVVNMDAAVQQQMLKLMSVRLCPPVPGQALLDL
  VVSPPAPTDPSFAQFQAEKQAVLAELAAKAKLTEQVFNEAPGISCNPVQGAMYSFPRVQL
  PPRAVERAQELGLAPDMFFCLRLLEETGICVVPGSGFGQREGTYHFRMTILPPLEKLRLL
  LEKLSRFHAKFTLEYS

• Sequence length: 496

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