GLUL (glutamate-ammonia ligase)
Gene | |
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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2752 |
Gene name
Gene Name - the full gene name approved by the HGNC.
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Glutamate-ammonia ligase |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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GLUL |
Synonyms (NCBI Gene)
Gene synonyms aliases
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DEE116, GLNS, GS, PIG43, PIG59 |
Disease Acronyms (UniProt)
Disease acronyms from UniProt database
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DEE116 |
Chromosome
Chromosome number
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1 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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1q25.3 |
Summary
Summary of gene provided in NCBI Entrez Gene.
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The protein encoded by this gene belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia in an ATP-dependent reaction. This protein plays a role in ammonia and glutamate detoxification, acid-base home |
SNPs
SNP information provided by dbSNP.
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein | ||||||||||||||||
UniProt ID | P15104 | |||||||||||||||
Protein name | Glutamine synthetase (GS) (EC 6.3.1.2) (Glutamate--ammonia ligase) (Palmitoyltransferase GLUL) (EC 2.3.1.225) | |||||||||||||||
Protein function | Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (PubMed:16267323, PubMed:30158707, PubMed:36289327). Its role depends on tissue localization: in the brain, it regulates the levels of toxic a | |||||||||||||||
PDB | 2OJW , 2QC8 , 7EVT , 8DNU | |||||||||||||||
Family and domains |
Pfam
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Tissue specificity | TISSUE SPECIFICITY: Expressed in endothelial cells. {ECO:0000269|PubMed:30158707}. | |||||||||||||||
Sequence | ||||||||||||||||
Sequence length | 373 | |||||||||||||||
Interactions | View interactions |
Associated diseases
Disease information provided by ClinVar, GenCC, and GWAS databases.
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