Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs Other IDs Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	9945
Gene name Gene Name - the full gene name approved by the HGNC.	Glutamine-fructose-6-phosphate transaminase 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	GFPT2
Synonyms (NCBI Gene) Gene synonyms aliases	GFAT, GFAT 2, GFAT2
Chromosome Chromosome number	5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	5q35.3

Show/Hide all(196)

miRTarBase ID	miRNA	Experiments	Reference
MIRT021918	hsa-miR-128-3p	Sequencing	20371350
MIRT022362	hsa-miR-124-3p	Microarray	18668037
MIRT023459	hsa-miR-30b-5p	Sequencing	20371350
MIRT027274	hsa-miR-101-3p	Sequencing	20371350
MIRT028277	hsa-miR-32-5p	Sequencing	20371350
MIRT045625	hsa-miR-149-5p	CLASH	23622248
MIRT537188	hsa-miR-199a-3p	PAR-CLIP	21572407
MIRT537187	hsa-miR-3129-5p	PAR-CLIP	21572407
MIRT537186	hsa-miR-199b-3p	PAR-CLIP	21572407
MIRT537185	hsa-miR-363-3p	PAR-CLIP	21572407
MIRT028277	hsa-miR-32-5p	PAR-CLIP	21572407
MIRT537184	hsa-miR-25-3p	PAR-CLIP	21572407
MIRT537183	hsa-miR-367-3p	PAR-CLIP	21572407
MIRT537182	hsa-miR-92b-3p	PAR-CLIP	21572407
MIRT537181	hsa-miR-92a-3p	PAR-CLIP	21572407
MIRT537180	hsa-miR-3681-5p	PAR-CLIP	21572407
MIRT537179	hsa-miR-6849-5p	PAR-CLIP	21572407
MIRT537178	hsa-miR-3675-3p	PAR-CLIP	21572407
MIRT537177	hsa-miR-767-3p	PAR-CLIP	21572407
MIRT537176	hsa-miR-4434	PAR-CLIP	21572407
MIRT537175	hsa-miR-4516	PAR-CLIP	21572407
MIRT537173	hsa-miR-5703	PAR-CLIP	21572407
MIRT537174	hsa-miR-6828-3p	PAR-CLIP	21572407
MIRT537172	hsa-miR-4531	PAR-CLIP	21572407
MIRT537188	hsa-miR-199a-3p	PAR-CLIP	22012620
MIRT537187	hsa-miR-3129-5p	PAR-CLIP	22012620
MIRT537186	hsa-miR-199b-3p	PAR-CLIP	22012620
MIRT537185	hsa-miR-363-3p	PAR-CLIP	22012620
MIRT028277	hsa-miR-32-5p	PAR-CLIP	22012620
MIRT537184	hsa-miR-25-3p	PAR-CLIP	22012620
MIRT537183	hsa-miR-367-3p	PAR-CLIP	22012620
MIRT537182	hsa-miR-92b-3p	PAR-CLIP	22012620
MIRT537181	hsa-miR-92a-3p	PAR-CLIP	22012620
MIRT537180	hsa-miR-3681-5p	PAR-CLIP	22012620
MIRT537179	hsa-miR-6849-5p	PAR-CLIP	22012620
MIRT537178	hsa-miR-3675-3p	PAR-CLIP	22012620
MIRT537177	hsa-miR-767-3p	PAR-CLIP	22012620
MIRT537176	hsa-miR-4434	PAR-CLIP	22012620
MIRT537175	hsa-miR-4516	PAR-CLIP	22012620
MIRT537173	hsa-miR-5703	PAR-CLIP	22012620
MIRT537174	hsa-miR-6828-3p	PAR-CLIP	22012620
MIRT537172	hsa-miR-4531	PAR-CLIP	22012620
MIRT734744	hsa-miR-27a-3p	Luciferase reporter assay, Western blotting, Microarray, Immunohistochemistry (IHC), Immunofluorescence, ChIP-seq, qRT-PCR	33910455
MIRT734744	hsa-miR-27a-3p	Luciferase reporter assay, Western blotting, Microarray, Immunoprecipitaion (IP), Immunofluorescence, qRT-PCR, Flow cytometry	33910455
MIRT537188	hsa-miR-199a-3p	PAR-CLIP	21572407
MIRT537187	hsa-miR-3129-5p	PAR-CLIP	21572407
MIRT537186	hsa-miR-199b-3p	PAR-CLIP	21572407
MIRT537185	hsa-miR-363-3p	PAR-CLIP	21572407
MIRT028277	hsa-miR-32-5p	PAR-CLIP	21572407
MIRT537184	hsa-miR-25-3p	PAR-CLIP	21572407
MIRT537183	hsa-miR-367-3p	PAR-CLIP	21572407
MIRT537182	hsa-miR-92b-3p	PAR-CLIP	21572407
MIRT537181	hsa-miR-92a-3p	PAR-CLIP	21572407
MIRT537180	hsa-miR-3681-5p	PAR-CLIP	21572407
MIRT537179	hsa-miR-6849-5p	PAR-CLIP	21572407
MIRT537178	hsa-miR-3675-3p	PAR-CLIP	21572407
MIRT537177	hsa-miR-767-3p	PAR-CLIP	21572407
MIRT537176	hsa-miR-4434	PAR-CLIP	21572407
MIRT537175	hsa-miR-4516	PAR-CLIP	21572407
MIRT537173	hsa-miR-5703	PAR-CLIP	21572407
MIRT537174	hsa-miR-6828-3p	PAR-CLIP	21572407
MIRT537172	hsa-miR-4531	PAR-CLIP	21572407
MIRT537188	hsa-miR-199a-3p	PAR-CLIP	22012620
MIRT537187	hsa-miR-3129-5p	PAR-CLIP	22012620
MIRT537186	hsa-miR-199b-3p	PAR-CLIP	22012620
MIRT537185	hsa-miR-363-3p	PAR-CLIP	22012620
MIRT028277	hsa-miR-32-5p	PAR-CLIP	22012620
MIRT537184	hsa-miR-25-3p	PAR-CLIP	22012620
MIRT537183	hsa-miR-367-3p	PAR-CLIP	22012620
MIRT537182	hsa-miR-92b-3p	PAR-CLIP	22012620
MIRT537181	hsa-miR-92a-3p	PAR-CLIP	22012620
MIRT537180	hsa-miR-3681-5p	PAR-CLIP	22012620
MIRT537179	hsa-miR-6849-5p	PAR-CLIP	22012620
MIRT537178	hsa-miR-3675-3p	PAR-CLIP	22012620
MIRT537177	hsa-miR-767-3p	PAR-CLIP	22012620
MIRT537176	hsa-miR-4434	PAR-CLIP	22012620
MIRT537175	hsa-miR-4516	PAR-CLIP	22012620
MIRT537173	hsa-miR-5703	PAR-CLIP	22012620
MIRT537174	hsa-miR-6828-3p	PAR-CLIP	22012620
MIRT537172	hsa-miR-4531	PAR-CLIP	22012620
MIRT1017166	hsa-miR-139-5p	CLIP-seq
MIRT1017167	hsa-miR-4700-3p	CLIP-seq
MIRT2234433	hsa-miR-3194-3p	CLIP-seq
MIRT2234434	hsa-miR-3681	CLIP-seq
MIRT2234435	hsa-miR-4459	CLIP-seq
MIRT2234436	hsa-miR-4709-3p	CLIP-seq
MIRT2538527	hsa-miR-1254	CLIP-seq
MIRT2538528	hsa-miR-1265	CLIP-seq
MIRT2538529	hsa-miR-1276	CLIP-seq
MIRT2538530	hsa-miR-128	CLIP-seq
MIRT2538531	hsa-miR-1284	CLIP-seq
MIRT2538532	hsa-miR-2392	CLIP-seq
MIRT2538533	hsa-miR-25	CLIP-seq
MIRT2538534	hsa-miR-27a	CLIP-seq
MIRT2538535	hsa-miR-27b	CLIP-seq
MIRT2538536	hsa-miR-28-3p	CLIP-seq
MIRT2538537	hsa-miR-30a	CLIP-seq
MIRT2538538	hsa-miR-30b	CLIP-seq
MIRT2538539	hsa-miR-30c	CLIP-seq
MIRT2538540	hsa-miR-30d	CLIP-seq
MIRT2538541	hsa-miR-30e	CLIP-seq
MIRT2538542	hsa-miR-3116	CLIP-seq
MIRT2538543	hsa-miR-3132	CLIP-seq
MIRT2538544	hsa-miR-3145-3p	CLIP-seq
MIRT2538545	hsa-miR-3158-3p	CLIP-seq
MIRT2538546	hsa-miR-3163	CLIP-seq
MIRT2234433	hsa-miR-3194-3p	CLIP-seq
MIRT2538547	hsa-miR-32	CLIP-seq
MIRT2538548	hsa-miR-340	CLIP-seq
MIRT2538549	hsa-miR-363	CLIP-seq
MIRT2538550	hsa-miR-3655	CLIP-seq
MIRT2538551	hsa-miR-3664-5p	CLIP-seq
MIRT2538552	hsa-miR-367	CLIP-seq
MIRT2234434	hsa-miR-3681	CLIP-seq
MIRT2538553	hsa-miR-3690	CLIP-seq
MIRT2538554	hsa-miR-383	CLIP-seq
MIRT2538555	hsa-miR-4255	CLIP-seq
MIRT2538556	hsa-miR-4528	CLIP-seq
MIRT2538557	hsa-miR-4638-3p	CLIP-seq
MIRT2538558	hsa-miR-4685-5p	CLIP-seq
MIRT2538559	hsa-miR-4698	CLIP-seq
MIRT2234436	hsa-miR-4709-3p	CLIP-seq
MIRT2538560	hsa-miR-4714-5p	CLIP-seq
MIRT2538561	hsa-miR-4715-3p	CLIP-seq
MIRT2538562	hsa-miR-4722-3p	CLIP-seq
MIRT2538563	hsa-miR-4738-3p	CLIP-seq
MIRT2538564	hsa-miR-4755-3p	CLIP-seq
MIRT2538565	hsa-miR-4772-5p	CLIP-seq
MIRT2538566	hsa-miR-498	CLIP-seq
MIRT2538567	hsa-miR-513a-5p	CLIP-seq
MIRT2538568	hsa-miR-548v	CLIP-seq
MIRT2538569	hsa-miR-606	CLIP-seq
MIRT2538570	hsa-miR-618	CLIP-seq
MIRT2538571	hsa-miR-665	CLIP-seq
MIRT2538572	hsa-miR-92a	CLIP-seq
MIRT2538573	hsa-miR-92b	CLIP-seq
MIRT2538574	hsa-miR-935	CLIP-seq
MIRT2538527	hsa-miR-1254	CLIP-seq
MIRT2538528	hsa-miR-1265	CLIP-seq
MIRT2681518	hsa-miR-1270	CLIP-seq
MIRT2681519	hsa-miR-1273	CLIP-seq
MIRT2538529	hsa-miR-1276	CLIP-seq
MIRT2538530	hsa-miR-128	CLIP-seq
MIRT2538531	hsa-miR-1284	CLIP-seq
MIRT2681520	hsa-miR-204	CLIP-seq
MIRT2681521	hsa-miR-211	CLIP-seq
MIRT2538532	hsa-miR-2392	CLIP-seq
MIRT2538533	hsa-miR-25	CLIP-seq
MIRT2538534	hsa-miR-27a	CLIP-seq
MIRT2538535	hsa-miR-27b	CLIP-seq
MIRT2538536	hsa-miR-28-3p	CLIP-seq
MIRT2538537	hsa-miR-30a	CLIP-seq
MIRT2538538	hsa-miR-30b	CLIP-seq
MIRT2538539	hsa-miR-30c	CLIP-seq
MIRT2538540	hsa-miR-30d	CLIP-seq
MIRT2538541	hsa-miR-30e	CLIP-seq
MIRT2538542	hsa-miR-3116	CLIP-seq
MIRT2538543	hsa-miR-3132	CLIP-seq
MIRT2538544	hsa-miR-3145-3p	CLIP-seq
MIRT2538545	hsa-miR-3158-3p	CLIP-seq
MIRT2538546	hsa-miR-3163	CLIP-seq
MIRT2234433	hsa-miR-3194-3p	CLIP-seq
MIRT2538547	hsa-miR-32	CLIP-seq
MIRT2538548	hsa-miR-340	CLIP-seq
MIRT2538549	hsa-miR-363	CLIP-seq
MIRT2538551	hsa-miR-3664-5p	CLIP-seq
MIRT2538552	hsa-miR-367	CLIP-seq
MIRT2234434	hsa-miR-3681	CLIP-seq
MIRT2538553	hsa-miR-3690	CLIP-seq
MIRT2538554	hsa-miR-383	CLIP-seq
MIRT2681522	hsa-miR-3938	CLIP-seq
MIRT2538555	hsa-miR-4255	CLIP-seq
MIRT2681523	hsa-miR-4279	CLIP-seq
MIRT2538556	hsa-miR-4528	CLIP-seq
MIRT2538557	hsa-miR-4638-3p	CLIP-seq
MIRT2538558	hsa-miR-4685-5p	CLIP-seq
MIRT2538559	hsa-miR-4698	CLIP-seq
MIRT2234436	hsa-miR-4709-3p	CLIP-seq
MIRT2538560	hsa-miR-4714-5p	CLIP-seq
MIRT2538561	hsa-miR-4715-3p	CLIP-seq
MIRT2538562	hsa-miR-4722-3p	CLIP-seq
MIRT2538563	hsa-miR-4738-3p	CLIP-seq
MIRT2538564	hsa-miR-4755-3p	CLIP-seq
MIRT2681524	hsa-miR-4755-5p	CLIP-seq
MIRT2538565	hsa-miR-4772-5p	CLIP-seq
MIRT2538566	hsa-miR-498	CLIP-seq
MIRT2538567	hsa-miR-513a-5p	CLIP-seq
MIRT2538568	hsa-miR-548v	CLIP-seq
MIRT2538569	hsa-miR-606	CLIP-seq
MIRT2538570	hsa-miR-618	CLIP-seq
MIRT2681525	hsa-miR-620	CLIP-seq
MIRT2681526	hsa-miR-623	CLIP-seq
MIRT2538571	hsa-miR-665	CLIP-seq
MIRT2538572	hsa-miR-92a	CLIP-seq
MIRT2538573	hsa-miR-92b	CLIP-seq
MIRT2538574	hsa-miR-935	CLIP-seq

Show/Hide all(23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004360	Function	Glutamine-fructose-6-phosphate transaminase (isomerizing) activity	IBA
GO:0004360	Function	Glutamine-fructose-6-phosphate transaminase (isomerizing) activity	IDA	35229715
GO:0004360	Function	Glutamine-fructose-6-phosphate transaminase (isomerizing) activity	IEA
GO:0004360	Function	Glutamine-fructose-6-phosphate transaminase (isomerizing) activity	TAS	10198162
GO:0005515	Function	Protein binding	IPI	21044950, 33961781
GO:0005829	Component	Cytosol	TAS
GO:0006002	Process	Fructose 6-phosphate metabolic process	IBA
GO:0006002	Process	Fructose 6-phosphate metabolic process	IDA	35229715
GO:0006002	Process	Fructose 6-phosphate metabolic process	IEA
GO:0006002	Process	Fructose 6-phosphate metabolic process	TAS	10198162
GO:0006047	Process	UDP-N-acetylglucosamine metabolic process	IBA
GO:0006048	Process	UDP-N-acetylglucosamine biosynthetic process	IDA	35229715
GO:0006048	Process	UDP-N-acetylglucosamine biosynthetic process	IEA
GO:0006048	Process	UDP-N-acetylglucosamine biosynthetic process	TAS
GO:0006112	Process	Energy reserve metabolic process	IEA
GO:0006112	Process	Energy reserve metabolic process	TAS	10198162
GO:0006487	Process	Protein N-linked glycosylation	IBA
GO:0008483	Function	Transaminase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0097367	Function	Carbohydrate derivative binding	IEA
GO:1901135	Process	Carbohydrate derivative metabolic process	IEA
GO:1901137	Process	Carbohydrate derivative biosynthetic process	IEA
GO:1990830	Process	Cellular response to leukemia inhibitory factor	IEA

MIM	HGNC	e!Ensembl
603865	4242	ENSG00000131459

Protein

UniProt ID

O94808

Protein name

Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 (EC 2.6.1.16) (D-fructose-6-phosphate amidotransferase 2) (Glutamine:fructose-6-phosphate amidotransferase 2) (GFAT 2) (GFAT2) (Hexosephosphate aminotransferase 2)

Protein function

Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13522	GATase_6	68 → 212		Domain
PF01380	SIS	363 → 492	SIS domain	Domain
PF01380	SIS	534 → 665	SIS domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Highest levels of expression in heart, placenta, and spinal cord.

Sequence

MCGIFAYMNYRVPRTRKEIFETLIKGLQRLEYRGYDSAGVAIDGNNHEVKERHIQLVKKR
GKVKALDEELYKQDSMDLKVEFETHFGIAHTRWATHGVPSAVNSHPQRSDKGNEFVVIHN
GIITNYKDLRKFLESKGYEFESETDTETIAKLIKYVFDNRETEDITFSTLVERVIQQLEG
AFALVFKSVHYPGEAVATRRGSPLLIGVRSKYKLSTEQIPILYRTCTLENVKNICKTRMK
RLDSSACLHAVGDKAVEFFFASDASAIIEHTNRVIFLEDDDIAAVADGKLSIHRVKRSAS
DDPSRAIQTLQMELQQIMKGNFSAFMQKEIFEQPESVFNTMRGRVNFETNTVLLGGLKDH
LKEIRRCRRLIVIGCGTSYHAAVATRQVLEELTELPVMVELASDFLDRNTPVFRDDVCFF
ISQSGETADTLLALRYCKDRGALTVGVTNTVGSSISRETDCGVHINAGPEIGVASTKAYT
SQFISLVMFGLMMSEDRISLQNRRQEIIRGLRSLPELIKEVLSLEEKIHDLALELYTQRS
LLVMGRGYNYATCLEGALKIKEITYMHSEGILAGELKHGPLALIDKQMPVIMVIMKDPCF
AKCQNALQQVTARQGRPIILCSKDDTESSKFAYKTIELPHTVDCLQGILSVIPLQLLSFH
LAVLRGYDVDFPRNLAKSVTVE

Sequence length

682

Interactions

View interactions

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Colorectal Cancer	Colorectal cancer	N/A	N/A	GWAS

Show/Hide Text Mining Associations (16)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenocarcinoma	Associate	29760045
Adenocarcinoma of Lung	Associate	29760045
Breast Neoplasms	Associate	34923141, 37287069
Carcinoma Non Small Cell Lung	Stimulate	30885209
Diabetes Complications	Associate	20353610
Diabetes Mellitus Type 2	Associate	20353610
Giant Cell Tumor of Tendon Sheath	Associate	36007098
Glioblastoma	Associate	25356585
Lymphatic Metastasis	Associate	37395335
Neoplasms	Associate	29760045, 36007098, 37395335
Neoplasms	Stimulate	30885209
Ophthalmoplegia painful	Associate	38233749
Ovarian Neoplasms	Associate	39961214
Pulmonary Disease Chronic Obstructive	Associate	34764646
Renal Insufficiency Chronic	Associate	20353610
Stomach Neoplasms	Associate	37395335

GFPT2 (glutamine-fructose-6-phosphate transaminase 2)