Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2335
Gene name Gene Name - the full gene name approved by the HGNC.
Fibronectin 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
FN1
Synonyms (NCBI Gene) Gene synonyms aliases
CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF, SMDCF
Disease Acronyms (UniProt) Disease acronyms from UniProt database
GFND2, SMDCF
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2q35
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to generate the mature p
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs113683179 C>G,T Pathogenic Splice donor variant
rs137854488 T>C Pathogenic Missense variant, coding sequence variant, genic downstream transcript variant
rs797044906 C>A Pathogenic Coding sequence variant, missense variant, genic downstream transcript variant
rs869025199 GAG>- Pathogenic Inframe deletion, coding sequence variant, genic downstream transcript variant
rs1064795155 G>C Likely-pathogenic Missense variant, coding sequence variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT004009 hsa-miR-200b-3p Microarray 17875710
MIRT003959 hsa-miR-200c-3p Microarray 17875710
MIRT006132 hsa-miR-1-3p GFP reporter assay, qRT-PCR, Western blot 21924268
MIRT006132 hsa-miR-1-3p GFP reporter assay, qRT-PCR, Western blot 21924268
MIRT006162 hsa-let-7g-5p Luciferase reporter assay, Microarray, Western blot 21868760
Transcription factors
Transcription factor Regulation Reference
AR Unknown 21055159
ATF2 Unknown 10471826
CEBPA Unknown 1320003
EGR1 Activation 15608673;9933644
EGR1 Unknown 10783396
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001525 Process Angiogenesis IEA
GO:0001932 Process Regulation of protein phosphorylation IDA 11792823
GO:0002020 Function Protease binding IPI 22952693
GO:0002576 Process Platelet degranulation TAS
GO:0005102 Function Signaling receptor binding IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
135600 3778 ENSG00000115414
Protein
UniProt ID P02751
Protein name Fibronectin (FN) (Cold-insoluble globulin) (CIG) [Cleaved into: Anastellin; Ugl-Y1; Ugl-Y2; Ugl-Y3]
Protein function Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin (PubMed:3024962, PubMed:3593230, PubMed:3900070, PubMed:7989369). Fibronectins are involved in cell adhesion, cell motility, opsonization,
PDB 1E88 , 1E8B , 1FBR , 1FNA , 1FNF , 1FNH , 1J8K , 1O9A , 1OWW , 1Q38 , 1QGB , 1QO6 , 1TTF , 1TTG , 2CG6 , 2CG7 , 2CK2 , 2CKU , 2EC3 , 2FN2 , 2FNB , 2GEE , 2H41 , 2H45 , 2HA1 , 2MNU , 2N1K , 2OCF , 2RKY , 2RKZ , 2RL0 , 3CAL , 3EJH , 3GXE , 3M7P , 3MQL , 3R8Q , 3T1W , 3ZRZ , 4GH7 , 4JE4 , 4JEG , 4LXO , 4MMX , 4MMY , 4MMZ , 4PZ5 , 5DC0 , 5DC4 , 5DC9 , 5DFT
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00039 fn1 52 87 Fibronectin type I domain Domain
PF00039 fn1 97 135 Fibronectin type I domain Domain
PF00039 fn1 141 179 Fibronectin type I domain Domain
PF00039 fn1 186 225 Fibronectin type I domain Domain
PF00039 fn1 231 270 Fibronectin type I domain Domain
PF00039 fn1 308 342 Fibronectin type I domain Domain
PF00040 fn2 360 401 Fibronectin type II domain Domain
PF00040 fn2 420 461 Fibronectin type II domain Domain
PF00039 fn1 470 508 Fibronectin type I domain Domain
PF00039 fn1 518 555 Fibronectin type I domain Domain
PF00039 fn1 561 599 Fibronectin type I domain Domain
PF00041 fn3 609 692 Fibronectin type III domain Domain
PF00041 fn3 723 801 Fibronectin type III domain Domain
PF00041 fn3 812 891 Fibronectin type III domain Domain
PF00041 fn3 908 988 Fibronectin type III domain Domain
PF00041 fn3 998 1078 Fibronectin type III domain Domain
PF00041 fn3 1093 1163 Fibronectin type III domain Domain
PF00041 fn3 1175 1258 Fibronectin type III domain Domain
PF00041 fn3 1268 1349 Fibronectin type III domain Domain
PF00041 fn3 1359 1439 Fibronectin type III domain Domain
PF00041 fn3 1449 1530 Fibronectin type III domain Domain
PF00041 fn3 1543 1623 Fibronectin type III domain Domain
PF00041 fn3 1633 1713 Fibronectin type III domain Domain
PF00041 fn3 1723 1803 Fibronectin type III domain Domain
PF00041 fn3 1815 1894 Fibronectin type III domain Domain
PF00041 fn3 1904 1984 Fibronectin type III domain Domain
PF00041 fn3 2110 2182 Fibronectin type III domain Domain
PF00039 fn1 2206 2245 Fibronectin type I domain Domain
PF00039 fn1 2251 2288 Fibronectin type I domain Domain
PF00039 fn1 2295 2330 Fibronectin type I domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in the inner limiting membrane and around blood vessels in the retina (at protein level) (PubMed:29777959). Plasma FN (soluble dimeric form) is secreted by hepatocytes. Cellular FN (dimeric or cross-linked multimeric forms),
Sequence
MLRGPGPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQ
INQQWERTYLGNALVCTCYGGSRGFNC
ESKPEAEETCFDKYTGNTYRVGDTYERPKDSMI
WDCTCIGAGRGRISC
TIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCK
PIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSY
RIGDTWSKKDNRGNLLQCICTGNGRGEWKC
ERHTSVQTTSSGSGPFTDVRAAVYQPQPHP
QPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPC
VLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFC
TDHTVLVQTRGGNSNGALC
HFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFC
PMAAHEEICTTNEGVMYRI
GDQWDKQHDMGHMMRCTCVGNGRGEWTC
IAYSQLRDQCIVDDITYNVNDTFHKRHEEGHM
LNCTCFGQGRGRWKC
DPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQ
PLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQPSHISKYILRWRPKNSVGRWKEATIP
GHLNSYTIKGLKPGVVYEGQLISIQQYGHQEV
TRFDFTTTSTSTPVTSNTVTGETTPFSP
LVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDL
LPGRKYIVNVYQISEDGEQSL
ILSTSQTTAPDAPPDTTVDQVDDTSIVVRWSRPQAPITG
YRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTP
VVIQQETTG
TPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNT
FAEVTGLSPGVTYYFKVFAVSHGRESKP
LTAQQTTKLDAPTNLQFVNETDSTVLVRWTPP
RAQITGYRLTVGLTRRGQPRQYNVGPSVSKYPLRNLQPASEYTVSLVAIKGNQESPKA
TG
VFTTLQPGSSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQGGEAPREVTSDSGSIVV
SGLTPGVEYVYTIQVLRDGQERD
APIVNKVVTPLSPPTNLHLEANPDTGVLTVSWERSTT
PDITGYRITTTPTNGQQGNSLEEVVHADQSSCTFDNLSPGLEYNVSVYTVKDDKESVP
IS
DTIIPEVPQLTDLSFVDITDSSIGLRWTPLNSSTIIGYRITVVAAGEGIPIFEDFVDSSV
GYYTVTGLEPGIDYDISVITLINGGESAP
TTLTQQTAVPPPTDLRFTNIGPDTMRVTWAP
PPSIDLTNFLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYVVSVSSVYEQHEST
P
LRGRQKTGLDSPTGIDFSDITANSFTVHWIAPRATITGYRIRHHPEHFSGRPREDRVPHS
RNSITLTNLTPGTEYVVSIVALNGREESPL
LIGQQSTVSDVPRDLEVVAATPTSLLISWD
APAVTVRYYRITYGETGGNSPVQEFTVPGSKSTATISGLKPGVDYTITVYAVTGRGDSPA
SSK
PISINYRTEIDKPSQMQVTDVQDNSISVKWLPSSSPVTGYRVTTTPKNGPGPTKTKT
AGPDQTEMTIEGLQPTVEYVVSVYAQNPSGESQ
PLVQTAVTNIDRPKGLAFTDVDVDSIK
IAWESPQGQVSRYRVTYSSPEDGIHELFPAPDGEEDTAELQGLRPGSEYTVSVVALHDDM
ESQ
PLIGTQSTAIPAPTDLKFTQVTPTSLSAQWTPPNVQLTGYRVRVTPKEKTGPMKEIN
LAPDSSSVVVSGLMVATKYEVSVYALKDTLTSRP
AQGVVTTLENVSPPRRARVTDATETT
ITISWRTKTETITGFQVDAVPANGQTPIQRTIKPDVRSYTITGLQPGTDYKIYLYTLNDN
ARSS
PVVIDASTAIDAPSNLRFLATTPNSLLVSWQPPRARITGYIIKYEKPGSPPREVVP
RPRPGVTEATITGLEPGTEYTIYVIALKNNQKSEPLIGRKKTDELPQLVTLPHPNLHGPE
ILDVPSTVQKTPFVTHPGYDTGNGIQLPGTSGQQPSVGQQMIFEEHGFRRTTPPTTATPI
RHRPRPYPPNVGEEIQIGHIPR
EDVDYHLYPHGPGLNPNASTGQEALSQTTISWAPFQDT
SEYIISCHPVGTDEEPLQFRVPGTS
TSATLTGLTRGATYNVIVEALKDQQRHKVREEVVT
VGNSVNEG
LNQPTDDSCFDPYTVSHYAVGDEWERMSESGFKLLCQCLGFGSGHFRCDSSR
WCHDNGVNYKIGEKWDRQGENGQMMSCTCLGNGKGEFKCDPHEATCYDDGKTYHVGEQWQ
KEYLGAICSCTCFGGQRGWRCDNCRRPGGEPSPEGTTGQSYNQYSQRYHQRTNTNVNCPI
ECFMPLDVQADREDSRE
Sequence length 2477
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Spondylometaphyseal Dysplasia spondylometaphyseal dysplasia, 'corner fracture' type GenCC
Glomerulopathy With Fibronectin Deposits glomerulopathy with fibronectin deposits 2 GenCC
Fibronectin Glomerulopathy fibronectin glomerulopathy GenCC
Coronary Heart Disease Coronary Heart Disease GWAS
Associations from Text Mining
Disease Name Relationship Type References
Abdominal Abscess Associate 34238216
Achondrogenesis type 2 Associate 25146392, 39367925
Acute Coronary Syndrome Associate 33672727
Adenocarcinoma Associate 15136764, 16158954, 24047237, 35322195, 36171259
Adenocarcinoma Follicular Associate 16675914
Adenocarcinoma of Lung Associate 22896658, 33728331
Adenoma Associate 26749005, 31784980
Adenoma Stimulate 33516765
Adenoma Pleomorphic Associate 33727696
Adrenocortical Carcinoma Associate 32207273, 33626208