Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs Other IDs Associated diseases
Entrez ID	2241
Gene name	FER tyrosine kinase
Gene symbol	FER
Synonyms (NCBI Gene)	PPP1R74TYK3p94-Fer
Chromosome	5
Chromosome location	5q21.3
Summary	The protein encoded by this gene is a member of the FPS/FES family of non-transmembrane receptor tyrosine kinases. It regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors. Alternative sp

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Show/Hide all (131)

miRTarBase ID	miRNA	Experiments	Reference
MIRT051027	hsa-miR-17-5p	CLASH	23622248
MIRT050063	hsa-miR-26a-5p	CLASH	23622248
MIRT038279	hsa-miR-26a-2-3p	CLASH	23622248
MIRT626663	hsa-miR-582-3p	HITS-CLIP	23824327
MIRT626662	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT626661	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT626660	hsa-miR-4469	HITS-CLIP	23824327
MIRT626659	hsa-miR-4326	HITS-CLIP	23824327
MIRT626658	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT626657	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT626656	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT626655	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT626654	hsa-miR-33a-5p	HITS-CLIP	23824327
MIRT626653	hsa-miR-33b-5p	HITS-CLIP	23824327
MIRT626652	hsa-miR-218-1-3p	HITS-CLIP	23824327
MIRT626651	hsa-miR-450b-5p	HITS-CLIP	23824327
MIRT626650	hsa-miR-507	HITS-CLIP	23824327
MIRT626649	hsa-miR-557	HITS-CLIP	23824327
MIRT626648	hsa-miR-3680-3p	HITS-CLIP	23824327
MIRT626663	hsa-miR-582-3p	HITS-CLIP	23824327
MIRT648989	hsa-miR-4686	HITS-CLIP	23824327
MIRT626662	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT626661	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT626660	hsa-miR-4469	HITS-CLIP	23824327
MIRT648988	hsa-miR-93-3p	HITS-CLIP	23824327
MIRT648987	hsa-miR-3692-5p	HITS-CLIP	23824327
MIRT648986	hsa-miR-6882-3p	HITS-CLIP	23824327
MIRT626659	hsa-miR-4326	HITS-CLIP	23824327
MIRT626658	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT626657	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT626656	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT626655	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT648985	hsa-miR-6071	HITS-CLIP	23824327
MIRT626654	hsa-miR-33a-5p	HITS-CLIP	23824327
MIRT626653	hsa-miR-33b-5p	HITS-CLIP	23824327
MIRT626652	hsa-miR-218-1-3p	HITS-CLIP	23824327
MIRT626651	hsa-miR-450b-5p	HITS-CLIP	23824327
MIRT626650	hsa-miR-507	HITS-CLIP	23824327
MIRT626649	hsa-miR-557	HITS-CLIP	23824327
MIRT626648	hsa-miR-3680-3p	HITS-CLIP	23824327
MIRT626663	hsa-miR-582-3p	HITS-CLIP	23824327
MIRT626662	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT626661	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT626660	hsa-miR-4469	HITS-CLIP	23824327
MIRT626659	hsa-miR-4326	HITS-CLIP	23824327
MIRT626658	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT626657	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT626656	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT626655	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT626654	hsa-miR-33a-5p	HITS-CLIP	23824327
MIRT626653	hsa-miR-33b-5p	HITS-CLIP	23824327
MIRT626652	hsa-miR-218-1-3p	HITS-CLIP	23824327
MIRT626651	hsa-miR-450b-5p	HITS-CLIP	23824327
MIRT626650	hsa-miR-507	HITS-CLIP	23824327
MIRT626649	hsa-miR-557	HITS-CLIP	23824327
MIRT626648	hsa-miR-3680-3p	HITS-CLIP	23824327
MIRT447435	hsa-miR-1277-5p	PAR-CLIP	22100165
MIRT447434	hsa-miR-5011-5p	PAR-CLIP	22100165
MIRT447433	hsa-miR-4635	PAR-CLIP	22100165
MIRT447432	hsa-miR-190a-3p	PAR-CLIP	22100165
MIRT447431	hsa-miR-5585-3p	PAR-CLIP	22100165
MIRT447436	hsa-miR-6507-5p	PAR-CLIP	22100165
MIRT447435	hsa-miR-1277-5p	PAR-CLIP	22100165
MIRT447434	hsa-miR-5011-5p	PAR-CLIP	22100165
MIRT447433	hsa-miR-4635	PAR-CLIP	22100165
MIRT447432	hsa-miR-190a-3p	PAR-CLIP	22100165
MIRT447431	hsa-miR-5585-3p	PAR-CLIP	22100165
MIRT626663	hsa-miR-582-3p	HITS-CLIP	23824327
MIRT626662	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT626661	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT626660	hsa-miR-4469	HITS-CLIP	23824327
MIRT626659	hsa-miR-4326	HITS-CLIP	23824327
MIRT626658	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT626657	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT626656	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT626655	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT626654	hsa-miR-33a-5p	HITS-CLIP	23824327
MIRT626653	hsa-miR-33b-5p	HITS-CLIP	23824327
MIRT626652	hsa-miR-218-1-3p	HITS-CLIP	23824327
MIRT626651	hsa-miR-450b-5p	HITS-CLIP	23824327
MIRT626650	hsa-miR-507	HITS-CLIP	23824327
MIRT626649	hsa-miR-557	HITS-CLIP	23824327
MIRT626648	hsa-miR-3680-3p	HITS-CLIP	23824327
MIRT626663	hsa-miR-582-3p	HITS-CLIP	23824327
MIRT648989	hsa-miR-4686	HITS-CLIP	23824327
MIRT626662	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT626661	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT626660	hsa-miR-4469	HITS-CLIP	23824327
MIRT648988	hsa-miR-93-3p	HITS-CLIP	23824327
MIRT648987	hsa-miR-3692-5p	HITS-CLIP	23824327
MIRT648986	hsa-miR-6882-3p	HITS-CLIP	23824327
MIRT626659	hsa-miR-4326	HITS-CLIP	23824327
MIRT626658	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT626657	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT626656	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT626655	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT648985	hsa-miR-6071	HITS-CLIP	23824327
MIRT626654	hsa-miR-33a-5p	HITS-CLIP	23824327
MIRT626653	hsa-miR-33b-5p	HITS-CLIP	23824327
MIRT626652	hsa-miR-218-1-3p	HITS-CLIP	23824327
MIRT626651	hsa-miR-450b-5p	HITS-CLIP	23824327
MIRT626650	hsa-miR-507	HITS-CLIP	23824327
MIRT626649	hsa-miR-557	HITS-CLIP	23824327
MIRT626648	hsa-miR-3680-3p	HITS-CLIP	23824327
MIRT626663	hsa-miR-582-3p	HITS-CLIP	23824327
MIRT626662	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT626661	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT626660	hsa-miR-4469	HITS-CLIP	23824327
MIRT626659	hsa-miR-4326	HITS-CLIP	23824327
MIRT626658	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT626657	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT626656	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT626655	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT626654	hsa-miR-33a-5p	HITS-CLIP	23824327
MIRT626653	hsa-miR-33b-5p	HITS-CLIP	23824327
MIRT626652	hsa-miR-218-1-3p	HITS-CLIP	23824327
MIRT626651	hsa-miR-450b-5p	HITS-CLIP	23824327
MIRT626650	hsa-miR-507	HITS-CLIP	23824327
MIRT626649	hsa-miR-557	HITS-CLIP	23824327
MIRT626648	hsa-miR-3680-3p	HITS-CLIP	23824327
MIRT447435	hsa-miR-1277-5p	PAR-CLIP	22100165
MIRT447434	hsa-miR-5011-5p	PAR-CLIP	22100165
MIRT447433	hsa-miR-4635	PAR-CLIP	22100165
MIRT447432	hsa-miR-190a-3p	PAR-CLIP	22100165
MIRT447431	hsa-miR-5585-3p	PAR-CLIP	22100165
MIRT447436	hsa-miR-6507-5p	PAR-CLIP	22100165
MIRT447435	hsa-miR-1277-5p	PAR-CLIP	22100165
MIRT447434	hsa-miR-5011-5p	PAR-CLIP	22100165
MIRT447433	hsa-miR-4635	PAR-CLIP	22100165
MIRT447432	hsa-miR-190a-3p	PAR-CLIP	22100165
MIRT447431	hsa-miR-5585-3p	PAR-CLIP	22100165

Show/Hide all (98)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000226	Process	Microtubule cytoskeleton organization	IMP	12972546
GO:0000785	Component	Chromatin	IDA	1990274
GO:0001932	Process	Regulation of protein phosphorylation	ISS
GO:0004672	Function	Protein kinase activity	IEA
GO:0004713	Function	Protein tyrosine kinase activity	IBA
GO:0004713	Function	Protein tyrosine kinase activity	IEA
GO:0004713	Function	Protein tyrosine kinase activity	TAS	2725517
GO:0004715	Function	Non-membrane spanning protein tyrosine kinase activity	IDA	12972546, 19738202
GO:0004715	Function	Non-membrane spanning protein tyrosine kinase activity	IEA
GO:0005154	Function	Epidermal growth factor receptor binding	IDA	21518868
GO:0005515	Function	Protein binding	IPI	15226396, 22939624, 25036637, 32707033, 33961781
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IDA	19147545
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IDA	1990274
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005912	Component	Adherens junction	IEA
GO:0005938	Component	Cell cortex	IEA
GO:0006468	Process	Protein phosphorylation	TAS	2725517
GO:0006935	Process	Chemotaxis	IBA
GO:0006935	Process	Chemotaxis	IEA
GO:0007155	Process	Cell adhesion	IBA
GO:0007155	Process	Cell adhesion	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007260	Process	Tyrosine phosphorylation of STAT protein	IDA	19147545
GO:0007281	Process	Germ cell development	IEA
GO:0008157	Function	Protein phosphatase 1 binding	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	IMP	25540073
GO:0008284	Process	Positive regulation of cell population proliferation	TAS	20111072
GO:0008286	Process	Insulin receptor signaling pathway	IEA
GO:0008286	Process	Insulin receptor signaling pathway	ISS
GO:0008289	Function	Lipid binding	IDA	19738202
GO:0008289	Function	Lipid binding	IEA
GO:0008584	Process	Male gonad development	IEA
GO:0009898	Component	Cytoplasmic side of plasma membrane	IDA	19738202
GO:0010591	Process	Regulation of lamellipodium assembly	IDA	19738202
GO:0010762	Process	Regulation of fibroblast migration	IEA
GO:0015629	Component	Actin cytoskeleton	IDA	19738202
GO:0015630	Component	Microtubule cytoskeleton	IDA	12972546
GO:0016020	Component	Membrane	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0018108	Process	Peptidyl-tyrosine phosphorylation	IDA	12972546, 19738202
GO:0019221	Process	Cytokine-mediated signaling pathway	IMP	9722593
GO:0030027	Component	Lamellipodium	IDA	19738202
GO:0030036	Process	Actin cytoskeleton organization	IEA
GO:0030036	Process	Actin cytoskeleton organization	ISS
GO:0030054	Component	Cell junction	IDA	12972546
GO:0030335	Process	Positive regulation of cell migration	IMP	19738202
GO:0030838	Process	Positive regulation of actin filament polymerization	IMP	19738202
GO:0032273	Process	Positive regulation of protein polymerization	IEA
GO:0032496	Process	Response to lipopolysaccharide	IEA
GO:0032496	Process	Response to lipopolysaccharide	ISS
GO:0032991	Component	Protein-containing complex	IEA
GO:0033007	Process	Negative regulation of mast cell activation involved in immune response	IEA
GO:0033007	Process	Negative regulation of mast cell activation involved in immune response	ISS
GO:0034333	Process	Adherens junction assembly	IEA
GO:0034446	Process	Substrate adhesion-dependent cell spreading	IEA
GO:0034446	Process	Substrate adhesion-dependent cell spreading	ISS
GO:0034614	Process	Cellular response to reactive oxygen species	IEA
GO:0034614	Process	Cellular response to reactive oxygen species	ISS
GO:0035426	Process	Extracellular matrix-cell signaling	IEA
GO:0035426	Process	Extracellular matrix-cell signaling	ISS
GO:0035556	Process	Intracellular signal transduction	TAS	2209086
GO:0036006	Process	Cellular response to macrophage colony-stimulating factor stimulus	IMP	9722593
GO:0036119	Process	Response to platelet-derived growth factor	IEA
GO:0036119	Process	Response to platelet-derived growth factor	ISS
GO:0038095	Process	Fc-epsilon receptor signaling pathway	IBA
GO:0038095	Process	Fc-epsilon receptor signaling pathway	IEA
GO:0038095	Process	Fc-epsilon receptor signaling pathway	ISS
GO:0038109	Process	Kit signaling pathway	IEA
GO:0038109	Process	Kit signaling pathway	ISS
GO:0042058	Process	Regulation of epidermal growth factor receptor signaling pathway	IMP	21518868
GO:0042995	Component	Cell projection	IEA
GO:0044331	Process	Cell-cell adhesion mediated by cadherin	IEA
GO:0044331	Process	Cell-cell adhesion mediated by cadherin	ISS
GO:0046777	Process	Protein autophosphorylation	IDA	7623846
GO:0048008	Process	Platelet-derived growth factor receptor signaling pathway	IEA
GO:0048008	Process	Platelet-derived growth factor receptor signaling pathway	ISS
GO:0048008	Process	Platelet-derived growth factor receptor signaling pathway	TAS	11994747
GO:0050904	Process	Diapedesis	IEA
GO:0050904	Process	Diapedesis	ISS
GO:0051092	Process	Positive regulation of NF-kappaB transcription factor activity	IMP	21518868
GO:0051495	Process	Positive regulation of cytoskeleton organization	IEA
GO:0051897	Process	Positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA
GO:0060009	Process	Sertoli cell development	IEA
GO:0070102	Process	Interleukin-6-mediated signaling pathway	IMP	19147545
GO:0070161	Component	Anchoring junction	IEA
GO:0072520	Process	Seminiferous tubule development	IEA
GO:0120035	Process	Regulation of plasma membrane bounded cell projection organization	IEA
GO:0120179	Process	Adherens junction disassembly	IEA
GO:1902905	Process	Positive regulation of supramolecular fiber organization	IEA

MIM	HGNC	e!Ensembl
176942	3655	ENSG00000151422

P16591

Protein name

Tyrosine-protein kinase Fer (EC 2.7.10.2) (Feline encephalitis virus-related kinase FER) (Fujinami poultry sarcoma/Feline sarcoma-related protein Fer) (Proto-oncogene c-Fer) (Tyrosine kinase 3) (p94-Fer)

Protein function

Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. A

PDB

2KK6 , 6KC4

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00611	FCH	10 → 87	Fes/CIP4, and EFC/F-BAR homology domain	Family
PF00017	SH2	460 → 531	SH2 domain	Domain
PF07714	PK_Tyr_Ser-Thr	563 → 814	Protein tyrosine and serine/threonine kinase	Domain

Tissue specificity

TISSUE SPECIFICITY: Isoform 1 is detected in normal colon and in fibroblasts (at protein level). Isoform 3 is detected in normal testis, in colon carcinoma-derived metastases in lung, liver and ovary, and in colon carcinoma and hepato carcinoma cell lines

Sequence

MGFGSDLKNSHEAVLKLQDWELRLLETVKKFMALRIKSDKEYASTLQNLCNQVDKESTVQ
MNYVSNVSKSWLLMIQQTEQLSRIMKTHAEDLNSGPLHRLTMMIKDKQQVKKSYIGVHQQ
IEAEMIKVTKTELEKLKCSYRQLIKEMNSAKEKYKEALAKGKETEKAKERYDKATMKLHM
LHNQYVLALKGAQLHQNQYYDITLPLLLDSLQKMQEEMIKALKGIFDEYSQITSLVTEEI
VNVHKEIQMSVEQIDPSTEYNNFIDVHRTTAAKEQEIEFDTSLLEENENLQANEIMWNNL
TAESLQVMLKTLAEELMQTQQMLLNKEEAVLELEKRIEESSETCEKKSDIVLLLSQKQAL
EELKQSVQQLRCTEAKFSAQKELLEQKVQENDGKEPPPVVNYEEDARSVTSMERKERLSK
FESIRHSIAGIIRSPKSALGSSALSDMISISEKPLAEQDWYHGAIPRIEAQELLKKQGDF
LVRESHGKPGEYVLSVYSDGQRRHFIIQYVDNMYRFEGTGFSNIPQLIDHHYTTKQVITK
KSGVVLLNPIPKDKKWILSHEDVILGELLGKGNFGEVYKGTLKDKTSVAVKTCKEDLPQE
LKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKDELKLKQ
LVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGENNVLKISDFGMSRQEDGGVYSSSGLK
QIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMS
APQHCPEDISKIMMKCWDYKPENRPKFSELQKELTIIKRKLT

Sequence length

822

Interactions

View interactions

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Colon adenocarcinoma	Uncertain significance	rs771260179	RCV005932698
Duane retraction syndrome	Uncertain significance	rs2534099165, rs2534099223	RCV003883433 RCV003883434
Gastric cancer	Uncertain significance	rs149945605	RCV005927206

Show/Hide Text Mining Associations (21)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Breast Neoplasms	Associate	35385742
Carcinoma Hepatocellular	Associate	19835603
Carcinoma Non Small Cell Lung	Associate	23573306, 23931849
Carcinoma Pancreatic Ductal	Associate	31404611
Carcinoma Renal Cell	Associate	23445469
Colonic Neoplasms	Associate	33430475
Hypoxia	Associate	33430475
Hypoxia Brain	Associate	33430475
Lung Neoplasms	Associate	23573306
Lymphoma T Cell Peripheral	Associate	34147695
Neoplasm Metastasis	Associate	23445469, 29099290
Neoplasms	Associate	21097718, 23445469, 23573306, 25540073, 33430475, 37196766
Neoplasms	Stimulate	22238358
Ovarian Neoplasms	Associate	29099290, 29920310, 37196766
Pancreatic Neoplasms	Associate	31404611
Pneumonia	Associate	28851893
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	24367274
Prostatic Neoplasms	Associate	19147545, 25238935, 34417538
Respiratory Distress Syndrome	Associate	28851893
Stomach Neoplasms	Associate	21097718
Triple Negative Breast Neoplasms	Associate	35385742

FER (FER tyrosine kinase)