F3 (coagulation factor III, tissue factor)

Gene
Gene SNPs Transcription factors Other IDs Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2152
Gene name Gene Name - the full gene name approved by the HGNC.
Coagulation factor III, tissue factor
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
F3
Synonyms (NCBI Gene) Gene synonyms aliases
CD142, TF, TFA
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p21.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provi
miRNA miRNA information provided by mirtarbase database.
Gene SNPs Transcription factors Other IDs Associated diseases
Show/Hide all(777)
miRTarBase ID miRNA Experiments Reference
MIRT019927 hsa-miR-375 Microarray 20215506
MIRT020315 hsa-miR-130b-3p Sequencing 20371350
MIRT022817 hsa-miR-124-3p Microarray 18668037
MIRT028146 hsa-miR-93-5p Sequencing 20371350
MIRT029798 hsa-miR-26b-5p Microarray 19088304
Transcription factors
Gene SNPs Transcription factors Other IDs Associated diseases
Show/Hide all(7)
Transcription factor Regulation Reference
EGR1 Unknown 10707957;8576248
JUN Unknown 11057875
JUND Unknown 11057875
NFKB1 Unknown 11057875;11157486;19167713;9867853
REL Unknown 11057875
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs Transcription factors Other IDs Associated diseases
Show/Hide all(34)
GO ID Ontology Definition Evidence Reference
GO:0001938 Process Positive regulation of endothelial cell proliferation IDA 17898544
GO:0002020 Function Protease binding IPI 3455766
GO:0002541 Process Activation of plasma proteins involved in acute inflammatory response IDA 17469850
GO:0002543 Process Activation of blood coagulation via clotting cascade IDA 17469850
GO:0004252 Function Serine-type endopeptidase activity IDA 24998411
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs Transcription factors Other IDs Associated diseases
MIM HGNC e!Ensembl
134390 3541 ENSG00000117525
Protein
Gene SNPs Transcription factors Other IDs Associated diseases
UniProt ID P13726
Protein name Tissue factor (TF) (Coagulation factor III) (Thromboplastin) (CD antigen CD142)
Protein function Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly a
PDB 1AHW , 1BOY , 1DAN , 1FAK , 1J9C , 1JPS , 1O5D , 1TFH , 1UJ3 , 1W0Y , 1W2K , 1WQV , 1WSS , 1WTG , 1WUN , 1WV7 , 1Z6J , 2A2Q , 2AEI , 2AER , 2B7D , 2B8O , 2C4F , 2CEF , 2CEH , 2CEZ , 2CFJ , 2EC9 , 2F9B , 2FIR , 2FLB , 2FLR , 2HFT , 2PUQ , 2ZP0 , 2ZWL , 2ZZU , 3ELA , 3TH2 , 3TH3 , 3TH4 , 4IBL , 4M7L , 4YLQ , 4Z6A , 4ZMA , 5W06 , 6R2W , 6Z9W , 8CN9 , 8QOD
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01108 Tissue_fac 17 → 118 Tissue factor Family
PF09294 Interfer-bind 138 → 245 Interferon-alpha/beta receptor, fibronectin type III Domain
Tissue specificity TISSUE SPECIFICITY: Lung, placenta and pancreas. {ECO:0000269|PubMed:12652293}.
Sequence
Sequence length 295
Interactions View interactions
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene SNPs Transcription factors Other IDs Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Glioblastoma Glioblastoma N/A N/A GWAS
Show/Hide Text Mining Associations (305)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Abortion Spontaneous Associate 27929073
Acute Coronary Syndrome Associate 14640893, 16938121, 18029910, 25298206
Acute Coronary Syndrome Stimulate 19093728
Acute Lung Injury Stimulate 17356058
Acute Lung Injury Associate 18310227, 21913843
Acute On Chronic Liver Failure Associate 30867825
Adenocarcinoma Associate 22929889
Adenocarcinoma of Lung Associate 20445954, 40453647
Adenocarcinoma Papillary Associate 20700124
Adenoma Associate 9466567