Gene Gene information from NCBI Gene database.
Entrez ID 2150
Gene name F2R like trypsin receptor 1
Gene symbol F2RL1
Synonyms (NCBI Gene)
GPR11PAR2
Chromosome 5
Chromosome location 5q13.3
Summary This gene encodes a member of the G-protein coupled receptor 1 family of proteins. The encoded cell surface receptor is activated through proteolytic cleavage of its extracellular amino terminus, resulting in a new amino terminus that acts as a tethered l
miRNA miRNA information provided by mirtarbase database.
458
miRTarBase ID miRNA Experiments Reference
MIRT023577 hsa-miR-1-3p Microarray 18668037
MIRT724017 hsa-miR-483-3p HITS-CLIP 19536157
MIRT724016 hsa-miR-6747-3p HITS-CLIP 19536157
MIRT724015 hsa-miR-1304-3p HITS-CLIP 19536157
MIRT629097 hsa-miR-367-5p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
107
GO ID Ontology Definition Evidence Reference
GO:0001648 Function Proteinase-activated receptor activity IEA
GO:0001965 Function G-protein alpha-subunit binding IEA
GO:0001965 Function G-protein alpha-subunit binding ISS
GO:0002020 Function Protease binding IPI 18434511
GO:0002286 Process T cell activation involved in immune response IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
600933 3538 ENSG00000164251
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P55085
Protein name Proteinase-activated receptor 2 (PAR-2) (Coagulation factor II receptor-like 1) (G-protein coupled receptor 11) (Thrombin receptor-like 1) [Cleaved into: Proteinase-activated receptor 2, alternate cleaved 1; Proteinase-activated receptor 2, alternate clea
Protein function Receptor for trypsin and trypsin-like enzymes coupled to G proteins (PubMed:28445455). Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protei
PDB 5NDD , 5NDZ , 5NJ6
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1 92 344 7 transmembrane receptor (rhodopsin family) Family
Tissue specificity TISSUE SPECIFICITY: Widely expressed in tissues with especially high levels in pancreas, liver, kidney, small intestine, and colon (PubMed:7556175, PubMed:8615752). Moderate expression is detected in many organs, but none in brain or skeletal muscle (PubM
Sequence
Sequence length 397
Interactions View interactions