Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs Other IDs
Entrez ID	1978
Gene name	Eukaryotic translation initiation factor 4E binding protein 1
Gene symbol	EIF4EBP1
Synonyms (NCBI Gene)	4E-BP14EBP1BP-1PHAS-I
Chromosome	8
Chromosome location	8p11.23
Summary	This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subu

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miRTarBase ID	miRNA	Experiments	Reference
MIRT000347	hsa-miR-125b-5p	MicroarrayqRT-PCR	17891175
MIRT021307	hsa-miR-125a-5p	Sequencing	20371350
MIRT022876	hsa-miR-124-3p	Microarray	18668037
MIRT000347	hsa-miR-125b-5p	ImmunoblotImmunohistochemistryIn situ hybridizationLuciferase reporter assayMicroarrayqRT-PCR	22071331
MIRT682577	hsa-miR-508-5p	HITS-CLIP	23706177
MIRT682576	hsa-miR-25-3p	HITS-CLIP	23706177
MIRT682575	hsa-miR-32-5p	HITS-CLIP	23706177
MIRT682574	hsa-miR-363-3p	HITS-CLIP	23706177
MIRT682573	hsa-miR-367-3p	HITS-CLIP	23706177
MIRT682572	hsa-miR-92a-3p	HITS-CLIP	23706177
MIRT682571	hsa-miR-92b-3p	HITS-CLIP	23706177
MIRT682570	hsa-miR-6849-3p	HITS-CLIP	23706177
MIRT682569	hsa-miR-939-3p	HITS-CLIP	23706177
MIRT682568	hsa-miR-766-3p	HITS-CLIP	23706177
MIRT682567	hsa-miR-661	HITS-CLIP	23706177
MIRT682566	hsa-miR-4640-5p	HITS-CLIP	23706177
MIRT682565	hsa-miR-4726-5p	HITS-CLIP	23706177
MIRT682564	hsa-miR-6508-3p	HITS-CLIP	23706177
MIRT682563	hsa-miR-6512-3p	HITS-CLIP	23706177
MIRT682562	hsa-miR-6720-5p	HITS-CLIP	23706177
MIRT682561	hsa-miR-7703	HITS-CLIP	23706177
MIRT682560	hsa-miR-4325	HITS-CLIP	23706177
MIRT615742	hsa-miR-4677-3p	HITS-CLIP	23824327
MIRT615741	hsa-miR-4679	HITS-CLIP	23824327
MIRT624047	hsa-miR-5186	HITS-CLIP	23824327
MIRT615740	hsa-miR-5702	HITS-CLIP	23824327
MIRT615739	hsa-miR-937-5p	HITS-CLIP	23824327
MIRT615738	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT615737	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT615742	hsa-miR-4677-3p	HITS-CLIP	23824327
MIRT615741	hsa-miR-4679	HITS-CLIP	23824327
MIRT624047	hsa-miR-5186	HITS-CLIP	23824327
MIRT615740	hsa-miR-5702	HITS-CLIP	23824327
MIRT615739	hsa-miR-937-5p	HITS-CLIP	23824327
MIRT615738	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT615737	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT615742	hsa-miR-4677-3p	HITS-CLIP	23824327
MIRT615741	hsa-miR-4679	HITS-CLIP	23824327
MIRT624047	hsa-miR-5186	HITS-CLIP	23824327
MIRT615740	hsa-miR-5702	HITS-CLIP	23824327
MIRT615739	hsa-miR-937-5p	HITS-CLIP	23824327
MIRT615738	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT615737	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT615742	hsa-miR-4677-3p	HITS-CLIP	23824327
MIRT615741	hsa-miR-4679	HITS-CLIP	23824327
MIRT615740	hsa-miR-5702	HITS-CLIP	23824327
MIRT615739	hsa-miR-937-5p	HITS-CLIP	23824327
MIRT615738	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT615737	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT363750	hsa-miR-3173-3p	PAR-CLIP	20371350
MIRT363764	hsa-miR-6891-5p	PAR-CLIP	20371350
MIRT363762	hsa-miR-5582-5p	PAR-CLIP	20371350
MIRT567683	hsa-miR-5094	PAR-CLIP	20371350
MIRT363759	hsa-miR-4686	PAR-CLIP	20371350
MIRT363756	hsa-miR-4457	PAR-CLIP	20371350
MIRT567682	hsa-miR-5693	PAR-CLIP	20371350
MIRT567681	hsa-miR-194-3p	PAR-CLIP	20371350
MIRT363767	hsa-miR-93-3p	PAR-CLIP	20371350
MIRT363753	hsa-miR-3692-5p	PAR-CLIP	20371350
MIRT363747	hsa-miR-202-3p	PAR-CLIP	20371350
MIRT567680	hsa-miR-7112-3p	PAR-CLIP	20371350
MIRT567679	hsa-miR-4711-5p	PAR-CLIP	20371350
MIRT363752	hsa-miR-3612	PAR-CLIP	20371350
MIRT363748	hsa-miR-650	PAR-CLIP	20371350
MIRT363765	hsa-miR-7847-3p	PAR-CLIP	20371350
MIRT363763	hsa-miR-6071	PAR-CLIP	20371350
MIRT363754	hsa-miR-4443	PAR-CLIP	20371350
MIRT477545	hsa-miR-6165	PAR-CLIP	23592263
MIRT477544	hsa-miR-4459	PAR-CLIP	23592263
MIRT477543	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT477542	hsa-miR-6894-5p	PAR-CLIP	23592263
MIRT477541	hsa-miR-1273e	PAR-CLIP	23592263
MIRT363746	hsa-miR-138-5p	Luciferase reporter assay	26891291
MIRT363746	hsa-miR-138-5p	Luciferase reporter assayqRT-PCR	28075468
MIRT363746	hsa-miR-138-5p	Luciferase reporter assayqRT-PCR	28075468
MIRT021307	hsa-miR-125a-5p	Luciferase reporter assayqRT-PCRWestern blot	26646586
MIRT021307	hsa-miR-125a-5p	Luciferase reporter assayqRT-PCRWestern blot	26646586
MIRT000347	hsa-miR-125b-5p	Luciferase reporter assayqRT-PCRWestern blot	26646586
MIRT000347	hsa-miR-125b-5p	Luciferase reporter assayqRT-PCRWestern blot	26646586
MIRT682577	hsa-miR-508-5p	HITS-CLIP	23706177
MIRT682576	hsa-miR-25-3p	HITS-CLIP	23706177
MIRT682575	hsa-miR-32-5p	HITS-CLIP	23706177
MIRT682574	hsa-miR-363-3p	HITS-CLIP	23706177
MIRT682573	hsa-miR-367-3p	HITS-CLIP	23706177
MIRT682572	hsa-miR-92a-3p	HITS-CLIP	23706177
MIRT682571	hsa-miR-92b-3p	HITS-CLIP	23706177
MIRT682570	hsa-miR-6849-3p	HITS-CLIP	23706177
MIRT682569	hsa-miR-939-3p	HITS-CLIP	23706177
MIRT682568	hsa-miR-766-3p	HITS-CLIP	23706177
MIRT682567	hsa-miR-661	HITS-CLIP	23706177
MIRT682566	hsa-miR-4640-5p	HITS-CLIP	23706177
MIRT682565	hsa-miR-4726-5p	HITS-CLIP	23706177
MIRT682564	hsa-miR-6508-3p	HITS-CLIP	23706177
MIRT682563	hsa-miR-6512-3p	HITS-CLIP	23706177
MIRT682562	hsa-miR-6720-5p	HITS-CLIP	23706177
MIRT682561	hsa-miR-7703	HITS-CLIP	23706177
MIRT682560	hsa-miR-4325	HITS-CLIP	23706177
MIRT615742	hsa-miR-4677-3p	HITS-CLIP	23824327
MIRT615741	hsa-miR-4679	HITS-CLIP	23824327
MIRT624047	hsa-miR-5186	HITS-CLIP	23824327
MIRT615740	hsa-miR-5702	HITS-CLIP	23824327
MIRT615739	hsa-miR-937-5p	HITS-CLIP	23824327
MIRT615738	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT615737	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT615742	hsa-miR-4677-3p	HITS-CLIP	23824327
MIRT615741	hsa-miR-4679	HITS-CLIP	23824327
MIRT624047	hsa-miR-5186	HITS-CLIP	23824327
MIRT615740	hsa-miR-5702	HITS-CLIP	23824327
MIRT615739	hsa-miR-937-5p	HITS-CLIP	23824327
MIRT615738	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT615737	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT615742	hsa-miR-4677-3p	HITS-CLIP	23824327
MIRT615741	hsa-miR-4679	HITS-CLIP	23824327
MIRT624047	hsa-miR-5186	HITS-CLIP	23824327
MIRT615740	hsa-miR-5702	HITS-CLIP	23824327
MIRT615739	hsa-miR-937-5p	HITS-CLIP	23824327
MIRT615738	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT615737	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT615742	hsa-miR-4677-3p	HITS-CLIP	23824327
MIRT615741	hsa-miR-4679	HITS-CLIP	23824327
MIRT615740	hsa-miR-5702	HITS-CLIP	23824327
MIRT615739	hsa-miR-937-5p	HITS-CLIP	23824327
MIRT615738	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT615737	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT363750	hsa-miR-3173-3p	PAR-CLIP	20371350
MIRT363764	hsa-miR-6891-5p	PAR-CLIP	20371350
MIRT363762	hsa-miR-5582-5p	PAR-CLIP	20371350
MIRT567683	hsa-miR-5094	PAR-CLIP	20371350
MIRT363759	hsa-miR-4686	PAR-CLIP	20371350
MIRT363756	hsa-miR-4457	PAR-CLIP	20371350
MIRT567682	hsa-miR-5693	PAR-CLIP	20371350
MIRT567681	hsa-miR-194-3p	PAR-CLIP	20371350
MIRT363767	hsa-miR-93-3p	PAR-CLIP	20371350
MIRT363753	hsa-miR-3692-5p	PAR-CLIP	20371350
MIRT363747	hsa-miR-202-3p	PAR-CLIP	20371350
MIRT567680	hsa-miR-7112-3p	PAR-CLIP	20371350
MIRT567679	hsa-miR-4711-5p	PAR-CLIP	20371350
MIRT363752	hsa-miR-3612	PAR-CLIP	20371350
MIRT363748	hsa-miR-650	PAR-CLIP	20371350
MIRT363765	hsa-miR-7847-3p	PAR-CLIP	20371350
MIRT363763	hsa-miR-6071	PAR-CLIP	20371350
MIRT363754	hsa-miR-4443	PAR-CLIP	20371350
MIRT477545	hsa-miR-6165	PAR-CLIP	23592263
MIRT477544	hsa-miR-4459	PAR-CLIP	23592263
MIRT477543	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT477542	hsa-miR-6894-5p	PAR-CLIP	23592263
MIRT477541	hsa-miR-1273e	PAR-CLIP	23592263
MIRT958333	hsa-miR-1207-5p	CLIP-seq
MIRT958334	hsa-miR-1252	CLIP-seq
MIRT958335	hsa-miR-1291	CLIP-seq
MIRT958336	hsa-miR-1298	CLIP-seq
MIRT958337	hsa-miR-1343	CLIP-seq
MIRT958338	hsa-miR-1909	CLIP-seq
MIRT958339	hsa-miR-1976	CLIP-seq
MIRT958340	hsa-miR-202	CLIP-seq
MIRT958341	hsa-miR-3127-3p	CLIP-seq
MIRT958342	hsa-miR-3170	CLIP-seq
MIRT958343	hsa-miR-3189-3p	CLIP-seq
MIRT958344	hsa-miR-3202	CLIP-seq
MIRT958345	hsa-miR-328	CLIP-seq
MIRT958346	hsa-miR-342-5p	CLIP-seq
MIRT958347	hsa-miR-3655	CLIP-seq
MIRT958348	hsa-miR-4436b-5p	CLIP-seq
MIRT958349	hsa-miR-4476	CLIP-seq
MIRT958350	hsa-miR-4533	CLIP-seq
MIRT958351	hsa-miR-4651	CLIP-seq
MIRT958352	hsa-miR-4660	CLIP-seq
MIRT958353	hsa-miR-4664-5p	CLIP-seq
MIRT958354	hsa-miR-4736	CLIP-seq
MIRT958355	hsa-miR-4763-3p	CLIP-seq
MIRT958356	hsa-miR-483-3p	CLIP-seq
MIRT958357	hsa-miR-578	CLIP-seq
MIRT958358	hsa-miR-608	CLIP-seq
MIRT958359	hsa-miR-668	CLIP-seq
MIRT958360	hsa-miR-885-3p	CLIP-seq
MIRT1548270	hsa-miR-138	CLIP-seq
MIRT1548271	hsa-miR-4694-5p	CLIP-seq
MIRT1548272	hsa-miR-4779	CLIP-seq
MIRT958336	hsa-miR-1298	CLIP-seq
MIRT1556274	hsa-miR-3652	CLIP-seq
MIRT1556275	hsa-miR-4430	CLIP-seq
MIRT1556276	hsa-miR-4492	CLIP-seq
MIRT1556277	hsa-miR-4498	CLIP-seq
MIRT1556278	hsa-miR-762	CLIP-seq
MIRT2219132	hsa-miR-1238	CLIP-seq
MIRT1548270	hsa-miR-138	CLIP-seq
MIRT2219133	hsa-miR-2110	CLIP-seq
MIRT2219134	hsa-miR-3150a-3p	CLIP-seq
MIRT2219135	hsa-miR-3183	CLIP-seq
MIRT958346	hsa-miR-342-5p	CLIP-seq
MIRT2219136	hsa-miR-3665	CLIP-seq
MIRT2219137	hsa-miR-4271	CLIP-seq
MIRT2219138	hsa-miR-4419a	CLIP-seq
MIRT2219139	hsa-miR-4510	CLIP-seq
MIRT958350	hsa-miR-4533	CLIP-seq
MIRT958351	hsa-miR-4651	CLIP-seq
MIRT958353	hsa-miR-4664-5p	CLIP-seq
MIRT1548271	hsa-miR-4694-5p	CLIP-seq
MIRT2219140	hsa-miR-4716-3p	CLIP-seq
MIRT2219141	hsa-miR-4723-3p	CLIP-seq
MIRT2219142	hsa-miR-4723-5p	CLIP-seq
MIRT2219143	hsa-miR-4725-3p	CLIP-seq
MIRT2219144	hsa-miR-4728-5p	CLIP-seq
MIRT958354	hsa-miR-4736	CLIP-seq
MIRT2219145	hsa-miR-4747-5p	CLIP-seq
MIRT1548272	hsa-miR-4779	CLIP-seq
MIRT2219146	hsa-miR-486-3p	CLIP-seq
MIRT958358	hsa-miR-608	CLIP-seq
MIRT2219147	hsa-miR-635	CLIP-seq
MIRT2219148	hsa-miR-764	CLIP-seq
MIRT958339	hsa-miR-1976	CLIP-seq
MIRT958340	hsa-miR-202	CLIP-seq
MIRT958352	hsa-miR-4660	CLIP-seq

Show/Hide all (23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000082	Process	G1/S transition of mitotic cell cycle	IMP	14673156
GO:0005515	Function	Protein binding	IPI	7651417, 10772338, 12150925, 12150926, 15094042, 15153109, 16189514, 16271312, 16504179, 17368478, 18337751, 18955708, 19834456, 20224576, 20671708, 20880835, 21191102, 22678294, 24211447, 24722188, 24981860, 25416956, 28514442, 28698298, 32296183, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA	23814182
GO:0005829	Component	Cytosol	TAS
GO:0006417	Process	Regulation of translation	IEA
GO:0008190	Function	Eukaryotic initiation factor 4E binding	IBA
GO:0008190	Function	Eukaryotic initiation factor 4E binding	IDA	23814182
GO:0008190	Function	Eukaryotic initiation factor 4E binding	IEA
GO:0008190	Function	Eukaryotic initiation factor 4E binding	IPI	38177902
GO:0017148	Process	Negative regulation of translation	IDA	9453748
GO:0017148	Process	Negative regulation of translation	IEA
GO:0030371	Function	Translation repressor activity	IBA
GO:0030371	Function	Translation repressor activity	IDA	22578813
GO:0031369	Function	Translation initiation factor binding	EXP	9453748
GO:0031369	Function	Translation initiation factor binding	IPI	17368478
GO:0031929	Process	TOR signaling	IDA	12150926, 22578813
GO:0045931	Process	Positive regulation of mitotic cell cycle	IMP	14673156
GO:0045947	Process	Negative regulation of translational initiation	IBA
GO:0045947	Process	Negative regulation of translational initiation	IDA	22578813
GO:0045947	Process	Negative regulation of translational initiation	IEA

MIM	HGNC	e!Ensembl
602223	3288	ENSG00000187840

Q13541

Protein name

Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I)

Protein function

Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hy

PDB

1EJ4 , 1EJH , 1WKW , 2JGB , 2JGC , 2V8W , 2V8X , 2V8Y , 3HXG , 3HXI , 3M93 , 3M94 , 3U7X , 4UED , 5BXV , 5EKV , 5NVN , 5WBJ , 6BCU , 6BCX , 8RCH , 8RCK , 8RCN

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05456	eIF_4EBP	1 → 118	Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)	Family

Sequence

MSGGSSCSQTPSRAIPATRRVVLGDGVQLPPGDYSTTPGGTLFSTTPGGTRIIYDRKFLM
ECRNSPVTKTPPRDLPTIPGVTSPSSDEPPMEASQSHLRNSPEDKRAGGEESQFEMDI

Sequence length

118

Interactions

View interactions

EIF4EBP1 (eukaryotic translation initiation factor 4E binding protein 1)