EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha)
Gene | |
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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1965 |
Gene name
Gene Name - the full gene name approved by the HGNC.
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Eukaryotic translation initiation factor 2 subunit alpha |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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EIF2S1 |
Synonyms (NCBI Gene)
Gene synonyms aliases
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EIF-2, EIF-2A, EIF-2alpha, EIF2, EIF2A |
Chromosome
Chromosome number
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14 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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14q23.3 |
Summary
Summary of gene provided in NCBI Entrez Gene.
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The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is |
miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein | ||||||||||||||||
UniProt ID | P05198 | |||||||||||||||
Protein name | Eukaryotic translation initiation factor 2 subunit 1 (Eukaryotic translation initiation factor 2 subunit alpha) (eIF-2-alpha) (eIF-2A) (eIF-2alpha) (eIF2-alpha) | |||||||||||||||
Protein function | Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed:16289705, PubMed:38340717). This complex binds to a 40S ribosomal subunit, followed by mRNA bindin | |||||||||||||||
PDB | 1KL9 , 1Q8K , 6K71 , 6K72 , 6O81 , 6O85 , 6O9Z , 6YBV , 6ZMW , 6ZP4 , 7A09 , 7D43 , 7D44 , 7D45 , 7F66 , 7F67 , 7NZM , 7QP6 , 7QP7 , 7SYR , 7SYS , 8OZ0 , 8PJ1 , 8PJ2 , 8PJ3 , 8PJ4 , 8PPL , 8QZZ | |||||||||||||||
Family and domains |
Pfam
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Sequence |
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Sequence length | 315 | |||||||||||||||
Interactions | View interactions |