Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs Transcription factors Other IDs Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	1848
Gene name Gene Name - the full gene name approved by the HGNC.	Dual specificity phosphatase 6
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	DUSP6
Synonyms (NCBI Gene) Gene synonyms aliases	HH19, MKP3, PYST1
Chromosome Chromosome number	12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	12q21.33
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regu

Show/Hide all(4)

SNP ID	Visualize variation	Clinical significance	Consequence
rs139318648	G>A,C	Risk-factor	Missense variant, intron variant, coding sequence variant
rs143946794	T>C	Pathogenic	Missense variant, intron variant, coding sequence variant
rs146089505	G>A	Risk-factor	Missense variant, coding sequence variant
rs587776978	A>T	Pathogenic	Coding sequence variant, missense variant

Show/Hide all(269)

miRTarBase ID	miRNA	Experiments	Reference
MIRT006481	hsa-miR-181a-5p	Luciferase reporter assay, Western blot	17382377
MIRT006481	hsa-miR-181a-5p	Luciferase reporter assay, Western blot	17382377
MIRT006481	hsa-miR-181a-5p	Luciferase reporter assay, Western blot	17382377
MIRT006481	hsa-miR-181a-5p	Luciferase reporter assay, Western blot	17382377
MIRT006481	hsa-miR-181a-5p	Luciferase reporter assay, Western blot	17382377
MIRT006481	hsa-miR-181a-5p	Luciferase reporter assay, Western blot	17382377
MIRT006481	hsa-miR-181a-5p	Luciferase reporter assay, Western blot	17382377
MIRT006481	hsa-miR-181a-5p	Luciferase reporter assay, Western blot	17382377
MIRT018633	hsa-miR-335-5p	Microarray	18185580
MIRT020032	hsa-miR-375	Microarray	20215506
MIRT438607	hsa-miR-125b-5p	Luciferase reporter assay, Western blot, qRT-PCR	25001178
MIRT438607	hsa-miR-125b-5p	Luciferase reporter assay, Western blot, qRT-PCR	25001178
MIRT613137	hsa-miR-5195-3p	HITS-CLIP	23824327
MIRT613136	hsa-miR-145-5p	HITS-CLIP	23824327
MIRT613135	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT624078	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT613134	hsa-miR-8485	HITS-CLIP	23824327
MIRT613133	hsa-miR-603	HITS-CLIP	23824327
MIRT613132	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT613131	hsa-miR-4328	HITS-CLIP	23824327
MIRT624077	hsa-miR-1178-3p	HITS-CLIP	23824327
MIRT613137	hsa-miR-5195-3p	HITS-CLIP	23824327
MIRT613136	hsa-miR-145-5p	HITS-CLIP	23824327
MIRT613135	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT624078	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT613134	hsa-miR-8485	HITS-CLIP	23824327
MIRT613133	hsa-miR-603	HITS-CLIP	23824327
MIRT658838	hsa-miR-300	HITS-CLIP	23824327
MIRT658837	hsa-miR-381-3p	HITS-CLIP	23824327
MIRT658836	hsa-miR-4666a-3p	HITS-CLIP	23824327
MIRT613132	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT613131	hsa-miR-4328	HITS-CLIP	23824327
MIRT615027	hsa-let-7a-3p	HITS-CLIP	23824327
MIRT615026	hsa-let-7b-3p	HITS-CLIP	23824327
MIRT615025	hsa-let-7f-1-3p	HITS-CLIP	23824327
MIRT615024	hsa-miR-98-3p	HITS-CLIP	23824327
MIRT615023	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT615022	hsa-let-7f-2-3p	HITS-CLIP	23824327
MIRT615021	hsa-miR-1185-1-3p	HITS-CLIP	23824327
MIRT615020	hsa-miR-1185-2-3p	HITS-CLIP	23824327
MIRT624077	hsa-miR-1178-3p	HITS-CLIP	23824327
MIRT613137	hsa-miR-5195-3p	HITS-CLIP	23824327
MIRT613136	hsa-miR-145-5p	HITS-CLIP	23824327
MIRT613135	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT624078	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT613134	hsa-miR-8485	HITS-CLIP	23824327
MIRT613133	hsa-miR-603	HITS-CLIP	23824327
MIRT613132	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT613131	hsa-miR-4328	HITS-CLIP	23824327
MIRT624077	hsa-miR-1178-3p	HITS-CLIP	23824327
MIRT613137	hsa-miR-5195-3p	HITS-CLIP	23824327
MIRT613136	hsa-miR-145-5p	HITS-CLIP	23824327
MIRT613135	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT624078	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT613134	hsa-miR-8485	HITS-CLIP	23824327
MIRT613133	hsa-miR-603	HITS-CLIP	23824327
MIRT613132	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT613131	hsa-miR-4328	HITS-CLIP	23824327
MIRT624077	hsa-miR-1178-3p	HITS-CLIP	23824327
MIRT613137	hsa-miR-5195-3p	HITS-CLIP	23824327
MIRT613136	hsa-miR-145-5p	HITS-CLIP	23824327
MIRT613135	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT624078	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT613134	hsa-miR-8485	HITS-CLIP	23824327
MIRT613133	hsa-miR-603	HITS-CLIP	23824327
MIRT613132	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT624077	hsa-miR-1178-3p	HITS-CLIP	23824327
MIRT613137	hsa-miR-5195-3p	HITS-CLIP	23824327
MIRT613136	hsa-miR-145-5p	HITS-CLIP	23824327
MIRT613135	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT624078	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT613134	hsa-miR-8485	HITS-CLIP	23824327
MIRT613133	hsa-miR-603	HITS-CLIP	23824327
MIRT613132	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT613131	hsa-miR-4328	HITS-CLIP	23824327
MIRT624077	hsa-miR-1178-3p	HITS-CLIP	23824327
MIRT613137	hsa-miR-5195-3p	HITS-CLIP	23824327
MIRT613136	hsa-miR-145-5p	HITS-CLIP	23824327
MIRT613134	hsa-miR-8485	HITS-CLIP	23824327
MIRT613133	hsa-miR-603	HITS-CLIP	23824327
MIRT613132	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT613131	hsa-miR-4328	HITS-CLIP	23824327
MIRT615027	hsa-let-7a-3p	HITS-CLIP	23824327
MIRT615026	hsa-let-7b-3p	HITS-CLIP	23824327
MIRT615025	hsa-let-7f-1-3p	HITS-CLIP	23824327
MIRT615024	hsa-miR-98-3p	HITS-CLIP	23824327
MIRT615023	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT615022	hsa-let-7f-2-3p	HITS-CLIP	23824327
MIRT615021	hsa-miR-1185-1-3p	HITS-CLIP	23824327
MIRT615020	hsa-miR-1185-2-3p	HITS-CLIP	23824327
MIRT613137	hsa-miR-5195-3p	HITS-CLIP	23824327
MIRT613136	hsa-miR-145-5p	HITS-CLIP	23824327
MIRT613135	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT613134	hsa-miR-8485	HITS-CLIP	23824327
MIRT613133	hsa-miR-603	HITS-CLIP	23824327
MIRT613132	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT613131	hsa-miR-4328	HITS-CLIP	23824327
MIRT006481	hsa-miR-181a-5p	Flow, Microarray, qRT-PCR	25477247
MIRT613137	hsa-miR-5195-3p	HITS-CLIP	23824327
MIRT613136	hsa-miR-145-5p	HITS-CLIP	23824327
MIRT613135	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT624078	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT613134	hsa-miR-8485	HITS-CLIP	23824327
MIRT613133	hsa-miR-603	HITS-CLIP	23824327
MIRT613132	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT613131	hsa-miR-4328	HITS-CLIP	23824327
MIRT624077	hsa-miR-1178-3p	HITS-CLIP	23824327
MIRT613137	hsa-miR-5195-3p	HITS-CLIP	23824327
MIRT613136	hsa-miR-145-5p	HITS-CLIP	23824327
MIRT613135	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT624078	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT613134	hsa-miR-8485	HITS-CLIP	23824327
MIRT613133	hsa-miR-603	HITS-CLIP	23824327
MIRT658838	hsa-miR-300	HITS-CLIP	23824327
MIRT658837	hsa-miR-381-3p	HITS-CLIP	23824327
MIRT658836	hsa-miR-4666a-3p	HITS-CLIP	23824327
MIRT613132	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT613131	hsa-miR-4328	HITS-CLIP	23824327
MIRT615027	hsa-let-7a-3p	HITS-CLIP	23824327
MIRT615026	hsa-let-7b-3p	HITS-CLIP	23824327
MIRT615025	hsa-let-7f-1-3p	HITS-CLIP	23824327
MIRT615024	hsa-miR-98-3p	HITS-CLIP	23824327
MIRT615023	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT615022	hsa-let-7f-2-3p	HITS-CLIP	23824327
MIRT615021	hsa-miR-1185-1-3p	HITS-CLIP	23824327
MIRT615020	hsa-miR-1185-2-3p	HITS-CLIP	23824327
MIRT624077	hsa-miR-1178-3p	HITS-CLIP	23824327
MIRT613137	hsa-miR-5195-3p	HITS-CLIP	23824327
MIRT613136	hsa-miR-145-5p	HITS-CLIP	23824327
MIRT613135	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT624078	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT613134	hsa-miR-8485	HITS-CLIP	23824327
MIRT613133	hsa-miR-603	HITS-CLIP	23824327
MIRT613132	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT613131	hsa-miR-4328	HITS-CLIP	23824327
MIRT624077	hsa-miR-1178-3p	HITS-CLIP	23824327
MIRT613137	hsa-miR-5195-3p	HITS-CLIP	23824327
MIRT613136	hsa-miR-145-5p	HITS-CLIP	23824327
MIRT613135	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT624078	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT613134	hsa-miR-8485	HITS-CLIP	23824327
MIRT613133	hsa-miR-603	HITS-CLIP	23824327
MIRT613132	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT613131	hsa-miR-4328	HITS-CLIP	23824327
MIRT624077	hsa-miR-1178-3p	HITS-CLIP	23824327
MIRT613137	hsa-miR-5195-3p	HITS-CLIP	23824327
MIRT613136	hsa-miR-145-5p	HITS-CLIP	23824327
MIRT613135	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT624078	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT613134	hsa-miR-8485	HITS-CLIP	23824327
MIRT613133	hsa-miR-603	HITS-CLIP	23824327
MIRT613132	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT624077	hsa-miR-1178-3p	HITS-CLIP	23824327
MIRT613137	hsa-miR-5195-3p	HITS-CLIP	23824327
MIRT613136	hsa-miR-145-5p	HITS-CLIP	23824327
MIRT613135	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT624078	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT613134	hsa-miR-8485	HITS-CLIP	23824327
MIRT613133	hsa-miR-603	HITS-CLIP	23824327
MIRT613132	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT613131	hsa-miR-4328	HITS-CLIP	23824327
MIRT624077	hsa-miR-1178-3p	HITS-CLIP	23824327
MIRT613137	hsa-miR-5195-3p	HITS-CLIP	23824327
MIRT613136	hsa-miR-145-5p	HITS-CLIP	23824327
MIRT613134	hsa-miR-8485	HITS-CLIP	23824327
MIRT613133	hsa-miR-603	HITS-CLIP	23824327
MIRT613132	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT613131	hsa-miR-4328	HITS-CLIP	23824327
MIRT615027	hsa-let-7a-3p	HITS-CLIP	23824327
MIRT615026	hsa-let-7b-3p	HITS-CLIP	23824327
MIRT615025	hsa-let-7f-1-3p	HITS-CLIP	23824327
MIRT615024	hsa-miR-98-3p	HITS-CLIP	23824327
MIRT615023	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT615022	hsa-let-7f-2-3p	HITS-CLIP	23824327
MIRT615021	hsa-miR-1185-1-3p	HITS-CLIP	23824327
MIRT615020	hsa-miR-1185-2-3p	HITS-CLIP	23824327
MIRT613137	hsa-miR-5195-3p	HITS-CLIP	23824327
MIRT613136	hsa-miR-145-5p	HITS-CLIP	23824327
MIRT613135	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT613134	hsa-miR-8485	HITS-CLIP	23824327
MIRT613133	hsa-miR-603	HITS-CLIP	23824327
MIRT613132	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT613131	hsa-miR-4328	HITS-CLIP	23824327
MIRT756268	hsa-miR-101-5p	Luciferase reporter assay, Western blotting, qRT-PCR	37300650
MIRT948222	hsa-miR-2114	CLIP-seq
MIRT2215976	hsa-miR-125a-5p	CLIP-seq
MIRT2215977	hsa-miR-125b	CLIP-seq
MIRT2215978	hsa-miR-1273c	CLIP-seq
MIRT2215979	hsa-miR-1284	CLIP-seq
MIRT2215980	hsa-miR-3121-5p	CLIP-seq
MIRT2215981	hsa-miR-3185	CLIP-seq
MIRT2215982	hsa-miR-3683	CLIP-seq
MIRT2215983	hsa-miR-4257	CLIP-seq
MIRT2215984	hsa-miR-4319	CLIP-seq
MIRT2215985	hsa-miR-450a	CLIP-seq
MIRT2215986	hsa-miR-452	CLIP-seq
MIRT2215987	hsa-miR-4676-3p	CLIP-seq
MIRT2215988	hsa-miR-4731-3p	CLIP-seq
MIRT2215989	hsa-miR-4732-3p	CLIP-seq
MIRT2215990	hsa-miR-4753-3p	CLIP-seq
MIRT2215991	hsa-miR-4797-5p	CLIP-seq
MIRT2215992	hsa-miR-4801	CLIP-seq
MIRT2215993	hsa-miR-548p	CLIP-seq
MIRT2215994	hsa-miR-590-3p	CLIP-seq
MIRT2215995	hsa-miR-670	CLIP-seq
MIRT2215976	hsa-miR-125a-5p	CLIP-seq
MIRT2215977	hsa-miR-125b	CLIP-seq
MIRT2428409	hsa-miR-145	CLIP-seq
MIRT2428410	hsa-miR-3117-5p	CLIP-seq
MIRT2215981	hsa-miR-3185	CLIP-seq
MIRT2428411	hsa-miR-369-3p	CLIP-seq
MIRT2428412	hsa-miR-374a	CLIP-seq
MIRT2428413	hsa-miR-374b	CLIP-seq
MIRT2428414	hsa-miR-377	CLIP-seq
MIRT2428415	hsa-miR-381	CLIP-seq
MIRT2215983	hsa-miR-4257	CLIP-seq
MIRT2428416	hsa-miR-4267	CLIP-seq
MIRT2215984	hsa-miR-4319	CLIP-seq
MIRT2215986	hsa-miR-452	CLIP-seq
MIRT2428417	hsa-miR-4666-3p	CLIP-seq
MIRT2215987	hsa-miR-4676-3p	CLIP-seq
MIRT2215989	hsa-miR-4732-3p	CLIP-seq
MIRT2215991	hsa-miR-4797-5p	CLIP-seq
MIRT2215994	hsa-miR-590-3p	CLIP-seq
MIRT2215995	hsa-miR-670	CLIP-seq
MIRT2215976	hsa-miR-125a-5p	CLIP-seq
MIRT2215977	hsa-miR-125b	CLIP-seq
MIRT2520151	hsa-miR-140-3p	CLIP-seq
MIRT2428409	hsa-miR-145	CLIP-seq
MIRT2520152	hsa-miR-216b	CLIP-seq
MIRT2520153	hsa-miR-223	CLIP-seq
MIRT2428410	hsa-miR-3117-5p	CLIP-seq
MIRT2520154	hsa-miR-3160-3p	CLIP-seq
MIRT2520155	hsa-miR-3180-5p	CLIP-seq
MIRT2215981	hsa-miR-3185	CLIP-seq
MIRT2428414	hsa-miR-377	CLIP-seq
MIRT2428415	hsa-miR-381	CLIP-seq
MIRT2215983	hsa-miR-4257	CLIP-seq
MIRT2520156	hsa-miR-4261	CLIP-seq
MIRT2520157	hsa-miR-4268	CLIP-seq
MIRT2520158	hsa-miR-4277	CLIP-seq
MIRT2215984	hsa-miR-4319	CLIP-seq
MIRT2520159	hsa-miR-4452	CLIP-seq
MIRT2520160	hsa-miR-4474-5p	CLIP-seq
MIRT2520161	hsa-miR-4496	CLIP-seq
MIRT2215986	hsa-miR-452	CLIP-seq
MIRT2428417	hsa-miR-4666-3p	CLIP-seq
MIRT2215987	hsa-miR-4676-3p	CLIP-seq
MIRT2520162	hsa-miR-4690-3p	CLIP-seq
MIRT2520163	hsa-miR-4709-3p	CLIP-seq
MIRT2520164	hsa-miR-4719	CLIP-seq
MIRT2215989	hsa-miR-4732-3p	CLIP-seq
MIRT2215990	hsa-miR-4753-3p	CLIP-seq
MIRT2215991	hsa-miR-4797-5p	CLIP-seq
MIRT2520165	hsa-miR-493	CLIP-seq
MIRT2520166	hsa-miR-520a-5p	CLIP-seq
MIRT2520167	hsa-miR-525-5p	CLIP-seq
MIRT2215994	hsa-miR-590-3p	CLIP-seq
MIRT2215995	hsa-miR-670	CLIP-seq
MIRT2520168	hsa-miR-9	CLIP-seq
MIRT2520151	hsa-miR-140-3p	CLIP-seq
MIRT2520152	hsa-miR-216b	CLIP-seq
MIRT2520154	hsa-miR-3160-3p	CLIP-seq
MIRT2520157	hsa-miR-4268	CLIP-seq
MIRT2520159	hsa-miR-4452	CLIP-seq
MIRT2520164	hsa-miR-4719	CLIP-seq
MIRT2215990	hsa-miR-4753-3p	CLIP-seq
MIRT2215991	hsa-miR-4797-5p	CLIP-seq
MIRT2520168	hsa-miR-9	CLIP-seq

Transcription factors

Show/Hide all(1)

Transcription factor	Regulation	Reference
ETS1	Unknown	20097731

Show/Hide all(39)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000165	Process	MAPK cascade	TAS
GO:0004721	Function	Phosphoprotein phosphatase activity	IEA
GO:0004722	Function	Protein serine/threonine phosphatase activity	IEA
GO:0004725	Function	Protein tyrosine phosphatase activity	IEA
GO:0004725	Function	Protein tyrosine phosphatase activity	TAS
GO:0005515	Function	Protein binding	IPI	12840032, 18060821, 27880917, 31980649, 32296183, 32707033, 32721402, 32814053
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	8670865, 9788880
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0007165	Process	Signal transduction	IBA
GO:0008138	Function	Protein tyrosine/serine/threonine phosphatase activity	IEA
GO:0008138	Function	Protein tyrosine/serine/threonine phosphatase activity	TAS
GO:0008330	Function	Protein tyrosine/threonine phosphatase activity	IBA
GO:0009410	Process	Response to xenobiotic stimulus	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0017017	Function	MAP kinase tyrosine/serine/threonine phosphatase activity	IBA
GO:0017017	Function	MAP kinase tyrosine/serine/threonine phosphatase activity	IDA	8670865
GO:0017017	Function	MAP kinase tyrosine/serine/threonine phosphatase activity	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0033550	Function	MAP kinase tyrosine phosphatase activity	IBA
GO:0035335	Process	Peptidyl-tyrosine dephosphorylation	IDA	8670865
GO:0043065	Process	Positive regulation of apoptotic process	IBA
GO:0043065	Process	Positive regulation of apoptotic process	IDA	10846176
GO:0043409	Process	Negative regulation of MAPK cascade	IDA	8670865
GO:0043409	Process	Negative regulation of MAPK cascade	IEA
GO:0051409	Process	Response to nitrosative stress	IEP	10846176
GO:0060420	Process	Regulation of heart growth	IBA
GO:0060420	Process	Regulation of heart growth	IEA
GO:0070371	Process	ERK1 and ERK2 cascade	IEA
GO:0070371	Process	ERK1 and ERK2 cascade	TAS
GO:0070373	Process	Negative regulation of ERK1 and ERK2 cascade	IBA
GO:0070373	Process	Negative regulation of ERK1 and ERK2 cascade	IEA
GO:0070373	Process	Negative regulation of ERK1 and ERK2 cascade	IMP	18771677
GO:0070848	Process	Response to growth factor	IEA

MIM	HGNC	e!Ensembl
602748	3072	ENSG00000139318

Protein

UniProt ID

Q16828

Protein name

Dual specificity protein phosphatase 6 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase PYST1) (Mitogen-activated protein kinase phosphatase 3) (MAP kinase phosphatase 3) (MKP-3)

Protein function

Dual specificity protein phosphatase, which mediates dephosphorylation and inactivation of MAP kinases (PubMed:8670865). Has a specificity for the ERK family (PubMed:8670865). Plays an important role in alleviating chronic postoperative pain (By

PDB

1HZM , 1MKP

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00581	Rhodanese	19 → 142	Rhodanese-like domain	Domain
PF00782	DSPc	214 → 346	Dual specificity phosphatase, catalytic domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in keratinocytes (at protein level). {ECO:0000269|PubMed:29043977}.

Sequence

MIDTLRPVPFASEMAISKTVAWLNEQLELGNERLLLMDCRPQELYESSHIESAINVAIPG
IMLRRLQKGNLPVRALFTRGEDRDRFTRRCGTDTVVLYDESSSDWNENTGGESVLGLLLK
KLKDEGCRAFYLEGGFSKFQAEFSLHCETNLDGSCSSSSPPLPVLGLGGLRISSDSSSDI
ESDLDRDPNSATDSDGSPLSNSQPSFPVEILPFLYLGCAKDSTNLDVLEEFGIKYILNVT
PNLPNLFENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRS
VTVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTLGLSSPCDNRVPAQ
QLYFTTPSNQNVYQVDSLQST

Sequence length

381

Interactions

View interactions

Show/Hide Unknown Diseases (10)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Alzheimer disease	Alzheimer's disease or family history of Alzheimer's disease	N/A	N/A	GWAS
Attention Deficit Hyperactivity Disorder	Attention deficit hyperactivity disorder	N/A	N/A	GWAS
Heart Failure	Heart failure	N/A	N/A	GWAS
Hypogonadotropic Hypogonadism	hypogonadotropic hypogonadism	N/A	N/A	GenCC
Hypogonadotropic Hypogonadism With Or Without Anosmia	hypogonadotropic hypogonadism 19 with or without anosmia	N/A	N/A	ClinVar, GenCC
Insomnia	Insomnia	N/A	N/A	GWAS
Kallmann Syndrome	Kallmann syndrome	N/A	N/A	GenCC
Melanoma	Melanoma	Together, these data suggest that genetic suppression of DUSP4/6 induces growth arrest in NRAS mutant cutaneous melanoma cells through their phosphatase activity.	34857952	CBGDA
Metabolic Syndrome	Metabolic syndrome	N/A	N/A	GWAS
Myocardial Infarction	Myocardial infarction	N/A	N/A	GWAS

Show/Hide Text Mining Associations (59)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Acute Aortic Syndrome	Associate	36309656
Acute Kidney Injury	Associate	37026010
Adenocarcinoma of Lung	Associate	26301689, 30475204
Adenoma	Associate	15832194, 30111351
Aortic Aneurysm Abdominal	Associate	22797469
Breast Neoplasms	Associate	20413845, 20554528, 23921636, 25201346, 26859151, 34970732
Cap Myopathy	Associate	37681336
Carcinogenesis	Associate	15832194, 19608870
Carcinogenesis	Inhibit	31553703
Carcinoma Ductal	Inhibit	15832194
Carcinoma in Situ	Stimulate	12759238
Carcinoma Intraductal Noninfiltrating	Associate	15832194
Carcinoma Non Small Cell Lung	Associate	17202451, 25344212, 27418131, 28231233, 29578153, 31170692
Carcinoma Squamous Cell	Associate	22427941, 27613525, 29578153
Cardiovascular Diseases	Associate	24184689
Colorectal Neoplasms	Associate	25339833, 29270670, 29368606, 33658394
COVID 19	Associate	37026010
Death	Associate	27613525
Drug Related Side Effects and Adverse Reactions	Associate	30572643
Endometrial Neoplasms	Associate	20638106
Endometrial Neoplasms	Inhibit	31553703
Enterocolitis Necrotizing	Associate	31985475
Epilepsy	Associate	17910586
Epilepsy Partial with Variable Foci	Stimulate	17910586
Glioblastoma	Associate	32771050, 35441887, 36814929
Hemochromatosis	Associate	40508017
Hereditary Breast and Ovarian Cancer Syndrome	Associate	26859151
Hirschsprung Disease	Associate	26097584
Hypogonadism	Associate	37108593, 40508017
Ischemia	Associate	22848708
Kallmann Syndrome	Associate	37108593
Kidney Neoplasms	Associate	30075554
Leukemia Large Granular Lymphocytic	Associate	34873301
Leukemia Lymphocytic Chronic B Cell	Associate	37792532
Lung Neoplasms	Inhibit	19608870
Lung Neoplasms	Associate	20097731, 28231233, 29578153
Malformations of Cortical Development Group I	Associate	19833733
Malocclusion	Associate	28257739
Malocclusion Angle Class III	Associate	28257739
Melanoma	Associate	28423600, 30630828, 35189148, 35999349
Mitochondrial Diseases	Associate	30572643
Neoplasm Invasiveness	Inhibit	15832194
Neoplasm Metastasis	Associate	29050982, 36462498, 36624125
Neoplasms	Inhibit	12759238, 15832194, 18694935, 18771677, 20097731, 22427941, 28423600, 31553703, 36017891
Neoplasms	Associate	19608870, 20413845, 20638106, 25344212, 28231233, 29368606, 30111351, 30475204, 32771050, 37681336, 38039779
Osteoporosis	Associate	35188450
Pancreatic Intraductal Neoplasms	Associate	15832194
Pancreatic Neoplasms	Associate	12759238, 15832194, 18694935, 20638106, 36017891
Pediatric Obesity	Associate	31985475
Pleural Effusion	Associate	37095178
Pleural Effusion Malignant	Associate	37095178
Prostatic Neoplasms	Associate	28876465, 37681336
Renal Insufficiency Chronic	Associate	37026010
Retinitis Pigmentosa	Stimulate	22848708
Stomach Neoplasms	Associate	24716913
Stomach Neoplasms	Stimulate	29050982
Thyroid Cancer Papillary	Associate	25499223
Triple Negative Breast Neoplasms	Associate	25201346, 34970732
Uterine Cervical Dysplasia	Associate	15832194

DUSP6 (dual specificity phosphatase 6)